Carboxylic Acids

<p>Applications DL-CITRAMALIC ACID (cas# 2306-22-1) is a useful research chemical.<br></p>

<p>Applications N-Undecylbenzenesulfonic Acid is an anionic surfactant.<br>References Mottaleb, M. A.: Anal. Sci., 15, 1137 (1999), Kolb, M., et al.: LaborPraxis, 22, 56 (1998); Ferrer D., et al.: Tenside, Surfact., Det., 34, 278 (1997)<br></p>

<p>Applications Ethyl Acetate is generally used as a solvent in organic reactions.Environmental contaminants; Food contaminants<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Reyes L et al. J Org Chem. 2013 Mar 15;78(6):2327-35.<br></p>

<p>Applications (2E)-2,4-Pentadienoic Acid (cas# 21651-12-7) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2,4-Dihydroxybenzoic acid is a useful synthetic intermediate. An organic building block for plastics and rubber products.<br>References Gautam, R., et al.: Cryst. Growth Des., 18, 1501 (2018); Shvedene, N. V., et al.: J. Anal. Chem., 72, 95 (2017);<br></p>

<p>Applications 2-(carboxymethyldisulfanyl)acetic acid (cas# 505-73-7) is a useful research chemical.<br></p>

<p>Applications Octadecylphosphonic acid (cas# 4724-47-4) is a useful research chemical.<br></p>

<p>Applications 6-(6-(6-Aminohexanamido)hexanamido)hexanoic Acid is used in the making of a preconjugate which serves as immunoreactive conjugate useful as a developer antigen in a competitive inhibition immunoassay for the polymorphic analyte. Also used in the efficient synthesis of a heterobifunctional coupling agent.<br>References Oh, C. S., et al.: PCT Int. Appl. (1994), WO 9416330 A1 19940721; Reddy, R. E., et al.: Bioconjug. Chem., 16, 1323 (2005)<br></p>

<p>Applications Ethyl Cyano(hydroxyimino)acetate is used in peptide synthesis and has shown to suppress racemiztion, has high coupling efficiency in both solution and solid phase synthesis and is a non-explosive alternative to 1-hydroxybenzotriazole (HOBt) and 1-hydroxy-7-azabenzotriazole (HOAt).<br>References Khattab, S.N.: Bull. Chem. Soc. Jpn., 83, 1374 (2010)<br></p>

<p>Applications Benzensulfonic Acid Monohydrate is used in the synthesis of HER2/EFGR dual inhibitors in the treatment of cancers and displaying potency towards anti-tumor activity.<br>References Kawakita, Y. et al.: Bioorg. Med. Chem. Lett., 20, 6171 (2012);<br></p>

<p>Applications Used for the preparation of bisphosphonic acid derivatives as anti-osteoporosis agents.<br>References Amin, D., et al.: Drug Res., 46, 759 (1996), Martin, M., et al.: J. Med. Chem., 45, 2904 (2002),<br></p>

<p>Applications Antioxidant.<br>References Arnous, A., et al.: J. Agr. Food Chem., 49, 5736 (2001), Guendez, R., et al.: Food Chem., 89, 1 (2005), Proestos, C., et al.: Food Control,16, 319 (2005)<br></p>

<p>Applications 4-(Methoxymethyl)benzoic acid<br></p>

<p>Applications Ethyl Diazoacetate is used in the synthesis of Arteludovicinolide A as well as pyrimidoazepine analogs as seritonin 5-HT2A/C receptor ligands for treatment of obesity. This compound contains solvent for added stability.<br> E0<br>References Yang, H. et al.: Eur. J. Med. Chem., 63, 558 (2013); Kreuzer, A. et al.: Org. Lett., 15, 3420 (2013);<br></p>

<p>Applications Nonadecanedioic Acid (cas# 6250-70-0) is a useful research chemical.<br></p>

<p>Applications A redox buffer that increases the folding rate of disulfide-containing proteins realative to traditional buffers such as glutathione and glutathione-disulfide. A useful synthetic intermediate for the preparation of novel antiinflammatory agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gough, J.D., et al.: JACS, 124 (15), 3885 (2002)<br></p>

