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CAS 86386-73-4

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Fluconazole

Description:
Fluconazole is an antifungal medication primarily used to treat fungal infections, particularly those caused by Candida species and Cryptococcus neoformans. It belongs to the triazole class of antifungals and works by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes, thereby disrupting their integrity and function. Fluconazole is characterized by its high oral bioavailability, allowing for effective systemic treatment, and it is often administered in both oral and intravenous forms. The substance is generally well-tolerated, with common side effects including gastrointestinal disturbances and headache. It has a relatively long half-life, enabling once-daily dosing for many indications. Fluconazole is also notable for its ability to penetrate various body tissues, including the central nervous system, making it effective for treating meningitis. However, it can interact with other medications due to its effects on liver enzymes, necessitating careful monitoring in patients on multiple therapies. Overall, fluconazole is a critical agent in the management of systemic and superficial fungal infections.
Formula:C13H12F2N6O
InChI:InChI=1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2
InChI key:InChIKey=RFHAOTPXVQNOHP-UHFFFAOYSA-N
SMILES:C(CN1C=NC=N1)(CN2C=NC=N2)(O)C3=C(F)C=C(F)C=C3
Synonyms:
  • 1-(2,4-Difluorophenyl)-1,1-bis[(1H-1,2,4-triazol-1-yl)methyl]methanol
  • 1H-1,2,4-Triazole-1-ethanol, α-(2,4-difluorophenyl)-α-(1H-1,2,4-triazol-1-ylmethyl)-
  • 2-(2,4-Difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)-propan-2-ol
  • 2-(2,4-Difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol
  • Alkanazole
  • Biozolene
  • Diflucan
  • Difluconazole
  • Elazor
  • Floroxan
  • See more synonyms
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