Steroids

Applications A metabolite of Desoxymetasone (D296970).
References Schriks, M., et al.: Environ. Sci. Technol., 44, 4766 (2010), Baeck, M., et al.: Eur. J. Dermatol., 20, 102 (2010), Lee, P., et al.: Bioorg. Med. Chem. Lett., 20, 69 (2010),

Stability Light Sensitive
Applications A metabolite of Letrozole.
References Koyama, E., et al.: Ther. Drug Monit., 15, 224 (1993), Pfister, C., et al.: J. Pharm. Sci., 83, 520 (1994), Vander H.Y., et al.: J. Pharm. Biomed. Anal., 24, 723 (2001), Cohen, M., et al.: Clin. Cancer Res., 8, 665 (2002),

Impurity Beclomethasone Dipropionate EP Impurity E
Applications 6α-Chlorobeclomethasone Dipropionate (Beclomethasone Dipropionate EP Impurity E) is an analogue of Beclomethasone Dipropionate (B131030), an antiallergic, antiasthmatic (inhalate). Anti-inflammatory (topical).
References Laube, B., et al.: J. Allergy Clin. Immunol., 101, 475 (1998); Harrison, L., et al.: Eur. J. Clin. Pharmacol., 58, 191 (2002); Maneechotesuwan, K., et al.: J. Allergy Clin. Immunol., 121, 43 (2008)

Impurity Fulvestrant EP Impurity B
Applications A metabolite of Fulvestrant (F862500).
References Rao, P., et al.: J. Steroid Biochem., 25, 417 (1986), Wakeling, A., et al.: J. Steroid Biochem. Mol. Biol., 43, 173 (1992), DeFriend, D., et al.: Cancer Res., 54, 408 (1994),

Applications 5α-Androstenone is a volatile steroid found in human perspiration, boar saliva, truffles, and celery. It was also identified as the first mammalian pheromone.
References Wysocki, C.J., et al.: P. Natl. Acad. Sci. USA, 86, 7976 (1989); Dorries, K.M., et al.: Brain Behav. Evol., 49, 53 (1997)

Applications 6α-Methyl-9α-fluoro-11β,17α-dihydroxyprogesterone is an impurity of Fluorometholone (F593145), a glucocorticoid; anti-inflammatory.
References Kupferman, A., et al.: Arch. Ophthlmol., 640, 100 (1982), Tokunaga H., et al.: Chem. Pharm. Bull., 32, 4012 (1984),

Applications Cyclofenil is a weak nonsteroidal estrogen with ovulation induction properties. Mammalian hormone.
References Miquel, et al.: J. Med. Chem., 6, 774 (1963),

Applications Amcinonide (A576150) analog as glucocorticoid receptor agonists for the treatment of inflammation and allergic conditions.
References Woodford, R., et al.: Curr. Ther. Res., 26, 301 (1979),

Applications 17α-Methyl-5α-androstane-2β,3α,17β)-triol is a derivative of Madol (M108000, which is an anabolic steroid recently identified to be misused as a doping agent. The potency of Madol (DMT) to transactivate androgen receptor (AR) dependent reporter gene expression was two times lower as compared to dihydrotestosterone (DHT).
References Zierau, O., et al.: Planta Med., 69, 856 (2003), Takahashi, M., et al.: Endocr. J., 51, 425 (2004), Labrie, F., et al.: J. Endocrinol., 184, 427 (2005),Friedel, A., et al.: Toxicol. Lett., 164, 16(2006),

Applications A metabolite of Desogestrel.
References Back, D., et al.: Br. J. Clin. Pharmacol., 26, 23 (1988), Wienkers, L., et al.: Drug Metab. Dispos., 1990, 24, 610 (1990), Bourrie, M., et al.: J. Pharmacol. Exp. Ther., 277, 321 (1996), Ono, S., et al.: Xenobiotica, 26, 681 (1996),

Applications Quillaic Acid an unglycosylated saponin from the Quillaja saponaria bark is used as a topical antiinflammatory.
References Arrau, S. et al.: J. Ethnopharm., 133, 164 (2011);

Applications Cholesteryl Acetate Dibromide is an brominated intermediate in the synthesis of Cholesterol (C432501) derivatives.
References Kandutsch, A.A., et al.: J. Biol. Chem., 249, 6057 (1974);

Applications Estra-5(10),9(11)-diene-3,17-dione, can be used as an intermediate for the synthesis of 3-keto-desogestrel.
References Wang, R., et al.: Zhongguo Yaowu Huaxue Zazhi, 4, 187 (1994);

Zuclomiphene is a selective estrogen receptor modulator (SERM), which is derived from clomiphene citrate, a mixture containing two isomers, zuclomiphene and enclomiphene. Zuclomiphene acts by binding to estrogen receptors, exhibiting both estrogenic and anti-estrogenic effects depending on the target tissue. This dual action makes it a valuable tool in modulating estrogen receptor activity for scientific research.