Carbohydrates and glycoconjugates

<p>This is a custom synthesis of a polysaccharide.</p>

<p>GM3-ganglioside NBD (ammonium salt) has a core disaccharide structure (Galβ1,4Glc) with sialic acid linked α2,3 to the galactose residue with nitrobenzoxadiazole (NBD) linked β to position 1 on the reducing terminal glucose residue, in place of the ceramide fatty acid (Ledeen, 2009). Ganglioside GM3 is strongly associated with human tumors, such as, lung, brain, and melanomas, where it is frequently found to be overexpressed. GM3 ganglioside is seen as a possible tumor-associated carbohydrate antigen for cancer immunotherapy (Changping, 2019). GM3 ganglioside is implicated in various other diseases involving chronic inflammation, such as: insulin resistance, leptin resistance, T-cell function, and immune disorders (e.g. allergic asthma). It has also been shown to play an essential role in murine and human auditory systems, and is a common pathological feature of GM3S deficiency is deafness (Inokuchi, 2018).</p>

<p>4-Aminophenyl b-D-thiocellobiose is a modified sugar that has been synthesized and fluorinated. 4-Aminophenyl b-D-thiocellobiose is used in the synthesis of glycosylated bioactive molecules, including oligosaccharides and monosaccharides. The modification of this sugar is done by glycosylation, methylation, and conjugation. It can be used in the synthesis of complex carbohydrates as well as saccharides. This product's CAS No. is 68636-49-7.</p>

<p>Lacto-N-difucohexaose I-APD-HSA is a custom synthesis of an oligosaccharide with a molecular weight of 5,000 Da. It is modified with fluorine and methyl groups at the C6 and C1 positions. Lacto-N-difucohexaose I-APD-HSA is synthesized by click chemistry and has been shown to be effective in inhibiting the growth of cancer cells. This sugar can be modified by glycosylation or carbohydrate modification.</p>

<p>Hyaluronate rhodamine is a modified, fluorinated, methylated, and monosaccharide-containing polysaccharide. It is synthesized by the addition of a click modification to an oligosaccharide. The saccharide is used in glycosylation reactions to produce complex carbohydrates. Hyaluronate rhodamine has a molecular weight of 2500kDa.</p>

<p>Blood group B trisacchharide-APE-HSA is a synthetic carbohydrate that inhibits the synthesis of complex carbohydrates. The methylation of saccharides and polysaccharides can be accomplished by the addition of an amine to the 3′ hydroxyl group. In this reaction, the sugar is attached to a protein carrier (e.g., human serum albumin) via an amide bond, which prevents its degradation by proteases in the body. The modification of saccharides and polysaccharides is also accomplished through click chemistry, which is based on copper catalysis. This process involves attaching two functional groups through a copper-mediated reaction, forming a new carbon-carbon bond. Modification of saccharides and oligosaccharides can be accomplished using either chemical or enzymatic methods. Sugar modification can be achieved using high purity enzymes that have been custom synthesized for specific purposes (e.g., glycosylation). Carbohydrate modification can</p>

<p>Ganglioside GM3 (ammonium salt) has a core disaccharide structure (Galβ1,4Glc) with sialic acid linked a2,3 to the galactose residue and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). Ganglioside GM3 is strongly associated with human tumors, such as, lung, brain and melanomas where it is over expressed. It is seen as a possible tumor-associated carbohydrate antigen for cancer immunotherapy (Changping, 2019). GM3 ganlioside is implicated in various other diseases involving chronic inflammation, such as, insulin resistance, leptin resistance, T-cell function and immune disorders (e.g. allergic asthma). GM3 ganglioside has also been shown to play an essential role in murine and human auditory systems, and a common pathological feature of GM3S deficiency is deafness (Inokuchi, 2018).</p>

<p>A disaccharide</p>

<p>3-O-(2-Acetamido-2-deoxy-D-glucopyranosyl)-1,2-di-O-benzyl-4,6-O-benzylidene-D-mannopyranoside is a synthetic sugar that is used in the synthesis of glycosylations. It has been fluorinated and methylated to increase its stability and reactivity. It is also synthetically derived from a saccharide and modified for use in Click chemistry. 3-O-(2-Acetamido-2-deoxy--D--glucopyranosyl)-1,2--di--O--benzyl--4,6--O--benzylidene--D--mannopyranoside is soluble in water and ethanol. This product has CAS No. 5118876–78–3 and can be custom synthesized by us.</p>

<p>4-O-(2-O-Methyl-b-D-galactopyranosyl)-D-glucopyranose is a disaccharide. The lacto-n-biose unit is a nonreducing sugar that contains an alpha, beta unsaturated 1,6 glycosidic bond and a lactose molecule. 4-O-(2-O-Methyl-b-D-galactopyranosyl)-D-glucopyranose has been found to stimulate the synthesis of galectin in vitro, which may be due to its ability to bind to lectins. This disaccharide can also cause denaturation at high temperatures.</p>

