Carboxylic Acids

Applications 17-Amino-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanoic Acid is used for preparation of glutamic acid-containing acylating reagents for selective acylation of amino group(s) in peptides or proteins.
References Christensen, C., et al.: PCT Int. Appl. (2010), WO 2010084169 A2 20100729.

Applications 4-(Acetamidomethyl)benzoic acid

Applications 4-Hydroxybut-2-ynoic Acid (cas# 7218-52-2) is a useful reagent for the green preparation of polyseleno-substituted enamines.
References Wang, Y. C., et al.: Green Chem., 20, 604 (2018)

Applications 9-Ethyl-9H-carbazole-3-carboxylic Acid is a useful reagent for the preparation of an oxime ester photoinitiator.
References Hu, C., & Yu, P.: Faming Zhuanli Shenqing (2020), CN 111320714 A

Applications 5-Ethyl-6-hydroxyhexanoic Acid is an intermediate in the synthesis of metabolites of Bis(2-ethylhexyl) Phthalate (DEHP) (B433850).
References Kaulen, J., et al.: Tetrahedron., 38, 3299 (1982);

Applications 2-Ethoxy-4-ethoxysulfonylbenzoic Acid is a derivative of Methyl 2-Ethoxybenzoate (M220113), a useful chemical reagent, used in the synthesis and antibacterial triazoles and oxadiazoles, as well as sulfonamide compounds.
References Shi, Z. et al.: Compt. Rend. Chim., 18, 1320 (2015);

Applications Methyl 3-chlorosulfonylthiophene-2-carboxylate

Applications Synthesis and receptor binding of 5-(amino[3H]2methyl)-3-isothiazolol ([3H]thiomuscimol), a specific GABAA agonist photoaffinity label.
References Frolund, B., et al.: J. Labelled Compounds Radiopharm., 36, 877 (1995),

Applications 2,2-Dimethylbutyrate (DMB) is a potential treatment for thalassemia and hemoglobinopathies.
References Yeh, K., et al.: J. Pharmacokinet. Biopharm., 6, 79 (1978), Cunningham, M., et al.: Blood, 104, 34 (2004), Rund, D., et al.: N. Engl. J. Med., 353, 1135 (2005),

Applications Methyl 5-chlorothiophene-2-carboxylate (cas# 35475-03-7) is a useful research chemical.

Applications 1-Hydroxycyclopentanecarboxylic Acid is a reagent used in the preparation of pyridone-conjugated monobactam antibiotics showing gram-negative activity.
References Brown, M. et al.: J. Med. Chem., 56, 5541 (2013); Rozhko, E. et al.: ChemCatChem., 5, 1998 (2013);

Applications 5-[2-(Trifluoromethoxy)phenyl]-2-furancarboxylic Acid is a reactant used in the preparation of (phenyl)-N-[(mercapto)(pyrrolyl)triazolyl]furancarboxamide and (phenoxy)-N-[(mercapto)(pyrrolyl)triazolyl]acetamide derivatives as herbicides.
References Xue, S., Lu, C.: Youji Huaxue, 28, 1083 (2008)

Stability Air Sensitive
Applications (2S)-2-Mercaptopropanoic Acid is an intermediate in synthesizing (R)-(+)-Thiolactomycin (T350880). It is a natural product inhibitor of β-Ketoacyl-AcpM Synthase A (KasA). It inhibits the synthesis of mycolic acid which is a major cell wall component of Mycobacterium tuberculosis. Also an inhibitor of D-Aspartate oxidase (DDO).
References Kapilashrami, K., et al.: J. Biol. Chem., 288, 6045 (2013); Paneerselvam, V., et al.: J. Pharm. Res., 4, 4618 (2011); Katane, M., et al.: Biochimie, 92, 1371 (2010)

Applications 6-cyano-2-oxaspiro[3.3]heptane-6-carboxylic acid (cas# 1934971-05-7) is a useful research chemical.

Applications 5-Hydroxyisophthalic Acid is used as a reagent in the synthesis of silver carboxylate metal organic framework (MOF) complexes. 5-Hydroxyisophthalic Acid is also used as the starting material in the synthesis of N,N’-Bis(2,3-dihydroxypropyl)-5-[(N-(2-hydroxyethyl)carbamoyl)methoxy]-2,4,6-triiodoisophthalamide (B426310); a compound related to Ioversol( I737000) which is a nonionic, low osmolality, radiographic contrast agent.
References Lu, X., et al.: J. Inorg. Biochem., 138, 114 (2014); Wilkins, R.A., et al.: Invest. Radiol., 24, 781 (1989); Kaufman, A.J., et al.: Urol. Radiol., 12, 56 (1990)

Impurity Ketoprofen EP Impurity G
Applications 3-​(2-Hydroxyethyl)​benzoic Acid (Ketoprofen EP Impurity G) is an impurity in the synthesis of Ketoprofen (K200800), anti-inflammatory (1,2); analgesic.
References 1. Ueno, K. et al.: J Med Chem. 1976 Jul;19(7):941-6. 2. Jamali, F. et al.: Clin Pharmacokinet. 1990 Sep;19(3):197-217.

