Benzimidazole and Imidazole Derivatives
Benzimidazole is a compound consisting of a benzene ring fused to an imidazole ring, a five-membered structure containing two nitrogen atoms. Benzimidazole derivatives, such as albendazole, are known for their antiparasitic and antifungal activity, used in the treatment of parasitic infections and certain parasitic diseases in animals and humans. Imidazole, on the other hand, is a five-membered structure with two nitrogen atoms found in various biologically active compounds. Imidazole derivatives, such as metronidazole, have antimicrobial and antiparasitic properties. These compounds are also used in the pharmaceutical industry for treating bacterial infections, parasitic diseases, and some fungal infections, as well as in organic chemistry as catalysts.
At CymitQuimica, we offer high-purity benzimidazoles and imidazoles for research in medicinal chemistry, pharmacology, and biotechnology.
Found 10345 products of "Benzimidazole and Imidazole Derivatives"
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Triazolam-d3
CAS:Controlled Product<p>Applications Labelled Triazolam (T767380(M)). Triazolam in an hypnotic drug used in the short term treatment of insomnia.<br>References Lomen, P., et al.: J. Int. Med. Res., 4, 55 (1976), Allens, G.S., et al.: J. Int. Med. Res., 6, 343 (1978), Pakes, G.E., et al.: Drugs, 22, 81 (1981).<br></p>Formula:C17H9D3Cl2N4Color and Shape:NeatMolecular weight:346.2310-Chloro Carbamazepine
CAS:<p>Applications 10-Chloro Carbamazepine is a derivative of Carbamazepine (C175840) which is used in treatment of pain associated with trigeminal neuralgia.<br>References Stenger, E.G., et al.: Med. Exp., 11, 191 (1964), Pynnonen, S., et al.: Ther. Drug Monit., 1, 409 (1979), Sidebottom, A., et al.: J. Clin. Pharm. Ther., 20, 31 (1995)<br></p>Formula:C15H11ClN2OColor and Shape:White PowderMolecular weight:270.71(3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl Acetate
CAS:Controlled Product<p>Impurity Lansoprazole<br>Applications (3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl Acetate is an impurity of Lansoprazole (L175000). Lansoprazole is used as a gastric proton pump inhibitor and an antiulcerative. It May limit the severity of tuberculosis.<br>References Figgitt, D., et al.: Drugs, 60, 925 (2000); Katsuki, H., et al.: Eur. J. Clin. Pharmacol., 57, 709 (2001); Barradell, L.B., et al.: Drugs, 44, 225 (1992); Kim, K., et al.: Clin. Pharmacol. Ther., 72, 90 (2002); Niioka, T., et al.: Ther. Drug Monit., 28, 321 (2006); Chem. and Eng. News. p. 28 July 20 (2018)<br></p>Formula:C11H12F3NO3Color and Shape:NeatMolecular weight:263.213(S)-Rivastigmine
CAS:<p>Applications S-Rivastigmine is an isomer of Rivastigmine ( an acetylcholinesterase inhibitor used in the treatment of neurological disorders such as Alzheimer’s disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Howes, L et al.: Drug. Safe., 37, 391 (2014); Shahar, O. et al.: Nucl. Acids Res., 42, 5869 (2014);<br></p>Formula:C14H22N2O2Color and Shape:ColourlessMolecular weight:250.344-Desmethoxypropoxyl-4-chloro Rabeprazole Sulfide
CAS:Controlled Product<p>Applications A process impurity of Rabeprazole (R070500).<br>References Pingili, R.R., et al.: Pharmazie, 60, 814 (2005),<br></p>Formula:C14H12ClN3SColor and Shape:NeatMolecular weight:289.781,2-Bismethylenecyclohexane (~75%)
CAS:Controlled ProductFormula:C8H12Purity:~75%Color and Shape:NeatMolecular weight:108.182-Cyclopropylmethylamino-5-chlorobenzophenone
