Carboxylic Acids

Applications Methyl Diethylphosphonoacetate (cas# 1067-74-9) is a useful research chemical.

Applications Methyl 2-Aminothiazole-5-carboxylate (cas# 6633-61-0) is a compound useful in organic synthesis.

Stability Very Very Moisture sensitive
Applications Chloroformic Acid Chloromethyl Ester is used as a reagent in the synthesis of carbamates and carbonates.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Safadi, M. et al.: Pharm. Res. 10, 1350 (1993); Loren, J.C. et al.: Synlett, 18, 2847 (2005);

Applications 2-benzylcyclopropane-1-carboxylic acid (cas# 103986-55-6) is a useful research chemical.

Applications methyl 2,4-dichlorothiazole-5-carboxylate (cas# 861708-66-9) is a useful research chemical.

Applications 1,1,2-Ethanetricarboxylic Acid 1,1,2-Triethyl Ester is a useful synthetic intermediate. It can be used to prepare Isobutylsuccinic Acid (I780660) which was used to synthesize succinimide derivatives as inhibitors of human leukocyte elastase, cathepsin G and proteinase 3.
References Groutas, W., et al.: Bioorg. Med. Chem., 3, 375 (1995);

Applications Reagent used in the addition of cyclopropane.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Cave, C., et al.: Eur. J. Med. Chem., 25, 75 (1990), Kiyama, R., et al.: Chem. Pharm. Bull., 43, 960 (1995), Humphries, P., et al.: Bioorg. Med. Chem. Lett., 16, 6120 (2006),

Stability Light Sensitive
Applications Ethyl 1-Bromocyclobutanecarboxylate is a reactant in the preparation of aroylindole-substituted phenoxyacetic acid derivatives, which has PPARγ and PPARα agonist activity, pharmacokinetics, and glucose and triglyceride lowering properties.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Liu, W., et al.: J. Med. Chem., 52, 14 (2009)

Applications 3,4-Bis(isobutoxycarbonyl)benzoic Acid is a useful reagent in organic synthesis.

Applications Ethyl Acetate (2-13c, 99%) (cas# 58735-82-3) is a useful research chemical. This isotopic compound is used as a tracer in various experiments, for instance, during the conversion of oxygenated and hydrocarbon molecules to particulate matter for fuel purposes, and biosynthesis of terpenes.
References Aaron, E., et.al., Combust Flame, 161,2966-2974,(2014); Citron,C., et.al., Chem Comm,50,5224-5226,(2014);

Stability Light Sensitive
Applications Vinylacetic Acid can be used as a reagent in the synthesis of 4-Phenyl-3-butenoic Acid which is an in vivo inhibitor of the peptide amidating enzyme peptidylglycine hydroxylase.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bradbury, A.F., et al.: Eur. J. Biochem., 189, 33 (1990)

Applications tert-Butyl (5-Chloro-2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamate is used as a reactant in the synthesis of BRAF-kinase inhibitors.
References Repik, Alexey E., et al.: PCT Int. Appl., WO 2017146604 A1 20170831 (2017)

Applications 2-[(Dipropylamino)sulfonyl]benzoic Acid, is a building block used in various chemical synthesis.

Applications 5-(Benzyloxy)-2-((benzyloxy)carbonyl)-3-hydroxy-5-oxopentanoic Acid is an intermediate used in the synthesis of 2-[2-[(5-carboxypentyl)amino]-2-oxoethyl]-2-hydroxybutanedioic Acid (C181175), which is derived from Methyl 6-Aminohexanoate Hydrochloride (M287100), which is used as a reagent to synthesize straight chain hydroxamates, compounds that act as inhibitors of Human Histone Deacetylase (HDAC) that have the potential to treat cancer. Methyl 6-aminohexanoate is also sometimes used as a spacer unit for peptide synthesis.
References Matthews, S., et al.: J. Chem. Soc. Chem. Commun., 17, 1809 (1995); Remiszewski, S., et al.: J. Med. Chem., 45, 753 (2002)

Applications Butylboronic Acid is a boronic acid derivative that can be used as a transport carriers in membrane-based sugar separations. Butylboronic Acid is used as an analytical reagent in the determination of serum glucose.
References Smith, B.D. et al.: ACS Symp. Ser., 642, 194 (1996); Prendergast, J.L. et al.: Anal. Bional. Chem., 397, 1779 (2010);

Applications Methylboronic Acid is a methylated derivative of boronic acid, a building block towards various intermediates in suzuki coupling.
References Baker, J. O., et al.: Biochem.. 22, 2098 (1983); Garner, C.W., et al.: J. Biol. Chem., 255, 5064 (1980)

Applications 7-Chloro-4-oxo-4H-chromene-2-carboxylic acid (cas# 114741-22-9) is a useful research chemical.

