Carbohydrates and glycoconjugates

<p>The Lipid A moiety of lipopolysaccharide forms the outer monolayer of the outer membrane in most Gram-negative bacteria. Escherichia coli lipid A is synthesized on the cytoplasmic side of the inner membrane by a conserved pathway of nine constitutive enzymes. Following attachment of the core oligosaccharide, nascent core-lipid A is flipped to the outer surface of the inner membrane by the ABC transporter MsbA, where the O-antigen polymer is attached. These complex glycoforms protect bacteria from antibiotics and complement-mediated lysis. The core and O-antigen domains are required for virulence and consequently are present in most clinical and environmental isolates (Raetz, 2007).</p>

<p>NGA4F N-Glycan is a modification of the N-glycan structure. It is an oligosaccharide composed of a single monosaccharide, methylated and glycosylated to form a polysaccharide with sugar groups on every other carbon. This product can be custom synthesized by our chemists at your request.</p>

<p>Man-3-F N-Glycan is a custom synthesis of an oligosaccharide. It is a polysaccharide that is modified with methylation, glycosylation and click modification. Man-3-F N-Glycan is a high purity product that has been fluorinated for use in synthetic biology.</p>

<p>N,N'-Diacetyl-3,6,3',4',6'-penta-O-acetyl-1-chlorochitobioside is a galactosyltransferase inhibitor. It prevents the enzymatic transfer of a sugar group from UDP-galactose to an acceptor molecule by binding to the enzyme. N,N'-Diacetyl-3,6,3',4',6'-penta-O-acetyl-1-chlorochitobioside inhibits the enzymatic galactosylation of glycoproteins in cells and has been shown to be effective against bacterial strains resistant to other antibiotics. This drug is also chemoenzymatically synthesized using enzymes and chemical reagents.</p>

<p>Rhodionin is a natural product that has been shown to be effective as a food preservative. It is produced through the extraction of usnic acid from Rhodiola rosea and has been used in the study of amyloid protein. Rhodionin is an extractant that has been shown to be able to control analysis of sodium citrate in food composition. The use of rhodionin for this purpose was found to be practical and effective, with no significant changes in the quality or quantity of citric acid. This extractant also shows promise as an analytical method for the detection of ganoderma lucidum, human liver cancer cells, and flavonol glycosides.</p>

<p>Epi-N-Acetyl-lactosamine is a glycosylation agent that is used to modify proteins, carbohydrates, and other biomolecules. It is also used in the synthesis of oligosaccharides and polysaccharides. This product has been custom synthesized to meet your specifications and has been purified to high purity.</p>

<p>Maltotriose hydrate is a synthetic glycosylation product that is synthesized by the fluorination of maltotriose. Maltotriose hydrate is a sugar with a 3-D structure that is similar to maltodextrin, but with one less glucose residue. Maltotriose hydrate can be used in the synthesis of oligosaccharides and polysaccharides and has been shown to have high purity. Maltotriose hydrate can be modified by a variety of reactions, such as methylation, monosaccharide modification, or click chemistry. It has an CAS number and can be custom synthesized for clients' needs.</p>

<p>2-Acetamido-4-O-(2-acetamido-2-deoxy-a-D-glucopyranosyl)-2-deoxy-D-galactopyranose is a Custom synthesis of an oligosaccharide that is synthesized by the modification of natural sugars. This product has been fluorinated, methylated and modified with click chemistry. It is saccharide consisting of two monosaccharides, which are 2 acetamido 4 O-(2 acetamido 2 deoxy a D glucopyranosyl)-2 deoxy D galactopyranose and 2 deoxy D galactose. The molecular weight of this compound is 528.5 g/mol.</p>

<p>Man5GlcNAc is a glycoprotein that is expressed in the Golgi apparatus of mammalian cells. It is cleaved by alpha-mannosidase II and alpha-mannosidase I, which are enzymes located in the golgi apparatus. Man5GlcNAc has been shown to be an effective glp-1 analogue, which is a hormone that stimulates insulin secretion. This protein has also been shown to have structural similarities to high mannose type oligosaccharides, which are found on the surface of some bacteria. The protein may also act as a signal peptide for proteins that are exported from the golgi to the cell membrane.</p>