CAS:Controlled Product<p>Applications: 2-Cyclopropylmethylamino-5-chlorobenzophenone is a benzodiazepine derivative.<br>References Japp, M. et al.: J. Chrom., 439, 317 (1988); Guan, F. et al.: J. Anal Toxicol., 23, 54 (1999);<br></p>Formula:C17H16ClNOColor and Shape:NeatMolecular weight:285.774-Acetoxy Midazolam
CAS:Controlled Product<p>Applications A metabolite of Midazolam (M343000).<br></p>Formula:C20H15ClFN3O2Color and Shape:NeatMolecular weight:383.80N-[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl] Rabeprazole Sulfide
CAS:Controlled Product<p>Applications Rabeprazole (R070500) N-aralkyl impurity.<br>References Fujisaki, H., et al.: Biochem. Pharmacol., 42, 321 (1991), Morri, M., et al.: J. Biol. Chem., 268, 21553 (1993), Pingili, R., et al.: Pharmazie, 60, 814 (2005),<br></p>Formula:C29H36N4O4SColor and Shape:NeatMolecular weight:536.692,5-Dichlorobenzoyl Cyanide
CAS:Controlled Product<p>Applications 2,5-Dichlorobenzoyl Cyanide is a reagent applied for research purposes<br>References Veerareddy, A., et al.: J. Heterocyclic Chem., 51, 1311 (2014)<br></p>Formula:C8H3Cl2NOColor and Shape:NeatMolecular weight:200.022(Chloromethyl)cyclohexane
CAS:Controlled Product<p>Applications (Chloromethyl)cyclohexane is a common chemical reagent used in the synthesis of imidazole inhibitors of cytokine release which suppresses the response to tumor necrosis factor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Laufer, S. et al., J. Med. Chem., 45, 1695 (2002); Rabinowitz, M. et al.: J. Med. Chem., 44, 4252 (2001);<br></p>Formula:C7H13ClColor and Shape:NeatMolecular weight:132.63Isometronidazole-D4
CAS:Controlled Product<p>Applications Isometronidazole-D4 is a labelled analogue of Isometronidazole (I821342). Isometronidazole is an impurity of Metronidazole (M338880), a chemotherapeutic agent that is used as a first line defense against Clostridium difficile (C.diff). Isometronidazole is also a hypoxic cell sensitizer in humans and mice.<br>References Hentschel, M. & Schmidt, W.: Die Pharm., 47, 221 (1992); Musher, D., et al.: Clin. Inf. Dis., 40, 1586 (2005); Rosenkranz, H. & Speck, W.: Biochem. Biophys. Res. Comm., 66, 520 (1975)<br></p>Formula:C6D4H5N3O3Color and Shape:NeatMolecular weight:175.18N-Methyl Omeprazole-d3 (Mixture of isomers with the methylated nitrogens of imidazole)
CAS:Controlled Product<p>Applications Labelled Omeprazole (O635000) impurity.<br>References Allenmark, S., et al.: Anal. Biochem., 136, 293 (1984), Besancon, M., et al.: J. Biol. Chem., 272, 22438 (1997),<br></p>Formula:C18H18D3N3O3SColor and Shape:NeatMolecular weight:362.46N-Desmethyl Dextrorphan β-D-O-Glucuronide
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications A labelled metabolite of Dextromethorphan.<br>References Gonzalez, F., et al.: Nature, 331, 442 (1988), Chen, S., et al.: Clin. Pharmacol. Ther., 60, 522 (1996), Hartter, S., et al.: Ther. Drug Monit., 18, 297 (1996), Garcia-Martin, E., et al.: Clin. Pharmacol. Ther., 71, 196 (2002),<br></p>Formula:C22H29NO7Color and Shape:NeatMolecular weight:419.47α-Methyl-phenothiazine-10-ethanol
CAS:Controlled Product<p>Applications A promethazine (P757000) metabolite.<br>References Clement, B. A. & Beckett, A. H.; Xenobiotica 11, 609 (1981)<br></p>Formula:C15H15NOSColor and Shape:NeatMolecular weight:257.35N-Ethylcarbamic Acid 3-[(1S)-1-(Dimethylamino)ethyl]phenyl Ester
CAS:Controlled ProductFormula:C13H20N2O2Color and Shape:NeatMolecular weight:236.314-Hydroxy Triazolam
