Amides

<p>Applications 4-Hydroxybenzamide is a secondary metabolite from marine sponge Phakellia fusca.<br>References Deng, Z., et. al.: Zhongyaocai, 36, 919 (2013)<br></p>

<p>Applications N,N-Bis(2-hydroxyethyl)benzenesulfonamide is used in the synthesis of N,N-Bis(2-chloroethyl)benzenesulfonamide (B418910), which is a novel intermediate in the synthesis of Cetirizine (C281100).<br></p>

<p>Applications α-Hydroxy-4-(2-oxiranylmethoxy)-benzeneacetamide is an intermediate in the synthesis of hydroxyatenolol (H802480), which is a metabolite of Atenolol (A790075); a cardioselective β-adrenergic blocker, antihypertensive, antianginal, and antiarrhythmic (class II).<br>References Escher, B., et al.: Environ. Sci. Technol., 40, 7402 (2006); Caplar, V., et al.: Anal. Profiles Drug Subs., 13, 1 (1984)<br></p>

<p>Applications p-Hydroxymandelamide is a useful synthetic intermediate in the synthesis of Hydroxyatenolol (H802480); a metabolite of Atenolol (A790075) which is a cardioselective β-adrenergic blocker, antihypertensive, antianginal, and antiarrhythmic (class II).<br>References Escher, B., et al.: Environ. Sci. Technol., 40, 7402 (2006); Caplar, V., et al.: Anal. Profiles Drug Subs., 13, 1 (1984)<br></p>

<p>Applications N-[2-[3,4-Bis(phenylmethoxy)phenyl]ethyl]-3,4,5-trimethoxybenzeneacetamide is an intermediate used in the synthesis of S-(-)-Tretoquinol Hydrochloride (T798100), which belongs to the class of adrenergic inhalants, selective β-2-adrenoreceptor agonists. S-(-)-Tretoquinol is used in the treatment of obstructive airway diseases. S-(-)-Tretoquinol is a bronchodilator.<br>References Meshi, et al.: Biochem. Pharmacol., 19, 2937 (1970), Satoh, et al.: Chem. Pharm. Bull., 19, 667 (1971),<br></p>

<p>Applications N-(3-Chloro-4-fluorophenyl)-2-cyanoacetamide (cas# 219529-31-4) is a compound useful in organic synthesis.<br></p>

<p>Applications rac-trans-[3-Hydroxycyclohexyl]benzamide (cas# 177366-90-4) is a compound useful in organic synthesis.<br></p>

<p>Stability Moisture Sensitive<br>Applications N-Trimethylsilylacetamide is a silylating agent used in organic synthesis. N-Trimethylsilylacetamide is used in the preparation of the antibacterial agent Cefdinir (C242670).<br>References Takano, R. et al.: J. Carb. Chem., 14, 885 (1995); Rao, K. et al.: Synth. Comm., 37, 2275 (2007);<br></p>

<p>Applications N-(2-Chloroethyl)benzenesulfonamide is an intermediate for the synthesis of Bensulide (B166000), which is an organophosphate acetylcholinesterase inhibitor used as an herbicide (1) in the protection of crops through pesticides (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br></p>

<p>Applications p-Vinylguaiacol-d3 is the isotope labelled analog of p-Vinylguaiacol (V424960); an aromatic substance, one of the compounds responsible for the natural aroma of buckwheat, and also one of the major pyrolytic products of (E)-N-[(4-hydroxy-3-methoxy)-phenethyl]-3-[(3-methoxy-4-O-β-D-glucopyranosyloxy) phenyl] acrylamide; a new gycloside in tobacco.<br>References Janes, Damjan., et al.: Food Chem., 112(1), 120-124 (2009); Zhou, Rong., et al.: Yancao Keji, (7), 34-36, 42 (2013)<br></p>

<p>Applications 2-Cyano-N-((furan-2-ylmethyl)carbamoyl)acetamide is an intermediate in the synthesis of novel 1- and 8-substituted-3-furfuryl xanthines as adenosine receptor antagonists.<br>References Balo, M. C., et al.: Bioorg. Med. Chem., 17, 6755 (2009);<br></p>

<p>Applications rac-cis-[3-Hydroxycyclohexyl]benzamide (cas# 177366-89-1) is a compound useful in organic synthesis.<br></p>

<p>Applications N,N-DIMETHYLFORMAMIDE DINEOPENTYL ACETAL (cas# 4909-78-8) is a useful research chemical.<br></p>

<p>Applications (αS)-α-Amino-4-nitrobenzenepropanamide (cas# 81677-61-4) is a compound useful in organic synthesis.<br></p>

<p>Applications N-(3-Acetylphenyl)-N-ethylacetamide is a reactant used in the preparation of 5-Oxo-Zaleplon (O870470), a metabolite of Zaleplon (Z145000).<br></p>

