Pharmaceutical Standards

Applications 3-Amino-3-oxo-propanoic Acid Phenylmethyl Ester is an intermediate in the synthesis of Malonuric Acid (M158100), which is produced during degradation of sodium barbiturates.
References Fretwurst, F., et al.: Arzneimittel-Forschung, 8, 44-50 (1958)

Applications Intermediate in the synthesis of polycyclic aromatic systems.

Applications Methyl-(4-nitrophenylethyl)-4-(nitrophenoxyethyl)amine-d4 (cas# 1189869-42-8) is a compound useful in organic synthesis.

Applications (-)-Galanthaminyl (-)-Camphanate (cas# 1025881-27-9) is a compound useful in organic synthesis.

Applications N-METHYLTHIOUREA (cas# 598-52-7) is a useful research chemical.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 8-Bromoguanosine-13C2,15N is an intermediate in the synthesis of 8-Aminoguanosine-13C2,15N (A609877). 8-Aminoguanosine-13C2,15N is an isotopic labelled compound of 8-Aminoguanosine (A609875), which is a potent inhibitor of purine nucleoside phosphorylase.
References Kazmers, I.S., et al.: Science, 214, 1137 (1981); Chern, J-W., et al.: J. Med. Chem., 36, 1024 (1993)

Applications Methyl 3-Nitrophthalate is an intermediate in the synthesis of (αS)-3-Ethoxy-4-methoxy-α-[(methylsulfonyl)methyl]-N-[(1S)-1-phenylethyl]-benzenemethanamine which is an impurity of Apremilast (A729700), which is an oral phosphodiesterase 4 inhibitor used for treating psoriatic arthritis.
References Gan, E. et al.: BioDrugs, 27, 359 (2013); Pathan, E. et al.: Annal. Rheum. DIs., 72, 1475 (2013)

Applications The labelled epimer of Medroxyprogesterone acetate (M203560). Progesterone impurity.
References Tang, M., et al.: Endocrinol., 151, 1320 (2010), Lee, K., et al.: Mol. Cell. Endocrinol., 319, 109 (2010), Rodgers, A., et al.: Chem., Res. Toxicol., 23, 724 (2010), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010),

Applications Palbociclib 1,2,3,4-Tetra-O-acetyl-β-D-glucuronic Acid Methyl Ester is an intermediate in synthesizing Palbociclib N-β-D-Glucuronide Sodium Salt (P139910), a derivative of Palbociclib (P139900) which is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.
References Finn, R., et al.: Breast Cancer Res., 11, 5 (2009)

Applications 4-​[Bis(2-​methoxy-​2-​oxoethyl)​amino]​-​3-​[2-​[2-​[bis(2-​methoxy-​2-​oxoethyl)​amino]​-​5-​methylphenoxy]​ethoxy]​-benzoic Acid is an intermediate in synthesizing N-[2-[2-[2-[Bis(carboxymethyl)amino]-5-(diazoacetyl)phenoxy]ethoxy]-4-methylphenyl]-N-(carboxymethyl)-glycine Tetrapotassium Salt (B416505), which is more stable as dilute aqueous solution since solid form is light sensitive and is susceptible to decomposition. It is used in the photolysis of caged calcium and measurement of calcium concentration in cardiac myocytes.
References Lipp, P., et al.: Cell Calcium, 19, 255 (1996);

Applications Phinothricin metabolite.
References Komossa, D. et al.: Pestic. Biochem. Phys. 43, 95 (1992)

Applications trans-Cinnamoyl chloride (cas# 102-92-1) is a useful research chemical.

Applications 4-[1-(4-Iodophenyl)-5-(2,4-dinitrophenyl)-formaz-3-yl]-1,3-benzene Disulfonate, Disodium Salt (cas# 161617-44-3) is a compound useful in organic synthesis.

Applications Gibberellic Acid Methyl Ester 2-p-Toluenesulfonate is an intermediate in the synthesis of Gibberellin A5 (G377465). Gibberellin A5 is a plant hormone which promotes floral development but have little effect on stem elongation.
References Cross, B.E., et al.: Tetrahedron., 8, 451 (1962); Meijon, M., et al.: J. Plant. Growth. Regulat., 30, 74 (2011); Ward, D.A., et al.: Phytochem., 71, 2010 (2010)

Applications N-Ethyl-N-methyl-O-(4-nitrophenyl)carbamate (cas# 90870-20-5) is a compound useful in organic synthesis.

Applications 2’,3’,5’-Tri-O-acetyl Guanosine-13C2,15N is an intermediate in the synthesis of 8-Aminoguanosine-13C2,15N (A609877). 8-Aminoguanosine-13C2,15N is an isotopic labelled compound of 8-Aminoguanosine (A609875), which is a potent inhibitor of purine nucleoside phosphorylase.
References Kazmers, I.S., et al.: Science, 214, 1137 (1981); Chern, J-W., et al.: J. Med. Chem., 36, 1024 (1993)

Applications An intermediate for the synthesis of a benzimidazole PARP inhibitor I (succinate salt) (ABT-472).
References Denny, W., et al.: J. Med. Chem., 33, 814 (1990), Anon., et al.: Curr. Med. Chem., 10, 321 (2003),

Applications N-Nitro-N'-[(tetrahydro-3-furanyl)methyl]carbamimidothioic Acid Methyl Ester is an intermediate in the synthesis of Dinoteturan (D482100), a neonicotinoid insecticide.