Pharmaceutical Standards

Applications Benzoic-3,5-d2 Acid (CAS# 37960-84-2) is a useful isotopically labeled research compound.

Applications Metopimazine (MPZ) is used to prevent emesis during chemotherapies. Antiemetic.
References Catz, P., et al.: Int. J. Pharm., 58, 93 (1990), Sato, K., et al.: J. Pharm. Sci., 80, 104 (1991), Herrstedt, J., et al.: Cancer Chemother. Pharmacol., 33, 53 (1996), Sigsgaard, T., et al.: J. Clin. Onc., 19, 2091 (2001),

Stability Hygroscopic
Applications 3,​3',​3''-​(2,​4,​6-​boroxintriyl)​tris-Pyridine Hydrochloride is a compound useful in organic synthesis.

Applications Bivalirudin 1-11 Fragment is an impurity of Bivalirudin, a direct thrombin inhibitor acting as an anticoagulant through inhibition of the enzyme thrombin.
References Bertrand, O. et al.: Am. J. Cardio., 110, 599 (2012); Patti, G. et al.: Am. J. Cardio., 110, 478 (2012)

Applications Aprindine is a long-acting antiarrhythmic agent, effective when administered orally or intravenously in the treatment of ventricular arrhythmias of varying etiologies.
References Danilo, P. Jr., et al.: Am. Heart. J., 97, 119 (1979); Atarashi, H., et al.: Circulation. J., 66, 553 (2002);

Applications naphthalene-2-sulfonohydrazide (cas# 10151-46-9) is a useful research chemical.

Applications [2-(Methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium Hydroxide is a reagent in the synthesis of PVA/SBMA crosslinked hydrogels used in tissue mimicking, vascular cell culturing and implanting. For use in soft-tissue surgery and keeping it minimally invasive.
References Jian, S. et al.: J. Mech. Bwhav. Biomed. Mat., 4, 1228 (2011); Xu, S. et al.: Ann. Tech. Conf. Soc. Plastics Emg., 71, 1032 (2013);

Impurity Irbesartan Bromo N2-Trityl Impurity
Stability Moisture Sensitive
Applications An intermediate in the synthesis of Losartan and Valsartan.

Applications Aluminum Glycinate is an antacid which is used in the treatment of peptic ulceration. It is used in the development of a transdermal hydrogel patch for ferulic acid to treat skin damage induced by UV radiation.
References Rice, M., et al.: Am. J. Gastroenterol., 25, 74 (1956); Bai, J., et al.: Pak. J. Pharm Sci., 27, 369 (2014);

Applications 1,3-Di(methyl-d3)-naphthalene is the labeled analogue of 1,3-Dimethylnaphthalene (D476385), a polycyclic aromatic hydrocarbon (PAH) that has been shown to have cytochrome P 450 2A6 and 2A5 inhibitory activities.
References Wammer, K.H., Peters, C.A.: Environ. Sci. Technol., 39, 2571 (2005); Roy, K., Roy, P.P.: Eur. J. Med. Chem., 44, 1941 (2009)

Stability Hygroscopic
Applications 4-Amino-4'-nitrostilbene-2,2'-disulfonic Acid Disodium Salt (cas# 6634-82-8) is a compound useful in organic synthesis.
References Taylor, A., et al.: Biochem., 38, 11172 (1999),

Stability Hygroscopic
Applications 3,3'-Diaminobenzidine

Applications 5,6,7,8-Tetrahydronaphthalene-1-carbonyl Chloride is used in the synthesis of a sweetening agent, N-5,6,7,8-Tetrahydro-1-naphthoyl-α-L-glutamyl-5-amino-2-pyridine carbonitrile.
References Nofre, C., et al.: Eur. Pat. Appl. (1992), EP 511087 A1

Applications L-Methionine-13C5 is the isotope labelled analog of L-Methionine, which is an essential aminoacid for human development. Hepatoprotectant; antidote (acetominophen poisoning); urinary acidifier.
References Benevenga, N.J., et al.: J. Agric. Food Chem., 22, 2 (1974), Fleisher, L.D., et al.: Clin. Endocrinol. Metab., 3, 37 (1974), Meinnel, T., et al.: Biochimie, 75, 1061 (1993),

Applications 1-(1-Chloroethyl)naphthalene is used in the synthesis of substituted imidazoles and imidazole analogs of naphthalene which exhibits α1-(aorta) and α2-(platelet) activities;Also, it is derived from 1-(1-Naphthyl)ethanol (N378368), which is a useful chemical in organic synthesis.
References Amemiya, Y., et al.: Egypt J. Pharm. Sci., 35, 91-112 (1994); Kadotani, Shiho, et al.: ACS Sustainable Chem. & Eng., 5(10), 8541-8545 (2017);Helberg, Julian, et al.: Synthesis, 49(15), 3460-3470 (2017);Cozett, Rudy E., et al.: Org. & Biomol. Chem., 14(46), 10914-10925 (2016)

