Complement System
The complement system is a crucial part of the immune response, consisting of a series of small proteins that enhance the ability of antibodies and phagocytic cells to clear pathogens from an organism. These proteins work together to opsonize pathogens, induce inflammatory responses, and directly lyse pathogen membranes, playing a vital role in innate immunity and overall immune function. At CymitQuimica, we provide high-quality complement system proteins to support your immunological studies and clinical research.
Found 156 products of "Complement System"
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Complement factor D-IN-2
CAS:<p>Complement factor D-IN-2 is an inhibitor of Complement factor D and reduces the excessive activation of complement factor D.</p>Formula:C27H24BrN7O3Purity:99.53%Color and Shape:SolidMolecular weight:574.43Complement C5a Protein, Human, Recombinant
<p>Complement C5 Protein, Human, Recombinant (Complement C5a) is expressed in E.</p>Purity:SDS-PAGE: 94.9%; SEC-HPLC: 93.5%Color and Shape:Lyophilized PowderMolecular weight:8.3 kDa (predicted); 8.3 kDa (reducing conditions)AMY-101 acetate
<p>AMY-101 acetate (Cp40 acetate) is a peptide, an inhibitor of C3 Complement in gingivitis and periodontitis, reduces inflammation and lowers MMP-8 and MMP-9.</p>Formula:C85H121N23O20S2Purity:98.80% - 99.98%Color and Shape:SolidMolecular weight:1849.14Complement factor I Protein, Rat, Recombinant (His & Myc)
<p>Complement factor I Protein, Rat, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag.</p>Color and Shape:Lyophilized PowderMolecular weight:69.2 kDa (predicted)Complement C5 Protein, Rat, Recombinant (His & Myc)
<p>Complement C5 Protein, Rat, Recombinant (His & Myc) is expressed in E.</p>Color and Shape:Lyophilized PowderMolecular weight:14.0 kDa (predicted)C1QA Protein, Mouse, Recombinant (E. coli, His)
<p>C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system.</p>Purity:98%Color and Shape:Lyophilized PowderMolecular weight:29.1 kDa (predicted)Complement factor B Protein, Mouse, Recombinant (His)
<p>Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb.</p>Color and Shape:Lyophilized PowderMolecular weight:87.0 kDa (predicted)Complement C8a Protein, Human, Recombinant (His)
<p>Complement C8a Protein, Human, Recombinant (His) is expressed in E. coli.</p>Color and Shape:Lyophilized PowderMolecular weight:65.8 kDa (predicted)Complement C5a Protein, Pig, Recombinant (His)
<p>Derived from proteolytic degradation of complement C5, C5a anaphylatoxin is a mediator of local inflammatory process.</p>Color and Shape:Lyophilized PowderMolecular weight:10.6 kDa (predicted)Complement C8b Protein, Human, Recombinant (His)
<p>Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of</p>Color and Shape:Lyophilized PowderMolecular weight:67.0 kDa (predicted)Properdin Protein, Mouse, Recombinant (His & Myc)
<p>A positive regulator of the alternate pathway of complement.</p>Color and Shape:Lyophilized PowderMolecular weight:53 kDa (predicted)C1QL3 Protein, Mouse, Recombinant (His & Myc)
<p>May regulate the number of excitatory synapses that are formed on hippocampus neurons.</p>Color and Shape:Lyophilized PowderMolecular weight:28.6 kDa (predicted)Complement C4-B Protein, Human, Recombinant (His & SUMO)
<p>Complement C4-B Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.</p>Color and Shape:Lyophilized PowderMolecular weight:49.1 kDa (predicted)C1QL1 Protein, Mouse, Recombinant (His)
<p>May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses.</p>Color and Shape:Lyophilized PowderMolecular weight:26.9 kDa (predicted)C5AR1 Protein, Mouse, Recombinant (His & KSI)
