Benzimidazole and Imidazole Derivatives
Benzimidazole is a compound consisting of a benzene ring fused to an imidazole ring, a five-membered structure containing two nitrogen atoms. Benzimidazole derivatives, such as albendazole, are known for their antiparasitic and antifungal activity, used in the treatment of parasitic infections and certain parasitic diseases in animals and humans. Imidazole, on the other hand, is a five-membered structure with two nitrogen atoms found in various biologically active compounds. Imidazole derivatives, such as metronidazole, have antimicrobial and antiparasitic properties. These compounds are also used in the pharmaceutical industry for treating bacterial infections, parasitic diseases, and some fungal infections, as well as in organic chemistry as catalysts.
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Pantoprazole N-oxide sodium
CAS:<p>Pantoprazole N-oxide sodium is a custom synthesis drug product that is being developed as an impurity standard in the synthesis of Pantoprazole. The compound is also used as a pharmacopoeia analytical standard and a HPLC standard.</p>Formula:C16H15F2N3O5S·NaPurity:Min. 95%Color and Shape:PowderMolecular weight:422.36 g/molPantoprazole sulfide N-oxide
CAS:<p>Pantoprazole sulfide N-oxide is a metabolite of pantoprazole, which is a proton pump inhibitor used to reduce stomach acid production. Pantoprazole sulfide N-oxide is an impurity in pantoprazole that can be detected by HPLC. It has been shown to have about the same biological activity as pantoprazole when given orally.</p>Formula:C16H15F2N3O4SPurity:Min. 95%Color and Shape:Off-White To Yellow SolidMolecular weight:383.37 g/mol4-Isobutyl-2-pyrrolidinone
CAS:<p>4-Isobutyl-2-pyrrolidinone is a colorless liquid that belongs to the category of phosphites. It has a high boiling point, which makes it suitable for use in organic solvents and as a heat transfer agent. The thermodynamic properties of 4-Isobutyl-2-pyrrolidinone have been evaluated using the protonation theory. It can be protonated at either the nitrogen or the methyl group, and both forms are present in solution. This means that 4-Isobutyl-2-pyrrolidinone is acidic and can react with other compounds to form salts called lactams. There are two isomers of this compound: cis and trans. Both isomers exist in equilibrium; however, the cis isomer predominates at room temperature. The most common impurities of 4-Isobutyl-2-pyrrolidinone are dehydration products formed during synthesis or</p>Formula:C8H15NOPurity:Min. 95%Color and Shape:White PowderMolecular weight:141.21 g/mol2-[[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl]thio]-1H-benzimidazole
CAS:<p>Rabeprazole is a proton pump inhibitor that is used to treat acid-related disorders such as gastroesophageal reflux disease and peptic ulcers. Rabeprazole inhibits the production of gastric acid by blocking the hydrogen/potassium ATPase that is found in the parietal cells of the stomach. The main mechanism of action for rabeprazole is competitive inhibition of the proton pump, which leads to decreased gastric acid secretion. Rabeprazole can be administered orally or intravenously, with a half-life of about 2 hours. It has been shown to have an effect on human liver cytochrome P450s, but does not affect the activity of recombinant cytochrome P450 3A4 (CYP3A4). In clinical studies, rabeprazole was shown to have no adverse effects on CYP3A4 activity and may even increase it slightly.</p>Formula:C18H21N3O2SPurity:Min. 95%Color and Shape:White PowderMolecular weight:343.44 g/mol5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole N-oxide