<p>Applications 4-Aminohippuric Acid is used in the measurement of renal plasma flow as a diagnostic tool which may be applied towards kidney disorders.<br>References Phillips, R. et al.: Am. J. Physiol., 152, 523 (1948);<br></p>

<p>Applications Methyl (S)-N-Tritylaziridine-2-carboxylate (cas# 75154-68-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Difluoroacetic acid<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Boric Acid, Pinacol Ester was a useful reagent in the study of hydrogen peroxide inducible DNA croslsinking agents as anticancer prodrugs.<br>References Kuang, Y., et al.: J. Am. Chem. Soc., 133, 19278 (2011);<br></p>

<p>Applications A metabolite of Trimebutine (T795605(P)), which is an opioid receptor agonist and an antispasmodic.<br>References Dieks, H., et al.: J. Labelled Comp. Radiopharm., 28, 1093 (1990), Delvaux, M., et al.: J. Int. Med. Res., 25, 225 (1997), Lavit, M., et al.: Arzneim.-Forsch., 50, 640 (2000),<br></p>

<p>Applications Maleic Acid is used in the synthesis of pyridoindolones as potent inhibitors of Aurora kinases. Also is a reagent in the preparation of TiO2/carbon nanotube composites.<br>References Le, L. et al.: ChemMedChem., 8, 289 (2013); Yao, Y. et al.: Env. Sci. Tech., 42, 4952 (2008)l<br></p>

<p>Applications 2-Azidobenzoic Acid (cas# 31162-13-7) is a useful research chemical.<br></p>

<p>Applications 3-O-Ethyl-L-ascorbic Acid could be a useful stabilizing agent for a para-​hydroxyacetophenone solution.<br>References Zhang, H., et al.: Faming Zhuanli Shenqing (2020), CN 111937874 A<br></p>

<p>Applications Benzyl Acetate, is found naturally in many flowers, It has pleasant sweet aroma reminiscent of jasmine, and thus is used widely in perfumery industry, and also as a flavouring agent. It is also used as a solvent.<br>References Schiestl, F. P., et al.: J. Chem. Ecology, 29 (2004); Qian-qian, M., et al.: Jingxi Huagong, 30, 442 (2013);<br></p>

<p>Applications Cyclohexanecarboxylic acid<br></p>

<p>Applications 4-carbamoylfuran-2-carboxylic acid (cas# 1315367-95-3) is a useful research chemical.<br></p>

<p>Applications Reagent used for Horner-Emmons modification.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hediger, M., et al.: Bioorg. Med. Chem., 12, 4995 (2004), Kim, J., et al.: Nat., 452, 239 (2008),<br></p>

<p>Applications Ethyl hydrazinoacetate, HCl<br></p>

<p>Applications tert-butyl N-[3-(chlorosulfonyl)propyl]carbamate (cas# 1196153-59-9) is a useful research chemical.<br></p>

<p>Applications Occurs in unripe fruit and in young green leaves; has also been found in very young sugar beets.<br>References Lelieveld, J., et al.: Nature, 452, 737 (2008), da Silva, G., et al.: Environ. Sci. Technol., 44, 250 (2010),<br></p>

<p>Applications N-[4-(-Carboxycyclohexylmethyl)]maleamidic Acid (cas# 72748-87-9) is a compound useful in organic synthesis.<br></p>

<p>Stability Stench<br>Applications 2,2-Dimethylcyclopropylcarboxylic acid<br></p>

<p>Applications Intermediate in the preparation of Modafinil<br>References Stark, H., et al.: Eur. J. Med. Chem., 29, 695 (1994), Cass, Q., et al.: J. Pharm. Biomed. Anal., 46, 937 (2008),<br></p>

<p>Stability Hygroscopic<br>Applications α-Aleuritic acid is a major ingredient of shellac and is also a starting reagent in the manufacture of perfumes.<br>References Jakubowska, M., et al.: Polimery ., 15, 295 (1970); Shamsuzzaman, L.A., et al.: Pakistan. J. Biol. Agri. Sci., 11, 68 (1968);<br></p>

