Pharmaceutical Standards

Applications 5'-S-(3-Aminophenyl)-5'-thioadenosine is an intermediate used in the synthesis of S-adenosylhomocysteine analogs with biological activities.
References 5'-S-(3-Aminophenyl)-5'-thioadenosine is an intermediate used in the synthesis of S-adenosylhomocysteine analogs with biological activities.

Applications 6-Chloro-7-deaza-9-(5’-O-tert-butyldimethylsilyl-2’,3’-O-isopropylidine-β-D-ribofuranosyl)purine (cas# 115479-39-5) is a compound useful in organic synthesis.

Applications 3-Methoxy Acetaminophen-d3 is deuterium labeled 3-Methoxy Acetaminophen (M226050). 3-Methoxy Acetaminophen is a metabolite of Acetaminophen (A161220), an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3).
References (1) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(2) Fairbrother, J.E., et al.: Anal. Profiles Drug Subs., 3, 1 (1974) (3) Hinson, J.A., et al.: Rev. Biochem. Toxicol., 2, 103 (1980)

Applications 2-Quinoxalinecarboxylic Acid Methyl Ester has been used as a reactant in the synthesis of quinoxaline derivatives that show antimycobacterial activity, while displaying minor activity itself. In addition to having the substructure that exhibits antitumor activity, it is also used in the design of guanine-guanine selective DNA cleaving agents.
References Seitz, L.E. et al.: J. Med. Chem., 45, 5604 (2002); Toshima, K. et al.: Chem. Comm., 3, 212 (2002);

Applications Methyl 1,4-Dihydro-4-(2’-trifluoromethyl)phenyl-pyridine-3-carboxylate-5-ethyl Carboxamide (cas# 887407-06-9) is a compound useful in organic synthesis.

Applications Isotope labelled (R)-(-)-2-Oxothiazolidine-4-carboxylic Acid (O870505), a precursor to glutathione (GSH) which is an important antioxidant in plants, animals and fungi.
References Meister, A., et al,: J. Am. Coll. Nutr., 5, 137 (1986);

Applications Sappanone A is a natural product flavonoid with some antioxidant properties that can be isolated from C. sappan.
References Namikoshi, M., et al.: Chem. Pharm. Bull., 35, 2761 (1987); Foroumadi, A., et al.: Bioorg. Med. Chem. Lett., 17, 6764 (2007);

Applications γ-Valerolactone-d3 is the isotope labelled analog of γ-Valerolactone. γ-Valerolactone is a naturally occurring chemical found in fruits and is frequently used as a food additive. It can be converted to liquid alkenes which can be used as transportation fuels.
References Horvath, I.T., et al.: Green Chem., 10, 238 (2008); Bond, J.Q., et al.: Science, 327, 1110 (2010)

Applications Labelled Dimethylaminopropyl chloride hydrochloride (D461800), used as a pharmaceutical intermediate for the synthesis of drugs, agricultural chemicals, photographic chemical and biochemical reagent. Displays mutagenic activity.
References Sanderson, D., et al.: Hum. Exp. Toxicol., 10, 261 (1991), Richard, A., et al.: Mutat. Res., 400, 493 (1998), McKinney, J., et al.: Toxicol. Sci., 56, 8 (2000),

Stability Light Sensitive, Moisture Sensitive, Temperature Sensitive
Applications A major metabolite of Irinotecan.
References Canal, P., et al.: J. Clin. Oncol., 14, 2688 (1996), Haaz, M., et al.: Cancer Res., 58, 468 (1998), Kehrer, D., et al.: Clin. Cancer Res., 6, 3451 (2000), Hanioka, N., et al.: Xenobiotica, 31, 687 (2001), Satoh, T., et al.: Drug Metab. Dispos., 30, 488 (2002),

Applications 2,6-Dimethyl-3,5-dicarboxy-4-(2-nitrophenyl)-1,4-dihydropyridine is used as a reactant in the preparation of hydroxyindolecarboxylate and hydroxycarbolinecarboxylate from nifedipine analogous cyanoethyl ester.
References Gorlitzer, K., et al.: Pharmazie, 55, 35 (2000)