<p>Man-3Xyl N-Glycan is a high purity, custom synthesized, synthetic and fluorinated monosaccharide. It is an Oligosaccharide that contains 3 mannose sugar residues. Man-3Xyl N-Glycan is used for Glycosylation in the synthesis of complex carbohydrate polymers, such as glycoproteins and glycolipids. Click modification can be used to introduce methyl groups onto the sugar residues of Man-3Xyl N-Glycan. This monosaccharide has been shown to have high stability and resistance to oxidation.</p>

<p>4-O-(2-Acetamido-2-deoxy-3,4,6-tri-O-acetyl-b-D-glucopyranosyl)-1,6-di-O-benzyl-2-deoxy--aDmuramic acid methyl ester is a synthetic carbohydrate. It is a modification of an oligosaccharide and can be used as a starting material in the synthesis of complex carbohydrates. 4ODBGMEM is synthesized by acetylation of 1,6 di O benzyl 2 deoxy a D muramic acid methyl ester with acetic anhydride and triethylamine. The compound has been shown to be effective in fluoroquinolone resistance and methicillin resistance.</p>

<p>3,4-Di-O-benzyl-2,6-di-O-(3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-b-D-glucopyranosyl)-a-D -mannopyranosyl trichloroacetimidate is a fluorinated monosaccharide that is synthesized by the glycosylation of 2,6 di O-(3,4,6 tri O acetyl 2 deoxy 2 phthalimido b D glucopyranosyl) a D mannopyranosyl chloride with 3,4 di O benzyl 2 chloroacetimidate. The complex carbohydrate has been modified with methylation and click chemistry. It has been shown to be active against Mycobacterium tuberculosis and Mycobacterium avium complex.</p>

<p>1,5-α-L-Arabinopentaose is a sugar that is found in plants. It inhibits the growth of bacteria by sequencing and binding to the enzyme L-arabinose isomerase, which converts L-arabinose to D-xylulose. 1,5-α-L-Arabinopentaose has been shown to have inhibitory effects on the metabolism of sugars in plants. This sugar binds tightly to immobilized enzymes and can be used for immobilization processes.</p>

<p>2,3,6,2',3',4',6'-Hepta-O-acetyl-b-D-maltosyl isothiocyanate is a custom synthesis of a complex carbohydrate. It has been modified by fluorination and click chemistry. The product is available in high purity with CAS No. 81319-58-6. This product is synthesized from a monosaccharide and polysaccharide. The product is produced by methylation of the complex carbohydrate followed by modification with fluoro groups to create the desired product.</p>

<p>Lewisa-BSA is a modified form of BSA that contains 6-O sulfated sugars. This carbohydrate is used in the treatment of diabetes and other metabolic disorders. Lewisa-BSA is synthesized by the modification of BSA with a series of oligosaccharide residues. The carbohydrate chains are then methylated, glycosylated, and finally sulfated. This process provides Lewisa-BSA with high purity and high stability.</p>

<p>3'-Sialyllactose-APD-HSA is a complex carbohydrate with Oligosaccharide and Polysaccharide. It is a modification of saccharides, which are composed of monosaccharides or simple sugars. 3'-Sialyllactose-APD-HSA is a synthetic compound that has been modified by the addition of fluorine atoms to the sugar molecule. This modification prevents the sugar from being broken down by enzymes in the body and ensures that it remains intact until it reaches its target site. 3'-Sialyllactose-APD-HSA is used as a drug delivery system for cancer drugs, such as doxorubicin and paclitaxel.</p>

<p>NGA4B N-Glycan is a custom synthetic compound that can be modified to include methylation, fluorination, and other modifications. It is an oligosaccharide that is a polysaccharide composed of saccharides. The saccharides are monosaccharides or simple sugars. NGA4B N-Glycan is available at high purity for use in research and as a reagent.</p>

<p>This is a custom synthesis of a complex carbohydrate. The CAS number, polysaccharide, modification, saccharide and methylation are all listed. This is a high purity product that has been fluorinated and synthesized with a click modification. It is glycosylated and modified with methyl groups. This product is made from sugar, which is also listed.</p>

<p>3-Fucosyllactose is a high purity synthetic sugar that is custom synthesized to order. It has a click modification, fluorination and glycosylation. 3-Fucosyllactose is a monosaccharide with CAS No. 160159-69-2. 3-Fucosyllactose has the ability to be modified for glycoengineering and glycobiology studies. It can be used in the synthesis of complex carbohydrates, such as oligosaccharides and monosaccharides.</p>