<p>2-Hydroxy-N-(2-hydroxyethyl)propanamide is a cationic surfactant that has been shown to inhibit the activity of tyrosinase and tnf-α. 2-Hydroxy-N-(2-hydroxyethyl)propanamide is used as a skin conditioning agent in cosmetic formulations and also has antimicrobial properties. It has been shown to be effective against a range of microorganisms, including gram positive bacteria, gram negative bacteria, yeast, and fungi. 2-Hydoxy-N-(2-hydroxyethyl)propanamide does not damage the skin but may cause dryness if it is left on for an extended period of time. It is also an antioxidant compound with a phase transition temperature of -19 degrees Celsius.</p>

<p>2-(Indenylamino)acetamide, hydrochloride salt is a potential drug that is an uptake inhibitor. It prevents the uptake of dopamine in the brain and has been shown to be neuroprotective in animal research. It also has potential to treat diabetic neuropathy, inflammatory diseases, and pain. The kinetic properties of this drug were studied using rat striatal cells. 2-(Indenylamino)acetamide, hydrochloride salt inhibits the transport of dopamine into these cells by blocking the movement of dopamine from outside the cell to inside the cell. This drug could potentially be used for treatment of Parkinson's disease or other conditions involving dopaminergic dysfunction.</p>

<p>Beta-naphthamide is an inhibitor binding to the dinucleotide phosphate (DNP) in bacterial cells. This binding prevents the enzyme from carrying out its normal function, which is the production of ATP, and it also inhibits various other enzymes. Beta-naphthamide inhibits the growth of Gram-positive bacteria by inhibiting their cell wall assembly and also has a bactericidal effect on Gram-negative bacteria. Beta-naphthamide has been shown to be active against multidrug efflux pump proteins that are present in Gram-negative bacteria, such as Escherichia coli. DNP is a receptor for dopamine and beta-naphthamide inhibits dopamine receptors in mammalian cells, which may lead to Parkinson's disease. Beta-naphthamide has been shown to inhibit the polymerase chain reaction (PCR) mechanism by binding to DNA polymerase. Beta-naphthamide binds to receptors on trigeminal nerve endings, which leads to paralysis of</p>

<p>N-Benzyltrifluoroacetamide is an amide that inhibits the activity of the enzyme fatty acid synthase, which catalyzes the synthesis of fatty acids. It has been shown to be effective against a number of cancers and has been used in the treatment of patients infected with HIV. N-Benzyltrifluoroacetamide is active against a range of cancer cell lines, including breast, pancreatic, ovarian, prostate, and colorectal carcinomas. Its mechanism of action is not known but may involve inhibition of protein synthesis or induction of apoptosis.</p>

<p>4-(tert-Butyl)benzenesulfonamide is a pyrimidine derivative that has an affinity for metal ions and can be used as a catalyst. It is insoluble in water but soluble in acetonitrile and other organic solvents. This compound is a strong oxidant when it reacts with ethylene, styrene, or propyl gallate. 4-(tert-Butyl)benzenesulfonamide has been shown to be highly reactive with the oxygen in air, leading to the formation of 4-dimethylaminobenzoic acid, formyl group, and phosphorus oxychloride.</p>

<p>Gly-pro-4-methoxy-beta-naphthylamide is a synthetic substrate that is used to measure the activity of human plasma phosphatases. Gly-pro-4-methoxy-beta-naphthylamide is synthesized in an organic solvent and then reacted with diazonium salt to form a glycosylated aminophosphonic acid. The product is purified by chromatography and identified by mass spectrometry. Gly-pro-4-methoxy beta naphthylamide has been shown to inhibit the growth of cancer cells in vitro, as well as having antiinflammatory properties. This drug also has been shown to be effective in treating patients with severe hyperbilirubinemia who are undergoing hematopoietic stem cell transplantation.</p>

<p>3,5-Dimethoxycinnamide is a compound that has been shown to inhibit the C1-4 alkoxy and C1-4 alkyl esterase activity of the enzyme secretase. This enzyme is involved in the production of amyloid beta peptides and is thought to be an important contributor to Alzheimer's Disease. 3,5-Dimethoxycinnamide also inhibits the aspartyl protease activity of aspartyl proteases, which are enzymes that may play a role in Alzheimer's disease. 3,5-Dimethoxycinnamide binds to the hydrophobic region of these enzymes and prevents them from binding to their substrates. The affinity of this compound for these enzymes precludes its ability to bind with other proteins in the brain, thereby reducing its potential toxicity. 3,5-Dimethoxycinnamide can be labeled with halogeno groups or other chemical moieties for profiling purposes.</p>

<p>Sulfamide is a pharmacological agent that inhibits the growth of bacteria. Sulfamide has been shown to be reactive with hydrogen fluoride, which may result in the formation of sulfamoyl chloride. This reactive form of sulfamide may react with other compounds and cause unwanted side-effects. <br>Sulfamides are used for the treatment of infectious diseases such as pneumonia and urinary tract infections, as well as for the treatment of other conditions like congestive heart failure and rheumatoid arthritis. They work by inhibiting enzymes necessary for bacterial growth, including target enzymes such as dihydropteroate synthase, which is involved in folate synthesis. Sulfamides also have inhibitory properties on human osteosarcoma cell proliferation.</p>