<p>Expression system: E. coli<br>Length: 306-351, Partial<br>Activity: Not Tested</p>Color and Shape:Lyophilized PowderMolecular weight:20.4 kDa (Predicted)Complement factor D Protein, Rat, Recombinant (His & Myc)
<p>Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate</p>Color and Shape:Lyophilized PowderMolecular weight:29.8 kDa (predicted)C5AR1 Protein, Human, Recombinant (Cell-Free, His)
<p>Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a.</p>Purity:90%Color and Shape:Lyophilized PowderMolecular weight:40.7 kDa (predicted)Complement C4-B Protein, Mouse, Recombinant (His)
<p>Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway.</p>Color and Shape:Lyophilized PowderMolecular weight:39.0 kDa (predicted)C1RA Protein, Mouse, Recombinant (His & Myc)
<p>C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.</p>Color and Shape:Lyophilized PowderMolecular weight:85.7 kDa (predicted)Complement C3 Protein, Mouse, Recombinant (His & SUMO)
<p>Complement C3 Protein, Mouse, Recombinant (His & SUMO) is expressed in E.</p>Color and Shape:Lyophilized PowderMolecular weight:55.3 kDa (predicted)C1QA Protein, Human, Recombinant (His & Myc)
<p>C1QA Protein, Human, Recombinant (His & Myc) is expressed in E. coli.</p>Color and Shape:Lyophilized PowderMolecular weight:30.7 kDa (predicted)C5AR1 Protein-VLP, Human, Recombinant (His)
<p>Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a.</p>Color and Shape:Lyophilized PowderMolecular weight:41.1 kDa (predicted)Properdin Protein, Mouse, Recombinant (His)
<p>A positive regulator of the alternate pathway of complement.</p>Color and Shape:Lyophilized PowderMolecular weight:51.9 kDa (predicted)C5AR1 Protein, Mouse, Recombinant (MBP & His-Avi), Biotinylated
<p>Expression system: E. coli<br>Length: 306-351, Partial<br>Activity: Not Tested</p>Color and Shape:Lyophilized PowderMolecular weight:52.8 kDa (Predicted)Complement C8g Protein, Human, Recombinant (His)
<p>C8 is a constituent of the membrane attack complex.</p>Purity:95%Color and Shape:Lyophilized PowderMolecular weight:26.4 kDa (predicted)CR1 Protein, Human, Recombinant
<p>Expression system: E. coli<br>Length: 41-234, Partial<br>Activity: Not Tested</p>Color and Shape:Lyophilized PowderMolecular weight:21.6 kDa (Predicted)C1SB Protein, Mouse, Recombinant (His & Myc)
<p>C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system.</p>Color and Shape:Lyophilized PowderMolecular weight:82.4 kDa (predicted)C1QA Protein, Mouse, Recombinant (His)
<p>C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system.</p>Purity:90% - 92%Color and Shape:Lyophilized PowderMolecular weight:25.6 kDa (predicted)Complement C3 Protein, Bovine, Recombinant (His & SUMO)
<p>Complement C3 Protein, Bovine, Recombinant (His & SUMO) is expressed in E.</p>Color and Shape:Lyophilized PowderMolecular weight:39.5 kDa (predicted)Complement factor D Protein, Rat, Recombinant (His)
<p>Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate</p>Color and Shape:Lyophilized PowderMolecular weight:27.8 kDa (predicted)Empasiprubart
CAS:<p>Empasiprubart (anti-C2 mAb) inhibits classical & lectin complement pathways upstream of C3, showing efficacy in autoimmune models.</p>Purity:95%Color and Shape:LiquidCrovalimab
CAS:<p>Crovalimab (SKY59; RO7112689) is an humanised monoclonal antibody that binds to complement C5 , paroxysmal nocturnal haemoglobinuria (PNH).</p>Purity:95%Color and Shape:LiquidGefurulimab
CAS:<p>Gefurulimab (ALXN-1720) is a bispecific antibody derived from humans, targeting complement C5 and albumin.</p>Color and Shape:LiquidRiliprubart
CAS:<p>Riliprubart (SAR445088) is a humanized monoclonal antibody that acts as an anti-C1s inhibitor in the proximal part of the classical complement system. It selectively targets activated C1s, inhibiting its enzymatic activity on substrates C4 and C2, thereby preventing the formation of the classical pathway C3 convertase, C4b2a [1].</p>Purity:95% - 95%Color and Shape:LiquidIsocyclosporin A