CAS:Controlled Product<p>Stability Light Sensitive<br>Applications A metabolite of Triazolam (T767380).<br>References Gall, M., et al.: J. Med. Chem., 21, 1290 (1978), Jones, H., et al.: Drug Metab. Dispos., 32, 973 (2004), Hallifax, D., et al.: Drug Metab. Dispos., 33, 1852 (2005).<br></p>Formula:C17H12Cl2N4OColor and Shape:NeatMolecular weight:359.21Scopolamine β-D-Glucuronide
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications A metabolite of Scopolamine.<br>References Shutt, L., et al.: Anaesthesia, 34, 476 (1979), Wada, S., et al.: Xenobiotica, 21, 1289 (1991), Chen, X., et al.: Acta Pharm. Sin., 33, 849(1998),<br></p>Formula:C23H29NO10Purity:>85%Color and Shape:NeatMolecular weight:479.48(S)-Aclidinium Bromide
CAS:Controlled Product<p>Applications (S)-Aclidinium Bromide is an isomer of Aclidinium Bromide (A190180) a novel long-acting antimuscarinic bronchodilator in phase II clinical trials for the treatment of chronic obstructive pulmonary disease (1,2).<br>References (1) Gupta, V. and Singh, D.: Expert Rev Respir Med. 6, 581 (2012)(2) De La Motte, S., et al.: Int. J. Clin. Pharmacol. Therap., 50,403 (2012)<br></p>Formula:C26H30BrNO4S2Color and Shape:Off-WhiteMolecular weight:564.551',4-Dihydroxy Midazolam
CAS:Controlled Product<p>Applications A metabolite of Midazolam (M343000).<br>References Soucek, P., et al.: Xenobiotica, 22, 83 (1992), Ghosal, A., et al.: Drug Metab. Dispos., 24, 940 (1996), Kobayashi, K., et al.: Biochem. Pharmacol., 63, 889 (2002),<br></p>Formula:C18H13ClFN3O2Color and Shape:NeatMolecular weight:357.778-Demethyl Zolazepam
CAS:Controlled Product<p>Applications N-Demethylated metabolite of the anesthetic agent, Zolazepam (Z613500).<br>References Baukema, J. et al.: Res. Comm. Chem. Pathol. Pharmacol., 10, 227 (1975);<br></p>Formula:C14H13FN4OColor and Shape:NeatMolecular weight:272.28N-Nitroso Albendazole (mixtures of regional isomers)
Controlled ProductFormula:C13H16N4O3SColor and Shape:NeatMolecular weight:616.712(2Z)-2-[Cyano(2,3-dichlorophenyl)methylene]hydrazinecarboximidamide
CAS:Controlled ProductFormula:C9H7Cl2N5Color and Shape:NeatMolecular weight:256.0910-Acetyloxy Oxcarbazepine
CAS:Controlled Product<p>Applications An intermediate in the preparation of Carbamazepine metabolites.<br>References Heckendorn, R., et al.: Helv. Chimica Acta, 70, 1955 (1987),<br></p>Formula:C17H14N2O4Color and Shape:NeatMolecular weight:310.30Itraconazole Desethylene-seco-piperazine Mono-N-formyl Impurity
CAS:Controlled Product<p>Applications Itraconazole Desethylene-seco-piperazine Mono-N-formyl Impurity of Itraconazole (I937500). Itraconazole is an orally active antimycotic structurally related to Ketoconazole. Antifungal. It is a COVID19-related research product.<br>References Espinel-Ingroff, A., et al.: Antimicrob. Agents Chemother., 26, 5 (1984), Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989), Sugar, A.M.,et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1993),<br></p>Formula:C34H36Cl2N8O5Color and Shape:NeatMolecular weight:707.61Hydroxy Varenicline N-Trifluoroacetic Acid Salt
CAS:Controlled Product<p>Applications Protected Varenicline metabolite.<br></p>Formula:C15H12F3N3O2Color and Shape:NeatMolecular weight:323.279-Acridinecarboxylic acid
CAS:Controlled Product<p>Applications 9-Acridinecarboxylic acid is used in the synthesis of short DNA-binding peptides.<br></p>Formula:C14H9NO2Color and Shape:YellowMolecular weight:223.23(S)-5,6-Dehydro Pregabalin