<p>2-Chloroacetamide is a useful building block that can be used to synthesize a variety of compounds. This chemical is also a versatile intermediate and can be used in the preparation of fine chemicals, research chemicals, and speciality chemicals. It is also a reaction component that can be used in the synthesis of complex compounds. 2-Chloroacetamide has been shown to have high quality properties and is often used as a reagent.</p>

<p>Diacetone acrylamide is a chemical compound that has the molecular formula C3H6O2N2. It is a colorless liquid with a low boiling point and an unpleasant odor. Diacetone acrylamide has been used as an intermediate in the production of polyvinyl acetate. It can also be used as an additive to rubber, plastics, and other materials. The thermal expansion coefficient of diacetone acrylamide is similar to that of polyvinyl chloride and polystyrene, making it a useful material for constructing models of those substances.</p>

<p>Thiophene-2-sulfonamide is a fungal biomass inhibitor that binds to specific receptors in the human liver, which decreases the production of hemolytic substances. Thiophene-2-sulfonamide has been shown to have a reversible effect on the metabolism of peptide hormones and metabolic disorders in vivo. The drug also has diagnostic properties and can be used to measure receptor binding activity. Thiophene-2-sulfonamide is an intermediate in the synthesis of diagnostic agents such as 3-(4'-aminophenyl)thiophene-2,5-diol (APTD).</p>

<p>3,5-Diacetoxybenzamide technical is a solvent that can be used in organic synthesis. It is soluble in hydrochloric acid and has a boiling point of 210 degrees Celsius. 3,5-Diacetoxybenzamide technical is soluble in water and has an LD50 (lethal dose) of over 5 g/kg when administered orally to pigs. 3,5-Diacetoxybenzamide technical is also used as a reagent for the preparation of peracetates and esters of aromatic ketones. This product can be used as a reaction medium for lipase or porcine pancreatic lipase. It is also used in the manufacture of pharmaceuticals, fragrances, dyes, herbicides and pesticides.</p>

<p>2-Amino-2-cyanoacetamide is a chemical compound that has been shown to be reactive in the human liver and animal models. It is a purine derivative with a diatomic molecule, which has been shown to inhibit cancer cells in animals. 2-Amino-2-cyanoacetamide has been shown to inhibit the replication of pestivirus, an RNA virus that causes encephalitis and other diseases in humans. The nitrogen atoms on this molecule are responsible for its transport properties, including uptake by the gut and its ability to cross the blood brain barrier. 2-Amino-2-cyanoacetamide also inhibits the activity of amide hydrolase, which is an enzyme responsible for hydrolyzing peptides into amino acids. This process leads to a decrease in protein synthesis, which can lead to cell death.</p>

<p>1-Methyl-nicotinamide iodide is a drug that has been used in clinical trials for the treatment of type 2 diabetes mellitus. It is thought to work by increasing the sensitivity of cells to insulin, which may be related to its ability to bind to protein amide groups and form hydrogen bonds with the amino acid side chains. The compound also has been shown to increase the activity of the enzyme glycogen synthase in rats. 1-Methyl-nicotinamide iodide is soluble in water and human serum, and shows low solubility in ethanol. It has not been studied in humans, but animal studies have shown that it can be absorbed orally and metabolized into hippuric acid, which is excreted as a metabolic product through urine. Animal studies also showed that 1-methyl-nicotinamide iodide inhibits glucose production by pancreatic beta cells, which may lead to an increased insulin response after eating.</p>

<p>Orazamide is a piperazine derivative that is used in the treatment of high blood pressure. It works by binding to the skeleton and the liver, preventing the accumulation of sodium and chloride ions. This results in a decrease in blood pressure. Orazamide has been shown to decrease insulin resistance and also has an important role in the prevention of symptoms such as edema, headache, dizziness, nausea, vomiting, and fatigue. It also has a diuretic effect on the kidneys with sodium citrate as its main excipient. The chlorine atom binds to the heterocycle group to form a coordination complex that can bind to heme proteins, thus inhibiting its function.<br>Orazamide is an analog of chlorothiazide with a chlorine atom replacing one oxygen atom on the heterocycle group.</p>

<p>2-Iodo-N-(4-methoxyphenyl)-N-methylbenzamide is a versatile building block that can be used in research and as a reagent. It is a high quality chemical and useful as a building block or intermediate for the synthesis of more complex compounds. This chemical is also a useful scaffold for the synthesis of more complex molecules.</p>

<p>N-[3-(Diethylaminomethyl)-4-hydroxyphenyl]acetamide is a molecule that has been shown to have acetylcholine esterase (AChE) inhibitory activity. It binds to the active site of AChE, preventing it from breaking down acetylcholine, leading to the accumulation of this neurotransmitter. The inhibition of AChE by N-[3-(Diethylaminomethyl)-4-hydroxyphenyl]acetamide prevents muscle contraction and leads to paralysis and death by asphyxiation. This drug has been used in the treatment of sarin gas poisoning. The molecular structure of N-[3-(Diethylaminomethyl)-4-hydroxyphenyl]acetamide is similar to that of pyridinium chlorides, which are used for synthesizing nerve agents such as sarin and soman. This drug also has a proton</p>