Nucleotides
Subcategories of "Nucleotides"
Found 2638 products of "Nucleotides"
2'-Deoxy-N2-DMF-5'-O-DMT-guanosine
CAS:2'-Deoxy-N2-DMF-5'-O-DMT-guanosine is a monophosphate nucleoside that has antiviral, anticancer, and high purity properties. It is synthesized by the phosphoramidite method from 2'-deoxy-N2-DMF and 5'-O-DMT guanosine. This compound has been shown to inhibit the growth of human cancer cells in vitro and in vivo. It also inhibits HIV replication in vitro and is not toxic to normal cells.Formula:C34H36N6O6Purity:Min. 95%Color and Shape:White PowderMolecular weight:624.7 g/mol1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)uracil
CAS:1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)uracil is a nucleoside analog and contains a uracil base, and a 2'-deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl sugar moiety. The 2'-fluoro modification is of particular interest due to its potential to alter the chemical and biological properties of the resulting oligonucleotides. Fluorinated nucleosides and their analogs have been extensively studied for their antiviral and anticancer activities. The incorporation of fluorine into nucleoside analogs can also affect their interaction with DNA and RNA, leading to changes in their therapeutic potential.Formula:C30H29FN2O7Purity:Min. 95%Color and Shape:White To Off-White SolidMolecular weight:548.56 g/mol1-Methylpseudouridine
CAS:1-Methylpseudouridine is a substitute for uridine in modified mRNA. This substitution has shown to increase transfection by reducing immuogenicity. The 1-methylpseudouridine substituted mRNA increases protein expression due to low immune stimulation as it evades detection by the edosomal Toll-like receptor (TLR3).Formula:C10H14N2O6Purity:Min. 98.0 Area-%Molecular weight:258.23 g/molRef: 3D-M-4320
-Unit-ggTo inquire1gTo inquire5gTo inquire250mgTo inquire500mgTo inquire2500mgTo inquire1-(2'-Deoxy-2'-fluoro-β-D-arabinofuranosyl)-5-iodouracil
CAS:1-(2'-Deoxy-2'-fluoro-β-D-arabinofuranosyl)-5-iodouracil is a nucleoside analog with antiviral properties. It consists of a modified uracil base (5-iodouracil) attached to a fluorinated arabinofuranosyl sugar moiety. In cell culture, it inhibits the replication of varicella-zoster virus, herpes simplex virus type 1 and 2 and cytomegalovirus.Formula:C9H10FIN2O5Purity:Min. 98 Area-%Color and Shape:White Off-White PowderMolecular weight:372.09 g/mol9-(b-D-Ribofuranosyl)purine
CAS:9-(b-D-Ribofuranosyl)purine (9-BRP) is a purine nucleoside that is used in the synthesis of dyes. It has been shown to be an effective inhibitor of the enzyme phosphodiesterase 3B, which breaks down cyclic adenosine monophosphate (cAMP), and therefore can prevent kidney fibrosis. 9-BRP has also been shown to inhibit the synthesis of collagen by binding to cAMP. In addition, 9-BRP binds to DNA and forms hydrogen bonds with nitrogen atoms on the phosphate groups in DNA. This interaction prevents the formation of hydrogen bonds between water molecules in water vapor and phosphate groups, thus slowing down their rate of dissociation from each other. 9-BRP also has a high affinity for Toll-like receptor 4 (TLR4), which is involved in the inflammatory response, making it an ideal therapeutic candidate for treating inflammation and renal fibrosis.Formula:C10H12N4O4Purity:Min. 97 Area-%Color and Shape:PowderMolecular weight:252.23 g/molb-Nicotinamide mononucleotide
CAS:b-Nicotinamide mononucleotide, or NMN, is a precursor to nicotinamide adenine dinucleotide (NAD+), a coenzyme found in all living cells that is essential for various metabolic processes. NAD+ is involved in critical functions such as DNA repair, gene expression, and cellular stress responses.Formula:C11H15N2O8PPurity:Min. 95 Area-%Color and Shape:PowderMolecular weight:334.22 g/mol3-Methyl-2-nitropyridine
CAS:3-Methyl-2-nitropyridine is a high yield byproduct of formamide, which can be activated to form an intermediate for the synthesis of nucleosides. The kinetics and labeling of this intermediate were studied using a transfer experiment. 3-Methyl-2-nitropyridine is acidic, with a pKa value of 3.6, and is reactive towards nucleophiles. It is also catalytic, yielding methyl groups and dioxane as products when heated at temperatures between 180°C and 220°C. In addition, it undergoes nucleophilic substitutions at methoxy groups.