<p>Applications Citric Acid Monohydrate is a useful buffer component for antigen and epitope unmasking.<br></p>

<p>Applications Hydrazine acetate (cas# 7335-65-1) is a useful research chemical.<br></p>

<p>Applications 4-GUANIDINOBENZOIC ACID METHANESULFONATE (cas# 148720-07-4) is a useful research chemical.<br></p>

<p>Applications Tiglic acid is the stable isomer of angelic acid. Tiglic acid was found as glyceride in croton oil, as butyl ester in the oil of the Roman camomile, and as geranyl tiglate in oil of geranium. Tiglic acid is formed during the charcoaling of maple wood.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bueding, et al.: J. Biol. Chem., 202, 505 (1953),<br></p>

<p>Applications Tetradecanedioic acid (cas# 821-38-5) is a useful research chemical.<br></p>

<p>Applications Methyl-3-hydroxyisothiazole-5-carboxylate (cas# 100241-89-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-(Benzyloxy)butanoic acid<br></p>

<p>Applications Decanoic acid is used in manufacturing of esters for artificial fruit flavors and perfumes.<br>References Oro, L., et al.: Acta Pharmacol. Toxicol., 18, 141 (1961),<br></p>

<p>Applications 3,5-DINITRO-4-HYDROXYBENZOIC ACID (cas# 1019-52-9) is a useful research chemical.<br></p>

<p>Applications 3-Amino-4-(carboxymethyl)benzoic acid<br></p>

<p>Applications 3-Hydroxytetradecanoic Acid is used in the preparation of liposomes coated with N-acylated molecular-weight. Also used in the synthesis of pseudomycin side-chain analogs. Also used in the study of Lipid A, a major constituent of the lipopolysaccharides, which are responsible for the toxicity of gram negative bacteria.<br>References Naberezhnykh, G. et al.: Chem. Nat. Comp., 46, 852 (2011); Chen, S. et al.: Bioorg. Med. Chem. Lett., 10, 2107 (2000); Carillo, S. et al.: Marine Drugs., 11, 184 (2013);<br></p>

<p>Applications 1,2,3,4-Cyclobutanetetracarboxylic Acid 1,2,3,4-Tetramethyl Ester is product from the formation of a mixture of maleic anhydride and hexamethylbenzene when exposed to ultraviolet irradiation.<br>References Raciszewski, Z.: J. Chem. Soc., 12, 1147-1155 (1966);<br></p>

<p>Applications 2,2,5-Trimethyl-1,3-dioxane-5-carboxylic Acid (cas# 16837-14-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Hydroxymandelic Acid is used in the synthesis of an enzyme activity-based labeling molule.<br>References Komatsu, T. et al.: J. Am. Chem. Soc., 128, 15946 (2006);<br></p>

<p>Applications DL-3-Aminoisobutyric acid (cas# 144-90-1) is a useful research chemical.<br></p>

<p>Applications Used in the synthesis of substituted terphenyls.<br>References Strukelj, M., et al.: Science, 267, 1969 (1995), Burroughes, J., et al.: Nature, 347, 589 (1990),<br></p>

<p>Applications Isostearic Acid may be a useful reagent in the regioselective preparation of alkenes via photoredox/cobaloxime dual-catalytic decarboxylative elimination of carboxylic acids,<br>References Cartwright, K. C., et al.: Chem. Eur. J., 26, 12454 (2020)<br></p>

<p>Applications Perfluorohexanoic Acid is a perfluorinated compound (FPC) that can cause acute toxicity to humans and the environment. Perfluorohexanoic Acid is also used as a reagent in the synthesis of 3,3,4,4,5,5,6,6,7,7,7-Undecafluoro-2-heptanol (U787500).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Latala, A., et al.: Environ. Toxicol. Phar., 28, 167 (2009); Mulkiewicz, E., et al.: Environ. Toxicol. Phar., 23, 279 (2007)<br></p>

