Antifungals

Beta-Amyrin acetate: HMGCR & sEH inhibitor (IC50 3.4 μM), anti-inflammatory, antifungal, antioxidant, anti-hyperlipidemic.

<p>Compound 3b is a potent broad-spectrum fungicide with strong respiratory and ATP synthesis inhibition.</p>

<p>SDH-IN-2: Strong SDH blocker (IC50 0.55 μg/mL), antifungal; EC50 3.82-9.81 μg/mL against plant fungi.</p>

<p>Gamma-Glutamyl Transferase-IN-1 (compound 4de), a β-carboline 1-hydrazide inhibitor, exhibits antifungal and antibacterial properties by targeting</p>

<p>Aspyrone, a polyketide from Aspergillus, has antifungal, antibacterial (20 µg/mL, 100 µg/disc), and nematocidal properties (10-1000 mg/L).</p>

<p>1-O-Methylemodin, a natural product isolated from Zopfiella longicaudata, exhibits antifungal activity [1].</p>

<p>Harzianopyridone is an atpenin-like compound that functions as an inhibitor of mammalian and nematode mitochondrial complex II, also known as succinate:ubiquinone oxidoreductase (SQR), demonstrating IC50 values of 0.017, 0.2, and 2 μM against bovine, rat, and nematode complex II, respectively. Additionally, it inhibits nematode quinol-fumarate reductase (QFR) with an IC50 value of 0.36 μM. Significantly selective for complex II over complexes I and III in rats and cattle, as well as complex I in nematodes, with IC50 values exceeding 100 μM, it exhibits notable antibacterial and antifungal properties, with EC50 values of 35.9, 42.2, 60.4, and 50.2 μg/ml against R. solani, S. rolfsii, M. phaseolina, and F. oxysporum, respectively.</p>

<p>Cytochalasin A, a cell-penetrating fungal toxin, blocks HIV-1 protease (IC50 = 3 μM) and hinders actin and microtubule assembly. It's an antibiotic.</p>

<p>Flutianil is a chemical compound from the group of thiazolidines .</p>

<p>SDH-IN-8 (compound G40) is a potent inhibitor of succinate dehydrogenase (SDH), demonstrating an IC50 value of 27 nM against porcine SDH and exhibits fungicidal</p>

<p>Amphotericin B methyl ester: a cholesterol-binding antifungal derivative of Amphotericin B; inhibits HIV-1.</p>

<p>Ajoene from garlic has antibacterial, anticancer, antiplatelet, and antioxidant effects; it combats various bacteria, yeasts, and cancer cells.</p>

<p>Ratjadon is an antifungal compound isolated from Sorangium cellulosum.</p>

<p>Iturin A: antifungal compound targeting cell membranes, forms ion pores in yeast/fungi.</p>

<p>Paclobutrazol ((R,R)-paclobutrazol) is a triazole-containing plant growth retardant that is known to inhibit the biosynthesis of gibberellins.1,2It also has</p>

<p>Compound 6c, a tetrazole derivative, inhibits ergosterol synthesis and disrupts C. albicans cell membranes with potent antifungal effects.</p>

<p>LW3 is an effective broad-spectrum antifungal compound.</p>

FR-901235, from Paecilomyces carneus, normalizes suppressed lymphocyte growth.