Carboxylic Acids

<p>Hydrocinnamic acid: white, sweet-smelling crystalline solid; used in cosmetics, food, and pharma.</p>

<p>Methyl acetylacetate found in urine indicates propionyl-CoA carboxylase or 2-methylacetoacetyl-CoA thiolase deficiency.</p>

<p>2-Hydroxyisobutyric acid, a MTBE metabolite, is excreted in air &amp; breaks down into TBA, formaldehyde, and others; used as a bactericide.</p>

<p>N-Methyl-D-aspartic acid is an amino acid that, as the D-isomer, is the defining agonist for the NMDA (N-Methyl-D-aspartic acid) receptor subtype of glutamate</p>

<p>N-Methylsarcosine improves athletic performance, boosts immunity, treats autism/epilepsy, tracks COPD, and aids in ionic liquid development.</p>

<p>L-Norvaline: arginase inhibitor, non-protein amino acid, in Bacillus peptide, used in E. coli proteins.</p>

<p>D-Leucine stops seizures post-onset and lessens long-term potentiation without affecting basal synaptic transmission.</p>

<p>Beta-hydroxybutyrate aids in ketone body metabolism and is elevated in ketosis; it's a byproduct of valine from muscles.</p>

<p>N-(3-Phenylpropionyl)glycine, an acyl glycine, indicates medium-chain acyl-CoA dehydrogenase deficiency when detected in urine.</p>

<p>4-Acetamidobutanoic acid, a GABA derivative in eukaryotes, found in blood, feces, urine, and human prostate.</p>

<p>4,4'-Disulfanediylbis(2-aminobutanoic acid) (DL-Homocystine) is one of the endogenous metabolites, is the double-bonded form of homocysteine.</p>

<p>Sodium D-lactate is a chiral organic acid, more common as L-isomer in organisms, and a microbial metabolite.</p>

<p>(±)-Leucine (DL-2-Aminmo-4-methylvalerianic acid) can be found in Green bell peppers, Green zucchinis, Italian sweet red peppers, and Red bell peppers.</p>

<p>Applications Citric Acid Monohydrate is a useful buffer component for antigen and epitope unmasking.<br></p>

<p>Applications Pimelic Acid is a metabolite found in four biofluids from dairy cows that may be used as biomarkers of milk.<br>References Sun, H., et. al.: J. Proteome Res., 14, 1287 (2015)<br></p>

<p>Applications Ethyl 4-Phenylacetoacetate is a useful synthetic intermediate. It is used to prepare pyrazolone derivatives as antiprion compounds. It is also used to prepare pyrrolinylaminopyrimidine analogs as inhibitors of AP-1 and NF-κB mediated gene expression.<br>References Kimata, A., et al.: J. Med. Chem., 50, 5053 (2007); Palanki, M., et al.: Bioorg. Med. Chme. Lett., 12, 2573 (2002)<br></p>

<p>Applications Methyl 2-Cyano-2-oximinoacetate is an intermediate in synthesizing 2-Cyano-2-(methoxyimino)acetic Acid (C989423), which is a cyano-oxime derivative used as a fungicide.<br>References Tellier, F., et al.: Pestic Biochem Physiol., 78, 151-160 (2004)<br></p>

<p>Applications rac 3-Hydroxydecanoic Acid (cas# 5561-87-5) is a compound useful in organic synthesis.<br></p>

<p>Applications Difluoroacetic acid<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications A solid phase organic linker for synthesis of tethering carboxylic acids to support.<br>References Backes, B.J. and Ellman, J. A.: J. Org. Chem., 64, 2322 (1999)<br></p>

<p>Applications Z-2-Fluoro-3-(3-pyridyl)acrylic Acid (cas# 359435-42-0) is a compound useful in organic synthesis.<br></p>

<p>Applications PERFLUORO-3,6-DIOXAHEPTANOIC ACID (cas# 151772-58-6) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 6-[(6-Aminohexyl)amino]-6-oxo-hexanoic acid is a nylon oligomer with flame retardant properties.<br>References Zahn, Helmut et al.: Chemische Berichte, 92, 1381 (1959)<br></p>

<p>Applications An effective agent for increasing nicotinamide adenine dinucleotide (NAD) concentrations in mammalian cells.<br>References Yang, T. et al.: J. Med. Chem., 50, 6458 (2007);<br></p>

<p>Applications Reagent used in the addition of Phenothiazine (P318040).<br>References Zhang, Y., et al.: Bioorg. Med. Chem. Lett., 17, 707 (2007), Bansode, T., et al.: Pharm. Chem. J., 43, 311 (2009), Chelikani, R., et al.: App. Biochem. Biotechnol., 157, 263 (2009),<br></p>

<p>Applications Repaglinide intermediate.<br>References Wolfenbuttel, B., et al.: Eur. J. Clin. Pharmacol., 45, 113 (1993), Grell, W., et al.: J. Med. Chem., 41, 5219 (1998), Anon., et al.: Drugs Future, 24, 815 (1999),<br></p>

<p>Applications β-Formylpropionic Acid is used in the synthesis of potent and orally available nonpeptide antagonist of human gonadotropin-releasing hormone receptor. It is also a reagent in the synthesis of human melanocortin-4 receptor antagonists with a pyrrolidinone moiety.<br>References Chen, C. et al.: J. Med. Chem., 51, 7478 (2008); Jiang, W. et al.: Bioorg. Med. Med. Chem. Lett., 17, 5610 (2007);<br></p>