Applications Phosphoric acid diethyl octyl ester is part of a group of phosphate derivatives that enhance drug penetration through the skin. Phosphoric acid diethyl octyl ester is also used as a reagent to prepare trialkyl phosphate and phosphorothiolate anticholinesterases.
References Aoyagi, T., et al.: Drug Des. Discovery, 8, 47 (1991); Bracha, P. & O’Brien, R.: Biochemistry, 7, 1555 (1968)

Applications (R)-Benzyl (3-Oxo-1-(phenylthio)heptan-2-yl)carbamate is a derivative of N-Carbobenzyloxy-3-phenylthio-L-alanine (C176530) which is an intermediate in the synthesis of Nelfinavir.
References Kaldor, S., et al.: J. Med. Chem., 40, 3979 (1997),

Applications 5-Aminononane-5-carboxylic Acid is a reagent used in the synthesis of Fmoc-α-​dialkylamino acids.
References Suresh B. et al.: Indian J. Chem. Section B: Chem. Inc. Med., 40B, 70 (2001);

Applications Ethyl 5-amino-1-benzofuran-2-carboxylate is used as an synthetic intermediate in the preparation of indolebutylpiperazines, a class of dual 5-HT1A receptor agonists and serotonin reuptake inhibitors. Ethyl 5-amino-1-benzofuran-2-carboxylate was also used as a potential radiolabelled analog for melanoma imaging and targeted radiotherapy.
References Chezal, J.M., et al.: J. Medn. Chem., 51, 3133 (2008); Heinrich, T., et al.: J. Medn. Chem., 47, 4684 (2004);

Applications Dimethyl-1,3-acetonedicarboxylate is used in the preparation of optically active lycorane. It has also been substituted into bispidone derivatives for their use as ligands in PET imaging.
References Yoshizaki, H. et al.: J. Org. Chem., 60, 2016 (1995); Legdali, T. et al.: J. Org. Chem., 77, 11167 (2012);

Applications N-Caproic Acid Isopropyl Ester (cas# 2311-46-8) is a useful research chemical.

Applications (1S,3R,4S)-Ethyl 4-Amino-3-((tert-butoxycarbonyl)amino)cyclohexanecarboxylate Oxalate has been used as a reactant for the preparation of oxadiazole compounds containing cyclohexanediamine moiety.

Stability Moisture Sensitive
Applications Methyl 3-Phenyloxirane-2-carboxylate (cas# 37161-74-3) is a useful research chemical.

Stability Light Sensitive
Applications Oleyl Acetate (cas# 693-80-1) is a useful research chemical.

Applications 5-Hydroxy-3-phenylbenzoic Acid can be used in biological study of preparation and identification of hydroxybenzoic acids as lactate receptor agonists and antilipolytics. It can also be used in discovery of new series of BRD4(1) inhibitors using protein-ligand docking and structure-guided design.
References Duffy, B. C., et al.: Bioorg Med Chem Lett, 25, 2818 (2015), Dvorak, C. A., et al.: ACS Med Chem Lett, 3, 637 (2012)

Applications Benzyl Acetoacetic Amide (cas# 882-36-0) is a compound useful in organic synthesis.
References Sakaki, J., et al.: Chem. Pharm. Bull., 37, 2952 (1989),

Applications 3-((E)-(2,4-Dimethylphenyl)diazenyl)-2,4-dihydroxy-5-((4-sulfophenyl)diazenyl)benzoic Acid is an intermediate in the synthesis of Acid Orange 24 (A189835), which is used in trickling biofilters for wastewater treatment. Acid Orange 24 is used in suncare compositions. It also serves as a raw material for cosmetics. Mutagenicity test for dye compositions in cosmetics.
References Garzon-Zuniga, M. A., et al.: Water Environ. Res., 83, 107 (2011); Anon.: IP.com Journal, 11, 5 (2011); Muzzall, J. M., et al.: Mutat. Res., Genet. Toxicol. Testing, 67, 1 (1979)

Applications 5-Chloronicotinic Acid is used as reagent/reactant luminescence and hydrothermal preparation of cobalt/cadmium/lead chloronicotinate phenanthroline MOF.
References Gao, Z.Q., et al.: J. Solid State Chem., 241, 121-130 (2016)

Applications 4-Amino-1,3-benzenedisulfonic Acid is used as a reagent in the synthesis of arylazopyridoxal phosphate and phosphonate derivatives as P2 receptor antagonists.
References Kim, Y., et al.: Drug Develop. Res., 45, 52 (1998)

Applications 4-​Hydrazinobenzoic acid hydrochloride (cas# 24589-77-3) is a useful research chemical.

Applications tert-Butyl 2-(3-Aminophenyl)acetate can be used as anti-heparanase to treat diseases and disorders associated with heparanase activity.
References Giannini, G., et.al.: PCT Int. Appl., 103, (2018);