CAS:<p>5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole N-oxide is an ammonium salt of a sulfoxide with a chloride. It is also known as esomeprazole magnesium. This drug is used in the preparation of pharmaceutical preparations and is used to treat gastroesophageal reflux disease (GERD), peptic ulcers, and other conditions. The magnesium salt form is a polymorphic substance that has a crystalline form that occurs in nature, called alpha form, and a synthetic form that occurs in laboratory experiments and has been designated beta form. The alpha form exhibits enantioselectivity when it binds to the enzyme pepsin, which causes the drug to have an antiulcer effect.</p>Formula:C17H19N3O4SPurity:Min. 95%Color and Shape:PowderMolecular weight:361.42 g/molPantoprazole sodium hydrate - Mixture of impurities D and F
CAS:<p>Pantoprazole sodium hydrate is a custom synthesis that is used as a drug product. The CAS number for this compound is 624742-53-6. This compound has the following impurities: D and F. Pantoprazole sodium hydrate has been shown to be metabolized in vitro by human liver microsomes to its metabolites, including the following: (1) pantoprazol acid, (2) 4-hydroxypantoprazol acid, (3) 4-hydroxyisoxazole acid, and (4) 5-(4-hydroxyphenyl)-2H-1,2-benzoxazin-3(4H)-one. The metabolite 4-hydroxypantoprazol acid has been found to be pharmacologically active in animal models of gastric ulceration and healing.</p>Formula:C17H17F2N3O4SPurity:Min. 95%Color and Shape:Off-white to yellow powder.Molecular weight:397.4 g/molN-[5-Amino-6-(2,3-dichlorophenyl)-1,2,4-triazin-3-yl]-2,3-dichlorobenzamide
CAS:<p>N-[5-Amino-6-(2,3-dichlorophenyl)-1,2,4-triazin-3-yl]-2,3-dichlorobenzamide is a pharmaceutical dosage form that is titrated to achieve the desired therapeutic effect. It is used to treat epilepsy and bipolar disorder. Lamotrigine binds to sodium channels in nerve cells and blocks their opening. This prevents the influx of sodium ions that are necessary for neuronal transmission. Lamotrigine has been shown to have an anticonvulsant effect by reducing the frequency of seizures in patients with epilepsy.</p>Formula:C16H9Cl4N5OPurity:Min. 95%Color and Shape:White Off-White PowderMolecular weight:429.09 g/molAlbendazole sulfoxide
CAS:<p>Albendazole sulfoxide is a sulfoxide of albendazole. The molecular docking analysis of the two molecules showed that the sulfoxide group is located in the same position as the hydroxyl group on albendazole. It has been shown that this replacement of hydroxyl with a sulfoxide group increases the solubility and stability of albendazole, which may be due to hydrogen bonding interactions between these groups. Albendazole sulfoxide has been shown to be an effective treatment for infections caused by parasites such as helminths. However, it should not be used in combination with drugs that are metabolized by cytochrome P450 enzymes because it can inhibit their activity.</p>Formula:C12H15N3O3SPurity:Min. 97 Area-%Color and Shape:White PowderMolecular weight:281.33 g/molOmeprazole impurity F and G
CAS:<p>Omeprazole is a proton pump inhibitor that inhibits the H+/K+-ATPase enzyme in gastric parietal cells. Omeprazole impurity F and G are metabolites of omeprazole. Omeprazole impurity F is a metabolite of omeprazole that forms by oxidation of the methylthio group in omeprazole to form a sulfoxide. Omeprazole impurity G is formed by hydrolysis of the methylthio group in omeprazole to form an alcohol. The purity of this product is high and can be custom synthesized based on customer's needs. It is also available as an HPLC standard or as an API impurity for use in metabolism studies.</p>Formula:C16H13N3O2SPurity:Min. 95%Color and Shape:Red PowderMolecular weight:311.36 g/molPantoprazole sulphone
CAS:<p>Pantoprazole sulphone is a proton-pump inhibitor that inhibits the production of stomach acid and protects the esophagus from damage. Pantoprazole sulphone has been shown to be effective in treating heart disease patients and reducing their risk of death. It also has biological properties, including modulating the effects of bosentan, which is used to treat pulmonary arterial hypertension. Pantoprazole sulphone has been shown to be chemically stable and stereoselective, which means it binds more strongly to one site than another. Clinical pharmacology studies have found that pantoprazole sulphone has no effect on abomasal motility or gastric emptying time.</p>Formula:C16H15F2N3O5SPurity:Min. 97 Area-%Color and Shape:PowderMolecular weight:399.37 g/mol2-(3-(1-Benzylpiperidin-4-yl)-2-oxopropyl)-4,5-dimethoxybenzoic acid sodium salt
