Carbohydrates and glycoconjugates

<p>Hyaluronate is a naturally occurring glycosaminoglycan (GAG) found in the extracellular matrix of animal tissues. It is a linear polymer composed of alternating units of N-acetylglucosamine and glucuronic acid. The molecular weight of hyaluronate ranges from 10,000 Da to 1,000,000 Da. Hyaluronate has been modified by fluorination, methylation, and click modification reactions. These modifications affect the physical properties of hyaluronate, including its reactivity with other molecules. Click modification reactions are often used to link two different molecules together. This may include linking an oligosaccharide or saccharide to the hydroxyl groups on the glucuronic acid residues in hyaluronate.</p>

<p>3'-Sialyllacto-N-biose is a regiospecific, biochemically defined carbohydrate. It is a component of the glycan chains that are present on the surface of cell membranes. Lacto-n-biose has been shown to have inhibitory activity against the growth of Mycobacterium tuberculosis and Mycobacterium avium complex bacteria.</p>

<p>Sulpho Lewisx Na is a high purity, custom synthesized sugar that has been modified using a click chemistry reaction. It has been fluorinated and glycosylated to produce a complex carbohydrate. Sulpho Lewisx Na is a synthetic oligosaccharide produced with the intention of mimicking the structure of Lewisx in order to study its properties. The CAS number for this compound is 2641-19-2 and it can be found under the name Oligosaccharide, Monosaccharide, saccharide, Carbohydrate on Pubchem CID 1039264.</p>

<p>2,3,4-Tri-O-acetyl-6-O-(2,3,4,6-tetra-O-acetyl-b-D-glucopyranosyl)-D-glucopyranose is a synthetic sugar. It is a monosaccharide that is synthesized from 2,3,4,6 tetraacetyl b D glucopyranosyl b D glucose and triethylene glycol. This compound can be used in the synthesis of polysaccharides or complex carbohydrates.</p>

<p>Monofucosyl-para-lacto-N-hexaose I is an oligsaccharide that is found in human milk</p>

<p>2-Acetamido-3-O-(2,3,4,6-tetra-O-acetyl-b-D-galactopyranosyl)-4-O-acetyl-6-O-(2,3,4,6-tetra-O-benzoyl-b-D -galactopyranosyl)-2 deoxy a D galactopyranosyl Fmoc threonine tert butyl ester is a custom synthesis with high purity and custom synthesis. This product is recommended for methylation and glycosylation reactions. It is a complex carbohydrate that has been modified by fluorination and saccharide.</p>

<p>Fluorogenic substrate is used for detection of hyaluronidase activity. Urinary hyaluronidase activity is elevated in patients with intermediate and high grade bladder cancer; the expression of hyaluronidase and hyaluronan synthase-1 mRNA in malignant tissue can predict bladder cancer metastasis and disease recurrence (Kramer, 2011). These findings underscore the potential utility of the hyaluronidases to serve as biomarkers for bladder cancer. A novel fluorescent substrate labelled with two dyes: fluorescein as a green donor fluorophore, and rhodamine B as a red acceptor fluorophore, was therefore developed to measure hyaluronidase enzyme kinetics (Zhang, 2008). It was then demonstrated that simultaneous measurements of green and red emission of HA–FRET could be used to measure hyaluronidase presence and activity (Fudala, 2011).</p>

<p>Globo-H is a high purity, custom-synthesized hexasaccharide with a spacer arm and biotin at the non-reducing end. Globo-H is synthesized by reacting glycosylation reagents with an oligosaccharide on a solid support. The reaction generates an activated glycosylant, which is then reacted with the spacer arm and biotin to form the desired product. Globo-H has been modified for use in click chemistry reactions.</p>

<p>Computational fluid dynamics (CFD) is the study of fluid flow, a subject which has been studied for over two thousand years. The idea of CFD is to use computers to solve the equations that govern fluid flow and to make predictions about the behavior of gases, liquids and complex fluids in various situations. Computational analysis can be used to calculate how air flows around an object such as a car or plane. This allows engineers to create designs with less drag. Computational analysis can also be used in designing buildings, bridges, and other structures that are exposed to large amounts of wind. <br>CFD is a "convective" computational method because it solves problems by using convection-diffusion equations with appropriate boundary conditions. A "transport" computational method solves problems by solving momentum equations and energy conservation equations simultaneously; this method is often more accurate than convective methods but computationally more expensive. A "laminar" computational method solves problems by solving continuity equations. A "nature</p>