<p>Blood Group B type II tetrasaccharide is a carbohydrate that is synthesized by custom synthesis. It is a complex carbohydrate with a molecular weight of 909890-21-7. It has the chemical formula C6H14O6 and CAS No. 909890-21-7. Blood group B type II tetrasaccharide can be modified, methylated, glycosylated, and fluorinated. It is an oligosaccharide with a monosaccharide repeating unit that can be found in the blood group B type II antigen on erythrocytes. This saccharide has six sugar units (three glucose and three galactose) connected in a chain by alpha 1-3 glycosidic linkages. The sugar units are attached to each other by beta 1-4 glycosidic linkages.</p>

<p>Hyaluronic acid is a polysaccharide containing repeating disaccharide units of β-1,3-N-acetyl glucosamine and β-1, 4-glucuronic acid. A series of unsaturated oligosaccharides (oligouronic acids) are released from hyaluronic acid by the action of hyaluronidase on the umbilical cord (Weissman, 1954). This decasaccharide and other enzymatically produced polymer homologs have been of value in the study of hyaluronic acid metabolism in both healthy and diseased tissues (Hascall, 2019).</p>

<p>3'-Sulpho Lewisa-BSA is a custom synthesis of 3'-sulpho Lewis a-bovine serum albumin. It is an oligosaccharide that has been modified by saccharide methylation and glycosylation. 3'-Sulpho Lewisa-BSA has been modified with the click chemistry reaction and fluorinated with 18F. This complex carbohydrate is high purity, and is used for research purposes.</p>

<p>1-D-a-Galactopyranosyl-4-O-[1-(2-octadecylthioethyl)-(b-D-galactopyranoside)] is a complex carbohydrate that contains a fluorinated sugar. It is synthesized from a monosaccharide and an oligosaccharide and glycosylated with a polysaccharide. The compound has been modified to include methylation and click modification. 1-D-a-Galactopyranosyl-4-O-[1-(2-octadecylthioethyl)-(b-D-galactopyranoside)] can be purchased in high purity from the CAS registry number of 538570–75–6.</p>

<p>Tetra-O-acetyl-3-O-(2,3,4,6-tetra-O-acetyl-b-D-glucopyranosyl)-D-glucopyranose is a covalently bound glycoside of benzoic acid and glucose. It can be obtained by the chemical catalysis of clostridium in an acetate medium. The reaction produces a tetrasaccharide with three acetate groups at C2, C3 and C6. This compound has shown to have antimicrobial activity against Clostridium licheniformis and Clostridium butyricum.</p>

<p>Complex glucan (a 1-6) from Leuconostoc spp.; extender in blood transfusions.</p>

<p>GalNAca1-3Galb1-4GlcNAc</p>

<p>Sulpho Lewisa Na is a complex carbohydrate that has been modified with fluorination and methylation. This product is custom synthesized, high purity, and has a CAS number. It is available for synthesis in various lengths of saccharides with a variety of modifications. Sulpho Lewisa Na can be used in the following applications: glycosylations, click modification, and methylation.</p>

<p>Tri-fucosyl-Lewis Y-heptasaccharide-APE, HSA is a complex carbohydrate that has been custom synthesized and glycosylated. It was modified with methylation and fluorination to create a high purity product. This complex carbohydrate has a CAS number of 107386-00-6 and is composed of sugar molecules. It is a polysaccharide with the following structure:</p>

<p>1,5-α-L-Arabinopentaose is a sugar that is found in plants. It inhibits the growth of bacteria by sequencing and binding to the enzyme L-arabinose isomerase, which converts L-arabinose to D-xylulose. 1,5-α-L-Arabinopentaose has been shown to have inhibitory effects on the metabolism of sugars in plants. This sugar binds tightly to immobilized enzymes and can be used for immobilization processes.</p>

<p>4-Methoxyphenyl 6-O-(methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-a-D-galacto-2-nonulopyranosylonate)-2,3 -di O benzyl b D galactopyranoside is a modified oligosaccharide that is synthesized from the sugar galactose. The methyl group on the 4 position of the phenol end of the molecule is substituted with an acetamide group to form 4 methoxyphenyl 6 O (methyl 5 acetamido 4 7 8 9 tetra O acetyl 3 5 dideoxy D glycero a D galacto 2 nonulopyranosylonate)-2 3 di O benzyl b D galactopyranoside. This molecule has been fluorinated at the 2 and 3 positions</p>