Glycoscience

(1R) -1- [(2S, 3R) - 3- Hydroxy- 1- butyl - 2- azetidinyl] -1, 2- ethanediol is a glycosylase that catalyzes the hydrolysis of terminal sialic acid residues from oligosaccharides and monosaccharides. It is used in the synthesis of complex carbohydrates. This glycosylase has been shown to be highly specific for terminal sialic acids and can also be used to produce oligosaccharides with desired linkages between the sugars. The enzyme is most active at low pH and high temperatures.

1,3,4,6-Tetra-O-benzoyl-a-D-fructofuranose is a fluorinated monosaccharide. It is an artificial sugar that has been modified with a benzoyl group at the 1 position and a tetra-O-benzoyl group at the 3 position. This compound has been synthesized using a custom synthesis. The compound is soluble in water and ethanol and can be used as a glycosylation or polysaccharide modification reagent. Click chemistry reactions have been performed on this compound to introduce methyl groups to the 4 and 6 positions of the sugar ring. The purity of this product is >99%.

(2R, 3R, 3aS, 9aR) -3- (Benzoyloxy) - 2- [(benzoyloxy) methyl] - 2, 3, 3a, 9a- tetrahydro- 3a- methyl-6H- Furo[2', 3':4, 5] oxazolo[3,2- a]pyrimidin- 6- one is a custom synthesis of Methylation. It is only available in the form of a white solid and has a purity of 99.9%. It is soluble in methanol and ethanol.

1,2:3,4-Di-O-isopropylidene-a-D-galactopyranose, also known as diacetone-D-galactose and galactose diacetonide, is a partially protected monosaccharide building block with isopropylidene groups on the 1,2 and 3,4 hydroxyls. The 6-hydroxyl is unprotected and able to undergo a variety of chemical transformations, such as glycosylation acting as a glycosyl acceptor to form 1,6-linked disaccharides.

Tri-b-GalNAc-amine formate salt is an ASGPR-targeted ligand for therapeutics and diagnostics. With three terminal beta-GalNAc (N-acetylgalactosamine) sugars in a trivalent configuration, its high-affinity permits binding to the asialoglycoprotein receptor (ASGPR) on hepatocytes. Notably, the presence of a protonated primary amine group allows for chemoselective bioconjugation with various functional moieties via established amide bond formation techniques. Its salt form (TFA salt) enhances the water solubility of the molecule, facilitating its use in aqueous reaction buffers commonly employed in bioconjugation protocols. This combination of specific ASGPR targeting and a readily available conjugation site makes tri-b-GalNAc-amine TFA a valuable tool for developing customized and targeted drug-GalNAc conjugates, siRNA delivery vehicles, or ASGPR-specific probes. The use of TFA as a counterion ensures efficient deprotonation of the amine during conjugation, potentially improving reaction efficiency.

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2,3-O-Isopropylidene-D-apiose is a high purity product that can be custom synthesized. It is a sugar that can be modified with fluorination, glycosylation, and methylation. 2,3-O-Isopropylidene-D-apiose has been shown to be an effective synthetic carbohydrate and can be used as a drug delivery system. This product is soluble in methanol and water and has the CAS number 94943-41-6.

Tridecyl b-D-maltopyranoside is a high purity, custom synthesis sugar that can be fluorinated, glycosylated, methylated, and modified. It has CAS No. 93911-12-7 and can be used as an oligosaccharide or monosaccharide in the synthesis of complex carbohydrates. Tridecyl b-D-maltopyranoside is also used in click modifications.

N,N-Dimethyldodecylamine N-oxide, also known as lauryldimethylamine oxide (LDAO), is an amine oxide nonionic surfactant with a C12 alkyl chain used widely in cosmetics, washing, cleaning and personal care products. LDAO has antimicrobial properties and is effective against common bacteria such as S. aureus and E. coli.

Decyl b-D-thiomaltopyranoside is a glycosylation product of the monosaccharide, maltose. It is a complex carbohydrate that consists of two glucose molecules linked by alpha (1-4) glycosidic bonds. Decyl b-D-thiomaltopyranoside has been modified with methyl groups and fluorine atoms. This product is CAS No. 148565-56-4, and it can be custom synthesized to meet your specifications. The purity of this product ranges from 98% to 99%.

