Pharmaceutical Standards

Applications 8-Bromoguanosine (cas# 4016-63-1) is a compound useful in organic synthesis.
References Hu, H., et al.: Mol. Pharmacol., 69, 1542 (2006), Mallett, D., et al.: J. Pharm. Biomed. Anal., 49, 100 (2009),

Applications Adenose N-Oxide and its derivatives are used as an active ingredient in the preparation of therapeutic agents for inflammatory diseases and inhibitors of adenosine kinase.
References Long, M. & Parker, W.: Biochem. Pharmacol., 71, 1671 (2006)

Applications Used in the preparation of labeled cocaine analogs.
References Carroll, F.I., et al.: J. Med. Chem., 35, 2497 (1992),

Applications 1,2-Dimethylisothiourea-HI (cas# 41306-45-0) is a useful research chemical.

Applications (S)​-4-​[(Methoxycarbonyl)​amino]​-5-​hexenoic Acid Ethyl Ester is an intermediate in synthesizing (S)-Vigabatrin (V253000), a novel anti-epileptic drug. Antidepressant; antipsychotic; anxiolytic.
References Vajda, F., et al.: Clin. Neurosci., 7, 88 (2000); Beghi, E., et al.: Lancet. Neurol., 3, 618 (2004); Sagirli, O., et al.: J. Pharmaceut. Biomed., 42, 618 (2006);

Applications 2,​3,​4-​Triacetate 1-​(2,​2,​2-​Trichloroethanimidat​e) 6-​O-​(2,​3,​4,​6-​Tetra-​O-​acetyl-​β-​D-​glucopyranosyl)​-β-​D-​glucopyranose is an intermediate in the synthesis of Guaiacol-beta-D-gentiobioside (G245570), which is a Guaiacol Conjugate, that has shown to present in fermentation of grapes that had been exposed to bushfire smoke and can potentially yield unpalatable, smoke-affected wine.
References Hayasaka, Y.m et al.: J. Arg. Food Chem., Vol. 58, Issue 4, P: 2076; 2081 (2010);

Applications 4-(Benzyl(methyl)amino)benzoic Acid is an intermediate of α,α-Bis[4-(dimethylamino)phenyl]-4-(methylamino)-benzenemethanol which is a product from degradation of methyl green.
References Chen, C., et al.: Environ. Sci. Technol., 41, 4389 (2007)

Applications Bis[2-(2-mercaptobenzoyl)hydrazide] 2,2'-Dithiobis-benzoic Acid is an intermediate used in the synthesis of N,N’-Bis(2-mercaptobenzoyl)hydrazide (B481825), which is a selective inhibitor of HIV-1 integrase. Has no other effect on other retroviral targets, including reverse transcriptase, protease, and virus attachement, and exhibits no detectable activity against human topoisomerases I and II at concentrations that effectively inhibit integrase.
References Neamati, N., et al.: J. Med. Chem., 45, 5661 (2003)

Applications 2-Acetamido-3-(benzyloxy)benzoic Acid Methyl Ester is an intermediate in the synthesis of metabolites of Bentazon (B120580), a selective post-emergence herbicide.

Applications A 9-substituted derivative of the polycyclic aromatic hydrocarbon (PAH) Anthracene (A678400).

Applications 2-Amino-4-chloro-5-nitropyridine (cas# 24484-96-6) is a compound useful in organic synthesis.

Applications S-Deoxyo-5-Hydroxy Acetate Omeprazole is an isotope labelled intermediate in the synthesis of 5-Hydroxy Omeprazole (H948863), the main metabolite of Omeprazole (O635000), which binds covalently to proton pump. It inhibits gastric secretion. Used as an anttiulcerative.
References Wallmark, B., et al.: Biochim. Biophys. Acta., 778, 549 (1984); Morii, M., et al.: J. Biol. chem., 268, 21553 (1993); Ritter, M., et al.: Br. J. Pharmacol., 124, 627 (1998)

Applications O-TBS Hexadec-7-enoic acid is an intermediate in the synthesis of 3-Hydroxy-9-hexadecenoyl-L-carnitine which is an analogue of 3-Hydroxyhexadecanoylcarnitine Inner Salt (H943005), a derivative of Carnitine, essential cofactor of fatty acid metabolism; required for the transport of fatty acids through the inner mitochondrial membrane. Synthetized primarily in the liver and kidney; highest concentrations found in heart and skeletal muscle. Dietary sources include red meat, dairy products, beans, avocado. Also 3-Hydroxyhexadecanoylcarnitine works similar to the endogenous non-toxic molecule L-Carnitine (C184110) whose bioavailablity is improved due to the transport systems in place for Carnitine.
References Mitchell, M.E., et al.: Am. J. Clin. Nutr., 31, 293 (1978), Lango, R., et al.: Cardiovasc. Res., 51, 21 (2001), Vaz, F.M., et al.: Biochem. J., et al.: 361, 417 (2002), Karlic, H., et al.: Nutrition, 20, 709 (2004), O. Piermatti. et al.: Bioorg. Med. Chem., 16, 1444 (2008)

Applications 4,4,4-Trimethoxybutanoic Acid Methyl Ester is an substituent in the synthesis of Methyl Prednisolone (M325934).
References Ueno, H., et al.: J. Med. Chem., 34, 2468 (1991);

Applications 2',3',5'-Triacetate derivative of 6-Mercaptopurine-9-β-D-ribofuranoside (M257125), a substrate for adenosine deaminase.
References Kashida, T., et al.: Biol. Pharma. Bull., 18, 1492 (1995); Sloan, K.B., et al.: J. Pharma. Sci., 72, 372 (1983);

Applications Intermediate used in the addition of protected Glucopyranuronic Acid.

Applications N-Nitro-N'-[(tetrahydro-3-furanyl)methyl]carbamimidothioic Acid Methyl Ester is an intermediate in the synthesis of Dinoteturan (D482100), a neonicotinoid insecticide.

Applications N,N-Dimethyl-2,4-dinitro-1-naphthalenamine (cas# 39139-79-2) is a compound useful in organic synthesis.

Applications 2,2'-[Oxybis(2,1-ethanediylimino)]bis-ethanol is a useful synthetic intermediate. It is patented as one of the antibacterial oral compositions in mouthwash.
References Gaffar, A., et al.: U.S. (1980), US 4224309 A 19800923.

Applications (2R,4R)-2-[[[(1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]-4-hydroxy-1-pyrrolidinecarboxylic Acid 1,1-Dimethylethyl Ester is an intermediate in the synthesis of 2’-epi-Lincomycin which is an epimer of Lincomycin (L466200) which is a 6-amino, 6-deoxy-octopyraninose with strong antibiotic activity.
References Le Goffic, F. et al.: J. Antimicrob. Chemother., 16, 12 (1985); Prior, C. et al.: J. Pharmacol. Exp. Therap., 255, 1170 (1990)