Aminoacids and derivatives

<p>Stability Hygroscopic<br>Applications (S)-3-Aminopiperidin-2-one, is an building block , used in the synthesis of various pharmaceutical compounds. It is an intermediate in the synthesis of calpinactam derivatives, possessing antimycobacterial activity.<br>References Kenichiro, N., et al.: Bioorg. Med. Chem. Lett., 22, 7739 (2012);<br></p>

<p>Applications Minor Cisapride (C496400) metabolite.<br>References Meuldermans, W., et al.; Drug Metab. Disposition, 16, 410 (1988), Lowry J., et al.; Clin. pharmacol. ther., 73, 209 (2003), Shao L., et al.: Bioorg. Med. Chem. Lett., 19, 5679 (2009),<br></p>

<p>Applications Labelled analogue of Glycine, a non-essential amino acid for human development. Glycine is an inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.<br>References Scott, D. et al.: J. Neurosci., 21, 3063 (2001); Laube, B. et al.: Neuropharmacology, 47, 994 (2004); Papadakis, M. et al.: J. Biol. Chem., 279, 14703 (2004); Chen, P. et al.: Mol. Pharmacol., 67, 1470 (2005); Wolosker, H. et al.: Mol. Neurobiol., 36, 152 (2007);<br></p>

<p>Applications sn-Glycero-3-phosphocholine (Choline Alfoscerate) is a phospholipid; precursor in choline biosynthesis. sn-Glycero-3-phosphocholine is an intermediate in catabolic pathway of phosphatidylcholine. sn-Glycero-3-phosphocholine is used as an Nootropic.<br>References Schmidt, G., et al.: J. Biol. Chem., 161, 523 (1945), Frattola, L., et al.: Curr. Ther. Res., 49, 683 (1991), Olson, D., et al.: Science, 270, 1967 (1995),<br></p>

<p>Applications N-Hydroxyphthalimide is used in the synthesis of a new class of antibacterials potent against macrolide resistant bacteria. Also used in the synthesis of pyrazolidines, isoxazolidines and tetrahydrooxazines.<br>References Agouridas, C. et al.: J. Med. Chem., 41, 4080 (1998); La Londe, R. et al.: Angew. Chem. Int. Ed., 49, 598 (2010);<br></p>

<p>Applications Indole-3-pyruvic Acid is a compound involved in the biosynthesis of Indole-3-acetic acid, a plant hormone which plays important roles in regulating growth and responses to environmental changes.<br>References Kong, W., et al.: Plant Cell Physiol, 56, 715-726 (2015)<br></p>

<p>Applications N-Methyl Lacosamide is the methly analogue of Lacosamide (L098500), a medication used for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain. Lacosamide is a potent anticonvulsant.<br>References Lees, G., et al.: Brain Res., 612, 190 (1993), Kuo, C., et al.: Mol. Pharmacol., 51, 1077 (1997); Barton, M., et al.: Epilepsy Res., 47, 217 (2001); Beyreuther, B., et al.: Eur. J. Pharmacol., 539, 64 (2006); Beyreuther, B., et al.: CNS Drug Rev., 13, 21 (2007)<br></p>

<p>Applications δ-Guanido-α-ketovaleric Acid is a useful flavouring ingredient and a component of Cheddar cheese flavour.<br>References Van den Ouweland, G., et. al: PCT Int. Appl. WO 9610927 A1, 19960418 (1996); Ney, K., et, al.: Eur. Food Res. Technol., 146, 337 (1971)<br></p>

<p>Applications L-Homocysteine Thiolactone Hydrochloride is used to prepare substituted homocysteine analogs as inhibitors of peptidylglycine α-amidating monooxygenase. It is also used to synthesize (mercaptoacyl)alanylprolines as metalloprotease inhibitors.<br>References Erion, M., et al.: J. Med. Chem., 37, 4430 (1994); Slusarchyk, W., et al.: Bioorg. Med. Chem. Lett., 5, 753 (1995)<br></p>

<p>Applications Cadaverine is a polyamine produced by the decarboxylation of L-lysine, and is also produced by Escherichia coli (E.coli) cells when grown in acidic pH. Cadaverine is known to inhibit porin-mediated outer membrane permeability in E.coli.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mimitsuka, T., et al.: Biosci., Biotech., Bioch., 71, 2130 (2007); Sanartzidou, H., et al.: J. Bacteriol., 185, 13 (2003)<br></p>

<p>3,3'-(3,6-Dihydropyrazine-2,5-diyl)dipropanoic acid (DPPA) is a potent metal chelator that can be used in the treatment of cancer. DPPA binds to metal ions and prevents their access to vital cellular components such as DNA and proteins. This agent has been shown to inhibit the growth of carcinoma cells in culture. It also has an effect on the synthesis of demyelination, which may account for its ability to prevent reactive oxygen species from damaging DNA. DPPA is a strong inhibitor of mitochondrial function and at high concentrations it damages mitochondria by releasing hydrogen peroxide into the cell cytoplasm. The release of hydrogen peroxide causes catalase to become active, leading to cell death.</p>