Amides

<p>Applications 4-Hydroxythiobenzamide is used in the synthesis of PPARα agonists used in increasing HDLc levels. Also used in the synthesis of potent CDK5 inhibitors in the treatment of Alzheimer’s disease.<br>References Sierra, M. et al.: J. Med. Chem., 50, 685 (2007); Zhong, W. et al.: Bioorg. Med. Chem. Lett., 17, 5384 (2007);<br></p>

<p>Applications (1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxamide is a part of the synthetic preparation of the synthesis and inhibitory effect on ADP-induced platelet aggregation of ticagrelor derivatives as antiplatelets agents.<br>References Zhang, H., et al.: Bioorganic Med. Chem. Lett., 22, 3598 (2012).<br></p>

<p>Applications NN'-Bis(2-hydroxyethyl)urea (cas# 15438-70-7) is a useful research chemical.<br></p>

3-Cyanobenzamide is an organic compound with the formula CHC(N)NH. It is a white crystalline solid that can be obtained by reacting benzamide with cyanoacetylene. There are three possible isomers of 3-cyanobenzamide: 3-cyano-1-(substituted phenyl)benzamide, 3-cyano-2-(substituted phenyl)benzamide, and 3-cyano-3-(substituted phenyl)benzamide. The optimal reaction conditions for the synthesis of 3-cyanobenzamide are in the presence of hydrogen bonding, such as n-hexane, amide, and phase equilibrium. Studies have determined that 3-cyanobenzamide has the potential to cause cancer or liver toxicity in humans. In addition, this chemical has been shown to be an effective inhibitor of alpha glucosidase enzymes in vitro and in vivo.

<p>2-Chloro-5-nitrobenzene sulfonamide (2CNS) is a glycol ether that has been shown to inhibit the activity of carbonic anhydrase. It has been shown to be a competitive inhibitor of the enzyme, and can be used as a lead compound for developing new drugs. 2CNS has been shown to inhibit an anhydrase that is found in bacteria, such as Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus. This inhibition causes increased levels of hydrogen ions in the bacterial environment, which leads to the acidification of their surroundings. 2CNS also inhibits chloride ion uptake in these bacteria.<br>2CNS's pharmacophore includes two aromatic hydrocarbon rings with at least one hydrogen bond acceptor group on each ring. This pharmacophore is responsible for its inhibition of carbonic anhydrase and chloride ion binding site.</p>

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<p>Lacosamide is a drug that is used for the treatment of epilepsy. It has been shown to inhibit neuronal death in vitro and in animal models, and has been extensively studied for its potential benefits in the treatment of bowel disease. The mechanism of action for lacosamide involves inhibition of the transport of neurotransmitters from the synaptic cleft by binding to the neuronal sodium channels and increasing their recovery rate. Lacosamide has also been found to affect energy metabolism by inhibiting the activity of mitochondrial enzymes such as matrix effect and complex I/III.</p>