CAS:<p>Isocyclosporin A is a rearranged degradation product. It is formed by acid treatment of cyclosporin A under aqueous and non-aqueous conditions.</p>Formula:C62H111N11O12Color and Shape:SolidMolecular weight:1202.61C5aR-IN-2
CAS:<p>C5aR-IN-2, a potent C5aR inhibitor, shows promise for researching inflammatory diseases.</p>Formula:C36H40FN5O2Color and Shape:SolidMolecular weight:593.73BCX 1470
CAS:<p>BCX 1470 inhibits the esterolytic activity of factor D and C1s (IC50: 96 nM and 1.6 nM), 3.4- and 200-fold better than that of trypsin, respectively.</p>Formula:C14H10N2O2S2Purity:98%Color and Shape:SolidMolecular weight:302.37NRP1 antagonist 2
CAS:<p>NRP1 antagonist 2 (Compound 1) is an NRP1 antagonist.</p>Formula:C20H17ClN6OS2Color and Shape:SolidMolecular weight:456.97FD-IN-1
CAS:<p>FD-IN-1: Factor D inhibitor, IC50=12 nM; blocks FXIa, Tryptase β2 (IC50s: 7.7 μM, 6.5 μM); key in innate immunity.</p>Formula:C23H23NO4Color and Shape:SolidMolecular weight:377.43EG00229
CAS:<p>EG00229 blocks VEGF-A/NRP1 binding, IC50 of 3 μM; doesn't affect VEGFR-1/2. It's an NRP1 antagonist.</p>Formula:C19H20F3N7O7S3Purity:98.23%Color and Shape:SolidMolecular weight:611.6C3a Receptor Agonist
CAS:<p>C3a Receptor Agonist activates C3aRs, inhibits neutrophil mobilization in ischemia, and promotes neural progenitor differentiation.</p>Formula:C27H35N3O2Purity:99.76%Color and Shape:SolidMolecular weight:433.59NDT 9513727
CAS:<p>NDT 9513727 is a potent, selective and competitive C5aR1 inverse agonist for the study of inflammatory and immune disorders.</p>Formula:C36H35N3O4Purity:99.21%Color and Shape:SolidMolecular weight:573.68Complement C5-IN-1
CAS:<p>Complement C5-IN-1 is a small-molecule inhibitor of complement component 5 protein (C5).</p>Formula:C24H32N2O6Purity:98.27%Color and Shape:SolidMolecular weight:444.52Factor D inhibitor 6
CAS:<p>Factor D inhibitor 6 is a potent, highly selective, and orally active compound that specifically inhibits the activity of factor D (FD) with an IC50 of 30 nM and a Kd of 6 nM. It does not exhibit inhibitory effects against factor B, classical and lectin complement-pathway activation, or a broad array of receptors, ion channels, kinases, and proteases.</p>Formula:C23H22ClFN6O3Color and Shape:SolidMolecular weight:484.92W-54011
CAS:<p>W-54011: potent non-peptide C5a receptor blocker; binds 125I-C5a (Ki=2.2nM); stops Ca2+ movement, chemotaxis, ROS in neutrophils (IC50=1.6-3.1nM).</p>Formula:C30H37ClN2O2Purity:96.8%Color and Shape:SolidMolecular weight:493.08Factor B-IN-2
CAS:<p>Factor B-IN-2 is a potent inhibitor (IC50: 1.5 μM) of complement factor B. Factor B-IN-2 can be used to study inflammatory and immune-related diseases.</p>Formula:C25H32N2O4Color and Shape:SolidMolecular weight:424.53EG01377
CAS:<p>EG01377 is a NRP1 antagonist with antiangiogenic, antimigratory, and antitumor activity, Kd 1.32 μM, IC50s 609 nM for NRP1-a1/b1, inactive on NRP2.</p>Formula:C26H30N6O6S2Purity:98%Color and Shape:SolidMolecular weight:586.68C5aR-IN-1
CAS:<p>C5aR-IN-1, a potent C5aR inhibitor, may aid in researching autoimmune and inflammatory diseases.</p>Formula:C36H39F4N3O2Color and Shape:SolidMolecular weight:621.71Iptacopan
CAS:<p>Iptacopan (LNP023) is an inhibitor with high affinity to factor B, with a KD value of 7.9 nM and an IC50 value of 10 nM. Cost-effective and quality-assured.</p>Formula:C25H30N2O4Purity:99.07% - >99.99%Color and Shape:SolidMolecular weight:422.52C5aR-IN-3
CAS:<p>C5aR-IN-3, a potent C5aR inhibitor, may treat autoimmune and inflammatory diseases.</p>Formula:C36H40FN5O3Color and Shape:SolidMolecular weight:609.73
