Carbohydrates and glycoconjugates

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Core antigen fragment in ABO blood group system

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3'-b-Sialyl-N-acetyllactosamine is an oligosaccharide that is synthesized from L-arabinose and 3'-phosphoadenosine 5'-phosphosulfate. It has a high degree of purity and is custom synthesized to order. The CAS number for this product is 210418-18-1.

8-methoxycarbonyl ester of Gal-a1-3(Fuc-a1-2)Gal

D-Melibiose anhydrous is a disaccharide that is used as an excipient in the pharmaceutical industry. It has been shown to be an active enzyme, which may be due to its ability to sequester galactose. D-Melibiose anhydrous has a redox potential of -0.2 V, indicating that it has a high number of oxidizable groups. The molecular weight of this sugar is 324.14 g/mol, and it has a polarizability of 0.16 D, which classifies it as a polyol with hydrogen bonding properties. This sugar is not soluble in water but can be dissolved in ethanol or propylene glycol. D-Melibiose anhydrous also has carbohydrate properties and may be considered a sugar alcohol because it contains six carbon atoms and one oxygen atom.

Tetragalacturonic acid (α-1,4 galacturonotetraose) is derived from pectin or pectic acid by enzymatic or partial acid hydrolysis (Combo, 2012). It is used in galacturonic acid metabolism research as a substrate to identify, differentiate, and characterize endo- and exopolygalacturonase(s), and gluconase(s) (Jayani, 2005). The addition of very short fragments of homogalacturonan, tri-galacturonate, and tetra-galacturonate oligosaccharides restores development in dark-grown, de-etiolated seedling mutants, suggesting that they are unable to generate de-methylesterified pectin fragments. A model of spatiotemporally separated photoreceptive and signal-responsive cell types has been proposed, that contains overlapping subsets of the regulatory network of light-dependent seedling development (Sinclair, 2017).

2-Acetamido-3-O-(2-acetamido-2-deoxy-b-D-glucopyranosyl)-2-deoxy-D-galactopyranose is a methylated, saccharide, Polysaccharide. It is a custom synthesis of a carbohydrate sugar. It is fluorinated to increase its bioavailability. 2 Acetamido 3 O 2 acetamido 2 deoxy b D glucopyranosyl 2 deoxy D galactopyranose has CAS No. 95673 98 6 and the molecular weight is 524.87 g/mol. It has a purity of >99% and comes in powder form.

The objective of this project is to design a microcontroller-based system that can monitor and diagnose the level of damage in a composite material. The system will consist of an array of sensors, actuators, and microcontrollers that are connected by a wireless network. The sensors will measure the levels of damage at each point within the composite material. The actuators will provide feedback to the sensors, adjusting their frequency and amplitude based on the level of damage detected. Microcontrollers will be responsible for analyzing data from the sensors and diagnosing any faults in the system. A miniaturized dry skin patch could be used as an alternative to traditional wet skin tests for monitoring skin health.

Neutral difucosylated hexasasaccharide naturally present in human breast milk

DFP00173: Potent, selective AQP3 inhibitor; IC50 ~0.1-0.4 μM; less effective on AQP7, AQP9.

Trehalose 6-octanoate is a modified form of trehalose that has been synthesized and fluorinated. It is a monosaccharide, which means it is one of the simplest forms of sugar. Trehalose 6-octanoate is an oligosaccharide, which means it is a sugar molecule made up of several smaller sugar molecules. This sugar can be modified to include methyl groups, making it a polysaccharide. Polysaccharides are complex carbohydrates that can often be found in plants or animals. Trehalose 6-octanoate is used in the modification of proteins and lipids for the production of pharmaceuticals and other products.

Chondroitin sulphate is an inhibitor that has been extensively studied in human and animal models. This active agent has been shown to have a protein inhibitory effect on epithelial cells, as well as an inhibitory effect on cell growth in Chinese medicine and Chinese medicinal plants. Chondroitin sulphate has been found to exhibit inhibitory activity against endothelial cells, which may be due to its ability to inhibit the nuclear translocation of NF-κB. This compound can be detected by liquid chromatography and has been shown to have a significant inhibitory effect on the proliferation of HepG2 cells. Overall, chondroitin sulphate shows great potential for use in healthcare products aimed at regulating cell growth and inflammation.

Lipid IVA is a tetra-acylated precursor molecule of lipid A which is a component of lipopolysaccharides (LPS) on the outer membrane of gram-negative bacteria. On the innate immune cells of hosts there are toll-like receptor 4 (TLR4) and MD-2 which recognize LPS. This recognition event ultimately leads to the activation of NFκB which in turn results in pro-inflammatory cytokine production. Studies have suggested lipid A in Escherichia coli to be an agonist for both mouse and human TLR4, while lipid IVA can induce species specific TLR4 responses. For example for horse and mouse TLR4 and MD-2, Lipid IVA is an agonist where as it is an antagonist for TLR4 and MD-2 in humans.

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Chondroitin disaccharide di-6S (CDD6S) is a synthetic, fluorinated oligosaccharide that is used for glycosylation and modification of proteins, polysaccharides, and other biomolecules. It has been shown to be effective in inhibiting the growth of cancer cells by targeting the sugar moiety on cell surface receptors. CDD6S has been modified with methyl groups at various positions on the sugar chain to increase its activity against certain cancers.

Sodium alginate is the sodium salt of a polysaccharide obtained from brown seaweeds. The main use for alginate is in textile printing as a thickener in the printing of cottons with reactive dyes. In the food industry it is used as a thickener and gelling agent. The chemical structure consists of blocks of (1,4) linked-β-D-polymannuronic acid (poly M), (1,4) linked-α-L-polyguluronic acid (poly G) and alternating blocks of the two uronic acids (poly MG).

Heparin derived disaccharide sodium salt is a salt form of heparin. It is a heterogenous mixture of low molecular weight compounds that are composed of sugar residues and sulfation. Heparin derived disaccharide sodium salt has been used for the treatment of thrombocytopenic purpura, thrombotic thrombocytopenic purpura, and other bleeding disorders. This drug also has been used to prevent blood coagulation in patients undergoing surgery.

2-AB labeled core pentasaccharide found in most N-linked oligosaccharides.  Purified from the oligosaccharide pool released from bovine serum by hydrazinolysis using a combination of HPLC and glycosidase digestion.