CAS:Controlled Product<p>Applications (S)-5,6-Dehydro Pregabalin is derived from rac 5,6-Dehydro Pregabalin (D230055), which is an impurity of the anti-convulsant, Pregabalin (P704800).<br>References Dousa, M, et al.: J. Pharmac. Biomed. Anal., 53, 717 (2010);<br></p>Formula:C8H15NO2Color and Shape:NeatMolecular weight:157.212,4-Dicyano-3-(2-methylpropyl)-pentanediamide (Mixture of Diastereomers)
CAS:Controlled Product<p>Stability Hygrscopic<br>Applications 2,4-Dicyano-3-(2-methylpropyl)-pentanediamide is an impurity of Pregabalin (P704800), a GABA (A602920) analogue used as an anticonvulsant.<br>References Hoekstra, M.S., et al.: Org. Proc. Rec. Deve., 1, 26 (1997); Lowry, O., et al.: J. Biol. Chem., 193, 265 (1951); Gerlach, M., et al.: Brain Res., 741, 142 (1996); Taylor, C.P., at al.: Epilepsy Res., 14, 11 (1993), Field, M.J., et al.: Pain, 80, 391 (1999)<br></p>Formula:C11H16N4O2Color and Shape:NeatMolecular weight:236.2710,11-Dihydro Carbamazepine
CAS:Controlled ProductFormula:C15H14N2OColor and Shape:WhiteMolecular weight:238.282-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine Hydrochloride
CAS:Controlled Product<p>Impurity Omeprazole EP Impurity XI<br>Applications 2-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine Hydrochloride (Omeprazole EP Impurity XI) is an intermediate in the production of the antiulcer agent Omeprazole.<br>References Roma, G., et al.: J. Med. Chem., 50, 2886 (2007), Hoffmann, S., et al.: Toxicol. Lett., 180, 9 (2008),<br></p>Formula:C9H12ClNO·ClHColor and Shape:WhiteMolecular weight:222.11rac-6-Chloro Voriconazole
CAS:Controlled Product<p>Applications An achiral intermediate of Voriconazole (V760000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ferretti, R., et al.: Chromatographia, 47, 649 (1998),<br></p>Formula:C16H13ClF3N5OColor and Shape:NeatMolecular weight:383.76(2R,3R)-3-(2,4-Difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl methanesulfonate
CAS:Controlled ProductFormula:C13H15F2N3O4SColor and Shape:NeatMolecular weight:347.3410-Methoxy-5H-dibenz[b,f]azepine-5-carbonyl chloride
CAS:Controlled ProductFormula:C16H12ClNO2Color and Shape:NeatMolecular weight:286.001-(1H-Benzo[d]imidazol-2-yl)-3-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid (>75%)
CAS:<p>Impurity Rabeprazole EP Impurity C<br>Applications 1-(1H-Benzo[d]imidazol-2-yl)-3-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid (>75%) (Rabeprazole EP Impurity C) is a Rabeprazole (R070500) impurity. A degradation product formed in stressed tablets of Rabeprazole sodium.<br>References Kommanaboyina, B., et al.: Drug Dev. Ind. Pharm., 25, 857 (1999), Carswel, C., et al.: Drugs, 61, 2327 (2001), Garcia, C., et al.: J. Pharm. Biomed. Anal., 46, 88 (2008),<br></p>Formula:C14H11N3O3Purity:>75%Color and Shape:NeatMolecular weight:269.26(2-Chlorophenyl)diphenylmethane
CAS:Controlled Product<p>Applications (2-Chlorophenyl)diphenylmethane is a triarylmethane with antiproliferative activity. (2-Chlorophenyl)diphenylmethane is an impurity of the antifungal agent Clotrimazole (C587400).<br>References Al-Qawasmeh, R.A. et al.: Bioorg. Med. Chem. Lett., 14, 347 (2004);<br></p>Formula:C19H15ClColor and Shape:NeatMolecular weight:278.78Benzofuran-6-carboxylic Acid
CAS:Controlled Product<p>Applications Benzofuran-6-carboxylic Acid is a reagent in the development of potent LFA-1/ICAM antagonist SAR 118 as an opthalmic solution for treating dry eyes. Preparation of piperidinylpyrimidine derivatives as inhibitors of HIV-1 LTR activation.<br>References Zhong, M., et al.: ACS Med. Chem., 3, 203 (2012); Fujiwara, N., et al.: Bioorg. Med. Chem., 16, 9804 (2008)<br></p>Formula:C9H6O3Color and Shape:NeatMolecular weight:162.14Prazepam-d5
