Aminoacids and derivatives

<p>Applications CEL and CML are two stable, nonenzymatic chemical modifications of protein lysine residues resulting from glycation and oxidation reactions.<br>References Fu, M.X., et al.: J. Biol. Chem., 271, 9982 (1996), Ahmed M.U., et al.: Biochem.J., 324, 565 (1997), Schleicher, E.D., et al.: J. Clin. Invest., 99, 457 (1997), Shibayama, R., et al.: Diabetes, 48, 1842 (1999),<br></p>

<p>Stability Hygroscopic<br>Applications L-Carnitine-d3 Chloride is the isotope labelled analog of L-Carnitine (C184110); a vitamin (enzyme cofactor). It is an essential cofactor of fatty acid metabolism and is required for the transport of fatty acids through the inner mitochondrial membrane. Synthetized primarily in the liver and kidney with the highest concentrations found in heart and skeletal muscle. Dietary sources include red meat, dairy products, beans, avocado.<br>References Mitchell, M.E., et al.: Am. J. Clin. Nutr., 31, 293 (1978); Lango, R., et al.: Cardiovasc. Res., 51, 21 (2001); Vaz, F.M., et al.: Biochem. J., et al.: 361, 417 (2002); Karlic, H., et al.: Nutrition, 20, 709 (2004)<br></p>

<p>Applications 6-Aminocaproic Acid Dimer is a reactant with citric acid in the formation of 3-hydroxy-3,4-dicarboxy-butanamide-N-hexanoic acid.<br>References Schou-Pedersen, A. V., et al.: J. Pharm. Biomed. Anal., 107, 333-340 (2015)<br></p>

<p>Applications A lipid biomarker for stable and unstable heart disease.<br>References Gaziano, J., et al.: Circulation, 96, 2520 (1997), Thomas, A., et al.: Anal. Chem., 82, 6687 (2010),<br></p>

<p>Applications Used for the counterselection of TRP1, a commonly used genetic marker in the yeast Saccharoyces Cerevisiae. An antimetabolite for the tryptophan pathway in yeast, and is toxic by virtue of its antimetabolite conversion to 5-Fluorotryptophan. It can be used for the selection of tryptophan auxotroophs.<br>References Toyn, J.H., et al.: Yeast, 16, 553, 560 (2000)<br></p>

<p>Applications Iminodiacetic Acid is used as a reagent in the synthesis of poly(N-isopropylacrylamide) (PNIPAM) microgel particles for metal affinity binding of peptides.<br>References Tsai, H., et al.: Colloids Surf. B, 114, 104 (2014)<br></p>

<p>Applications Lacosamide impurity I: (R)-N-benzyl-2-(3-benzylureido)-3-methoxypropanamide is an impurity of lacosamide (L098500), a medication used for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain. Lacosamide is a potent anticonvulsant.<br>References Lees, G., et al.: Brain Res., 612, 190 (1993), Kuo, C., et al.: Mol. Pharmacol., 51, 1077 (1997), Barton, M., et al.: Epilepsy Res., 47, 217 (2001), Beyreuther, B., et al.: Eur. J. Pharmacol., 539, 64 (2006), Beyreuther, B., et al.: CNS Drug Rev., 13, 21 (2007),<br></p>

<p>Applications Epi-Lacosamide is an impurity of Lacosamide (L098500), a medication used for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain. Lacosamide is a potent anticonvulsant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Choi, D., et al.: J. Med. Chem., 39, 1907 (1996), Morieux, P., et al.: Bioorg. Med. Chem., 16, 8968 (2008),<br></p>

<p>Applications Baclofen-d4, is the labeled analogue of Baclofen (B108000), a specific GABA-B receptor agonist. Muscle relaxant (skeletal).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ahuja, S., et al.: Anal. Profiles Drug Subs., 14, 527 (1985), Brogden, R.N., et al.: Drugs, 8,1 (1974)<br></p>

<p>Applications 2-Hydroxy L-Tryptophan is a metabolic intermediate in the biosynthesis of the neurotransmitters serotonin and melatonin from Tryptophan.<br>References Southan, M.D., et al.: Med. Chem. Res., 6, 343 (1996);<br></p>

<p>Applications N-Methyl Lacosamide is derived from (R)-2-Amino-N-benzyl-3-methoxypropionamide (A598000), which is an impurity of Lacosamide which is a potent anticonvulsant.<br>References Letiran, A., et al.: J. Med. Chem., 45, 4762 (2002); Wadavrao, S., et al.: Synthesis, 45, 3383 (2013);<br></p>

<p>Stability Hygroscopic<br>Applications Oleoyl-L-carnitine is a long-chain fatty ester of carnitine which is accumulated and released into the circulation, in fatty-acid oxidation defects. Pattern of Oleoyl-L-carnitine can be diagnostic for a number of ß-oxidation defects.<br>References Adams, S., et al.: J. Nutrition, 139, 1073 (2009); Ventura, F., et al.: Clinica Chimica Acta, 281, 1 (1999); Pourfarzam, M., et al.: Clinical Chem,, 40, 2267 (1994); Schaefer, J., et al.: Pediatric Res., 37, 354 (1995)<br></p>

<p>Applications 2,5-Piperazinedione, can be used as an intermediate in the preparation of various pharmaceutical and biologically active compounds. It can be used in the synthesis of dipeptide isosteres by cross-metathesis.<br>References Enholm, J.E. et al.: Tetrahedron, 68, 6920 (2012);<br></p>

<p>Applications N-Methyl-N-nitroso-1-hexadecanamine is a compound found in a wide range of cosmetic products and cleaning emulsions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kamp, E.. et al.: Food. Chem. Toxicol., 29, 203 (1991); Lalljie, S. P. D., et al.: Adv. Mass. Spec., 14, 33790 (1998); Abidi, S.L., et al.: J. Chroma., 324, 209 (1985);<br></p>

<p>Applications D-Cysteine is a strong inhibitor of Escherichia coli growth and also functions to provide inorganic sulfates for the sulfation of xenobiotics. D-Cysteine is a non-physiological isomer of L-Cysteine (C995000), and is not involved in protein or glutathione synthesis.<br>References Glazenburg, E., et al.: Biochem. Pharm., 33, 625 (1984); Klassen, C. &amp; Boles, J.: FASEB J., 11, 404 (1997); Soutourina, J., et al.: J. Biol. Chem., 276, 40864 (2001);<br></p>

<p>Applications A metabolite of 3,4-methylenedioxyethylamphetamine (M303975).<br>References Nichols, D., et al.: J. Med. Chem., 29, 2009 (1986), Ricaurte, G., et al.: Brain Res., 446, 165 (1988), Colado, M., et al.: Br. J. Pharmacol., 111, 131 (1994), Helmlin, H., et al.: J. Anal. Toxicol., 20, 432 (1996), Maurer, H., et al.: Ther. Drug Monit., 18, 465 (1996),<br></p>

<p>Applications Benzylamine has been used as a reactant in the preparation of diacetylated benzylamide which has shown to induce a G1/G0 arrest in tumor cells and cytotoxicity against human ovarian cancer cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Siewert, B., et. al.: Bioorg. Med. Chem., 22, 594 (2014)<br></p>