<p>2-(3-(1-Benzylpiperidin-4-yl)-2-oxopropyl)-4,5-dimethoxybenzoic acid sodium salt is a white to off-white crystalline powder. It is soluble in water and sparingly soluble in alcohol. This product is used as an analytical standard and has been found to be a metabolite of the drug clozapine. 2-(3-(1-Benzylpiperidin-4-yl)-2-oxopropyl)-4,5-dimethoxybenzoic acid sodium salt has also been found to be an impurity in the drug product lamotrigine.</p>Formula:C24H29NO5•NaPurity:Min. 95%Molecular weight:434.49 g/mol5,6-Dimethoxy-2-(4-piperidinyl)methyleneindan-1-one (donepezil impurity)
CAS:<p>5,6-Dimethoxy-2-(4-piperidinyl)methyleneindan-1-one (donepezil impurity) is an analytical standard used as a reference in HPLC assays for donepezil. It is also a metabolite of donepezil and has been found to have pharmacological activity similar to that of the parent compound. This impurity is present in donepezil drug products at levels up to 0.5%.</p>Formula:C17H21NO3Purity:Min. 95%Molecular weight:287.35 g/molN-(2-Phenethyl)benzamide
CAS:<p>N-(2-Phenethyl)benzamide (NPEB) is a molecule that belongs to the group of reactive molecules. It has been shown to be toxic to gram-positive bacteria, such as Staphylococcus aureus and Bacillus subtilis, but not gram-negative bacteria such as Escherichia coli. NPEB also has been shown to have locomotor activity in animals, which may be due to its ability to inhibit the mitochondrial electron transport chain and inhibit ATP production. NPEB's biological properties are well characterized. FTIR spectroscopy showed that this molecule has an amide functional group and is a small molecule with a molecular weight of 176.4 g/mol. This molecule was also found to be able to bind to mitochondria in animals.</p>Formula:C15H15NOPurity:Min. 97 Area-%Color and Shape:PowderMolecular weight:225.29 g/mol(1S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline
CAS:<p>(1S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is a drug used to treat depression. It is an antidepressant drug that inhibits the reuptake of serotonin and norepinephrine in the brain by blocking their transport into the nerve cells. The drug acts as a weak inhibitor of monoamine oxidase (MAO). It also has an effect on bladder function. This compound is synthesized from 1-phenyl-2,5-dihydrothiazole by way of a sequence of reactions that includes the formation of an amine salt via reaction with phosphorus pentoxide and chloroacetic acid followed by conversion to the chloride with thionyl chloride.</p>Formula:C15H15NPurity:Min. 95%Color and Shape:White PowderMolecular weight:209.29 g/molDihydroxy diketo atorvastatin impurity
CAS:<p>Dihydroxy diketo atorvastatin impurity is a synthetic impurity that is generated by the metabolism of atorvastatin. This drug product is an analytical standard for the determination of purity, and can also be used to develop high purity drugs.</p>Formula:C26H24FNO5Purity:Min. 95%Molecular weight:449.47 g/molRabeprazole Impurity 2
CAS:<p>Rabeprazole Impurity 2 is a research and development impurity standard that is used for qualitative analysis. It can be custom synthesized to meet specific needs, and it can also be used in drug product synthesis. Rabeprazole Impurity 2 is a high purity synthetic compound that has been pharmacopoeia-qualified. It can also be used as a metabolite or analytical standard, and it has been studied for its metabolism studies with HPLC-MS. Rabeprazole Impurity 2 has CAS No. 1807988-36-8.</p>Formula:C18H19N3O4Purity:Min. 95%Molecular weight:341.36 g/mol2-Mercaptobenzimidazole