Nonyl β-D-glucopyranoside is an alkylglycoside non-ionic mild detergent used for cell lysis and membrane protein isolation. As it is uncharged it is unlikely to cause protein denaturation or refolding issues, allowing for the isolation of intact macromolecular complexes without affecting protein-protein interactions. Nonyl β-D-glucopyranoside is useful for the solubilization and crystallization of many biological membrane proteins and isolation of membrane-bound proteins. It has also been used for enantiomeric separation by capillary electrophoresis. Nonyl β-D-glucopyranoside is also known as B-Nonylglucoside or Nonyl D-glucoside and has an aggregation number of 133. It is dialyzable from membrane protein preparations and has a Critical Micelle Concentration (CMC) of 6.5mM.

Hexyl b-D-maltopyranoside is a biopharmaceutical that is used in drug development. It is used as a ligand for the μ-opioid receptor, which is a class of opioid receptors that are activated by morphine and endogenous peptides such as endorphins, dynorphins, and enkephalins. This ligand can be immobilized on a surface for use in immunoassays or other methods of detection. Hexyl b-D-maltopyranoside has been shown to have pharmacological effects in animal studies, although it has not yet been approved for clinical use in humans.

Octyl b-D-thiogalactopyranoside is a methylated derivative of galactose. It is a polysaccharide that is used to modify saccharides and oligosaccharides for research purposes. The product is used in glycosylation reactions and can be custom synthesized to meet specific requirements. Octyl b-D-thiogalactopyranoside has been modified with fluorine, which increases its stability against hydrolysis. The product is also available in high purity, making it ideal for use in synthesis reactions.

6-Cyclohexylhexyl b-D-maltoside (6CHBM) is a monoclonal antibody that inhibits the acetylcholine receptor. It binds to the hydroxyl group on the acetylcholine receptor and blocks nicotinic acetylcholine binding, preventing activation of the receptor. 6CHBM is a hydrophobic molecule with a hydroxyl group that can interact with other hydrophobic molecules in the membrane bilayer, such as fatty acids. 6CHBM has been shown to be an allosteric inhibitor of acetylcholine receptors by binding to a site outside of the active site and altering conformational changes required for channel opening. 6CHBM has also been shown to inhibit cation channels.
6CHBM was developed from mouse antibodies and has shown no adverse effects in mice or rabbits.

1-Decanoyl-rac-glycerol is a microbicide that has been shown to have a broad spectrum of activity against viruses and bacteria. It can be used in tissue culture as an antimicrobial agent, and inhibits the growth of human serum, hydroxyl group, and metal hydroxides. 1-Decanoyl-rac-glycerol has also been shown to cause cell lysis in cancer cells, but not normal cells. This drug is lipophilic and easily crosses biological membranes. In vivo models have shown that this compound is nontoxic to humans at doses up to 100 mg/kg body weight. In vitro tests have shown that 1-decanoyl-rac-glycerol does not inhibit the growth of bacteria or fungi at concentrations as high as 500 μg/mL.

4-Aminophenyl b-D-lactopyranoside is a chemical compound that has been used to optimize the production of human immunoglobulin. It has been shown to have diagnostic value for several viruses, including Epstein-Barr virus and cytomegalovirus. Electron microscopic studies have revealed organisms agglutinated by 4-aminophenyl b-D-lactopyranoside. The receptor binding properties and antigen concentration of this compound have been determined using agglutinin and lectin techniques. This molecule also has inhibitory potency on the synthesis of polypeptides, which are essential for the growth of certain organisms.

Myristoyl-DL-carnitine chloride (MC) is a prodrug that is hydrolyzed to form L-carnitine and myristic acid. The drug has been shown to be absorbed intranasally, and its absorption kinetics are enhanced by the presence of lipids. MC was found to increase the level of human growth hormone in Sprague-Dawley rats. It also decreased the amount of chloride excreted in the urine by inhibiting intestinal epithelial cells from absorbing chloride ions. This drug may be used as a nasal spray for treatment of gastrointestinal disorders such as chronic constipation.

b1-4 penta mannuronosaccharide-from alginate by enzyme or acid hydrolysis

Heptyl b-D-glucopyranoside is a natural product that belongs to the class of 5HT agonists. It was originally isolated from plants and has been shown to have antiinflammatory activity. It has also been observed to have effects on human serum, lymphocyte transformation, high salt, polymerase chain reaction (PCR), and kinetic energy. Heptyl b-D-glucopyranoside is synthesized by reacting heptanol with 5-hydroxybenzaldehyde in the presence of an acid catalyst.

Pharmaceutical intermediate