<p>Applications 2-Mercaptoisobutyric Acid, 90% (cas# 4695-31-2) is a compound useful in organic synthesis.<br>References McIntosh, J.M. and Siddiqui, M.A.: Can. J. Chem., 61, 1872-1875 (1983), Bienlarz, C. and Cornwall, M.J.: Tetrahedron Lett., 34 (6), 939-942 (1993)<br></p>

<p>Applications 3-(methylamino)-3-oxopropanoic acid (cas# 42105-98-6) is a useful research chemical.<br></p>

<p>Applications 2-[(phenylsulfanyl)methyl]benzenecarboxylic acid (cas# 1699-03-2) is a useful research chemical.<br></p>

<p>Applications Glutaconic Acid is used in the synthesis of dialkyltin derivatives of dicarboxylic acids which display antitumor properties. Also used in the synthesis of novel tetracyclic compounds as peripheral benzodiazepine receptor ligands with potential use for CNS illness treatments.<br>References Gielen, M. et al.: Hetero. Chem., 3, 449 (1992); Okubo, T. et al.: Bioorg. Med. Chem. Lett., 12, 3569 (2004);<br></p>

<p>Applications Isophthalic Acid is a useful reagent for preparing semiconductor sealing materials, prepregs, build-up films, solder resists, dry films, and printed wiring boards.<br>References Matsumura, Y., &amp; Nakamura, A.: PCT Int. Appl. (2021), WO 2021006164 A1<br></p>

<p>Applications Ethacrynic Acid Epoxide is an intermediate in the synthesis of Ethacrynic Acid (E676000), a diuretic used to treat high blood pressure and swelling caused by congestive heart failure, liver failure and kidney failure.<br>References Beyer, et al.: J. Pharmacol. Exp. Ther., 147, 1 (1965), Kim., et al.: Am. J. Cardiol., 27, 407 (1971), Williamson, H.E., et al.: J. Clin. Pharmacol., 17, 663 (1977),<br></p>

<p>Applications Phenyl N-​(2-​Chloro-​4-​hydroxyphenyl)​carbamate is a reagent used in the prepartion of quinoline-carboxamide compounds including Lenvatinib (L329400), an orally active inhibitor of multiple receptor tyrosine kinases including VEGF, FGF and SCF receptors.<br>References Wang, N. et al.: Faming Zhuanli Shenqing (2017), CN 106632033 A 20170510.<br></p>

<p>Applications 7-Bromoheptanoic Acid is a reagent that is used in the synthesis of N-Heptanoic Acid Tianeptine Disodium Salt (H281500) which are metabolite of Tianeptine (T436800), having psychostimulant, anti-ulcer and anti-emetic properties.<br>References Malen, C., et al.: Experientia, 28, 811 (1972), Safa, A., et al.: J. Biol. Chem., 262, 7884 (1987), Ford, J.M., et al.: Pharmacol. Rev., 42, 155, (1990), Pierre, A., et a.: Cancer Res., 51, 2312 (1991),<br></p>

<p>Applications Isotope labelled 1,2,4-Trioctyl Ester 1,2,4-Benzenetricarboxylic Acid is a widely used and often incorporated in plasticizer for PVC for a higher molecular weight.<br>References Jones, C., et al.: Int. J. Artificial. Organs., 12, 466 (1989); Khang, G., et al.: Bio-Med. Mater. Engineer., 12, 135 (2002);<br></p>

<p>Applications Formic Acid-d is labelled Formic Acid (F692900). Formic Acid (F692900) is used as a potential energy source in the preparation of fuel cells. Also used in chemical synthesis of various anti-inflammatory and anti-microbial agents.<br>References Yu, X. et al.: J. Power Source., 182, 124 (2008); Bekhit, A. et al.: Bioorg. Med. Chem., 12, 1935 (2004);<br></p>

<p>Applications A metabolite of aldehydes.<br>References Shiobara, Y., et al.: Xenobiotica, 9, 157 (1979),<br></p>

<p>Applications 3,4,9,10-Perylenetetracarboxylic diimide (cas# 81-33-4) is a useful research chemical.<br></p>

