Quinones

Bisvismiaquinone is a novel compound, which is a bioactive quinone derived from natural sources, specifically isolated from certain plant species. This compound is characterized by its distinct molecular structure, which contributes to its unique pharmacological properties. The mode of action of bisvismiaquinone involves the modulation of biochemical pathways, potentially including oxidative stress mechanisms, signaling pathways, or enzyme inhibition, making it of particular interest for therapeutic exploration.

3-Geranyloxy-6-methyl-1,8-dihydroxyanthraquinone is a natural anthraquinone compound, which is derived from certain plant species, notably those in the families Rubiaceae and Fabaceae. These compounds are often isolated through sophisticated extraction techniques that target bioactive substances present in botanical sources.

Seitomycin is an anthraquinone antibiotic. It exhibits moderate activity against Gram-positive bacteria, such as Staphylococcus aureus and Bacillus subtilis, as well as Gram-negative bacteria like Escherichia coli and Streptomyces viridochromogenes.

Neobulgarone D is an anthraquinone derivative from the ascomycete fungus Neobulgaria pura HA A07-97. It inhibits the formation of appressoria in the rice blast fungus and exhibits mild cytotoxicity with no antifungal, antibacterial, or phytotoxic activity.

4-Methoxy-p-toluquinone is an antibiotic in the quinone class with antibacterial, antimycobacterial, and antifungal properties, although it is less effective against Gram-negative bacteria. Its activity is inactivated by serum.

Aklaviketone is a bacterial metabolite identified in the Streptomyces galilaeus S 383 strain. It plays a role in the biosynthesis pathway of anthracycline antibiotics.

Baumycin B1 is an antitumor antibiotic (antibiotic).

Cytotrienin A is an ansamycin antibiotic with potent apoptosis-inducing activity.

Ochracenomicin C is produced by the bacterium Amicolatopsis sp. MJ 950-891 and exhibits weak antibacterial activity.

Fibrostatin D is a compound found in Streptomyces species known for its activity as a proline hydroxylase (proline hydroxylase).

Laccaridione A can inhibit the activity of anti-serine proteases. The IC50 values of Laccaridione A for inhibiting trypsin, papain, thermolysin, collagenase, and zinc proteases are 14.7 μg/mL, 2.5 μg/mL, 18.8 μg/mL, 7.2 μg/mL, and 18.2 μg/mL, respectively.

Laccaridione B inhibits the activity of serine proteases. It exhibits inhibitory effects on trypsin, papain, thermolysin, collagenase, and zinc metalloprotease with IC50 values of 10.9 μg/mL, 5.1 μg/mL, 8.4 μg/mL, 5.7 μg/mL, and 3.0 μg/mL, respectively. Additionally, Laccaridione B shows significant antiproliferative activity against L-929, K-562, and HeLa cells, with IC50 values of 2.4 μg/mL, 1.8 μg/mL, and 13.9 μg/mL, respectively.

Fibrostatin F is a compound found in Streptomyces, acting as a proline hydroxylase (proline hydroxylase).

Sakyomicin B is a benzoquinone antibiotic that exhibits activity against Gram-positive bacteria and mycobacteria.

Malvone A is a compound with antifungal properties found in Malva sylvestris, with an ED50 of 24 μg/mL against V. dahliae. It is applicable in research focused on anti-infective solutions.

Fibrostatin B is a compound identified in Streptomyces sp. that functions as a proline hydroxylase (proline hydroxylase) inhibitor.

16-Methyloxazolomycin is an antibiotic with antibacterial and antialgal properties. It exhibits activity against P388 leukemia cells and human lung adenocarcinoma cells.

4-Deoxybostrycin exhibits activity against Bacillus subtilis.