Stability Hygroscopic
Applications 3,3'-Oxydipropanol is an intermediate in the synthesis of 3,3'-[Oxybis(3,1-propanediyloxy)]bis[1-propanol] (O870290). 3,3'-[Oxybis(3,1-propanediyloxy)]bis[1-propanol] is derived from 3-(Benzyloxy)propyl 4-Toluenesulfonate (B288830), which is used as a reagent in the synthesis of Silodosin (S465000); an antidysuria drug. 3-(Benzyloxy)propyl 4-Toluenesulfonate is also used as a reagent in the preparation of aryloxyalkyl derivatives of adenine which have antiviral activity.
References Calogero, F., et al.: Eur. J. Org. Chem., 2015, 6011 (2015); Petrov, V.I., et al.: Chem. Heterocyc. Compd., 39, 1218 (2003)

Applications N-(1-Ethylpropyl)-N-methyl-β-alanine is a compound useful in organic synthesis.

Applications m-Hydroxyhippuric Acid-13C2, 15N is labelled m-Hydroxyhippuric Acid (H943125) which is a metabolite of caffeic and chlorogenic acids in human.
References Booth, A., et al.: J. Biol. Chem., 229, 51 (1957); Gonthier, M., et al.: Biomed. Pharmacother., 60, 536 (2006)

Applications Amlodipine-d4 maleic acid salt (2-chlorophenyl-d4) is deuterium labelled amlodipine maleic acid salt (A633500), which is a calcium channel blocker.
References Arrowsmith, J.E., et al.: J. Med. Chem., 29, 1696 (1986), burges, R.A., et al.: J. Cardiovasc Pharmacol., 9, 110 (1987), Packer, M., et al.: N. Engl. J. Med., 335, 1107 (1996)

Applications 9-Bromononanoic Acid is an intermediate in synthesizing Rumenic Acid (R701590), a trans fatty acid that may potentially reduce the risk of cancer and cardiovascular diseases. It may also prevent disease processes that lead to chronic inflammation, atherosclerosis, and diabetes.
References Baer, D. J.: Am J Clin Nutr 95, 267 (2012); Gebauer, S. K., et al.:  Adv Nutr 2, 332 (2011); Duffy, P. E., et al.: Tetrahedron 62, 4838 (2006)

Applications Cholesterol-d6 has been used in safe procedures to measure the percentage of cholesterol absorption, based on that of D. B. Zilversmit (1972), by using Cholesterol-d6 as a stable nonradioactive isotopic tracer of cholesterol that was administered orally into normal individuals to facilitate clinical investigation.
References Bosner, Matthew S., Journal of Lipid Research, 34, 1047-53, (1993)

Applications 4,4'-Diamino-2,2'-bipyridine is a bidendate chelator.

Applications 2,3,6,7-Tetramethyl Anthracene is an Anthracene (A678400) homologue. 2,3,6,7-Tetramethyl Anthracene is used in synthesis of naphthalenes, anthracenes, 9H-fluorenes, and other acenes.
References Robertson, D., et al.: J. Med. Chem., 29, 1577 (1986), de Koning, C., et al.: Tetrahedron, 59, 7 (2003), Smith, K., et al.: Org. Biomol. Chem., 1, 1552 (2003),

Applications The sex pheromone of Cigarette Beetle.

Stability Hygroscopic
Applications 3,3',5-triiodo-β-hydroxy-D/L-thyronine is an impurity or analog of 3,3’,5-Triiodo-D-thyronine (T795375), which is a structural analogue of the thyroid hormone Thyroxine (T425600). 3,3’,5-Triiodo-D-thyronine has been shown to reduce cholesterol in blood serum.
References Mintz, D.O., et. al.: New Engl. J. Med., 266, 808 (1962)

Applications Used in the new synthesis of coumarino(3,4:3',2')chromones. An antioxidant.
References Born, M., et al.: Helv. Chim. Acta, 79, 1147 (1996),

Applications 4'-(Imidazol-1-yl)acetophenone (cas# 10041-06-2) is a useful research chemical.

Applications 3-Amino-5-nitrophenylboronic acid

Applications Silver salt of Phosphoric Acid, used in various chemical processes as a phosphorylating compound. It is involved in the hydrolysis via phosphorylation of nanocrystals to obtain high-aspect-ratio cellulose nanocrystals. Also used in the preparation of superionic conducting glasses based upon silver halides.
References Camarero E. et al.: Biomacromol., 14, 1223 (2013); Minami, T. et al.: J. Non-Cryst. Sol., 56, 15 (1983);

Stability Hygroscopic
Applications Labelled Isonipecotic Acid Methyl Ester is a an ester derivative of 4-piperidinecarboxylic acid used as a reagent in the organic synthesis of neurochemicals, antibacterials and other biologically active compounds.
References Kim, E.-K. et al.: Yak. Hoechi, 48, 182 (2004); Tanitame, A. et al.: Bioorg. Med. Chem. Lett., 14, 2857 (2004);