Aminoacids and derivatives

<p>Applications CEL and CML are two stable, nonenzymatic chemical modifications of protein lysine residues resulting from glycation and oxidation reactions.<br>References Fu, M.X., et al.: J. Biol. Chem., 271, 9982 (1996), Ahmed M.U., et al.: Biochem.J., 324, 565 (1997), Schleicher, E.D., et al.: J. Clin. Invest., 99, 457 (1997), Shibayama, R., et al.: Diabetes, 48, 1842 (1999),<br></p>

<p>Applications L-Homocysteine Thiolactone Hydrochloride is used to prepare substituted homocysteine analogs as inhibitors of peptidylglycine α-amidating monooxygenase. It is also used to synthesize (mercaptoacyl)alanylprolines as metalloprotease inhibitors.<br>References Erion, M., et al.: J. Med. Chem., 37, 4430 (1994); Slusarchyk, W., et al.: Bioorg. Med. Chem. Lett., 5, 753 (1995)<br></p>

<p>Applications A metabolite of 5-Hydroxytryptamine, also known as Serotonin (S274990).<br>References Uutela, P. et al.: Anal. Chem., 81, 8417 (2009); Koehle, C. et al.: Biochem. Pharmacol., 69, 1397 (2005); Krishnaswamy, S. et al.: Xenobiotica, 33, 169 (2003);<br></p>

<p>Applications A metabolite of Malatonin.<br>References Young, I., et al.: J. Clin. Endocrinol. Metab., 60, 114 (1985), Barrenetxe, J., et al.: J. Physiol. Biochem., 60, 61 (2004),<br></p>

<p>Stability Hygroscopic<br>Applications Biogenic polyamine formed from spermidine and occurring in almost all tissues. Essential for both normal and neoplastic tissue growth. Involved in the modulation of calcium-dependent immune processes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Israel, et al.: J. Med. Chem., 7, 710 (1964), Janne, J., et al.: Biochim. Biophys. Acta, 473, 241 (1978). Theoharides, T.C., et al.: Life Sci., 27, 703 (1980), Horn, Y., et al.: Cancer Res., 42, 3248 (1982),<br></p>

<p>Stability Air Sensitive, Light Sensitive<br>Applications 5-Hydroxyindole-3-acetic acid is an impurity of chlorpheniramine (C424300), an antihistaminic agent.<br>References Josko, J., et al.: Annal. Acad. Med. Siles., 66, 13, (2012); Carson, R.P., et al.: Human. Molec. Genetics., 22, 140 (2013);<br></p>

<p>Applications A labelled, essential amino acid.<br>References Liu, F., et al.: Bioorg. Med. Chem., 18, 4167 (2010), Kumar, R., et al.: Eur. J. Med. Chem., 45, 2265 (2010), Cai, W., et al.: Bioorg. Med. Chem., 18, 1899 (2010),<br></p>

<p>Applications trans-4-Hydroxycyclohexylcarboxylic Acid acts as a reagent in the synthetic preparation of pyrazole-pyrimidine preparation as TTK inhibitors and potential antitumors, Preparation and Janus kinase 1 (JAK1)-selective inhibitory activity of benzimidazole derivatives.<br>References Liu, Y., et al.: ACS Med. Chem. Lett., 7, 671 (2016); Kim, H., et al.: Bioorg. Med. Chem. Lett., 26, 3213 (2016)<br></p>

<p>Applications ε-​Caprolactam is a synthetic precursor of Nylon-6 and other synthetic polymers. This compound also inhibits the growth of several Bacillus and Rhizobium species, but Arthrobacter species grow normally in the presence of this compound.<br>References Bomfim, Marcus V.J., et al.: Braz. J. Pharm. Sci., 45(1), 21-35 (2009); Kalinova, Jana P., et al.: Food Chem., 157, 380-384 (2014)<br></p>

<p>Applications Lacosamide is a medication used for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain. Lacosamide is a potent anticonvulsant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lees, G., et al.: Brain Res., 612, 190 (1993), Kuo, C., et al.: Mol. Pharmacol., 51, 1077 (1997), Barton, M., et al.: Epilepsy Res., 47, 217 (2001), Beyreuther, B., et al.: Eur. J. Pharmacol., 539, 64 (2006), Beyreuther, B., et al.: CNS Drug Rev., 13, 21 (2007),<br></p>

<p>Applications N-Octanoylglycine is a derivative of Glycine (G615990) and is an amphiphilic lipoamino acid commonly used in cosmetics for its antibacterial properties. N-Octanoylglycine is the active ingredient in products designed to treat seborrheic dermatitis on the scalp and acne prone skin.<br>References Georgalas, A.: Cosmet. Toiletries, 127, 96 (2012); Nakamura, S.: Frag. J., 39, 36 (2011);<br></p>

<p>Stability Hygroscopic<br>Applications (R)-2-Amino-N-benzyl-3-methoxypropionamide is an impurity of Lacosamide which is a potent anticonvulsant.<br>References Letiran, A., et al.: J. Med. Chem., 45, 4762 (2002); Wadavrao, S., et al.: Synthesis, 45, 3383 (2013)<br></p>