Valproic Acid and Impurities

Stability Hygroscopic
Applications A metabolite of Valproic acid.
References Rudy, A., et al.: J. Pharmacol. Exp. Ther., 259, 1133 (1991), Nagai, K., et al.: J. Antimicrob. Chemother., 39, 295 (1997), Yamamura, N., et al.: Drug Metab. Dispos., 27, 724 (1999)

Stability Hygroscopic
Applications A metabolite of Valproic Acid.
References Burchell, B., et al.: Dev. Pharmacol. Ther., 13, 70 (1989), Bjorge, S.M., et al.: Drug Metab. Dispos., 19, 823 (1991),

Applications A metabolite of Valproic Acid.
References McLean, M.J., et al.: J. Pharmacol. Exp. Ther., 237, 1001 (1986), Lee, R.D., et al.: J. Pharm. Sci., 78, 667 (1989), Mergen, F., et al.: J. Pharm. Pharmacol., 43, 815, (1991)

Applications 2-Ethyl-2-methylpentanoic Acid is a derivative of 2,5-Dimethyl-2-ethylhexanoic Acid (D461540), used in biological studies to evaluate environmental chemicals for estrogenicity.
References Rabinowitz, J.R., et al.: Chem. Res. Toxicol.,22, 1594 (2009); Judson, R., et al.: Environ. Health Perspect, 117, 685 (2009)

Stability Hygroscopic, Light and Temperature Sensitive
Applications A metabolite of Valproic Acid.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References McLean, M.J., et al.: J. Pharmacol. Exp. Ther., 237, 1001 (1986), Lee, R.D., et al.: J. Pharm. Sci., 78, 667 (1989), Mergen, F., et al.: J. Pharm. Pharmacol., 43, 815, (1991)

Applications 2-Methyl-Pentanoic acid is a useful building block for organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Impurity Valproic Acid USP Related Compound B
Applications A constitutional isomer of Valproic acid; a potent anticonvulsant. Sodium valproate impurity C. Valproic Acid USP Related Compound B.
References Levy, R., et al.: Pharm. Res., 8, 551 (1991), Barton, M., et al.: Epilepsy Res., 47, 217 (2001), Fox, A., et al.: Pain, 105, 355 (2003), Archer, D., et al.: Anesth. Analg., 104, 180 (2007),

Stability Hygroscopic,
Applications A metabolite of Valproic Acid.This compounds contains an undetermied amount of water and the analogous lactone.
References Burchell, B., et al.: Dev. Pharmacol. Ther., 13, 70 (1989), Bjorge, S.M., et al.: Drug Metab. Dispos., 19, 823 (1991),

Applications A metabolite of Valproic Acid.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References McLean, M.J., et al.: J. Pharmacol. Exp. Ther., 237, 1001 (1986), Lee, R.D., et al.: J. Pharm. Sci., 78, 667 (1989), Mergen, F., et al.: J. Pharm. Pharmacol., 43, 815, (1991)

Applications Valproic Acid Methyl Ester is the methyl ester derivative of Valproic Acid (V094750); one of the major antiepileptic drugs. Also an anticonvulsant that acts as a mood stabilizer for the treatment of bipolar disorder.
References Chang, Z.L., et al.: Anal. Profiles Drug Subs., 8, 529 (1979); Della Paschoa, O.E., et al.: Br. J. Pharmacol., 125, 1610 (1998); Grimes, C.A., et al.: J. Neirochem., 73, 1384 (1999); Loscher, W., Prog. Neurobiol., 58, 31 (1999)

Applications 2,2-Dipropylvaleramide, is an impurity of Valproic Acid (V094750), an antiepileptic; anticonvulsant that also acts as a mood stabilizer for those with bipolar disorder.
References Chang, Z.L., et al.: Anal. Profiles Drug Subs., 8, 529 (1979), Della Paschoa, O.E., et al.: Br. J. Pharmacol., 125, 1610 (1998), Grimes, C.A., et al.: J. Neirochem., 73, 1384 (1999), Loscher, W., Prog. Neurobiol., 58, 31 (1999),

Stability Hygroscopic
Applications A labelled metabolite of Valproic acid.
References Rudy, A., et al.: J. Pharmacol. Exp. Ther., 259, 1133 (1991), Nagai, K., et al.: J. Antimicrob. Chemother., 39, 295 (1997), Yamamura, N., et al.: Drug Metab. Dispos., 27, 724 (1999)

Applications 1-Methylethyl 2-Propylpentanoate is a derivative of Valproic Acid (V094750(P)), which has been used as an anti-epileptic. It is also an anti-convulsant that acts as a mood stabilizer for patients with bipolar disorder.
References Chang, Z.L., et al.: Anal. Profiles Drug Subs., 8, 529 (1979); Della Paschoa, O.E., et al.: Br. J. Pharmacol., 125, 1610 (1998); Grimes, C.A., et al.: J. Neirochem., 73, 1384 (1999); Loscher, W., Prog. Neurobiol., 58, 31 (1999);

2-Demethoxy-4-methoxy urapidil is a drug product that is used in the development of new drugs. It is a synthetic compound that is metabolized to form its natural metabolite, 2-demethoxyurapidil. This impurity standard has been shown to have anti-inflammatory effects and can be used as an API impurity for pharmacopoeia. 2DMO4MU has been shown to be useful in the study of metabolism and has been found to inhibit prostaglandin synthesis.