Nucleosides

<p>5,6-Dichloro-(1-b-D-ribofuranosyl) benzimidazole 3',5'-cyclic monophosphothioate, Sp-isomer sodium salt (SPP) is a cytostatic agent that binds to the α subunit of the voltage-dependent Ca2+ channel. It has been shown to inhibit tumor growth in mouse models of hyperproliferative diseases such as bladder cancer and pulmonary fibrosis. SPP also inhibits the proliferation of human bladder cells in culture by inhibiting cyclic nucleotide phosphodiesterase activity. This leads to an increase in intracellular calcium concentrations and activation of cation channels. SPP is an analog of rolipram, which has been shown to have anti-inflammatory effects on detrusor muscle cells.</p>

<p>3,5-Di-o-(p-toluoyl)-5-(2-hydroxyethyl)-2-deoxyuridine is a nucleoside analogue that has antiviral and anticancer activities. It is synthesized by the condensation of orotic acid with 2'-deoxyuridine in the presence of N,N'-dicyclohexylcarbodiimide (DCC). 3,5-Di-o-(p-toluoyl)-5-(2-hydroxyethyl)-2-deoxyuridine is an activator of ribonucleotide reductase, which is an enzyme involved in DNA synthesis and repair. 3,5-Di-o-(p-toluoyl)-5-(2-hydroxyethyl)-2-deoxyuridine is also capable of inhibiting DNA polymerases and RNA polymerases. This drug can be used for treatment against cancer and antiviral infections.</p>

<p>2'-Deoxy-5'-O-DMT-N2-(4-isopropylphenoxyacetyl)guanosine is a novel nucleoside analog. It is an activator of the ribonucleotide reductase and has antiviral activity. The phosphoramidite derivative of 2'-deoxy-5'-O-DMT-N2-(4-isopropylphenoxyacetyl)guanosine is used as a building block for oligodeoxynucleotides, phosphorothioate oligodeoxynucleotides, and phosphorodiamidate oligodeoxynucleotides. It has been shown to be active against human papilloma virus (HPV) type 16 in vitro and in vivo.</p>

<p>2'/3'-(N-Methylanthraniloyl)-adenosine-5'-triphosphate triethylammonium salt is a phosphoramidite, deoxyribonucleoside that is active as an antiviral. It inhibits the production of viral DNA and RNA by binding to the polymerase enzyme that copies the viral genome. This drug has been shown to be effective in vitro and in vivo against a wide range of viruses, including HIV, herpes simplex virus type 1 and 2, cytomegalovirus, varicella zoster virus, influenza A virus, and poliovirus. It also has anticancer activity by inhibiting cell proliferation.</p>

<p>O-propargyl-puromycin (OPP) is an alkyne analog of puromycin that is efficiently incorporated into newly translated proteins, which are rapidly turned over by the proteasome and can be visualized or captured by copper(I)-catalyzed azide-alkyne cycloaddition. Unlike methionine analogs, OPP does not require methionine-free conditions and, uniquely, can be used to label and assay nascent proteins in whole organisms.</p>

<p>N4-Benzoyl-3'-O-tert-butyldimethylsilyl-2'-deoxycytidine is a monophosphate nucleoside analogue. It has antiviral and anticancer properties, as well as the ability to activate DNA synthesis. This product is synthesized from 2'-deoxycytidine and 4-benzoyl chloride in the presence of tert-butyldimethylsilyl chloride. It is available for sale as a white powder with a purity of 99%.</p>

<p>2'-Deoxynebularine is a nucleoside analog that has been shown to inhibit the replication of human immunodeficiency virus type 1 (HIV-1) in vitro. 2'-Deoxynebularine binds to the viral DNA and inhibits its synthesis by hydrogen bonding with the sugar-phosphate backbone. This inhibition prevents the production of new viral DNA and stops viral replication. The drug also inhibits cellular proliferation, which may be due to its ability to inhibit oxidative DNA damage in animal cells. This drug has been shown to inhibit enzyme activities in both human skin cells and leukemia cells, which may be due to its ability to act as a substrate for various enzymes. It is also an effective inhibitor of cellular protein synthesis.</p>

<p>N6-Benzoyl-5'-O-DMT-adenosine 3'-CE phosphoramidite is a novel nucleoside that has been modified to protect the 2' hydroxyl group from attack by nucleases. This modification makes N6-Benzoyl-5'-O-DMT-adenosine 3'-CE phosphoramidite resistant to degradation and allows for its use in a variety of applications, such as anticancer, antiviral, and DNA sequencing.</p>

<p>E-5-(2-Carbomethoxyvinyl)-2'-deoxy-5'-O-DMT-uridine is a monophosphate nucleoside analog that has been modified to be resistant to antiviral ribonucleases. This drug is phosphorylated in vivo to the corresponding diphosphate and triphosphate, which inhibits viral DNA synthesis and thus prevents the virus from replicating. E-5-(2-Carbomethoxyvinyl)-2'-deoxy-5'-O-DMT-uridine can be used as an antiviral agent against herpes simplex virus (HSV).</p>

