Vitamins

<p>Applications Hydrocortisone 17-Valerate is a derivative of Hydrocortisone (H714615) which is a glucocorticoid that is produced by the zona fasciculata of the adrenal gland.<br>References Ponec, M. et. al.: J. Pharm. Sci., 75, 973 (1986); Vigore, L., et al.: Cancer Ther., 6, 699 (2008)<br></p>

<p>Applications Plumbagin induces apoptosis in cancer cells. It also inhibits NADPH oxidase 4 in a time- and dose-dependent manner.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Klotz, L., et al.: Molecules, 19 14902 (2014); Gupta, S., et al.: Cancer Metastasis Rev., 29, 405 (2010); Schramm, A., et al.: Vascul. Pharmacol., 56, 216 (2012)<br></p>

<p>Applications Coenzyme Q2 is a redox carrier in the mitochondrial respiratory chain in eukaryotic cells. It has been used to investigate interaction of coenzyme Q with phosphatidylethanolamine membranes.<br>References Do, T., et al.: J. Biol Chem. 276, 18161 (2001); Gomez-Fernandez, J. C., et al.: Eur. J. Biochem. 259, 739 (1999);<br></p>

<p>Stability Hygroscoipic, Light and Air Sensitive<br>Applications Dihydrofolic Acid is an intermediate in mammalian conversion of dietary folic acid to tetrahydrofolate by dihydrofolate reductase (DHFR). Folic acid (FA) and Dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF).<br>References Andres, J., et al.: Bioorg. Chem., 24, 10 (1996), Benkovic, S., et al.: Science, 301, 1196 (2003), ,,,,Williams, D; J Mol Biol 2003, 329, 389,,,Krahn, J., et al.: Biochemistry, 46, 14878 (2007),<br></p>

<p>Stability Light Sensitive, Temperature Sensitive<br>Applications Calcifediol is a metabolite of Vitamin D. The principal circulating form of vitamin D3, formed in the liver by hydroxylation at C-25. Calcium regulator.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Morii, et al.: Arch. Biochem. Biophys., 120, 513 (1967); Blunt, et al.: Biochemistry, 7, 3317 (1968), Liu, et al.: Science, 311, 1770 (2006);<br></p>

<p>Applications A cell-permeable chloro-nitro-benzamido compound that acts as a potent, specific, irreversible, and high-affinity antagonist of PPARγ with a Ki of 1 nM. Displays &gt;800-fold greater selectivity for PPARγ over PPARα and PPARδ (Ki = 0.85 µM and 1.8 µM, respectively). Blocks hormone- and agonist-induced adipogenesis in 3T3-L1 cells. It suppresses interactions between PPARγ and coactivator-derived peptides, while promotes the recruitment of corepressor-derived peptides. Shown to modulate the interaction of PPARγ2 with the cofactor proteins through covalent binding to Cys313 in its ligand-binding domain.<br>References Lee, G., et al: J. Biol. Chem., 277, 19649 (2003), Schaefer, K.L., et al: Cancer Res., 65, 2251 (2005), Masuda, T., et al.: Clin. Cancer Res., 11, 4012 (2005), Raikwar, H.P., et al.: J. Neuroimmunol., 167, 99 (2005)<br></p>

<p>Stability Hygroscopic<br>Applications Hydroxocobalamin is an intermediate in the synthesis of Nitritocobalamin(N490240) is a useful synthetic intermediate in the synthesis of Hydroxocobalamin Acetate (H826800); a physiological analog of vitamin B12 where the CN group is replaced with OH. Exists in aqueous solution as an equilibrium mixture of the hydroxy isomer and the ionic aqua isomer (aquacobalamin). Precursor of the coenzymes methylcobalamin and cobamamide. Coordination Compound. Vitamin (hematopoietic).<br>References Kaczka, E.A., et al.: Science, 112, 354 (1950); Friedrich, W., et al.: Vitamins, 837 (1988); Forsyth, J.C., et al.: Clin. Toxicol., 31, 277 (1993)<br></p>

<p>Applications SR 9011 is a synthetic REV-ERBα/β agonist with activity in vivo. It is a lead compound for a new class of cancer drugs associated with the body’s circadian clock.<br>References Solt, L.A., et. al.: Nature, 485, 7396 (2012); Chem. and Eng. News. p.8, Jan. 15, 2018<br></p>

