Naphthalenes

<p>Applications Naphthalene is an abundant polycyclic aromatic hydrocarbon that is persistent, bioaccumulative, toxic and found in tobacco smoke and urban air. This compound is a contaminant of emerging concern (CECs).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sutherland, K.M., et. al.: Am. J. Physiol., 302, L68 (2012); Bahuguna, A., et. al.: J. Pharm. Res., 5, 1600 (2012);<br></p>

<p>Applications Labelled analogue trans-1,2-Dihydroxy-1,2-dihydronaphthalene, a metabolite of Naphthalene.<br>References Sun, Y. et al.: Arch. Toxicol., 80, 280 (2006); Cho, T. et al.: Drug Metab. Drug Interact., 22, 235 (2007); Iwamoto, N. et al.: J. Biol. Chem., 282, 33396 (2007);<br></p>

<p>Applications 1-Naphthylamine is a reagent used to synthesize various dyes used in the textile industry.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Case, R., et al.: Brit. J. Ind. Med., 11, 75 (1954)<br></p>

<p>1,2-Naphthoquinone is a reactive chemical that binds to DNA. It has been shown to inhibit the growth of cultured tumor cells in a genotoxic and cytotoxic manner. 1,2-Naphthoquinone inhibits the activity of many enzymes and has been used in pharmacological experiments on animal models. It is also used as a reagent for organic synthesis and as an intermediate for the production of other chemicals. The redox potential of 1,2-naphthoquinone can be determined by titration calorimetry.</p>

<p>2-(Bromomethyl)naphthalene is a chemical that has been studied extensively for its ability to inhibit the growth of cancer cells. It binds with high affinity to the mitochondrial membrane potential and inhibits the production of ATP, leading to cell death. 2-(Bromomethyl)naphthalene has also been shown to produce reactive oxygen species (ROS), which can also induce tumor cell death. This compound has been used in a variety of biological samples, including urine samples, which have shown promising results. A potential target for this drug is an enzyme called hydrolysis, which may be found at higher concentrations in tumor cells. The proposed reaction mechanism is shown below: 2- (bromomethyl) naphthalene + H 2 O → bromide ion + 2- (hydroxymethyl) naphthalene The kinetic data and diphenyl sulfoxide are unknown at this time.</p>

<p>Please enquire for more information about Trisodium 7-hydroxynaphthalene-1,3,6-trisulphonate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>6-Hydroxy-1-naphthoic acid is a synthetic carboxylate compound with an analog structure that has been shown to be cytotoxic to cancer cells. It inhibits the activity of protein kinases by binding to ATP, which blocks the phosphorylation of tyrosine residues on proteins. 6-Hydroxy-1-naphthoic acid has been shown to inhibit growth factor receptors and induce apoptosis in tumor cells. The mechanism of action for this drug is believed to be through ring opening and hydrolysis of the naphthalene ring, followed by reaction with p-hydroxybenzoic acid. This results in inhibition of histone deacetylase activity, leading to decreased expression of genes involved in cell proliferation.</p>