Antivirals

Impurity Oseltamivir EP Impurity D
Applications 4-Acetylamino-3-hydroxybenzoic Acid Ethyl Ester (Oseltamivir EP Impurity D) is an impurity in the antiviral drug Oseltamivir (O700100).

Impurity Atazanavir Impurity (Pyridinyl Benzoic Acid)
Applications Reactive metabolite of Atazanavir (A790051). Atazanavir Impurity (Pyridinyl Benzoic Acid)
References Li, F. et al. Drug Metab. Disp., 39, 294 (2011);

Impurity Ribavirin EP Impurity C
Applications 1,2,4-Triazole-3-carboxylic Acid (Ribavirin EP Impurity C) is a major metabolite of the antiviral agent Ribavirin (R414475).
References Miller, J.P. et al.: Ann. N.Y. Acad. Sci., 284, 211 (1977); Catlin, D. et al.: Ribavirin: Broad Spec. Antivir. Ag., 83 (1980); Lin, C.C. et al.: Antimicrob. Ag. Chemother., 50, 2368 (2006);

Impurity Atazanavir Impurity C
Applications Atazanavir intermediate. Enantiomer R. Atazanavir Impurity C
References Vassar, R., et al.: Science, 286, 735 (1999), Maillard, M., et al.: J. Med. Chem., 50, 776 (2007), Stauffer, S., et al.: Bioorg. Med. Chem. Lett., 17, 1788 (2007),

Applications N2-Acetyl Acyclovir Methyl Acetate is an intermediate in the synthesis of Acyclovir (A192400), an orally active acyclic nucleoside with inhibitory activity towards several herpes viruses. Antiviral.
References Collins, P., et al.: J. Antimicrob. Chemother., 5, 431 (1979); Matsumoto, H., et al.: Chem. Pharm. Bull., 36, 1153 (1988); Whitley, R.J., et al.: N. Engl. J. Med., 327, 782 (1992)

Impurity Adapalene USP Related Compound B
Applications Adapalene intermediate, an ester of Adapalene. Adapalene USP Related Compound B.
References Charpentier, B., et al.: J. Med. Chem., 38, 4993 (1995),

Applications Elenolic Acid is an antiviral agent that inhibits reverse transcriptases, inhibited the growth of chicken embryo fibroblast cells as well as Escherichia coli and Bacillus subtilis strains.
References Heinze, J.E., et al.: Antimicrob. Agents Chemother., 8, 421 (1975); Renis, H,E..: Antimicrob. Agents Chemother., 8, 149 (1975)

Applications Antiviral nucleoside analog, also an impurity found in emtricitabine (E525000).
References Jeong, L., et al.: J. Med. Chem., 36, 181 (1993),

Applications Indinavir Sulfate is a member of the novel hydroxyaminopentane amide class of HIV-1 protease inhibitors. Antiviral. It is a COVID19-related research product.
References Vacca, J.P., et al.: Proc. Nat. Acad. Sci. USA, 91, 4096 (1994), Dorsey, B. D., et al.: J. Med. Chem., 37, 3443 (195), Balani, S.K., et al.: Drug Metab. Dispos., 23, 266 (1995)