CAS:<p>2-Mercaptobenzimidazole is a chemical compound that can be used for the treatment of infectious diseases. It has been shown to have antioxidative properties and inhibit the growth of bacteria. 2-Mercaptobenzimidazole also has an effect on human serum, which may be due to its ability to bind with proteins in serum and form hydrogen bonds. 2-Mercaptobenzimidazole is stable at high temperatures and has been shown as an effective antimicrobial agent against gram positive and gram negative bacteria.</p>Formula:C7H6N2SPurity:Min. 99 Area-%Color and Shape:White/Off-White SolidMolecular weight:150.19 g/molRabeprazole
CAS:<p>Rabeprazole is a proton pump inhibitor that suppresses the production of stomach acid by blocking the H+/K+ ATPase enzyme. It is used for the treatment of gastroesophageal reflux disease, peptic ulcers, and Zollinger-Ellison syndrome. Rabeprazole has been shown to be more effective than omeprazole in reducing gastric acid secretion in two-way crossover studies. Rabeprazole also has been shown to inhibit the growth of antibiotic-resistant strains of bacteria. In addition, rabeprazole binds to metal ions like iron and copper, which may affect its pharmacokinetics and efficacy. This drug is currently being investigated as an analytical method for determination of proton pump inhibitors in human serum and urine samples by electrochemical impedance spectroscopy (EIS).</p>Formula:C18H21N3O3SPurity:Min. 95%Color and Shape:White PowderMolecular weight:359.44 g/mol2-Hydroxy-2,2-bis(2-thienyl) acetic acid
CAS:<p>2-Hydroxy-2,2-bis(2-thienyl) acetic acid is a long-acting bronchodilator that can be administered by inhalation. It has been used in the clinical development of medicines for the treatment of asthma and chronic obstructive pulmonary disease. 2-Hydroxy-2,2-bis(2-thienyl) acetic acid is chemically related to pyridinium compounds. It is a potent inhibitor of muscarinic receptors and has an anticholinergic profile similar to atropine. The safety profile of this drug seems to be favourable in humans with no major side effects reported so far.</p>Formula:C10H8O3S2Purity:Min. 95%Color and Shape:Yellow PowderMolecular weight:240.3 g/molVarenicline
CAS:<p>Varenicline (CP 526555) is a selective partial agonist of the α4β2 nAChR and a full agonist of the α3β4 nAChR and α7 nAChR.</p>Formula:C13H13N3Purity:99.76%Color and Shape:SolidMolecular weight:211.26(3-METHYL-1H-INDAZOL-6-YL)BORONIC ACID PINACOL ESTER
CAS:Formula:C14H19BN2O2Purity:98%Color and Shape:SolidMolecular weight:258.135-Amino-1H-benzo[d]imidazol-2-(3H)-one
CAS:Formula:C7H7N3OPurity:98%Color and Shape:SolidMolecular weight:149.1531-Methyl-1H-indazole-5-carboxylic acid
CAS:Formula:C9H8N2O2Purity:95%Color and Shape:SolidMolecular weight:176.1754-Bromo-2-methyl-2H-indazole
CAS:Formula:C8H7BrN2Purity:98%Color and Shape:LiquidMolecular weight:211.0622-oxo-2,3-dihydro-1H-benzimidazole-5-sulfonyl chloride
CAS:Formula:C7H5ClN2O3SPurity:97%Color and Shape:SolidMolecular weight:232.641H-Indazole-7-carbaldehyde
CAS:Formula:C8H6N2OPurity:98%Color and Shape:SolidMolecular weight:146.1495-Bromo-1H-benzimidazole
CAS:Formula:C7H5BrN2Purity:97%Color and Shape:Chunks,Crystalline PowderMolecular weight:197.035TERT-BUTYL 3-METHYL-5-NITRO-1H-INDAZOLE-1-CARBOXYLATE
CAS:Formula:C13H15N3O4Purity:98%Molecular weight:277.282-(Piperidin-3-yl)-1H-benzo[d]imidazole
CAS:Formula:C12H15N3Purity:95%Color and Shape:SolidMolecular weight:201.2731H-Benzimidazole-4-carboxylic acid
CAS:Formula:C8H6N2O2Purity:97%Color and Shape:SolidMolecular weight:162.148Ethyl 4-amino-1-methyl-1H-imidazole-5-carboxylate
CAS:Formula:C7H11N3O2Purity:98%Color and Shape:SolidMolecular weight:169.184(S)-5-(aminomethyl)-3-(3-fluoro-4-iodophenyl)oxazolidin-2-one
CAS:Purity:98%Molecular weight:336.1050113-iodo-1-methyl-1H-indazole
CAS:Formula:C8H7IN2Purity:96%Color and Shape:CrystallineMolecular weight:258.062
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