Ethers

5-(Difluoromethoxy)-2-mercaptobenzimidazole is an organic solvent that is used in the crystallization process of pantoprazole, a benzimidazole derivative. It is also used as a corrosion inhibitor and pump inhibitor in analytical chemistry. The purity of 5-(difluoromethoxy)-2-mercaptobenzimidazole can be determined by chromatographic methods or by the use of analytical chemistry. Impurities may be genotoxic and include reactive impurities such as thiourea and 2-thiouracil. These impurities are removed during the synthetic process to produce 5-(difluoromethoxy)-2-mercaptobenzimidazole. This drug substance has been found to inhibit DNA polymerase activity in vitro, but its effects on human cells have not been studied.

3,4-Diethoxybenzylalcohol is a metabolite produced by the fungus Ustilago maydis. It has been shown to have pleiotropic effects on the metabolism of the organism. 3,4-Diethoxybenzylalcohol is involved in lignin biosynthesis and bond cleavage reactions. In addition to functioning as an intermediate in the pentose phosphate pathway, it is involved in the nature of the basidiomycete cell wall and also plays a role in carbon source utilization.

Bosentan is a potent inhibitor of the uptake of organic anions. It is used in the treatment of pulmonary arterial hypertension and has been shown to be effective against pravastatin-resistant HIV protease inhibitors, such as saquinavir, quinidine, and rosuvastatin. Bosentan inhibits uptake by binding to the transporter protein at a site that does not overlap with the binding site for organic anion substrates. This leads to a change in kinetic parameters for substrates, such as pravastatin and saquinavir. The binding site on bosentan may also be elucidated through monolayer experiments with efflux transporters.

3-(2-Fluoroethoxy)Propanenitrile is a chemical with toxic properties. It is classified as a fluoroacetic acid and has been used in the production of other chemicals. Fluoroacetic acid is toxic to humans, showing signs of skin irritation, respiratory tract irritation, and kidney damage. 3-(2-Fluoroethoxy)Propanenitrile is not found naturally and has been sponsored by many companies.