Pharmaceutical Standards

Applications 4,4’-Dithiobis[2-(1,1-dimethylethyl)-phenol is used as a reactant for the fabrication of coatings based on epoxy resins for environmental protection of microelectronics.
References Krysin, A. P., et al.: Russ. J. Appl. Chem., 86, 997-1000 (2013)

Stability Unstable in Solution
Applications β-Ketoglutaric Acid is used in the synthesis of benzodiazepine derivatives. Also used in the synthesis of orally available hepatitis C virus polymerase inhibitors.
References Jung, D. et al.: Synth. Comm., 29, 1941 (1999); Li, H. et al.: J. Med. Chem., 52, 1255 (2009);

Stability Hygroscopic
Applications A main Levomepromazine metabolite
References Hals, P., et al.: Human Toxicol., 3, 497 (1984), Cutroneo, P., et al.: J. Pharm. Biomed. Anal., 41, 333 (2006),

Applications Chloroethylnitrosourea derivative with antitumor activity. Similar to carmustine, chlorozotocin, nimustine, ranimustine. Antineoplastic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Johnston, T.P., et al.: J. Med. Chem., 9, 892 (1966), Oliverio, V.T., et al.: Cancer Res., 30, 1330 (1970), Thompson, G.R., et al.: Toxicol. Appl. Pharmacol., 21, 405 (1972), Al-Shammary, F.J., et al.: Anal. Profiles Drug Subs., 19, 315 (1990),

Applications Δ6-Gestodene, is an impurity of Gestodene (G368250), an orally active gestogen with progesterone-like profile of activity. Used in combination with estrogen as oral contraceptive.
References Duesterberg, B., et al.: Contraception, 24, 673 (1981); Duesterberg, B., et al.: Seroids, 43, 43 (1984); Losert, W., et al.: Arzneim.-Forsch., 35, 459 (1985);

Applications CMPD101 is a potent and selective GRK2/3 inhibitor.
References Lowe, J.D., et al.: Mol. Pharmacol., 88, 347 (2015); Ikeda, S., et al.: PCT Int. Appl. WO 2007034846 A1 20070329. Mar 29, 2007

Applications An intermediate of Rosuvastatin (R700500).
References Laufer, S., et al.: J. Med. Chem., 45, 2733 (2002), Palani, A., et al.: Bioorg. Med. Chem. Lett., 13, 709 (2003),

Applications N-Guanyl-S-Methyl-Isothiourea Hydroiodide is a reactant used in the synthesis of novel compounds that may be used as HIV entry inhibitors.
References Wilkinson, R. et al.: Antimicrob. Agents Chemother., 55, 255 (2011);

Applications 1-(4-Nitrophenyl)cyclopentanecarbonitrile-d8 is an intermediate used in the synthesis of Apatinib-d8 Hydrochloride (A726152), which is labelled Apatinib (A726150). Apatinib is an orally available, small molecule multitargeted tyrosine kinase inhibitor. Apatinib selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2). Apatinib functions by inhibiting VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. Recent studies have shown that Apatinib enhances the efficacy of conventional chemotherapeutical drugs in side population (SP) cells and ABCB1-overexpressing leukemia cells.
References Mi, Y. et al.: Cancer Res., 70, 7981 (2010); Tong, X.Z. et al.: Biochem. Pharmacol., 83, 586 (2012); Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);

Applications A metabolite of Eplerenone. Used in combination therapy for treatment of cardiovascular disorders.
References Staessen, J., et al.: J. Endocrinol., 91, 457 (1981), de Gasparo, M., et al.: J. Pharmacol. Exp. Ther., 240, 650 (1987), MacFadyen, R., et al.: Cardiovasc. Res., 35, 30 (1997),

Applications trans-2-Chloro-3-((1r,4r)-4-phenylcyclohexyl)naphthalene-1,4-dione is an intermediate in the synthesis of Atovaquone derivatives (A793500).

Applications A metabolite of Sitagliptin.
References Beconi, M.G. , et al.: Drug Metab. Dispos., 35, 525 (2007),

Applications 2,4'-Dibromoacetophenone-2-13C (CAS# 335081-05-5) is a useful isotopically labeled research compound.

Applications 3,5-Dibromosalicylic Acid