Applications 3-Isopropoxybenzoic acid is a useful reagent for organic synthesis and other chemical processes.
References Chiong, H. A., et al.: J. Am. Chem. Soc., 129, 9879 (2007); Kingston, D. G. I., et al.: J. Med. Chem., 41, 3715 (1998)

Applications 3-​Hydroxypivalic Acid is a general reagent used in the synthesis of AZD8835, a potent and selective inhibitor of PI3K and PI3Kδ in the treatment of cancers.
References Barlaam, B. et al.: Bioorg. Med. Chem. Lett., 25, 5155 (2015);

Applications 5-[3-(Trifluoromethoxy)phenyl-2-Furancarboxylic Acid is the structural analogue of 5-[2-(Trifluoromethoxy)phenyl]-2-furancarboxylic Acid (T790925), a reactant used in the preparation of (phenyl)-N-[(mercapto)(pyrrolyl)triazolyl]furancarboxamide and (phenoxy)-N-[(mercapto)(pyrrolyl)triazolyl]acetamide derivatives as herbicides.
References Xue, S., Lu, C.: Youji Huaxue, 28, 1083 (2008)

Applications Z-2-Fluoro-3-(3-pyridyl)acrylic Acid (cas# 359435-42-0) is a compound useful in organic synthesis.

Applications 5-Ethyl-2-fluorophenylboronic acid

Applications 3-(3-Furyl)acrylic Acid is a reactant in the preparation of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
References Hornberger, K.R., et. al.: Bioorg. Med. Chem. Lett., 23, 4517 (2013)

Applications 1-Cyclopentenecarboxylic Acid can be used for enantioselective 1,3-dipolar cycloadditions of diazoacetates and solid-phase synthesis of substituted indolines. It can also be used to develop antagonists for A1- and A2-adenosine receptors.
References Sibi, M. P., et al.: Org Lett. 9, 1553 (2007); Nicolaou, K. C., et al.: J. Am. Chem. Soc. 122, 2966 (2000); Jacobson, K. A., et al.: Biochem. Pharmacol. 37, 3653 (1988)

Applications 2-Aminomethylphenylacetic Acid is an intermediate of Ceforanide (C242930), a cephalosporin based antibiotic used in the sterilization in various medical procedures.
References Zhao, Y., et. al.: Res. Chem. Int. 40, 1637 (2014); Sifakis, S. et al.: Arch. Gyne. Obst., 272, 201 (2005); DiPiro, J. et al.: Antimicrob. Agents Chemother., 27, 287 (1985)

Applications 4-Carboxymethylphenylboronic acid

Applications Methyl Dimethoxyacetate is used as a reagent in the synthesis of benzimidazole derivatives for use as respiratory syncytial virus inhibitors.
References Cooymans, Ludwig Paul; D., et al. PCT Int. Appl. WO 2012080446 A1 20120621. Jun 21, 2012

Applications 3-(2,3-Dihydroxyphenyl)propionic acid is a degradation product of the aromatic compound Phenylpropionate (PP).
References Provencher, S., et al.: Biochemistry, 20, 33 (1981), Ferrandez, A., et al.: J. Bacteriol., 179, 2573 (1997), Torres, B., et al.: J. Biol. Chem., 278, 27575 (2003),

Applications 3,4-Diaminobenzenesulfonic Acid is a useful organic synthetic reagent and a sulfonate-aminium zwitterion.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Liu, J., et al.: Acta Crystallogr. B., 66, 3281 (2010)

Applications 3-(Phenylthio)acrylic Acid (cas# 63413-91-2) is a useful research chemical.

Applications 2-(bis(2-(tert-butoxy)-2-oxoethyl)amino)acetic acid (cas# 171557-31-6) is a useful research chemical.

Applications 3-Oxohexanoic Acid is an enzymatic metabolite and a building block for bacterial autoinducers.
References Naef, R., et al.: J. Agric. Food Chem., 56, 517-527 (2008);

Stability Hygroscopic
Applications 3-Sulfanylhexyl Acetate is a precursor of 3-mercaptohexan-1-ol (M225270) found in grape juice.
References Harsch, M.J., et al.: J. Agri. Food. Chem., 61, 3703 (2013); Makhotkina, O., et al.: Food. Chem., 135, 486 (2012);

Applications 3-PHENYLISONICOTINIC ACID (cas# 104096-15-3) is a useful research chemical.

Applications 1,2-Diaminopropane-N,N,N',N'-tetraacetic Acid is an aminopolycarboxylic acids found at ultra-trace levels in water; Also, it is used in the construction of Eu3+ ion-selective membrane electrode as suitable ionophore.
References Nette, D., et al.: Anal. Chim. Acta, 884, 124-132 (2015); Abedi, M. R., et al.: E-J. Chem., 8, S467-S473 (2011)