Ketones and derivatives
Ketones are organic compounds that contain a carbonyl group (C=O) bonded to two carbon atoms, forming a structure where the carbonyl group is flanked by alkyl or aryl groups. In pharmacology, ketones are used in API formulation due to their ability to enhance the solubility and stability of active ingredients. Some ketones have anti-inflammatory, analgesic, and antimicrobial properties. Ketone derivatives include compounds in which the carbonyl group is modified, such as enols, which have applications in drug synthesis and as chemical intermediates in the production of other bioactive compounds. Ketone derivatives are used in the design of new medicines, including those for treating neurodegenerative diseases, metabolic disorders, and certain types of cancer, thanks to their specific effects on enzymes and cellular processes.
Found 2393 products of "Ketones and derivatives"
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4′-(4-Fluorophenoxy)acetophenone
CAS:Formula:C14H11FO2Purity:97%Color and Shape:SolidMolecular weight:230.238Phenacetin
CAS:Controlled Product<p>Applications Analgesic, antipyretic. Component of APC tablets, analgesic mixture also containing aspirin and caffeine. Phenacetin is reasonably anticipated to be a human carcinogen; analgesic mixtures containing Phenacetin are listed as known human carcinogens.<br>References Boyd, et al.: Toxicol. Appl. Pharmacol., 1, 240 (1959), Dubach, C.U., et al.: N. Engl. J. Med., 308, 357 (1983),<br></p>Formula:C10H13NO2Color and Shape:WhiteMolecular weight:179.22rac-Ketoprofen Tris Base Amide
CAS:Controlled Product<p>Applications rac-Ketoprofen Tris Base Amide is derived from rac Ketoprofen (K200800), which is an anti-inflammatory and analgesic.<br>References Ueno, K., et al.: J. Med. Chem., 19, 941 (1976), Liversidge, G.G., Anal. Profiles Drug Subs., 10, 443 (1981), Jamali, F., et al.: Clin. Pharmacokinet., 19, 197 (1990);<br></p>Formula:C20H23NO5Color and Shape:NeatMolecular weight:357.15762285rac Ketorolac Acyl-β-D-glucuronide (Mixture of Diastereomers)
CAS:Controlled Product<p>Stability Moisture Sensitive, Light Sensitive<br>Applications A metabolite of Ketorolac.<br>References Mroszczak, E., et al.: Drug Metab. Dispos., 15, 618 (1987), Brocks, D., et al.: Clin. Pharmacokinet., 23, 415 (1992), Vakily, M., et al.: Pharm. Res., 12, 1652 (1995), Gillis, J., et al.: Drugs, 53, 139 (1997),<br></p>Formula:C21H21NO9Color and Shape:NeatMolecular weight:431.39Niflumic Acid
CAS:Controlled Product<p>Applications Anti-inflammatory. Selective cyclooxygenase-2 (COX-2) inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Glasson, et al.: Biochem, Pharmacol., 18, 633 (1969), Boissier, et al.: Therapie, 26, 211 (1971), Sorenson, J.R.J., et al.: J. Med. Chem., 19, 135 (1976), Barnett, J., et al.: Biochim. Biophys. Acta, 1209, 130 (1994), Johnson, J.L., et al.: Arch. Biochem. Biophys., 324, 26 (1995),<br></p>Formula:C13H9F3N2O2Color and Shape:Light YellowMolecular weight:282.225-[1-(2,3-Dimethylphenyl)ethenyl]-1H-imidazole
CAS:Controlled ProductFormula:C13H14N2Color and Shape:NeatMolecular weight:198.263'-Chloroacetophenone
CAS:Purity:97.0%Color and Shape:Liquid, ClearMolecular weight:154.589996337890624'-Methylacetophenone
CAS:Controlled Product<p>Impurity Celecoxib Impurity<br>Applications 4'-Methylacetophenone is a methylated acteophenone used in cosmetics and perfumery. The presence of 4'-Methylacetophenone has been shown to accelerate the photopolymerization of Methyl methacrylate.<br>References Dwivedi, U.N. et al.: Acta Polym., 39, 596 (1988); Opdyke, D.L.J. et al.: Food Cosm. Toxicol., 12, 933 (1974);<br></p>Formula:C9H10OColor and Shape:NeatMolecular weight:134.18Medetomidine