<p>S-(4-Nitrobenzyl)-6-thioguanosine is a transport inhibitor that has been shown to be active against leukemia. This drug inhibits the uptake of leukocytes into the bone marrow, which prevents their proliferation and development. S-(4-Nitrobenzyl)-6-thioguanosine also inhibits the synthesis of adenosine in erythrocytes, which leads to the accumulation of uridine and then to an increase in the levels of ATP. This drug can be used to treat chronic lymphocytic leukemia.</p>

<p>N6-Benzoyl-2'-deoxy-3'-O-levulinoyladenosine is an antiviral monophosphate nucleoside that has been shown to have significant activity against HIV and herpes simplex virus. It is also an anticancer drug and a novel synthetic nucleoside. N6-Benzoyl-2'-deoxy-3'-O-levulinoyladenosine has been shown to inhibit the growth of cancer cells in culture, as well as in animal models. It also inhibits the production of DNA and RNA, which may be due to its ability to act as a competitive inhibitor of DNA polymerase or RNA polymerase.</p>

<p>Benzyl-N, N-diisopropylchlorophosphoramidite is a novel nucleoside phosphoramidite with anticancer activity. It is synthesized from benzyl alcohol and diisopropylamine by reaction with phosphorus oxychloride in the presence of a base. This compound can be used to activate DNA for subsequent coupling reactions or for modification of DNA. Benzyl-N, N-diisopropylchlorophosphoramidite has been shown to have antiviral and antitumour activities in vitro and in vivo.</p>

<p>5-[N-(2-Aminoethyl)-3-E-acrylamido]-2'-deoxy-5'-O-DMT-uridine is a novel, activator ribonucleoside phosphoramidite. It is used in the synthesis of oligodeoxynucleotides and has antiviral, anticancer, and antimalarial activities. 5-[N-(2-Aminoethyl)-3-E-acrylamido]-2'-deoxy-5'-O-DMT-uridine is synthesized from 2'-deoxyadenosine monophosphate (dAMP) and N-(2 aminopropyl)-3-(E acryloyl) aminopropylphosphoramidite (APEAP). This nucleoside can be used as a building block for DNA synthesis or for other purposes such as the treatment of cancer and HIV.</p>

<p>2'-Deoxyuridine-5'-diphosphate sodium salt is a novel antiviral agent that inhibits viral replication by inhibiting the activity of viral DNA polymerase. It is a synthetic nucleoside that is not found in nature, but is an analog of deoxyuridine monophosphate. This compound has been shown to be effective against tumor cells and has high purity with a CAS number 102814-06-2. 2'-Deoxyuridine-5'-diphosphate sodium salt is also used as an activator for phosphoramidites and modified nucleosides.</p>

<p>2'-O-tert-Butyldimethylsilyl-5'-O-DMT-N6-methyladenosine 3'-CE phosphoramidite is a novel, synthetic phosphoramidite that is used as an activating group for the synthesis of DNA. This nucleoside has antiviral and anticancer properties. It is also a ribonucleoside that has been modified to include a tertiary butyl dimethyl silyl group and an N6 methyl adenosine moiety.</p>

<p>4-Amino-2,6-dimethyl-8-(2'-deoxy-3',5'-di-O-toluoyl-b-D-ribofuranosyl)-7-pteridone is a high purity, modified nucleoside that is synthesized from 2,4,6,8 tetramethylpyridine and 2'-deoxyribofuranosyl bromide. 4ADTP is an antiviral and anticancer agent that inhibits the viral DNA polymerase in the herpes family of viruses and the DNA polymerase in cancer cells. This drug has been shown to be active against HIV type 1 (HIV1) and HIV type 2 (HIV2).</p>

<p>2'-Amino-2'-deoxyuridine-5'-triphosphate (2dUDP) is a nucleotide that has been shown to be a potent inhibitor of cytosolic Ca2+ release. 2dUDP binds to the Ryanodine receptor (RYR) and inhibits the release of Ca2+ from the sarcoplasmic reticulum. It is also fluorescent, and can be used to detect Ca2+ in cells. This nucleotide has been shown to inhibit populations of heterologous and homologous RYR receptors.</p>

<p>Please enquire for more information about 8,5’(R)-Cycloadenosine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>3-(2'-Deoxy-β-D-2-ribofuranosyl)pyrido[2,3-d]pyrimidine-2,7(8H)-dione is a synthetic nucleoside analogue that has been modified by the replacement of the 2' oxygen atom. The phosphoramidite is used to produce 3-(2'-Deoxy-β-D-2-ribofuranosyl)pyrido[2,3-d]pyrimidine-2,7(8H)-dione in high purity and high quality. This product can be used as an antiviral agent and as an anticancer agent. It has also been shown to inhibit DNA synthesis and RNA synthesis.</p>

<p>A fluorescent analogue of deoxycytidine.  Used for monitoring RNA secondary structure formation, where its fluorescence is reversibly quenched upon base-pairing.  Emission max is at 473nm.</p>