Hormones in Recombinant Proteins

<p>Insulin-1 Protein, Mouse, Recombinant (His &amp; Myc) is expressed in Yeast.</p>

<p>Expression System: HEK293 Cells&lt;br&gt;Length: 25-54 90-110, Partial&lt;br&gt;Activity: Not Tested</p>

<p>Expression System: E. coli&lt;br&gt;Length: 24-51, Ghrelin&lt;br&gt;Activity: Not Tested</p>

<p>Expression System: E. coli&lt;br&gt;Length: 90-84, Hepcidin-25&lt;br&gt;Activity: Not Tested</p>

<p>PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion.</p>

<p>Applications The labelled epimer of Medroxyprogesterone acetate (M203560). Progesterone impurity.<br>References Tang, M., et al.: Endocrinol., 151, 1320 (2010), Lee, K., et al.: Mol. Cell. Endocrinol., 319, 109 (2010), Rodgers, A., et al.: Chem., Res. Toxicol., 23, 724 (2010), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010),<br></p>

<p>Applications Intermediate in the synthesis of a cholesterol absorption inhibitor.<br>References Kambara, T. et al.; J. Org. Chem. 64, 9282 (1999); Wu, G. et al.; J. Org. Chem. 62, 6412 (1997)<br></p>

<p>Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of</p>

<p>Applications 4-Androsten-11b,17b-diol-3-one-2,2,4,6,6-d5 is a useful isotopically labeled compound of 11β-Hydroxytestosterone (H956785)<br></p>

<p>Applications A labelled metabolite of 17β-Nandrolone (N315000).<br>References Dumasia, M., et al.: Xenobiotica, 14, 647 (1984), Schanzer, W., et al.: Clin. Chem., 42, 1001 (1996), Hartmann, C., et al.: J. Pharm. Biomed. Anal., 17, 193 (1998),<br></p>

<p>Applications 17α-Methyl-5α-androstane-2β,3α,17β)-triol is a derivative of Madol (M108000, which is an anabolic steroid recently identified to be misused as a doping agent. The potency of Madol (DMT) to transactivate androgen receptor (AR) dependent reporter gene expression was two times lower as compared to dihydrotestosterone (DHT).<br>References Zierau, O., et al.: Planta Med., 69, 856 (2003), Takahashi, M., et al.: Endocr. J., 51, 425 (2004), Labrie, F., et al.: J. Endocrinol., 184, 427 (2005),Friedel, A., et al.: Toxicol. Lett., 164, 16(2006),<br></p>

<p>Stability Acid Sensitive<br>Applications 17β-(Trimethylsiloxy)testosterone is an anabolic steriod, and a derivative compound of Testosterone (T155000), Principal hormone of the testes, produced by the interstitial cells. Major circulating androgen; converted by 5α-reductase in androgen-dependent target tissues to 5α-dehydrotestosterone which is required for normal male sexual differentiation. Also converted by aromatization to Estradiol.Testerone is a controlled substance (anabolic steroid). Androgen.<br>References McFarland, K., et al.: Science, 245, 494 (1989), Heckert, L., et al.: Mol. Endocrinol., 12, 1499 (1998), Themmen, A., et al.: Endocr. Rev. 21, 551 (2000), Kumar, R., et al.: Biol. Reprod., 65, 710 (2001),<br></p>

<p>Applications 5α-Pregnane-3-one-20α-ol, is a steroid metabolome, that can be used for in studies of a possible tool for laboratory diagnosis of schizophrenia. It is also a metabolite of Progesterone (P755900) in adipose cells.<br>References Bicikova, M., et al.: J. Steriod Biochem. Mol. Bio., 77, 133 (2013); Zhang, Y., et al.: Mol. Cell. Endocrinology, 298, 76 (2009);<br></p>

<p>Applications Testosterone-2,2,4,6,6-d5 Propionate is a useful isotopically labeled compound of Testosterone Propionate (T155045)<br></p>

<p>Applications Androstenedione (A637550) analog, an aromatase inhibitor.<br>References Marsh, D.A., et al.: J. Med. Chem., 28, 788 (1985),<br></p>

<p>Applications Testosterone-2,2,4,6,6-d5 Acetate is a useful isotopically labeled compound of Testosterone 17-O-Acetate (T155025)<br></p>

<p>Applications Testosterone-2,2,4,6,6-d5 Heptanoate is a useful isotopically labeled compound of Testosterone Enanthate (T155080)<br></p>