<p>Applications 18-(tert-Butoxy)-18-oxooctadecanoic Acid is used to engineer long-acting, potent exendin-4 based GLP-1 analog for microstructure-based transdermal delivery for glycemic control.<br>References Yang, P., et al.: Proc. Natl. Acad. Sci. USA, 113, 4140 (2016);<br></p>

<p>Applications 4-(4-PHENYLBUTOXY)BENZOIC ACID (cas# 30131-16-9) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications Heptafluorobutyric Acid (HFBA) is used in reversed-phase chromatography.<br> E0<br>References Satake, I., et al.: Biopolymers, 15, 2263 (1976), Aso, K., et al.: Biosci. Biotech. Biochem., 56, 755 (1992), Cecchi, T., et al.: J. Chromatogr., 1216, 1789 (2009),<br></p>

<p>Applications (8Z,11Z,14Z)-8,11,14-Heptadecatrienoic Acid, is a naturally occurring hydroxylated fatty acid that is found in Acinetobacter species. It acts as a partial agonist of free fatty acid receptor 1 (FFAR1/GPR40) and GPR84 receptors in vitro. It also inhibits bovine hepatic ligase (Ki = 4.4 μM) and mouse kidney mitochondrial medium-chain acyl-CoA synthetase by 48% at a concentration of 40 μM.<br>References Moss, C.W., et al.: J. Clin. Microbiol. 26(3), 484-492 (1988).; Kaspersen, M.H., et al.: Med. Chem. Commun. 8(6), 1360-1365 (2017).<br></p>

<p>Applications 3,4,5-Trimethoxyphenylacetic Acid is a reagent in the preparation of 3-phenylcoumarins as antidepressant agents.<br>References Sashidhara, K.V., et al.: Bioorg. Med. Chem. Lett., 24, 4876 (2014);<br></p>

<p>Applications 2-Benzoylbenzoic Acid is a reagent that is used in the synthesis of BzATP Triethylammonium Salt, which is a selective P2X purinergic agonist. It is more potent than ATP at homodimeric P2X7 receptors.<br>References Abou-Seri, S. M., et al.: Eur. J. Med. Chem., 107, 165 (2016);<br></p>

<p>Applications (±)-Jasmonic Acid can be used as reactant/reagent for synthetic preparation of fluorescent-labeled jasmonate and application to fluorescent imaging in cabbage seedlings.<br>References Liu, S., et al.: Tetrahedron Lett., 53, 4235-4239 (2012)<br></p>

<p>Applications β-Formylpropionic Acid is used in the synthesis of potent and orally available nonpeptide antagonist of human gonadotropin-releasing hormone receptor. It is also a reagent in the synthesis of human melanocortin-4 receptor antagonists with a pyrrolidinone moiety.<br>References Chen, C. et al.: J. Med. Chem., 51, 7478 (2008); Jiang, W. et al.: Bioorg. Med. Med. Chem. Lett., 17, 5610 (2007);<br></p>

<p>Applications 3-(4-tert-Butylbenzene)propionic Acid (cas# 1208-64-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Boric Acid is a common chemical component in insecticides, specifically for flea erradication. Also has the properties of an effective flame retardant.<br>References Hinkle, N. et al.: J. Med. Entomol., 32, 424 (1995); Dogan, M. et al.: Polym. Degrad. Stab., 99, 12 (2014);<br></p>

<p>Applications 3,5-Di-tert-butyl-4-hydroxybenzoic acid hexadecyl ester<br></p>

<p>Applications Octyl 3-Octyloxiraneoctanoic Acid (cas# 106-84-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-(7-Amino-2-oxo-2H-chromen-4-yl)acetic acid (cas# 85157-21-7) is a useful research chemical.<br></p>

<p>Applications m-Toluic acid is used as a reagent in the preparation of hybrid molecules containing oxadiazole and thiadiazole bearing Schiff base moiety as it has antitumor activities.<br>References Zhang, K., et al.; Bioorg. Med. Chem. Lett., 24, 5154 (2014);<br></p>

