Pharmaceutical Standards

Applications N,​N-​Dimethyl-​5-​(phenylmethoxy)​-1H-​indole-​3-​ethan-​α,​α,​β,​β-​d4-​amine is an intermediate in the synthesis of Bufotenine-d4 Hydrochloride (B689467), which is labelled bufotenine Hydrochloride (B689465) which is a weak hallucinogenic agent active by intravenous injection. It is a constituent of toad poison.
References Stoll, et al.: Helv. Chim. Acta, 38, 1452 (1955), Bhattacharya, S., et al.: Indian. J. Physiol. Pharmacol., 15, 133 (1971), Falkenberg, G., et al.: Acta Crystallogr., 28B, 3219 (1972)

Applications Intermediate in the synthesis of m-Fluoro Prasugrel (F595870).

Applications 2-Bromo-3'-hydroxyacetophenone (cas# 2491-37-4) is a compound useful in organic synthesis.

Applications (2S)-1-(Benzyloxycarbonyl)azetidine-2-carboxylic acid-d5 is a useful synthetic intermediate.

Applications 4-Fluoro-1-naphthoic acid (cas# 573-03-5) is a useful research chemical.

Applications 2-[(2-Amino-3-chlorophenyl)thio]-benzoic Acid Methyl Ester is an intermediate in the synthesis of 9-Chloro Quetiapine (C366040). 9-Chloro Quetiapine is an impurity of Quetiapine hemifumarate (Q510000), a dibenzothiazepine antipsychotic medication used in the treatment of schizophrenia.
References Kumar, K., et al.: Org. Chem.: An Indian Journal, 8, 164 (2012); Raju, I., et al.: Chromatographia, 70, 545 (2009)

Applications 3-Amino-3-oxo-propanoic Acid Phenylmethyl Ester is an intermediate in the synthesis of Malonuric Acid (M158100), which is produced during degradation of sodium barbiturates.
References Fretwurst, F., et al.: Arzneimittel-Forschung, 8, 44-50 (1958)

Applications Reagent used to synthesize many pyrrole derivatives

Applications rac-Naproxen Methyl Ester-13C,d3 is an Labelled Naproxen (N377525) intermediate, an anti-inflammatory, analgesic and antipyretic agent.

Applications (2E,6Z,8E)-2,6,8-Decatrienoic Acid Methyl Ester is an spilanthol (S681850) related amide found from Acmella ciliata.
References Martin, R., et al.: Phytochem., 23, 1781 (1984);

Applications 3-​(Benzyloxy)​-hippuric Acid Benzyl Ester is an intermediate during the synthesis of m-Hydroxyhippuric Acid-13C2, 15N (H943127), a labelled m-Hydroxyhippuric Acid (H943125) which is a metabolite of caffeic and chlorogenic acids in human.
References Booth, A., et al.: J. Biol. Chem., 229, 51 (1957); Gonthier, M., et al.: Biomed. Pharmacother., 60, 536 (2006)

Applications 2-(Ethoxymethyl)-α,α-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol-d5 is an intermediate in synthesizing Resiquimod-d5 (R144682), an isotope labelled Resiquimod (R144680) which is an imidazoquinoline derivative that acts as an immune response modifier. Resiquimod shows antitumor and antiviral activity and is used in the treatment of skin lesions such as herpes simplex virus. Resiquimod is a toll-like receptor 9 (TLR7) agonist.
References Wu, J.J. et al.: Antivir. Res., 64, 79 (2004); Fife, K.H. et al.: Antimicrob. Agents Chemother., 52, 477 (2008); Szeimies, R.M. et al.: Brit. J. Dermatol., 159, 205 (2008)

Applications 4-(Benzyl(methyl)amino)benzoic Acid is an intermediate of α,α-Bis[4-(dimethylamino)phenyl]-4-(methylamino)-benzenemethanol which is a product from degradation of methyl green.
References Chen, C., et al.: Environ. Sci. Technol., 41, 4389 (2007)

Applications Intermediate in the preparation of precursors for cyclic polysulfides.
References Abu-Yousef, I. et al.; J. Sulfur Chem. 28, 251 (2007)

Applications A deuterated acyclic phosphonate nucleotide.

Applications N-​(Methoxycarbonyl)​-L-​glutamic Acid 5-​Ethyl Ester is an intermediate in synthesizing (S)-Vigabatrin (V253000), a novel anti-epileptic drug. Antidepressant; antipsychotic; anxiolytic.
References Vajda, F., et al.: Clin. Neurosci., 7, 88 (2000); Beghi, E., et al.: Lancet. Neurol., 3, 618 (2004); Sagirli, O., et al.: J. Pharmaceut. Biomed., 42, 618 (2006);

Applications An intermediate for the synthesis of mivacurium and and other neuromuscular blocking agents.

Applications Labelled Vanillyl Methyl Ketone (V097625). Volatile aromatic compound released from hard woods. It is often found in wine that has been aged in wood barrels contributing to the wine’s flavor profile. It is also released during combustion, giving flavor to smoked meats.
References Zhang, B., et al.: App. Biochem. Biotechnol., 147, 119 (2008), Fernandez de Simon, B., et al.: J. Agric. Food Chem., 57, 3217 (2009), Conde, E., et al.: Food Chem., 114, 806 (2009),

Applications (R,S)-1-(2-Nitrophenyl)ethanol (cas# 3205-25-2) is a compound useful in organic synthesis.

Applications (T-4)-Triphenyl(P,P,P-triphenylphosphine imidato-κN)-phosphorus Diphosphate is an intermediate used in the synthesis of Ganciclovir Triphosphate Triethylamine Salt (G235030), which is an inhibitor of hepatitis B virus DNA polymerase and has shown potent antiviral activity against herpes viruses and hepadnaviruses.
References Rubsam, L.Z., et al.: Cancer. Res., 59, 669 (1999); Shaw, T., et al.: Hepatol., 24, 996 (1996);