<p>NeuAc-a2,3-Gal-b-1,4-Glc-GlycineNH2 is a carbohydrate that belongs to the group of saccharides. It is an oligosaccharide that has been synthesized via a custom synthesis. This product is high purity and has been modified with methylation, glycosylation, and click modification.</p>

<p>Gala1-3Gal-HSA is a modified glycan with three terminal alpha-galactoside units. It is synthesized by the modification of Gala1-3Gal (saccharide) with HSA. This product is also fluorinated, methylated and click-modified. The chemical name for this product is 3-[(2S,3S)-2,3-bis[(carboxymethyl)amino]propyl]-alpha-D-galactopyranosyl-(1→4)-O-[(carboxymethyl)(hydroxyethyl)]-.</p>

<p>A custom synthesis of benzyl-6-O-(2,3,4,6-tetra-O-acetyl-a-D-mannopyranosyl)-2,3,4-tri-O-benzyl-a-D-mannopyranoside was made with the following modifications: fluorination and methylation. The molecular weight is 636.81 g/mol. It is a white crystalline solid. CAS No.:</p>

<p>Lacto-N-neotetraose-GEL is a glycosylation product that is used in the synthesis of complex carbohydrates. It is a methylated, fluorinated, and saccharide-modified oligosaccharide. This product can be custom synthesized in high purity with a CAS number and has a very low endotoxin level. Lacto-N-neotetraose-GEL has been shown to have many uses including as an adjuvant for vaccines and monoclonal antibody production. It has also been shown to suppress inflammation and increase the efficacy of cancer treatments.</p>

<p>3'-a-Sialyl-N-acetyllactosamine-PAA-biotin is a biotin labelled sialylglycoside</p>

<p>Pinoresinol diglucopyranoside is a natural compound found in Chinese herb. It has been shown to have an anti-atherosclerotic effect, which may be due to the inhibition of nuclear factor kappa-light-chain-enhancer (NF-κB) and matrix metalloproteinase (MMP)-9. Pinoresinol diglucopyranoside also inhibits collagenase activity in vitro and reduces inflammation in vivo. The molecular mechanism of this compound may involve the toll-like receptor 4 (TLR4) pathway, which is responsible for immune responses to bacterial products. Pinoresinol diglucopyranoside has been shown to inhibit the transcription and polymerization of DNA by binding to DNA gyrase and topoisomerase IV, respectively.</p>

<p>Benzyl 2-acetamido-3-O-(2,3,4-tri-O-benzyl-a-L-fucopyranosyl)-4,6-O-benzylidene-2-deoxy-a-D-glucopyranoside is a high purity custom synthesis sugar. This compound has been synthesized by Click modification of the amino acid glycoside and fluorination of the sugar. It is an Oligosaccharide with a saccharide chain composed of Monosaccharides and Carbohydrates. The CAS number for this compound is 196941 – 73 – 8.</p>

<p>Hyaluronate fluorescein is a synthetic glycosaminoglycan. It is modified with fluorine and can be used for labeling proteins, lipids, and nucleic acids. This product has a molecular weight of about 1000kDa.</p>

<p>Ex algal/bacterial polysaccharides-value in b1-3 glucanase assays &amp; diagnostics</p>

<p>4-Methoxyphenyl 4-O-{4-O-[2,4-di-O-(3,4,6-tri-O-Ac-2-PhthN -bDGlc)-3,6-di-O-(3,4,6,-tri-OAc)aDMan]-bDMan} 3,6 di O-(3,4,6,-tri Ac) a D Man] 2 PhthN b D Glc} 6 O (tri Ac) a L Fuc} 2 PhthN b D Glc} 3 O Bn 6 O (tri Ac) a L Fuc} 2 PhthN b D Glc} is an oligosaccharide. It is custom synthesized to include methylation and glycosylation modifications. This product is for use in research only and should not be used in humans.</p>

<p>Sialyl-Lea-APD-HSA is a methylated, saccharide polysaccharide that has been modified with Click chemistry. It is a complex carbohydrate that has been synthesized by glycosylation and fluorination. The CAS number for this product is 123456-78-9. This product can be custom synthesized to order in high purity and with high quality.</p>