Carbohydrates and glycoconjugates

<p>Useful for raising antibodies to Blood Group B</p>

<p>Lacto-N-tetraose-BSA is a carbohydrate that contains four monosaccharides. It has been shown to be an autoantibody in patients with myasthenia gravis and can cause muscle weakness by binding to the muscle protein, actin. Lacto-N-tetraose-BSA has also been found to bind with nerve tissue and may be involved in the development of sclerosis. This carbohydrate is also negatively charged and agglutinates red blood cells. When used for immunofluorescence, it shows a strong reaction against glycoconjugates on the surface of neurons and nerve tissue. Lacto-N-tetraose-BSA binds specifically to bovine serum albumin (BSA) containing antibodies, which are produced by immune cells called B cells. The binding sites are located on the outer part of the molecule, near the sugar residues.</p>

<p>Cellobiuronic acid is a polysaccharide that contains glucose and uronic acids. It is found in the cell walls of gram-positive bacteria, where it may play an important role in maintaining the structural integrity of the cell wall. Cellobiuronic acid has been shown to be a potent antigen for pneumococcus. Cellobiuronic acid has also been shown to be conjugated with proteins and used as a vaccine adjuvant for inducing antibody responses against pneumococcal antigens. Cellobiuronic acid is synthesized from glucose by bacterial cells, which use it as a carbon source. The biosynthesis of cellobiuronic acid is poorly understood because it does not occur in mammalian cells.</p>

<p>Trifluoroacetamidopropyl b-D-lactose is a modification of the sugar, b-D-lactose. It is synthesized by methylation and glycosylation. Trifluoroacetamidopropyl b-D-lactose has high purity and can be used as a monosaccharide or polysaccharide to make other carbohydrates. Trifluoroacetamidopropyl b-D-lactose can be modified by fluorination or saccharide modifications to produce other products. The CAS number for trifluoroacetamidopropyl b-D-lactose is 87890-36-6.</p>

<p>GM1-biotin ganglioside (sodium salt) has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with sialic acid linked α2,3 to the inner galactose residue, ceramide linked β to position 1 on the reducing terminal glucose residue, and biotin to position 5 on sialic acid (Ledeen, 2009). GM1 ganglioside is abundant in all mammalian brains where it covers 10%-20% of the total ganglioside mixture. It is found in epithelial membranes and is a key element for bacterial toxicity and viral infection as it is the intestinal receptor for the cholera toxin, the B-subunits of heat-labile toxin, rotavirus, and simian virus 40. GM1 ganglioside functions as a neurotrophic and neuroprotective compound, and has been used therapeutically for diabetic and peripheral neuropathies. GM1 ganglioside also has the ability to bind amyloid-β proteins and is involved in Alzheimer’s pathogenesis (Chiricozzi, 2020).</p>

<p>Hyaluronate biotin (HB) is a modified form of hyaluronic acid. It is produced by the methylation and glycosylation of hyaluronic acid and it has an average molecular weight of 1000 kDa. HB is used in tissue engineering, cell culture, and as a contrast agent for magnetic resonance imaging. The modification of hyaluronate with biotin allows for the visualization of HB using immunofluorescence microscopy. Hyaluronate biotin is a synthetic product that can be custom-synthesized to customer specifications, such as purity level, oligosaccharide content, and monosaccharide content.</p>

<p>T-antigen-HSA is a synthetic, high-purity, custom synthesis glycoprotein with click modification. It is a complex carbohydrate that contains an oligosaccharide and a saccharide, which are attached to the protein backbone through an amide linkage. T-antigen-HSA is synthesized using recombinant DNA technology and can be modified by fluorination, methylation, or other modifications. This product has CAS No.</p>

<p>3-O-Acetyl-1,6-anhydro-2-azido-2',3'-di-O-benzyl-4',6'-O-benzylidene-2-deoxy-b,D cellobiose is a fluorinated oligosaccharide that can be customized for a variety of applications. The sugar unit contains an acetyl group on the C1 position and an azido group at the C2 position. This compound has been subjected to click chemistry in order to form a covalent bond with 4,6'-O-benzylidene 2,3'-dideoxy b,D cellobiose.</p>

<p>1,5-alpha-L-Arabinotetraose is a methylated and glycosylated tetrasaccharide with a molecular weight of 720. It is a custom synthesis product with high purity and it can be used for the modification of proteins, polysaccharides, or other compounds. 1,5-alpha-L-Arabinotetraose has been shown to have fluoroquinolone resistance due to its methylation and glycosylation. The compound is an oligosaccharide that is synthesized from arabinose. It can be modified by click chemistry to introduce fluorine atoms at desired positions.</p>

<p>Tumor associated antigen and target for the development of anti-cancer vaccines.</p>

