Pharmaceutical Standards

Cinnamtannin B-1 is a cytosolic Ca2+ modulator that binds to and inhibits the activity of ATPases, which are enzymes that hydrolyze ATP. This causes an increase in intracellular Ca2+ levels, which leads to altered cell physiology. Cinnamtannin B-1 also inhibits mitochondrial membrane potential and enzyme activities. Cinnamtannin B-1 is a bioactive phytochemical found in cinnamon extract, which has been shown to have anti-obesity effects due to its ability to reduce the number of fat cells. Cinnamtannin B-1 has been shown to inhibit 3T3-L1 preadipocyte differentiation by targeting proteins such as procyanidins.

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Perillaldehyde is a natural compound that has been used in food and medicine for centuries. It is an antimicrobial agent with dextran sulfate, which is a sugar polymer that inhibits the growth of fungi and bacteria. Perillaldehyde also has been shown to inhibit the energy metabolism of microorganisms by decreasing ATP production. Perillaldehyde has also been shown to have genotoxic activity, as it can cause DNA strand breaks. This compound also causes oxidative stress in cells by reducing mitochondrial membrane potential and inducing reactive oxygen species (ROS). Perillaldehyde has acute toxicities, as it causes electrochemical impedance spectroscopy changes that indicate cell death.

2-(2-Naphthyloxy)propanoic acid is a naphthalene derivative that is found in the plant species Carthamus tinctorius. It has been shown to have potent antagonist activity against the NMDA receptor, as well as antinociceptive and analgesic properties in vivo. 2-(2-Naphthyloxy)propanoic acid also shows potent anti-inflammatory and cardioprotective effects in vitro and in vivo. 2-(2-Naphthyloxy)propanoic acid can be used for the treatment of bone cancer, congestive heart failure, diabetic neuropathy, or other disorders of the peripheral nervous system.

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