Pharmaceutical Standards

Applications N-(Trifluoroacetyl)-thyroxine-13C6 4’-O-β-D-Glucuronide Triacetate Dimethyl Ester is an intermediate in the synthesis of Thyroxine-13C6 4’-O-β-D-Glucuronide Disodium Salt, which is labelled Thyroxine 4’-O-β-D-Glucuronide (T425630), a major metabolite and glucuronide conjugate of Thyroxine (T425600) formed via the glucuronidation of the phenyl hydroxyl group.
References Tong, Z. et al.: Drug Metab. Dispos., 35, 2203 (2007); West, C.D. et al.: J. Clin. INvest., 42, 1134 (1963)

Applications (3S)-3-Amino-4-tert-butoxy-4-oxobutanoic Acid (cas# 4125-93-3) is a useful research chemical.

Applications ((2S,4S)-2-(Chloromethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methyl 4-Methylbenzenesulfonate is an intermediate in the synthesis of Itraconazole (I937500), an orally active antimycotic structurally related to Ketoconazole. Antifungal.
References Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989), Sugar, A.M.,et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1993)

Applications [1,1'-Binaphthalen]-8-ol is an intermediate in the synthesis of Benzo[j]fluoranthene (B205690), a polycyclic aromatic hydrocarbon that has tumour initiating activity and can be found in soot, oil, water and soil extracts as a common pollutant.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Rice, J. E., et al.: J. Org. Chem., 58, 1415 (1993);

Applications N-Nitro-S-methylisothiourea is used as a reactant in the preparation of 1,5-substituted-1,3,5-hexahydrotriazine-2-N-nitroimines with insecticidal activity.
References Xue, S., et. al.: J Heterocyciic Chem., 50, 1067 (2013)

Applications (2S)-1-(Benzyloxycarbonyl)azetidine-2-carboxylic acid-d5 is a useful synthetic intermediate.

Applications 2-tert-Butyl-1,3-diisopropylisourea is a useful synthetic intermediate in the synthesis of 5-Oxo Atorvastatin tert-Butyl Ester (O847160) which is a Boc-protected derivative of Atorvastatin (A791750, Ca Salt). 2-tert-Butyl-1,3-diisopropylisourea is also used as a reagent in the total synthesis of Citrafungin A which is an antifungal natural product.
References Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993); Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996); Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000); Calo, F., et al.: J. Org. Chem., 73, 9692 (2008)

Applications Intermediate in the synthesis of m-Fluoro Prasugrel (F595870).

Applications α-Ionol derivative.

Applications An intermediate for the synthesis of the metabolite of Flurbiprofen, an anti-inflammatory used as an analgesic.

Applications (-)-Galanthaminyl (-)-Camphanate (cas# 1025881-27-9) is a compound useful in organic synthesis.

Applications 5-Chloro-1,2-dihydro-1-acenaphthylenol is used in the preparation of benzimidazole derivatives as receptor agonists for the treatment of central nervous system diseases.

Applications L-Aspartic Anhydride Hydrochloride is a chemical acylating reagent used in friedel-crafts reactions such as in the preparation of L-homophenylalanine.
References Lin, W. et al.: Synthesis, 7, 1007 (2001);

Applications 4-​(1,​2-​Dimethyl-​1-​propen-​1-​yl)​-​benzoic Acid Methyl Ester is an intermediate in synthesizing 1-Desmethyl-2-methylpropyl Amorolfine (D292315), an analogue of Amorolfine Hydrochloride (A634170). Amorolfine hydrochloride is a salt of Amorolfine which is a morpholine antifungal drug. It is a topical solution for the treatment of toenail infections.
References Rotta, I., et al.: JAMA Dermatol., 149, 341 (2013); Espinel-Ingroff, A., et al.: Antimicrob. Agents Ch., 26, 5 (1984)

Stability Moisture Sensitive
Applications alpha-Pinene oxide (cas# 1686-14-2) is a useful research chemical.

Applications 2-Bromo-1,6-dimethyl Ester Hexanedioic Acid is an intermediate in the synthesis of 2-Hydroxyhexanedioic Acid Disodium Salt (H943015). Accumulation and excretion of 2-Hydroxyhexanedioic Acid (with 2-ketoadipic and 2-aminoadipic) in urine can be caused by 2-ketoadipic acidemia, probably without adverse phenotypic effects, due to deficiency of 2-ketoadipic dehydrogenase.
References Svendsen, J., et al.: J. Chromatogr., 337, 9 (1985); Przyrembel, H., et al.: Clin. Chim. Acta 58, 257 (1975).

Applications 2-Bromo-6-nitrophenol is an intermediate used in the synthesis of N-Hydroxy Eltrombopag (H825795), which is a derivative compound of Eltrombopag (508000), an agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia.
References Bussel, J., et al.: New Eng. J. Med., 357, 2237 (2007), Marsilje, T., et al.: Bioorg. Med. Chem. Lett., 18, 5259 (2008), Alper, P., et al.: Bioorg. Med. Chem. Lett., 18, 5255 (2008),

Applications 7-​Chloro-​1-​ethyl-​6-​fluoro-​1,​4-​dihydro-​4-​oxo-3-​quinolinecarboxylic Acid Ethyl-d5 Ester is the unlabelled form of 7-​Chloro-​1-​ethyl-​6-​fluoro-​1,​4-​dihydro-​4-​oxo-3-​quinolinecarboxylic Acid Ethyl Ester (C315510), which is an impurity of Norfloxacin (N681000), an antibacterial agent and a contaminant of emerging concern (CECs). 7-​Chloro-​1-​ethyl-​6-​fluoro-​1,​4-​dihydro-​4-​oxo-3-​quinolinecarboxylic Acid Ethyl-d5 Ester is also an intermediate in the synthesis of Norfloxacin-d5 (N681003).
References Koga, H., et al.: J. Med. Chem., 23, 1358 (1980); Hirai, K., et al.: Antimicrob. Agents Chemother., 19, 188 (1981); Holmes, B., et al.: Drugs, 30, 482 (1985)

Applications 4-(Ethoxycarbonyl)phenyl 2,3,4-Triacetate β-D-Glucopyranosiduronic Acid Methyl Ester is an intermediate in the synthesis of p-Salicylic Acid 4-Glucuronide which is an anthocyanin-derived phenolic acid degraded to form 4' glucuronide of 4-hydroxybenzoic acid during simulated gastrointestinal digestion and in human liver microsome.
References Zhang, Q.Z., et al.: Tetrahedron/, 68l, 4194 (2012); Woodward, G.M., et al.: Molec. Nutrition. Food. Res., 55, 378 (2011);

Applications 5-Bromo-2',3',5'-tri-O-acetyluridine (cas# 105659-32-3) is a compound useful in organic synthesis.