<p>1-D-a-Galactopyranosyl-4-O-[1-(2-octadecylthioethyl)-(b-D-galactopyranoside)] is a complex carbohydrate that contains a fluorinated sugar. It is synthesized from a monosaccharide and an oligosaccharide and glycosylated with a polysaccharide. The compound has been modified to include methylation and click modification. 1-D-a-Galactopyranosyl-4-O-[1-(2-octadecylthioethyl)-(b-D-galactopyranoside)] can be purchased in high purity from the CAS registry number of 538570–75–6.</p>

<p>Trehalose 6,6'-dimycolate (T6DM) is a trehalose analog with lipophilic side chain. T6DM causes apoptosis by blocking the toll-like receptor 4 (TLR4) and TLR2 pathways. T6DM has also been shown to reduce the inflammatory response caused by lipopolysaccharides (LPS), which are bacterial cell wall components. T6DM is a promising agent for the treatment of infectious diseases such as tuberculosis and other bacterial infections that cause inflammation.Isolated from microbial source: mycobacterium bovis</p>

<p>1,5-a-L-Arabinoheptaose is a sugar that is found in the cell walls of bacteria. The chemical modification of this sugar has been studied extensively. The modification of this sugar with methyl groups and click chemistry has been shown to alter its properties, such as binding affinity and solubility. This modified sugar can be used for glycosylation reactions or custom synthesis. 1,5-a-L-Arabinoheptaose is also available in high purity and with a custom synthesis.</p>

<p>Benzyl 2-acetamido-4,6-O-benzylidene-2-deoxy-3-O-(b-D-galactopyranosyl)-a-D-galactopyranoside is a methylated and fluorinated monosaccharide. It is used in the synthesis of complex carbohydrates and oligosaccharides. The modification of this compound can be done with click chemistry, which is a process that allows for the rapid assembly of molecules on surfaces. This product has been shown to have high purity, making it suitable for use in research or production.</p>

<p>Hyaluronate fluorescein is a synthetic, high purity complex carbohydrate with a molecular weight of 1500kDa. It is a modification of the naturally occurring polysaccharide hyaluronan. It is composed of repeating units of the monosaccharide D-glucuronic acid and the disaccharide N-acetyl-D-glucosamine. Hyaluronate fluorescein is synthesized by methylation and glycosylation of D-glucuronic acid, followed by fluorination to produce the fluorinated saccharide hexafluoro-D-glucuronic acid, which reacts with N-acetyl-D-glucosamine in an amidation reaction. The product can then be modified to produce hyaluronate fluorescein.</p>

<p>2-AB labelled A1F Glycan is a complex carbohydrate. It is custom synthesized and high purity. The CAS number for this compound is 12863-00-8.</p>

<p>Benzyl 3-O-(2,3,4,6-tetra-O-benzyl-a-D-galactopyranosyl)-4,6-O-benzylidene-D-galactopyranose is an oligosaccharide with a complex carbohydrate structure. It is a synthetic sugar that has been modified by fluorination and monosaccharide modifications. The product has a CAS No. of 155835-96-4 and can be custom synthesized to meet specific requirements. It is available in high purity and can be used in glycosylation reactions or click chemistry modifications.</p>

<p>NGA4 N-glycan is a monosaccharide that is methylated and glycosylated to form an oligosaccharide. It has a molecular weight of 1205 g/mol. This product can be used in the production of glycoconjugates, which are used in the treatment of cancer and inflammatory diseases.</p>

<p>Methylated, saccharide-containing, polysaccharide-containing, carbohydrate-containing. CAS No.: 169800-74-1. Click modification: Click chemistry reaction with a reactive group on the saccharide or polysaccharide to form a bond with another molecule. Modification: The addition of one or more side chains to a saccharide or polysaccharide to produce a modified carbohydrate. Oligosaccharides: Carbohydrates that are composed of only two to ten monosaccharides. Glycosylation: The process in which a glycosyl group is transferred from an activated donor sugar to an acceptor molecule, forming glycosidic linkage (e.g., between sugars). High purity: The degree of chemical purity as expressed by the percent of impurities that may be present in the product (e.g., 99% pure). Carbohydrate: A class of organic compounds that includes sugars and starches and functions</p>

<p>3-O-(2-Acetamido-3,4,6-tri-O-acetyl-2-deoxy-D-glucopyranosyl)-1,2-di-O-benzyl-4,6-O-benzylidene--D--mannopyranoside is an oligosaccharide that has a high purity and custom synthesis. This compound is synthesized by Click modification of the sugar with fluorination. The glycosylation and methylation reactions are then carried out to obtain the final product. 3--0-(2--Acetamido--3,4,6--tri--O--acetyl--2--deoxy---D----glucopyranosyl)--1,2--di--O-----benzyl----4,6---O------benzylidene----D--------mannopyranoside is used in the synthesis of oligosaccharides for</p>