<p>Applications Reagent used in the addition of Phenothiazine (P318040).<br>References Zhang, Y., et al.: Bioorg. Med. Chem. Lett., 17, 707 (2007), Bansode, T., et al.: Pharm. Chem. J., 43, 311 (2009), Chelikani, R., et al.: App. Biochem. Biotechnol., 157, 263 (2009),<br></p>

<p>Applications 2-(Hydroxyimino)-3-phenylpropanoic acid (cas# 3682-17-5) is a useful research chemical.<br></p>

<p>Applications 4-(ETHOXYCARBONYL)BENZOIC ACID (cas# 713-57-5) is a useful research chemical.<br></p>

<p>Applications (Z)-11-Tetradecenyl Acetate is a sex pheremone component that can be found in various insect specie, such as O. nubilalis and Asian and European corn borers.<br>References Leary, G.P., et al.: Proc. Natl. Acad. Sci. U.S.A., 109, 14081 (2012);<br></p>

<p>Applications p-Toluic Acid is used as a reagent in the synthesis of several organic compounds including that of 2-aryl-1,3,4-oxadiazole derivatives which are potential antibacterial agents. Also used in the synthesis of 4-(bromomethyl) benzoic acid.<br>References Karimi, F., et al.: J. Chem. Pharm. Res., 7, 1028 (2015); Zheng, F., et al.: Guangdong Huagong, 42, 27 (2015);<br></p>

<p>Applications 3-Oxohexanedioic Acid is a degradation product of catechol in the presence of hydrogen peroxide; Also, it is derived from 3-Oxohexanedioic Acid Diethyl Ester (O856830), which is an intermediate used to prepare CMPF (C595000) which is a drug-binding inhibitor which is also a constituent of urine. CMPF can inhibit specific T4 binding in serum by increasing the free concentration of direct competitors.<br>References Gogoi, A., et al.: Chem. Eng. J., 311, 153-162 (2017); Mabuchi, H., Nakahashi, H.: Nephron, 44, 277 (1986); Lim, C.F., et. al.: Metabolism Clin. Exp., 42, 1468 (1993)<br></p>

<p>Applications Adipic Acid Dihydrazide is used to functionalize magnetic nanoparticles for gylcopeptitde enrichment and identification. Adipic Acid Dihydrazide can also be used as a chain extension for liquid rubber.<br>References Cao, Q., et. al.: Analyst, 139, 603 (2014); Cutts, E.: Chem. Industry, 7, 280 (1974)<br></p>

<p>Applications 3-(4-Hydroxy-3,5-dimethoxyphenyl)propanoic Acid (cas# 14897-78-0) is a useful research chemical.<br></p>

<p>Applications 7-Benzothiazolecarboxylic Acid is an intermediate used in the synthesis of pyrazole inhibitors of coactivator associated arginine methyltransferase 1 (CARM1). It is also used to prepare aminofuro-pyridine derivatives as inhibitors of TAK1.<br>References Huynh, T., et al.: Bioorg. Med. Chem. Lett., 19, 2924 (2009); Horneberger, K., et al.: Bioorg. Med. Chem. Lett., 23, 4517 (2013)<br></p>

<p>Applications Mesitoic acid can be used for its antioxidant.<br>References Thomas, P.S., et.al.: Medicines, 4, 1-7, (2017);<br></p>

<p>Applications Reagent used in labelled pyrimidine and purine synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Das, S., et al.: J. Med. Chem., 52, 5937 (2009), Kim, K., et al.: Bioorg. Med. Chem. Lett., 19, 5225 (2009),<br></p>

<p>Applications 2-(formylamino)benzoic acid (cas# 3342-77-6) is a useful research chemical.<br></p>

<p>Applications 2-Hydroxybutanoic Acid is an analyte used in the diagnoses of colorectal cancer as well as Type II diabetes. It is also used in the purification of the major Vibrio autoinducer and the study of its role in virulence factor production for cholera.<br>References Qiu, Y. et al.: J. Proteome Res., 8, 4844 (2009); Salek, R.. et al.: Phys. Genom., 29, 99, (2007); Higgins, D. et al.: Nature, 450, 883 (2007);<br></p>