Formula:C6H6N2O2Purity:Min. 95%Color and Shape:PowderMolecular weight:138.12 g/molN2-Isobutyryl-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)guanosine
CAS:N2-Isobutyryl-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxane-diyl)guanosine is a nucleoside that is activated by phosphorylation. It has been shown to be an inhibitor of cancer cell growth and proliferation in vitro. This compound was also found to inhibit the expression of two oncogenes (c-MYC and c-Ki67) and induce the expression of the tumor suppressor gene p53. This nucleoside is synthesized from 2'-deoxyadenosine monophosphate (2'-DAMP) with a modified DNA synthesis protocol.Formula:C26H45N5O7Si2Purity:Min. 95 Area-%Color and Shape:White Off-White PowderMolecular weight:595.84 g/mol2-Aminoadenosine
CAS:2-Aminoadenosine is a synthetic nucleoside analog of adenosine in which the purine base is 2,6-diaminopurine, featuring an additional amino group at the C2 position. This modification enhances hydrogen bonding potential and alters base-pairing specificity, allowing it to form three hydrogen bonds with uracil or thymine, in contrast to adenine's two. As a result, 2-aminoadenosine has been studied for its impact on nucleic acid stability, replication fidelity, and enzymatic recognition. It has also shown potential in antiviral and anticancer research due to its ability to disrupt normal RNA and DNA metabolism.Formula:C10H14N6O4Purity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:282.26 g/mol5-Chloro-2-iodopyrimidine
CAS:5-Chloro-2-iodopyrimidine is an organic molecule that belongs to the class of trifluoromethylated molecules. It was discovered by a team of chemists in 2006 and has been used as a reagent for the efficient trifluoromethylation of organic molecules. 5-Chloro-2-iodopyrimidine can be catalyzed with copper, which is responsible for its unique reactivity. The synthesis of this molecule has been shown to be efficient in organic chemistry. END>Formula:C4H2ClIN2Purity:Min. 95%Color and Shape:PowderMolecular weight:240.43 g/mol2,8-Dimethyladenosine
CAS:2,8-Dimethyladenosine is a methylated derivative of the purine nucleoside adenosine, in which methyl groups are added at the 2-position and 8-position of the adenine base.Formula:C12H17N5O4Purity:Min. 95%Color and Shape:White PowderMolecular weight:295.29 g/mol3'-Deoxythymidine
CAS:3'-Deoxythymidine (3DT) is a nucleoside analog that has high resistance to HIV. It is an analogue of the human insulin-like growth factor-1 (IGF-1), which binds to the IGF-1 receptor and inhibits the binding of IGF-1 to its receptor, thereby inhibiting the growth of cells. 3DT has been shown to have a protective effect against radiation in mice, with an LD50 at a dose of 5.0 mg/kg for radiation exposure. 3DT also has antiviral activity against murine sarcoma virus, as well as other biological properties such as enzyme activities and disease activity. This drug may be used in future research on polymerase chain reactions (PCRs) and DNA sequencing, since it is chemically stable and can be easily synthesized.Formula:C10H14N2O4Purity:Min. 95%Color and Shape:White PowderMolecular weight:226.23 g/molN4-Benzoyl-2'-deoxy-a-cytidine
CAS:N4-Benzoyl-2'-deoxy-a-cytidine is a novel, modified nucleoside that has shown anticancer and antiviral activity. It is synthesized by the enzymatic oxidation of 2'-deoxyadenosine with benzoyl chloride and sodium bicarbonate. N4-Benzoyl-2'-deoxy-a-cytidine has been shown to activate transcription, increase DNA synthesis, and inhibit virus replication. It also inhibits bacterial growth, but does not appear to have any effect on mammalian cells.Formula:C16H17N3O5Purity:Min. 95%Color and Shape:PowderMolecular weight:331.32 g/mol3'-Deoxycytidine
