Halogenated Compounds

<p>Stability Hygroscopic<br>Applications YttriumTrifluoroacetate is a useful reactant in engineering process of thermal reaction with sodium trifluoroacetate.<br>References Mai, H., et al.: J. Am. Chem. Soc., 128, 6426 (2006);<br></p>

<p>Applications 3-Fluorotoluene-alpha-d1 (CAS# 2118336-62-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Chloroadamantane-d15 is the isotope labelled analog of 1-Chloroadamantane, an adamantane derivative shown to exhibit virucidal activity against the Newcastle disease virus in chick embryo fibroblasts.<br>References Aigami, K., et al.: J. Med. Chem., 18, 713 (1975)<br></p>

<p>Applications N-(4-chloro-2-methylphenyl)acetamide (cas# 5202-86-8) is a useful research chemical.<br></p>

<p>Applications N-(2-Chloro-4-methylpyridin-3-yl)-2-(cyclopropylamino)benzamide is a useful intermediate for organic synthesis.<br></p>

<p>Applications 5-(4'-(Dibromomethyl)-[1,1'-biphenyl]-2-yl)-1H-tetrazole is a reagent in the preperation of sartan lateral chain compounds.<br>References Yan, Q.: Faming Zhuanli Shenqing. 7 pp. (2009)<br></p>

<p>Applications 1,4-dibromo-2,3-dimethyl-2-butene is a reagent used in the synthesis, spectroscopic characterization, and structural studies of novel aldehyde and thiosemicarbazone derivatives.<br>References Karakurt, T. et al.: Jour. of Mol. Stru. 1125, 470-480, (2016)<br></p>

<p>Applications (Z)-4-Amino-N,N'-bis(4-(trifluoromethyl)phenyl)benzimidamide is a useful intermediate for organic synthesis.<br></p>

<p>Applications 1,3-Diiodopropane is a useful research chemical. A reagent used in the preparation of synthetically challenging bridged achiral 1,2,4,5-tetraoxanes with antimalarial properties.<br>References Ellis, G. L., et al.: Bioorg. Med. Chem. Lett., 18, 1720 (2008)<br></p>

<p>Applications 1-(2-Aminophenyl)-2-chloroethanone is a reagent in the synthesis of 4-(2-Aminophenyl)-4-oxo-2-butenoic Acid (A638220) which is a novel human lens metabolite from normal and cataractous human lenses. A UV filter.<br>References Mizdrak, J., et al.: Tetrahedron, 63, 4990 (2007); Taylor, L. M., et al.: Exp. Eye Res., 75, 165 (2002)<br></p>

<p>Applications 1,3-Dichloro-5-ethyl-5-methylhydantoin is used in method and system for autonomous self-limiting generation of Chlorine Dioxide.<br>References Martin, Roy W., et al.: U.S. Pat. Appl. Publ., (2018);<br></p>

<p>Applications 1-Bromotridecane-10,10,11,11,12,12,13,13,13-d9 is a useful isotopically labeled compound of 1-Bromotridecane (B688365)<br></p>

<p>Applications 2,4'-Dibromobenzophenone (CAS# 78281-59-1) is a useful research chemical compound.<br></p>

<p>Applications 1-(3-Chloro-2-hydroxypropyl)-2-nitroimidazole is an intermediate in the synthesis of 1-(2,3-Epoxypropyl)-2-nitroimidazole (B592583) which is an intermediate in the synthesis of Pimonidazole-d10 (P447814). Isotope labelled Pimonidazole (P447813) is an effective and nontoxic hypoxia detection reagent. Pimonidazole forms adducts with thiol groups in proteins, peptides and amino acids. It abels hypoxic tumor cells in vivo. Also labels hypoxic mesenchymal stem cells in mouse bone marrow.<br>References Sato et al.: PLoS One 11 e0165946 PMID:(2016); Bennewith et al.: Cancer Res. 62 6827 PMID: 12460894, (2002)<br></p>

<p>Applications 4,5-Dibromo-2-benzoylpyrrole is used in preparation of 2,3-Dibromo-5-benzoyl Pyrrole via amidation of morpholine with Benzoyl Chloride, followed by Friedel-Crafts reaction with pyrrole and substitution with Br2.<br>References Yang, Q., et al.: Faming Zhuanli Shenqing, (2012);<br></p>