CAS:<p>Medetomidine (MPV785 free base) is a selective α2-adrenoceptor agonist, with sedative and analgesic and vasoconstrictive hypoxic , in small animal anesthesia.</p>Formula:C13H16N2Purity:99.88%Color and Shape:SolidMolecular weight:200.283-Hydroxy Medetomidine
CAS:Controlled Product<p>Applications A metabolite of Medetomidine (M203250).<br>References Salonen, J.S., et al.: Xenobiotica, 20, 471 (1990),<br></p>Formula:C13H16N2OColor and Shape:NeatMolecular weight:216.283-Carboxy-α-methylbenzeneacetic Acid(Ketoprofen Impurity)
CAS:<p>Impurity Ketoprofen EP Impurity C; Ketoprofen USP Compound C: (2-(3-Carboxyphenyl)propionic Acid)<br>Applications 3-Carboxy-α-methylbenzeneacetic Acid (Ketoprofen EP Impurity C) is a impurity of Ketoprofen (K200800). Ketoprofen USP Compound C: (2-(3-Carboxyphenyl)propionic Acid)<br>References Dvorak, J., et al.: J. Pharm. Biomed. Anal., 36, 625 (2004), Allegretti, M., et al.: J. Med. Chem., 48, 4312 (2005),<br></p>Formula:C10H10O4Color and Shape:Off-WhiteMolecular weight:194.183,4,5-Trimethoxybenzoic Acid
CAS:<p>Applications A metabolite of Trimebutine (T795605(P)), which is an opioid receptor agonist and an antispasmodic.<br>References Dieks, H., et al.: J. Labelled Comp. Radiopharm., 28, 1093 (1990), Delvaux, M., et al.: J. Int. Med. Res., 25, 225 (1997), Lavit, M., et al.: Arzneim.-Forsch., 50, 640 (2000),<br></p>Formula:C10H12O5Color and Shape:White To BeigeMolecular weight:212.20Desmethyl Ketoprofen
CAS:Controlled Product<p>Impurity Ketoprofen EP Impurity B<br>Applications Desmethyl Ketoprofen (Ketoprofen EP Impurity B) shows antiinflammatory and analgesic activities. It can be used as neoplasm inhibitors and for treatment of angiogenesis-related disorders.<br>References Allais, A., et al.: Eur. J. Med. Chem., 9, 381 (1974).<br></p>Formula:C15H12O3Color and Shape:WhiteMolecular weight:240.25rac N-Bisdesmethyl Tramadol, Hydrochloride
CAS:<p>Applications A metabolite of Tramadol.<br>References Lintz, V.W., et al.: Arzneim.-Forsch./Drug Res., 31, II, 11, 1932 (1981)<br></p>Formula:C14H22ClNO2Color and Shape:NeatMolecular weight:271.78Nitrobenzene
CAS:Controlled Product<p>Applications Nitrobenzene is a compound that exhibits chromosomal genotoxicity against hamster lung cells, and has the potential to cause cancer in humans (1,2). Nitrobenzene is also used as a starting material to synthesize 4-Aminophenol (A618920) through catalytic hydrogenation (3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Bonacker, D. et al.: Arch. Toxicol. 2004 Jan;78(1):49-57.2. Hsu, C. et al.: J. Environ. Sci. Health. C. Environ. Carcinog. Ecotoxicol. Rev. 2007 Apr-Jun;25(2):155-843. Rode, C. et al.: Org. Proc. Res. Dev. 1999 Nov;3(6), pp 465–470<br></p>Formula:C6H5NO2Color and Shape:Light YellowMolecular weight:123.114-Nitrophenol
CAS:Controlled ProductFormula:C6H5NO3Color and Shape:Light YellowMolecular weight:139.113-(1-Cyanoethyl)benzoic Acid
CAS:Controlled Product<p>Applications 3-(1-Cyanoethyl)benzoic Acid is an intermediate for the synthetic preparation of various pharmaceutical compounds. 3-(1-Cyanoethyl)benzoic Acid was used in studies examining the enantioselectivity of nitrile hydratases.<br>References Rzeznicka, K., et al.: App. Microbiol. Biotechnol., 85, 1417 (2010); Van Pelt. S., et al.: Org. Biomole. Chem., 9, 3011 (2011);<br></p>Formula:C10H9NO2Color and Shape:BeigeMolecular weight:175.18rac 1-Methoxy Ketorolac