<p>Applications Testosterone-2,2,4,6,6-d5 Benzoate is a useful isotopically labeled compound of Testosterone Benzoate (T155015)<br></p>

<p>Applications Testosterone-16,16,17-d3 17-Phenylpropionate, is the labeled analogue of Testosterone 17-Phenylpropionate (T155150), a Testosterone ester being misused by athletes in an attempt to improve sports performance. It can also be used as a therapy in glucocorticoid-treated patients to increase the circulating testosterone concentration.<br>References Shackleton, C. H. L., et al.: Steroids, 62 (7), 523 (1997); Reid, I. R., et al.: Archives Internal Med., 156 (11), 1173 (1996);<br></p>

<p>Applications Testosterone-16,16,17-d3 Hexanoate is a useful isotopically labeled compound of Testosterone Hexanoate (T155125)<br></p>

<p>Applications 4-Androsten-17alpha-methyl-17beta-ol-3-one-1,2-d2 is a useful isotopically labeled compound of 17α-Methyl Testosterone (M326400)<br></p>

<p>Applications 5-Androstenediol is a steroid androgen metabolite of Testosterone (T155000), the principal hormone of the testes, produced by the interstitial cells.<br>References Miller, M., et al.: Steroids., 78, 15 (2013); Baker, M.E., et al.: Steroids., 77, 1192 (2012); Ronis, M.J.J. et al.: Comp. Biochem. Physiol.-C: Pharmacol. Toxicol. Endocrinol., 121C, 221 (1998);<br></p>

<p>Applications Dydrogesterone (D826000) intermediate. Used in the preparation of 10α-steroids.<br></p>

<p>Applications Testosterone Heptanoate-6,6,7,7,7-d5 (CAS# 1263095-31-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications A labelled steroid hormone with weak androgenic activity. It is metabolized from Testosterone (T155000) in the liver and is used in doping analysis to detect testosterone misuse. Controlled Substance.<br>References Park, J., et al.: J. Anal. Toxicol., 14, 66 (1990),; Palonek, E., et al.: J. Steroid Mol. Biol., 55, 121 (1995); Aguilera, R., et al.: Clin. Chem. 47, 292 (2001); Flenker, U., et al.: Steroids, 73, 408 (2008); Saudan, C. et al.: Steroids, 70, 179 (2005);<br></p>

<p>Insulin Porcine is a two chain, glycosylated polypeptide chain containing 51 amino acids and having a molecular mass of 5777 Dalton.  The a and b chains are joined by two interchain disulfide bonds with the a chain containing an intrachain disulfide bond. Insulin regulates the cellular uptake, utilization, and storage of glucose, amino acids, and fatty acids and inhibits the breakdown of glycogen, protein, and fat.</p>

<p>Follicle Stimulating Hormone (FSH) is a protein hormone that plays a crucial role in the reproductive cycle. It stimulates the growth and development of follicles in the ovaries, which produce estrogen and progesterone. FSH also regulates spermatogenesis in men. Studies have shown that FSH has inhibitory activity on cyclin-dependent kinases, which are enzymes that regulate the cell cycle. This inhibitory activity leads to decreased cell proliferation and growth, making it a potential treatment for cancer. In vitro studies have demonstrated its effectiveness against breast and lung cancer cells lines when combined with kinase inhibitors. Additionally, FSH has been found to stimulate protein kinase activity, which may be useful in developing therapies for other diseases such as diabetes and osteoporosis.</p>

<p>Erythropoietin is a hormone that stimulates the production of red blood cells, and is used for patients with anemia. It is a recombinant human erythropoietin (rhEPO) that has been produced by genetic engineering. Erythropoietin binds to receptors on the surface of many types of cells, including those in the bone marrow. This binding stimulates the production of red blood cells from precursor cells in the bone marrow, and increases oxygen-carrying capacity in blood. The half-life of erythropoietin is approximately 36 hours. This drug also can be used to reduce high blood pressure and improve responsiveness to other drugs that are given intravenously. Erythropoietin can cause an increase in asialoglycoprotein levels in serum, which may be due to its effects on hepatocytes or erythrocytes.</p>

<p>Expression system: HEK294 Cells&lt;br&gt;Length: 27-217, Full Length of Mature Protein&lt;br&gt;Activity: Not Tested</p>