Antifungals

<p>AN2718, a benzoxaborole, halts fungi protein synthesis by inhibiting LeuRS in molds/yeasts; IC50: 2 μM (A. fumigatus), 4.2 μM (C. albicans).</p>

<p>FR194738 is an inhibitor of squalene epoxidase with an IC50 of 9.8 nM in HepG2 cell homogenates.</p>

<p>α-Santalol: antibacterial, antioxidant, anti-tumor, antimitotic, and antifungal against Trichophyton rubrum.</p>

<p>Applications (±)-α-Fenchol is found in essential oils from many plants. It has been studied for, insecticidal activity of essential oil from Helichrysum faradifani; antioxidant and antibacterial activity of essential oils from rhizome, leaf and stem of Etlingera sayapensis against growth of Bacillus subtilis, Escherichia coli and Candida albicans.<br>References Benelli G., et al., Nat. Prod. Res., 32, 690-1698 (2018); Mahdavi B., et al., Asian. Pac. J. Trop. Med., 10, 819-826 (2017)<br></p>

<p>Impurity Voriconazole EP Impurity A; Voriconazole USP Related Compound C<br>Applications 2,4-Difluoro-α-(1H-1,2,4-triazolyl)acetophenone (Voriconazole EP Impurity A; Voriconazole USP Related Compound C) is an antifungal activity, particularly toward Candida albicans and Candida parapsilosis<br>References Upadhayaya, R., et al.: Eur. J. Med. Chem., 39, 579 (2004), Sheng, C., et al.: J. Med. Chem., 49, 2512 (2006),<br></p>

<p>Applications 3(2H)-Isoxazolone is a 3-hydroxyisoxazole with fungicidal activity. 3(2H)-Isoxazolone is an impurity of Cycloserine (C988800).<br>References Takahi, Y.: San. Kenk. Nen., 25, 8 (1973);<br></p>

<p>Applications An Cysteine prodrug, protective aginst the fungal T-2 toxin. It is also a precursor to pharmaceuticals used in the treatment of cataracts.<br>References Shirota, F., et al.: Biochem. Pharmacol., 43, 916 (1992), Wlodek, L., et al.: Int. J. Biochem., 25, 107 (1993), Rathbun, W., et al.: Biochem. Pharmacol., 51, 1111 (1996),<br></p>

<p>Applications Used in the synthesis of new 5-nitroimidazoles as potential antibacterial drugs via VNS procedure.<br>References Cudmore, S., et al.: Clin. Microbiol. Rev., 17, 783 (2004), Upcroft, J., et al.: Antimicrob. Agents Chemother., 50, 344 (2006),<br></p>

<p>Applications Rhein 8-Glucoside has been seen to exhibit cytotoxic and DNA-damaging properties towards tumor and normal human cells. In addition it has been shown to be an inhibitor of PTP1B (Human Protein Tyrosine Kinase 1B) in vitro. It is an analog of Rhein (R318500) which is found in the free state and as glucoside in Rheum spp, Polygonaceae (rhubarb) and in Senna leaves. It is a potential antioxidant resource: endophytic fungi from medicinal plants.<br>References Wanitschke, Pharmacology, 20, Suppl. 1, 21 (1980); Raimondi, L., et al.: Pharmacol. Res. Commun., 14, 103 (1982); Franchi-Micheli, S., et al.: J. Pharm. Pharmacol., 35, 262 (1983); Li, S. et al.: J. Asian Nat. Prod. Res., 8, 281 (2006); Shi, Y.Q. et al.: Anticancer. Res., 21, 2847 (2001);<br></p>

<p>Impurity Bifonazole EP Impurity A<br>Applications [1,​1'-​Biphenyl]​-​4-​yl(phenyl)​methanol (Bifonazole EP Impurity A) is a Bifonazole (B383400), an anti-fungal agent used in the treatment of skin diseases. Causes an increase in Ca2+ concentration and triggers cell death in PC3 human prostate cancer cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cheng, J. et al.: J. Recep. Sign. Transduct., 34, 493 (2014); Chen, Z. et al.: Mol. Pharm., 12, 590 (2015);<br></p>

<p>Applications Potassium Pentathionate Sesquihydrate is potassium salt of Pentathionic acid which is the fungicidal factor of sulfur..<br>References Young, H., et al.: Science, 67, 19 (1928)<br></p>

<p>Applications Methyl 2-Cyano-2-oximinoacetate is an intermediate in synthesizing 2-Cyano-2-(methoxyimino)acetic Acid (C989423), which is a cyano-oxime derivative used as a fungicide.<br>References Tellier, F., et al.: Pestic Biochem Physiol., 78, 151-160 (2004)<br></p>

<p>Snail/HDAC-IN-1 is a Snail/HDAC inhibitor with antimicrobial and anticancer activity, known to reduce Snail protein expression and induce apoptosis, making it useful for the study of solid tumors.</p>

<p>Stilbamidine (Ba 2652) has antifungal and anticancer activity and can be used to study multiple myeloma and bladder migratory cell carcinoma.</p>

<p>Applications Difluocortolone is used as a topical therapy in the treatment of pediatric tinea corporis; a common mycotic infection in children.<br>References Veraldi, S., et al.: J. Dermatol. Treat., 29, 200 (2018)<br></p>

<p>Rezafungin acetate (Biafungin acetate) is a echinocandin with antibacterial activity, inhibiting 1,3-β-D-glucan synthase.</p>