Antivirals

<p>Boceprevir is a peptidomimetic, covalent inhibitor of NS3/4A serine protease from hepatitis C virus (HCV). Boceprevir also inhibits and acts as a substrate in the cytochrome P450 3A4 (CYP3A) metabolic pathway. Boceprevir was recently shown to inhibit the main protease Mpro (3CLpro) from SARS-CoV-2 with IC50 of 4.13 μM and EC50 of 1.31 μM.</p>

<p>Anti-viral; inhibits Hepatitis C virus NS3/4a protease</p>

<p>Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) with action on HIV reverse transcriptase to block viral replication and is used for treating HIV/AIDS in combination therapies.</p>

<p>Tenofovir is an acyclic nucleoside phosphonate that exhibits anti-viral properties through its inhibition of reverse transcriptases. In particular, Tenofovir is a potent inhibitor of Human Immunodeficiency Virus (HIV) and chronic Hepatitis B Virus (HBV) reverse transcriptases, thus preventing the replication of genetic viral material. This property is beneficial in virus research areas and developing antiviral treatments. Once inside the body tenofovir is metabolized into its active form, tenofovir diphosphate, by the lysosomal protease cathepsin A, nucleotide kinases and adenylate kinases. <br>Tenofovir is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&amp;D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>

<p>Abacavir sulfate is an antiviral drug that belongs to the class of HIV protease inhibitors. It is used in combination with other antiretroviral drugs to treat HIV-1 infection. Abacavir sulfate inhibits viral replication by blocking the activity of HIV-1 protease, which is necessary for the production of new virus particles.<br>Abacavir sulfate is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&amp;D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>

<p>A competitive inhibitor of HCV NS3/4A protease that blocks viral replication. Efficacious in treating HCV-infected patients in combination with daclatasvir. Asunaprevir-resistant replicons are sensitive to NS5A replication complex inhibitor, suggesting potential combination therapy.</p>

<p>Rimantadine is an anti-viral drug that is used for the prevention of influenza A infection. This drug is an RNA synthesis inhibitor and exerts its effects on the viral replication cycle. Although not fully understood, it is said that the M2 gene may play a role in Rimantadine susceptibility.</p>

<p>Fosamprenavir calcium is an antiretroviral medication, which is derived from the prodrug of amprenavir. It is synthesized through chemical processes to enhance oral bioavailability and improve pharmacokinetic properties. Through its mode of action, fosamprenavir is converted in vivo to amprenavir, which acts as an inhibitor of the HIV-1 protease enzyme. By inhibiting this enzyme, it prevents the cleavage of the Gag-Pol polyprotein, disrupting viral replication and processing, ultimately leading to the production of immature, non-infectious viral particles.</p>

<p>Antiviral; nonpeptidic HIV-1 protease inhibitor</p>

<p>Inhibitor of HCV NS5A</p>

<p>GS 5734, also known as remdesivir is a nucleoside prodrug with broad spectrum antiviral activity against RNA viruses. As remdesivir / GS 5734 is a prodrug, it requires to be triphosphorylated by cellular kinases in order to compete with ATP for incorporation in newly replicated viral RNA. A major benefit of remdesivir in comparison with other antiviral nucleoside analogs is its resistance to proofreading exonucleases, which occur in coronaviruses. This means remdesivir can overcome the repair mechanism and preserve its antiviral activity. Remdesivir was reported to have a therapeutic as well as prophylactic efficacy in a mouse model infected with SARS-CoV-1.</p>

<p>Penciclovir is an antiviral agent and acyclic guanine derivative that has proven efficient in the treatment of Herpes Simplex type 1 and 2 (HSV1 and HSV2) infection. Penciclovir is transformed by the virus into an active derivative able to block the deoxyguanosine triphosphate substrate binding site of the HSV polymerase.</p>

<p>Anti-viral; HIV-1 protease inhibitor</p>

<p>Atazanavir is a HIV-1 protease inhibitor, used in the anti-retroviral therapy of adult and sometimes paediatric patients infected with HIV. In in vitro studies with human pulmonary epithelial cells, atazanavir has been studied as a potential inhibitor of SARS-CoV-2 Mpro protease, with the aim of halting viral replication.</p>

<p>Tenofovir disoproxil is a nucleotide analog reverse transcriptase inhibitor that is used to treat infections such as Hepatitis-B and HIV. This drug is an antiretroviral agent that blocks reverse transcriptase, blocking viral replication.</p>

<p>Famciclovir is a guanosine analogue antiviral agent that is used for the treatment of various herpesvirus infections, most commonly for herpes zoster. It works by inhibiting the replication of the herpes virus. Famciclovir prevents viral DNA synthesis by inhibiting the viral DNA polymerase and by blocking viral DNA replication. Its active form is penciclovir.</p>

<p>Anti-viral; capsid inhibitor</p>

<p>BMS 806 is used as an anti-viral agent. It has been shown to inhibit the replication of HIV. BMS 806 inhibits viral life by binding to the surface glycoproteins and inhibiting viral entry into cells. The drug also inhibits viral replication by preventing DNA transcription and translation.</p>

<p>GSK 2838232 is a HIV-1 maturation inhibitor with action on HIV-1 Gag protein cleavage and is used for research on HIV treatment.</p>

<p>PS 3061 is a type of biostimulant, which is derived from activated charcoal. Activated charcoal serves as the source of this biostimulant, providing a unique substrate that interacts with soil and plant roots. Its mode of action involves enhancing nutrient uptake and improving soil microbial activity, thereby facilitating better plant growth and development.</p>