Aminoacids and derivatives

<p>Applications 6-(6-(6-Aminohexanamido)hexanamido)hexanoic Acid is used in the making of a preconjugate which serves as immunoreactive conjugate useful as a developer antigen in a competitive inhibition immunoassay for the polymorphic analyte. Also used in the efficient synthesis of a heterobifunctional coupling agent.<br>References Oh, C. S., et al.: PCT Int. Appl. (1994), WO 9416330 A1 19940721; Reddy, R. E., et al.: Bioconjug. Chem., 16, 1323 (2005)<br></p>

<p>Applications Glycine-15N is the labelled form of Glycine (G615990). Glycine is a non-essential amino acid for human development. Glycine is an inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.<br>References Scott, D., et al.: J. Neurosci., 21, 3063 (2001); Laube, B., et al.: Neuropharmacology, 47, 994 (2004); Papadakis, M., et al.: J. Biol. Chem., 279, 14703 (2004); Chen, P., et al.: Mol. Pharmacol., 67, 1470 (2005); Wolosker, H., et al.: Mol. Neurobiol., 36, 152 (2007)<br></p>

<p>Stability Hygroscopic<br>Applications One of the metabolites found in the lymph fluid collected from dietary stressed rats.<br>References Ardawi, M., et al.: Biochem. J., 212, 835 (1983), Otton, R., et al.: J. Endocrinol., 174, 55 (2002), Gu, H., et al.: Anal. Chem., 79, 89 (2007),<br></p>

<p>Stability Hygroscopic<br>Applications O-Acetyl Lacosamide is an impurity of Lacosamide (L098500) which is a potent anticonvulsant.<br>References Lees, G., et al.: Brain Res., 612, 190 (1993), Kuo, C., et al.: Mol. Pharmacol., 51, 1077 (1997), Barton, M., et al.: Epilepsy Res., 47, 217 (2001), Beyreuther, B., et al.: Eur. J. Pharmacol., 539, 64 (2006), Beyreuther, B., et al.: CNS Drug Rev., 13, 21 (2007),<br></p>

<p>Applications Benzylamine has been used as a reactant in the preparation of diacetylated benzylamide which has shown to induce a G1/G0 arrest in tumor cells and cytotoxicity against human ovarian cancer cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Siewert, B., et. al.: Bioorg. Med. Chem., 22, 594 (2014)<br></p>

<p>Applications N-Methyl Lacosamide is derived from (R)-2-Amino-N-benzyl-3-methoxypropionamide (A598000), which is an impurity of Lacosamide which is a potent anticonvulsant.<br>References Letiran, A., et al.: J. Med. Chem., 45, 4762 (2002); Wadavrao, S., et al.: Synthesis, 45, 3383 (2013);<br></p>

<p>Applications Lacosamide impurity I: (R)-N-benzyl-2-(3-benzylureido)-3-methoxypropanamide is an impurity of lacosamide (L098500), a medication used for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain. Lacosamide is a potent anticonvulsant.<br>References Lees, G., et al.: Brain Res., 612, 190 (1993), Kuo, C., et al.: Mol. Pharmacol., 51, 1077 (1997), Barton, M., et al.: Epilepsy Res., 47, 217 (2001), Beyreuther, B., et al.: Eur. J. Pharmacol., 539, 64 (2006), Beyreuther, B., et al.: CNS Drug Rev., 13, 21 (2007),<br></p>

<p>Applications Used for the counterselection of TRP1, a commonly used genetic marker in the yeast Saccharoyces Cerevisiae. An antimetabolite for the tryptophan pathway in yeast, and is toxic by virtue of its antimetabolite conversion to 5-Fluorotryptophan. It can be used for the selection of tryptophan auxotroophs.<br>References Toyn, J.H., et al.: Yeast, 16, 553, 560 (2000)<br></p>

<p>Applications An important metabolite of Benzene.<br></p>

<p>Applications Methyl 6-aminohexanoate is used as a reagent to synthesize straight chain hydroxamates, compounds that act as inhibitors of Human Histone Deacetylase (HDAC) that have the potential to treat cancer. Methyl 6-aminohexanoate is also sometimes used as a spacer unit for peptide synthesis.<br>References Matthews, S., et al.: J. Chem. Soc. Chem. Commun., 17, 1809 (1995); Remiszewski, S., et al.: J. Med. Chem., 45, 753 (2002)<br></p>

<p>Applications It is used as labelled biomarker for metabolic age.<br>References Selmer, T., et al.: Eur. J. Biochem., 268, 1363 (2001), Connelly, J., et al.: Drug Metab. Dispos., 30, 1357 (2002), Lindon, J., et al.: Pharm. Res., 23, 1075 (2006), Monteagudo, E., et al.: Xenobiotica, 37, 1000 (2007),<br></p>

<p>Applications Labelled sym-Homospermidine (H625000). sym-Homospermidine is an analogue of Spermidine. sym-Homospermidine is used as antineoplastic.<br>References Pegg, A., et al.: Cancer Res., 48, 759 (1988), Bergeron, R., et al.: J. Med. Chem., 37, 3464 (1994), Bergeron, R., et al.: Drug Metab. Dispos., 23, 1117 (1995),<br></p>

<p>Stability Hygroscopic<br>Applications Indole-3-carboxaldehyde- 13C8 is the labelled Indole-3-carboxaldehyde (I615020) which is a tryptophan (T947200) metabolite from Streptomyces staurosporeus and it is chemical constituent from Inula wissmanniana. Indole-3-carboxaldehyde and other tryptophan metabolites play an important role in mammalian gut immune homeostasis.<br>References Yang, S., et al.: J. Nat. Prod., 60, 44 (1997); Cheng, X. et al.: Chem. Nat. Compd., 49, 815 (2013); Zelante, T., et al,: Immunity, 39, 372 (2013)<br></p>

<p>Applications L-Glutamic-2,4,4-d3 Acid (CAS# 203805-84-9) can be used for rapid and sensitive quantitation of amino acids in malaria biological samples using LC-EI/MS. It can also be used to determine thyroxine levels in blood samples using mass spectrometry.<br>References Armenta, J.et.al., Anal.Chem., 82,548-5548,(2010); Chace, D., et.al., U.S. Pat. Appl Publ., 10,(2008);<br></p>