Carboxylic Acids

<p>Applications N-Propylboronic Acid is a chemical reagent used in the synthesis of pharmaceutical agents such as inhibitors of mTOR for use in anti-tumor treatments. Also used to synthesize endothelial lipase inhibitors<br>References Takeuchi, C. et al.: J. Med. Chem., 56, 2218 (2013); O'Connell, D. et al.: Bioorg. Med. Chem. Lett., 22, 1397 (2012);<br></p>

<p>Applications 3-Formylbenzene-1,2-disulfonoic Acid is derived from 5,6-Difluoro Anthranilic Acid (D445550), which is used in the preparation of 2-[[2-(phenylamino)-1H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]benzamide derivatives as inhibitors of IGF-1R and IR receptor tyrosine kinase as anticancer agents.<br>References Rubinstein, E., et al.: Chemotherapy, 47, 3 (2001), Grohs, P., et al.: Antimicrob. Agents Chemother., 47, 3542 (2003),<br></p>

<p>Applications 5-Chloro-2-fluorobenzoic Acid (cas# 394-30-9) is a compound useful in organic synthesis.<br></p>

<p>Applications Ethyl 5-amino-1-benzofuran-2-carboxylate is used as an synthetic intermediate in the preparation of indolebutylpiperazines, a class of dual 5-HT1A receptor agonists and serotonin reuptake inhibitors. Ethyl 5-amino-1-benzofuran-2-carboxylate was also used as a potential radiolabelled analog for melanoma imaging and targeted radiotherapy.<br>References Chezal, J.M., et al.: J. Medn. Chem., 51, 3133 (2008); Heinrich, T., et al.: J. Medn. Chem., 47, 4684 (2004);<br></p>

<p>Applications Methyl 2-Cyclopentanonecarboxylate is used in the synthesis of functionalized ketones.<br>References Mashima, K. et al.: J. Org. Chem., 59, 3064 (1994); Hamashima, Y. et al.: J. Am. Chem. Soc., 124, 11240 (2002);<br></p>

<p>Applications Bis[2-​(1-​methylethyl)​phenyl] Ester Phosphorochloridic Acid is an intermediate in the synthesis of Bis(2-isopropylphenyl) Phenyl Phosphate (B451445), which is a triaryl phosphate used as plasticizers in polyvinyl chloride (PVC) as well as a flame retardant. Studies show that Bis(2-isopropylphenyl) Phenyl Phosphate inhibits the human androgen receptor.<br>References Duke, A.J.: Chimia, 32, 457 (1978); Honkakoski, P. et al.: Biochem. Pharmacol., 67, 97 (2004); Nobile, E.R. et al.: Bull. Environ. Contam. Toxicol., 25, 755 (1980);<br></p>

<p>Applications (±)-2-Acetoxybutyric Acid is an intermediate in synthesizing 2-Hydroxy-N-(pyridin-4-yl)butanamide (H953495). It is a is a useful synthetic intermediate.<br></p>

<p>Applications Hexahydro-4-oxo-1(2H)-azocinecarboxylic Acid 1,1-Dimethylethyl Ester is a chemical reagent used in organic synthesis.<br></p>

<p>Stability Hygroscopic<br>Applications Tetrahydrophthalic acid is a useful building block in organic synthesis.<br></p>