<p>Applications The labelled aglucon of Daidzin.<br>References Am. J. Respir. Cell Mol. Biol., 7, 637 (1992), Biochim. Biophys. Acta 1221, 29 (1994), Huang, R.Q.; Fang, M.J.; Dillon, G.H., Mol. Brain Res. 67: 177-183 (1999)<br></p>

<p>Applications Acetyl Vitamin B12 is a derivative of Vitamin B12 (V676020). Vitamin B12 gets converted by the body into its bioactive forms, methylcobalamin and cobamamide, which serve as enzyme cofactors. Severe deficiency may result in megaloblastic anemia and/or neurological impairment.<br>References Rickes, et al.: Science, 107, 396 (1948); Kirschbaum, J., et al.: Anal. Profiles Drug Subs., 10, 183 (1981); Grasbeck, R., et al.: Clin. Biochem., 17, 99 (1984)<br></p>

<p>Stability Light Sensitive<br>Applications Retinyl Propionate is a Vitamin A ester derivative. Retinyl Propionate is a hypermitotic agent that is used in cosmetic formulations.This compound contains an unknown cis isomer.<br>References Ridge, B.D. et al.: Br. J. Dermatol., 118, 167 (1988); Oblong, J.E. et al.: Cosm. Sci. Technol., Ser., 27, 441 (2005); Weisse, S. et al.: J. Drug Del. Sci. Technol., 14, 77 (2004);<br></p>

<p>Stability Hygroscopic<br>Applications Oxythiamine HCl (cas# 136-16-3) is a useful research chemical.<br></p>

<p>Applications Oleuropein is a tyrosol ester derivative of elenolic acid and phenolic glycoside found in olive oil. Oleuropein shows antioxidant, anti-ischemic and hypolipidemic activity. Oleuropein has also been used as an immunomodulator .<br>References Speroni, E. et al.: Phytother. Res., 12, S98 (1998); Andreadou, I. et al.: J. Nutrit., 136, 2213 (2006):;Giamarellos-Bourboulis, E.J. et al.: Shock, 26, 410 (2006);<br></p>

<p>Applications A Vitamin D derivative.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Koeffler, M.R., et al.: Blood, 74, 82 (1989),<br></p>

<p>Stability Moisture Sensitive<br>Applications Succinimidyl-6-(biotinamido) Hexanoate is a biotinylation reagent incorporating an aminocaproyl “spacer”. This can reduce the steric hindrance in binding avidin to some biotinylated compounds when used to biotinylate both the antibody and the carrier in the Protein Avidin-Biotin Capture System. This system avoids the direct interaction of a captured antibody with solid surfaces, such as plastics, which may reduce antigenicity. It has also been used to enhance the detection of DNA on nitrocellulose. Has also been used as a cell surface labelling reagent<br>References Hofmann, K., et al.: Biochemistry, 21, 978 (1982); Leary, J.J., et al.: P. Natl. Acad. Sci. USA, 80, 4045, (1983); Suter, M., et al.: Immunology Letters, 13, 313 (1986); Gretch, D.R., et al.: Anal. Biochem., 163, 270 (1987), Burgess, T.L., et al.: J. Biol. Chem., 269 (32), 19188 (1995), Schumacher, T.N.M., et al.: Science, 271, 1854 (1996)<br></p>

<p>Stability Hygroscopic, Moisture Sensitive, Temperature Sensitive<br>Applications A stable folate lyophilized compound suitable for use in the treatment of cancer and other therapies.<br>References Park, H., et al.: Science, 268, 1866 (1995), Banerjee, R., et al.: J. Biol. Chem., 282, 14916 (2007), Klar, T., et al.: J. Mol. Biol., 366, 954 (2007),<br></p>

<p>Stability Hygroscopic<br>Applications Corotenoid component of the visual pigments. All-trans retinal is converted to retinoic acid in vivo by the action of retinal dehydrogenase.<br>References Ball, et al.: Biochem. J., 42, 516 (1948), O’Brien, D.F., et al.: Science, 218, 961 (1982),<br></p>