<p>Applications Ethyl 4-Chloroacetoacetate (E901800) is the parent compound for Ethyl 4-Chloro-2-ethyl-3-oxobutanoate. Ethyl 4-Chloroacetoacetateis used in the production of Ethyl (R)-4-Chloro-3-hydroxybutyrate. Also in preparation of Tricyclic substituted Piperidine dione comppunds useful for the treatment of diseases related to CRBN protein.<br>References Ding, X., et al.: Faming Zhuanli Shenqing, (2019); Luo, Y., et al.: PCT Int. Appl., (2020);<br></p>

<p>Applications 1-CHLOROHEXANE (cas# 544-10-5) is a useful research chemical.<br></p>

<p>Applications 4-((4-Chlorophenyl)(phenyl)methyl)-1,1-Bis(2-(2-hydroxyethoxy)ethyl)piperazin-1-ium Bromide is a useful research compound.<br></p>

<p>Applications 5-(4-Chloro-3-fluorophenyl)-2-furoic Acid is an impurity of 5-(3-Chlorophenyl)-2-furoic Acid (C378150); a reagent in the synthesis of Dantrolene (D185000) which has the potential to treat vascular dysfunction.<br>References Ellis, K.O., et al.: J. Pharm. Sci., 69, 327 (1980); Harrison, G.G., et al.: Brit. J. Anaesth., 60, 279 (1988); Murasawa, S., et al.: Bioorg. Med. Chem., 20, 6384 (2012)<br></p>

<p>Applications N-(2,4-Dichloro-5-methoxyphenyl)acetamide is a reactant used in the chlorination of acetanilides with benzyltrimethylammonium tetrachloroiodate(B316185).<br>References Kajigaeshi, S., et al.: Bull. Chem. Soc. Jpn., 63, 941 (1990)<br></p>

<p>Applications 5-FLUORO-2,3-DIHYDROBENZOFURAN (cas# 245762-35-0) is a useful research chemical.<br></p>

<p>Applications 1-Bromodecane-10,10,10-d3 (CAS# 284474-47-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,2,4-Trichlorobenzene- 13C6 is the labeled form of 1,2,4-Trichlorobenzene (T774220). It is an intermediate in the synthesis of PCB 101-13C12 (P216628) which is a related compound of PCB 189-13C12(P216622), which is a flame retardant and a standard for environmental testing and research.<br>References EPA. Method 1668, (EPA 821-R-00-002) (1999)<br></p>

<p>Applications N-(2-Bromo-5-fluorophenyl)acetamide is a reagent in the preparation of fluorinated rhodacyanine analogues with antileishmanial properties.<br>References Lasing, T., et al.: Bioorg. Med. Chem., 28, 115187 (2020)<br></p>

<p>Applications p-Chlorobenzoyl anisole is a reagent used in the synthesis of styrenyl ethers via Bamford-Stevens reaction of aryloxy/alkoxy acetophenones.<br>References Mete, T. B. et al.: Chem. Selec. 3(26), 7656-7659. (2018)<br></p>

<p>Applications 2-((3-(4-Chlorophenyl)-3-(pyridin-2-yl)propyl)dimethylammonio)acetate is a useful intermediate for organic synthesis.<br></p>

<p>Applications A chemical model used for the study and analysis of human buccal absorption of pharmaceuticals.A fundamental starting material for organic compound synthesis.<br>References Vora, K., et al.: J. Pharm. Sci., 61, 1785 (1972),<br></p>

<p>Applications 6-Fluoro-3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine is a useful research chemical.<br></p>

<p>Applications 2-iodo-4-methylphenol is a useful research chemical for organic synthesis and other chemical processes.<br>References Liu, Y., et al.: RSC Advances, 8, 28637 (2018); Xu, S., et al.: Mol. Catal., 452, 264 (2018); Alonso-Maranon, L., et al.: J. Org. Chem., 83, 7970 (2018)<br></p>

<p>Applications 1-Phenyl-2-methyl-6-chlorobenzimidazole is a useful research chemical.<br></p>

<p>Applications (3,5-Dichloropyrazin-2-yl)methanamine is a reagent used in the preparation of triazolopyrazines and related bicyclic nitrogen heterocycles as Ahr modulators for treatment of diseases.<br>References Beck, H. P. et al.: PCT Int. Appl. 86 pp. (2019)<br></p>