CAS:3'-Deoxycytidine is a nucleoside analog used to treat hepatitis. It is an inhibitor of the viral enzyme reverse transcriptase and prevents the synthesis of viral DNA by blocking the formation of low-energy hydrogen bonds between the 3'-hydroxyl group and the 5'-phosphate group of deoxyribonucleotide triphosphates. 3'-Deoxycytidine can be synthesized using solid-phase methods, and has been shown to inhibit human immunodeficiency virus (HIV) in control experiments. This drug also has been shown to have anti-inflammatory effects in experimental bladder inflammation models.Formula:C9H13N3O4Purity:Min. 95%Color and Shape:White PowderMolecular weight:227.22 g/mol7-Deaza-2',3'-dideoxyguanosine
CAS:7-Deaza-2',3'-dideoxyguanosine is a nucleoside analogue that is silylated on the 2' and 3' hydroxyl groups. It is also substituted with a deoxygenated 7-deaza-2',3'-dideoxyribose moiety. The substitution of the ribose sugar with deoxygenated 7-deaza-2',3'-dideoxyribose prevents the formation of hydrogen bonds between the sugar and phosphate backbones, which inhibits the enzyme ribonucleotide reductase from catalyzing the conversion of ribonucleotides to deoxynucleotides. This in turn blocks DNA synthesis, leading to cell death.br>
7-Deaza-2',3'-dideoxyguanosine has been shown to be effective against Mycobacterium tuberculosis and Mycobacterium avium complex.Formula:C11H14N4O3Purity:Min. 95%Color and Shape:PowderMolecular weight:250.26 g/mol2,2'-Anhydrocytidine HCl
CAS:2,2'-Anhydrocytidine HCl is a nucleoside for use as a DNA synthesis inhibitor
Formula:C9H11N3O4·HClPurity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:261.66 g/molN1-Methylguanosine
CAS:Controlled ProductN1-Methylguanosine is a methylated nucleotide that is incorporated into the growing DNA chain during protein synthesis. The incorporation of N1-methylguanosine into the growing DNA chain can cause frameshifting, which creates an unusual amino acid sequence. This effect has been shown in model organisms, such as Saccharomyces cerevisiae and Escherichia coli. In these organisms, N1-methylguanosine has been shown to induce cancer when added to the growth medium. It is also found in urine samples from people with bladder cancer and has been used to identify urinary tract cancers. Titration calorimetry studies have shown that N1-methylguanosine binds to a chelate ligand and forms a disulfide bond with cysteine residues on proteins or peptides, which may lead to mitochondrial dysfunction by interfering with hydrogen bonding interactions. Messenger RNA studies show that N1-methylguanosine inhibits translation of mRNA by binding to
Formula:C11H15N5O5Purity:Min. 95%Color and Shape:White PowderMolecular weight:297.27 g/molNelarabine
CAS:Nelarabine is a drug that prevents the growth of cells by inhibiting the bcr-abl kinase, which is an intracellular target. This drug has been shown to be effective against pediatric patients with t-cell acute lymphoblastic leukemia and adults with chronic myeloid leukemia. Nelarabine has minimal toxicity in humans and is not toxic to healthy cells. It has been shown to have anti-inflammatory properties and may be used as a biomarker for autoimmune diseases. Nelarabine also inhibits angiogenesis, which may be due to its effects on nuclear DNA.
Formula:C11H15N5O5Purity:Min. 95%Color and Shape:White PowderMolecular weight:297.27 g/molN-Phenylpyridin-4-amine
CAS:N-Phenylpyridin-4-amine is a tautomeric compound that has been shown to inhibit the growth of cancer cells. It is able to bind to tyrosine kinase and inhibit its activity, which affects the proliferation of cancer cells. N-Phenylpyridin-4-amine also inhibits mitochondrial functions by inhibiting cytochrome c oxidase. This drug also has an anti-inflammatory effect, inhibiting the production of cytokines such as IL1β, IL6, and TNFα. The biological function of N-Phenylpyridin-4-amine is not yet fully understood. It may be due to the inhibition of protein tyrosine phosphatases (such as PTP1B), which are involved in insulin signalling pathways.Formula:C11H10N2Purity:Min. 95%Color and Shape:White Off-White PowderMolecular weight:170.21 g/mol2,3,5-Tri-O-acetyl α-adenosine
CAS:2,3,5-Tri-O-acetyl α-adenosine is a nucleoside analog of adenosine that has been tri-acetylated. This molecule can be used in research.Formula:C16H19N5O7Purity:Min. 95%Color and Shape:PowderMolecular weight:393.35 g/mol