<p>Applications 2-hydroxyhexanoic acid (cas# 6064-63-7) is a useful research chemical.<br></p>

<p>Applications 4-Hydroxyphenylarsonic Acid could be useful for synthesizing flower-​like CoFe2O4 particles that are an attractive sorbent for removing aromatic organoarsenicals from wastewater.<br>References Liu, J., et al.: J. Colloid Interface Sci., 568, 63 (2020)<br></p>

<p>Applications Isophthalic Acid is a useful reagent for preparing semiconductor sealing materials, prepregs, build-up films, solder resists, dry films, and printed wiring boards.<br>References Matsumura, Y., &amp; Nakamura, A.: PCT Int. Appl. (2021), WO 2021006164 A1<br></p>

<p>Impurity Methyl Salicylate USP Related Compound A<br>Applications 4-Hydroxy-isophthalic Acid Dimethyl Ester (cas# 5985-24-0) is a compound useful in organic synthesis.<br></p>

<p>Applications Sebacic Acid is a urinary metabolite that has been identified as an anti-fatigue biomarker.<br>References Ma, C. et. al.: J. Pharmaceut. Biomed. Anal. 105, 84 (2015)<br></p>

<p>Applications β-Chlorolactic Acid (cas# 1713-85-5) is a compound useful in organic synthesis.<br></p>

<p>Stability Hygroscopic<br>Applications Used in the manufacturing of L-tryptophan by enzymic reaction.<br>References Franke, L., et al.: J. Med. Chem., 48, 6997 (2005), Fox, T., et al.: Curr. Top Med. Chem., 6, 1579 (2006),<br></p>

<p>Applications Vinyl Acetate used in the preparation of bis(heterocycles) with pyrazoline, used in the preparation of anti-inflammatory and analgesic activities. Also used in the synthesis of antimalarial compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sreenivasa, S. et al.: Open. J. Med. Chem., 3, 50 (2013); Verbrugghen, T. et al.: J. Med. Chem., 56, 376 (2013);<br></p>

<p>Applications 4-Pyridylthioacetic Acid (cas# 10351-19-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-(methylamino)-3-oxopropanoic acid (cas# 42105-98-6) is a useful research chemical.<br></p>

<p>Applications Crotonic Acid is found in water extracts from carrot seeds (Daucus carota L.) and is shown to have strong herbicidal properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jasicka-Misiak, I., et al.: Phytochemistry, 66, 1485 (2005)<br></p>

<p>Applications Cis-Pinic Acid is used to develop an exposure system for the toxicological evaluation of particles derived from coal-fired power plants. It is formed from α-pinene (P466605) oxidation.<br>References Ruiz, P., et al.: Inhal. Toxicol., 19, 607 (2007); Kristensen, K., et al.: Atmos. Chem. Phy., 13, 3763 (2013)<br></p>

<p>Applications 5,6-dibromonicotinic acid (cas# 29241-64-3) is a useful research chemical.<br></p>

<p>Applications 2-Benzoylbenzoic Acid is a reagent that is used in the synthesis of BzATP Triethylammonium Salt, which is a selective P2X purinergic agonist. It is more potent than ATP at homodimeric P2X7 receptors.<br>References Abou-Seri, S. M., et al.: Eur. J. Med. Chem., 107, 165 (2016);<br></p>

<p>Applications (±)-Jasmonic Acid can be used as reactant/reagent for synthetic preparation of fluorescent-labeled jasmonate and application to fluorescent imaging in cabbage seedlings.<br>References Liu, S., et al.: Tetrahedron Lett., 53, 4235-4239 (2012)<br></p>

<p>Applications Succinic Acid was identified in essential oil from Saxifraga stolonifera and has antibacterial activity.<br>References Zhang, Z.: Xibei Nongye Xuebao, 25, 1536 (2016)<br></p>

<p>Applications 2,4-Dihydroxybenzoic acid is a useful synthetic intermediate. An organic building block for plastics and rubber products.<br>References Gautam, R., et al.: Cryst. Growth Des., 18, 1501 (2018); Shvedene, N. V., et al.: J. Anal. Chem., 72, 95 (2017);<br></p>

<p>Applications Intermediate in the preparation of Modafinil<br>References Stark, H., et al.: Eur. J. Med. Chem., 29, 695 (1994), Cass, Q., et al.: J. Pharm. Biomed. Anal., 46, 937 (2008),<br></p>

<p>Applications Cyclopropanecarboxylic Acid is used as a reagent in the synthesis of substituted 4-(thiophen-2-ylmethyl)-2H-phthalazin-1-ones as potent PARP-1 inhibitors. Also used as a reagent in the synthesis of 2-alkyloxazoles as potent and selective PI4KIIIβ inhibitors demonstrating inhibition of HCV replication.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wang, L., et al.: Bioorg. Med. Chem. Lett., 24, 3739 (2014); Keaney, E.P., et al.: Bioorg. Med. Chem. Lett., 24, 3714 (2014)<br></p>

<p>Applications Heptadecanedioic Acid (cas# 2424-90-0) is a useful research chemical.<br></p>

<p>Applications Mesitoic acid can be used for its antioxidant.<br>References Thomas, P.S., et.al.: Medicines, 4, 1-7, (2017);<br></p>