<p>Applications 4-Iodopyrimidine is used as a reactant in the preparation of 1,3,8-triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia.<br>References Vachal, P., et. al.: J. Med. Chem., 55, 2945 (2012)<br></p>

<p>Applications 2-Bromo-3-methoxybenzoic acid (cas# 88377-29-1) is a useful research chemical.<br></p>

<p>Applications 2-Chlorotetrahydro-2-oxo-2H-1,3,2-oxazaphosphorin is an intermediate in the synthesis of N-Dides(2-chloroethyl) N-(2-Hydroxyethyl),N-(2-ethoxyethyl) Cyclophosphamide (C984610) which is a derivative of Cyclophosphamide Monohydrate (C988580), a known human carcinogen that is widely used in cancer chemotherapy because it can cross-link DNA causing strand breakage and mutation.<br>References Wheeler, A.G., et al.: Toxicol. Appl. Pharmacol., 4, 324 (1962), Fraiser, L.H., et al.: Drugs, 42, 781 (1991), Colvin, O.M., et al.: Curr. Pharmaceut. Design, 5, 555 (1999)<br></p>

<p>Applications 4,5-Dibromo-1,2-cyclohexanediol is an intermediate in the synthesis of Conduritol A (C645000). Conduritol A (cas# 526-87-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-(1-oxooctadecyl)-1-piperazinyl]-3-quinolinecarboxylic Acid is used in biological studies as a modifier or additive for the sustained release of norfloxacin.<br>References Dong, M. et al.: Fam. Zhu. She. (2016)<br></p>

<p>Applications 2,5-Bis(2,2,2-trifluoroethoxy)-1,4-benzenedicarboxylic Acid is used in the synthesis of new fluorinated ethers of aromatic acids and diesters.<br>References Ritter, J. C., et al.: From PCT Int. Appl. (2011), WO 2011028852 A2 20110310<br></p>

<p>Applications [5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetic acid (cas# 345637-71-0) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Octafluoro-4,4'-biphenol (cas# 2200-70-6) is a useful research chemical.<br></p>

<p>Applications (1,2-Dibromo-3,3-dimethylbutyl)trimethylsilane is an intermediate in the synthesis of 1-Bromo-3,3-dimethyl-1-butene (B740080) which is used as a reagent in the preparation of bromo(dimethyl)butenes via elimination of dibromo(dimethyl)butane in the preparation of alkynes.<br>References Sydnes, L. K., et al.: Monatsh. Chem., 136, 1737 (2005)<br></p>

<p>Applications 4,4-Dibromo-2,4-dihydro-5-methyl-3H-pyrazol-3-one is used in the preparation of antimoebic compounds such as thiosemicarbazide derivatives. Also used in the preparation of triazine molecules displaying antifungal activity.<br>References Singh, S. et al.: Eur. J. Pharm. Sci., 25, 255 (2005); Tewari, A. et al.: Indian. J. Chem. B., 41B, 664 (2002);<br></p>

<p>Applications 1,1-Dimethylethyl Ester N-(3-Iodopropyl)carbamic Acid (cas# 167479-01-8) is a useful research chemical.<br></p>

<p>Applications 6'-Bromo-2',3'-dihydro-spiro[imidazolidine-4,1'-[1H]indene]-2,5-dione has 5,5-Tetramethylenehydantoin in its structure. 5,5-Tetramethylenehydantoin is used in preparation of substituted heteroaryl compounds which are useful in the treatment of cognitive dysfunction and CNS disorders.<br>References Toop, H., et al.: PCT Int. Appl., (2020);<br></p>

<p>Applications 3,5-Dichlorobiphenyl-2',3',4',5',6'-d5 (CAS# 1276197-28-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Chlorohexadecane-d33 (CAS# 352431-13-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-(4-Bromophenyl)piperazine Hydrochloride is useful in the synthesis of large bifunctional heterocycles use in targeted degradation of rapidly accelerated fibrosarcoma polypeptides<br>References Crew, A., et al.: U.S. Pat. Appl. Publ., 1094 (2020)<br></p>

<p>Applications 4-(Bromomethyl)nonane can be used as both a reagent and is incorporated into anionic surfactants.<br>References Jin, Z., et al.: J. Dispersion. Sci. Technol., 32, 898-902 (2011)<br></p>