Vitamins

<p>Applications Arotinoid ethyl ester is a retinoid with a similar structure to vitamin A (R252000), and inhibits human epidermal keratinocyte RNase P activity, as well as tRNA biogenesis.<br>References Liao, W.; et al.: Zhongguo Linchuang Yaolixue Yu Zhiliaoxue, 19, 112 (2014); Papadimou, E.; et al.: Biol. Chem., 384, 457 (2003); Papadimou, E.; et al.: Skin Pharmacol. Physiol., 13, 345 (2000).<br></p>

<p>Applications SR9243 is used in new compounds targeting warburg effcts, killing cancer cells and inhibiting lipid production.<br>References Anon.: Cancer Discovery, 5, 898 (2015)<br></p>

<p>Stability Light and Temperature Sensitive<br>Applications 9-cis-13,14-Dihydroretinoic Acid, is a derivative of Retinal (R240000), corotenoid component of the visual pigments.<br>References Ball, et al.: Biochem. J., 42, 516 (1948), O’Brien, D.F., et al.: Science, 218, 961 (1982),<br></p>

<p>Applications MRL-871 is a novel RORγt inhibitor, binding to a previously unidentified allosteric pocket in the RORγt LBD.<br>References Scheepstra, Marcel., et al.:Nat. Commun., 6, 8833/1 (2015); Fauber, Benjamin P., et al.: Bioorganic Med. Chem. Lett., 25, 2907 (2015);<br></p>

<p>Applications HX 531 is a novel RXR antagonist used to enhance transactivation of PPARγ and ST 13 preadipocyte differentiation. Helps in the reduction of triglyceride content in white adipose tissue, skeletal muscle and liver.<br>References Yamauchi, T. et al.: J. Clin. Invest., 108, 1001 (2001);<br></p>

<p>Applications Α hydroxylated metabolite of Vitamin D2 (V676040); a synthetic analog of Vitamin D.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Matsuoka, M. et al.: J. Nutrit. Sci. Vitaminol., 35, 253 (1989); Jones, G. et al.: Arch. Biochem. Biophys., 202, 450 (1980); Goff, J. et al.: J. Nutrit., 112, 1387 (1982);<br></p>

<p>Applications SR 1078 is a selective agonist of RORα and RORγ that stimulates ROR transcriptional activity in HEK293 cell reporter assays.<br>References Wang, Y., et al.: ACS Chem. Biol., 5, 1029 (2010); Wang, Y., et al.: PLoS One, 7, 1 (2012)<br></p>

<p>Applications SC-58236 is a highly selective and potent cyclooxygenase-2 inhibitor which has been shown to induce apoptosis in gastric cells via down-regulation of Akt and then release of cytochrome c. Its anti-inflammatory effects allows for potential use in therapy for inflammatory allergic diseases.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fan, X.M. et al.: Digestion, 2, 75 (2006); Kim, S. et al.: Life Sci., 81, 863 (2007); Kim, S. et al.: J. Pharmacol. Exp. Therap., 313, 27 (2005);<br></p>