CAS:Controlled Product<p>Applications Prazepam-d5, is the labeled analogue of Prazepam (P702250), a benzodiazepine derivative drug having anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties.<br>References Shader R. I., et al.: Ciba. Found. Symp., (74), 141 (1979); Jacqmin, P., et al.: Neuropsychobiology, 19 (4), 186 (1988);<br></p>Formula:C192H5H12ClN2OColor and Shape:NeatMolecular weight:329.836-Chloro-2-methyl-4-(2-fluorophenyl)quinazoline
CAS:Controlled Product<p>Applications 6-Chloro-2-methyl-4-(2-fluorophenyl)quinazoline is a photochemical decomposition product of Midazolam (M343000), an anesthetic, anticonvulsant, sedative and hypotic agent.<br>References Anderson, R., et al.: J. Pharma. Biomed. Anal., 13, 667 (1995); Anderson, R., et al: Am. Clin. Lab., 16, 25 (1997);<br></p>Formula:C15H10ClFN2Color and Shape:NeatMolecular weight:272.70Modafinil-d5 Sulfone
CAS:Controlled Product<p>Applications A labelled metabolite of Modafinil (M482500), a central nervous system vigilance promoting agent, which possesses neuroprotective properties.<br>References Wong, Y., et al.: J. Clin. Pharmacol., 39, 281 (1999), Robertson, P., et al.: Drug Metab. Dispos., 28, 664 (2000), Roth, T., et al.: Clin. Ther., 28, 689 (2006),<br></p>Formula:C152H5H10NO3SColor and Shape:NeatMolecular weight:294.382-Chloromethyl-4-methoxy-3-methylpyridine Hydrochloride
CAS:Controlled Product<p>Applications A pyridine derivative used in the preparation of anti-ulcerative agents and other pharmaceutical compounds.<br>References Kuehler, T.C. et al.: J. Med. Chem., 38, 4906 (1995);<br></p>Formula:C8H10ClNO·ClHColor and Shape:NeatMolecular weight:208.08Scopolamine Sulfate
CAS:Controlled Product<p>Applications Scopolamine Sulfate is an impurity of Scopolamine (S200000), an acetylcholine antagonist used in the treatment of motion sickness and also used as antiemetic, antispasmodic, mydriatic, preanesthetic agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Trendelenburg P., et al.: Archiv fuer Exper. Pathol. Pharmacol., 73, 118 (1914);<br></p>Formula:C17H21NO7SColor and Shape:NeatMolecular weight:383.42Isopropyl Itraconazole
CAS:Controlled ProductFormula:C34H36Cl2N8O4Color and Shape:NeatMolecular weight:691.614-Nitro-5-desnitro Tinidazole
CAS:Controlled Product<p>Impurity Tinidazole EP Impurity B<br>Applications 4-Nitro-5-desnitro Tinidazole (Tinidazole EP Impurity B) is an impurity in the synthesis of Tinidazole (T443900), antiprotozoal (Trichomonas, Giardia); antiamebic; antibacterial.<br>References Miller, M.W., et al.: J. Med. Chem., 13, 849 (1970), Oderdea, G., et al.: Gut, 33, 1328 (1992),<br></p>Formula:C8H13N3O4SColor and Shape:NeatMolecular weight:247.272-Deschlorothien-3-yl Tioconazole Hydrochloride
CAS:Controlled Product<p>Applications 2-Deschloro Tioconazole Hydrochloride is an analog of Tioconazole (T444680), an antifungal that is more active than Fluconazole (F421000) or Voriconazole (V760000) against Candida glabrata mutant strains. Antifungal (topical).<br>References Jevons, S., et al.: Antimicrob. Agents Chemother., 15, 597 (1979), Clayton, Y.M., et al.: Clin. Exp. Dermatol., 7, 543 (1982), Marriott, M.S., et al.: Dermatologica, 166, 1 (1983),<br></p>Formula:C16H14Cl2N2OS·ClHColor and Shape:NeatMolecular weight:389.73Solifenacin EP Impurity A Nitroso Impurity
Controlled ProductFormula:C15H14N2OColor and Shape:NeatMolecular weight:238.293-Isobutylglutaric Anhydride
CAS:Controlled ProductFormula:C9H14O3Color and Shape:NeatMolecular weight:170.2057
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