CAS:Controlled Product<p>Applications An impurity of the analgesic Ketorolac (K235650).<br></p>Formula:C16H15NO4Color and Shape:NeatMolecular weight:285.29(R)-Apomorphine-10-sulfate
CAS:Controlled ProductFormula:C17H17NO5SColor and Shape:NeatMolecular weight:347.39Ketoprofen Ethyl Ester
CAS:Controlled Product<p>Applications Ketoprofen ethyl ester is an impurity of Ketoprofen (K200800).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Borodkin, S., et al.: J. Pharm. Sci., 59, 481 (1970), Shanbag, V., et al.: J. Pharm. Sci., 81, 149 (1991), Khan, M., et al.: Eur. J. Med. Chem., 40, 371 (2005),<br></p>Formula:C18H18O3Color and Shape:ColourlessMolecular weight:282.33(-)-Tramadol Hydrochloride
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications An analgesic. Used in the treatment of urinary incontinence.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Raffa, R.B., et al.: J. Pharmacol. Exp. Ther., 267, 331 (1993)<br></p>Formula:C16H25NO2·ClHColor and Shape:NeatMolecular weight:299.844-Acetylamino-2-chlorophenol
CAS:Controlled Product<p>Impurity Paracetamol EP Impurity C/ Acetaminophen impurity C<br>Applications 4-Acetylamino-2-chlorophenol is an impuirty of Acetaminophen (A161220), an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3).<br>References (1) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(2) Fairbrother, J.E., et al.: Anal. Profiles Drug Subs., 3, 1 (1974) (3) Hinson, J.A., et al.: Rev. Biochem. Toxicol., 2, 103 (1980)<br></p>Formula:C8H8ClNO2Color and Shape:White To Light PurpleMolecular weight:185.61Capsaicin-5,7-dene
Controlled ProductFormula:C18H25NO3Color and Shape:Off-WhiteMolecular weight:303.396Nordihydrocapsaicin
CAS:Controlled Product<p>Applications Nordihydrocapsaicin is a capsaicinoid and analog and congener of capsaicin in chili peppers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Iwai, K., et al.: Agri. Biol. Chem., 43, 2493 (1979); Kozukue, N., et al.: J. Agr. Food Chem., 53, 9172 (2005)<br></p>Formula:C17H27NO3Color and Shape:Off-WhiteMolecular weight:293.406-Methoxy-2-naphthaleneacetic Acid-d3 (Desmethyl Naproxen-d3)
CAS:Controlled Product<p>Applications A labelled metabolite of Nabumetone (N200500). A competitive, non-selective COX inhibitor.<br>References Turpeinen et. al.: Drug Metabolism and Dispositoin, 37: 1017 (2009); Daniels, F., et al.: J. Invest. Dermatol., 44, 259 (1965), Bosca, F., et al.: Photochem. Photobiol., 71, 173 (2000),<br></p>Formula:C13H9D3O3Color and Shape:White To Off-WhiteMolecular weight:219.25N-[5-(Acetylamino)-2-hydroxyphenyl]-N-(4-hydroxyphenyl)acetamide
CAS:Controlled Product<p>Impurity Acetaminophen Impurity B<br>Applications N-[5-(Acetylamino)-2-hydroxyphenyl]-N-(4-hydroxyphenyl)acetamide is an impurity of Acetaminophen (A161220), which is an analgesic and antipyretic (1,2,3,4). N-[5-(Acetylamino)-2-hydroxyphenyl]-N-(4-hydroxyphenyl)acetamide may be a useful reagent to investigate mechanisms related to liver and kidney damage from acetaminophen. Acetaminophen Impurity B.<br>References (1) Potter, D. W. and Hinson, J. A.: Drug Metab Rev. 20, 341 (1989) (2) Potter, D. W. and Hinson, J. A.: J. Biol. Chem. 260, 12174 (1985) (3) Fairbrother, J.E., et al.: Anal. Profiles Drug Subs., 3, 1 (1974)(4) Hinson, J.A., et al.: Rev. Biochem. Toxicol., 2, 103 (1980)<br></p>Formula:C16H16N2O4Color and Shape:NeatMolecular weight:300.312′,4′,5′-Trifluoropropiophenone
CAS:Formula:C9H7F3OColor and Shape:Low Melting SolidMolecular weight:188.149
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