Benzimidazole and Imidazole Derivatives
Benzimidazole is a compound consisting of a benzene ring fused to an imidazole ring, a five-membered structure containing two nitrogen atoms. Benzimidazole derivatives, such as albendazole, are known for their antiparasitic and antifungal activity, used in the treatment of parasitic infections and certain parasitic diseases in animals and humans. Imidazole, on the other hand, is a five-membered structure with two nitrogen atoms found in various biologically active compounds. Imidazole derivatives, such as metronidazole, have antimicrobial and antiparasitic properties. These compounds are also used in the pharmaceutical industry for treating bacterial infections, parasitic diseases, and some fungal infections, as well as in organic chemistry as catalysts.
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Found 10373 products of "Benzimidazole and Imidazole Derivatives"
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5-Methoxy-2-[[(4-Chloro-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-5-methoxy-1H-benzimidazole
CAS:<p>5-Methoxy-2-[(4-chloro-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-5-methoxy-1H benzimidazole is a synthetic drug product. It has been used as a positive control in metabolism studies and as an impurity standard. 5-Methoxy 2-[(4-chloro 3,5 dimethyl 2 pyridinyl)methyl]sulfinyl]-5 methoxy 1H benzimidazole is also a metabolite of the active pharmaceutical ingredient (API) which is used to develop drugs. This chemical is synthesized by custom synthesis and can be obtained at high purity levels. The metabolite of this compound is 5 methoxy 2-[(4 chloro 3,5 dimethyl 2 pyridinyl)methyl]sulfonyl]-5 methoxy 1H benzimidazole.</p>Formula:C16H16ClN3O2SPurity:Min. 95%Color and Shape:PowderMolecular weight:349.84 g/molRabeprazole
CAS:<p>Rabeprazole is a proton pump inhibitor that suppresses the production of stomach acid by blocking the H+/K+ ATPase enzyme. It is used for the treatment of gastroesophageal reflux disease, peptic ulcers, and Zollinger-Ellison syndrome. Rabeprazole has been shown to be more effective than omeprazole in reducing gastric acid secretion in two-way crossover studies. Rabeprazole also has been shown to inhibit the growth of antibiotic-resistant strains of bacteria. In addition, rabeprazole binds to metal ions like iron and copper, which may affect its pharmacokinetics and efficacy. This drug is currently being investigated as an analytical method for determination of proton pump inhibitors in human serum and urine samples by electrochemical impedance spectroscopy (EIS).</p>Formula:C18H21N3O3SPurity:Min. 95%Color and Shape:White PowderMolecular weight:359.44 g/mol3-Amino-6-(2,3-dichlorophenyl)-1,2,4-triazin-5(4H)-one
CAS:<p>3-Amino-6-(2,3-dichlorophenyl)-1,2,4-triazin-5(4H)-one is a triazine derivative that is used as an analytical reagent and intermediate. It has been used as a wastewater analysis method to measure the concentration of carbamazepine. 3-Amino-6-(2,3-dichlorophenyl)-1,2,4-triazin-5(4H)-one has also been shown to be useful in developing analytical methods for clinical trials. 3DCTKP has also been used to test the matrix effect of carbamazepine by analyzing it in different matrices such as water and human plasma.</p>Formula:C9H6Cl2N4OPurity:Min. 95 Area-%Color and Shape:PowderMolecular weight:257.08 g/mol(1R,3S,5S)-8-Methyl-8-azabicyclo[3.2.1]oct-6-en-3-yl-2'-hydroxy-2',2'-di(thiophen-2''-yl)acetate
CAS:<p>Tanshinone IIA is an enantioselective hydroxamic acid that inhibits matrix metalloproteinase. It is a structural analogue of the hydroxamic acid Tanshinone I and has been shown to inhibit aggrecanase, which is an enzyme that hydrolyzes the glycosaminoglycan aggrecan. It also has anti-cancer effects due to its inhibition of cell proliferation in cancer cells. Tanshinone IIA can be used as a chiral synthon for polymerase chain reactions (PCR) because it contains a stereogenic centre in its structure.</p>Formula:C18H19NO3S2Purity:Min. 95%Color and Shape:PowderMolecular weight:361.48 g/molAlbendazole sulfoxide
CAS:<p>Albendazole sulfoxide is a sulfoxide of albendazole. The molecular docking analysis of the two molecules showed that the sulfoxide group is located in the same position as the hydroxyl group on albendazole. It has been shown that this replacement of hydroxyl with a sulfoxide group increases the solubility and stability of albendazole, which may be due to hydrogen bonding interactions between these groups. Albendazole sulfoxide has been shown to be an effective treatment for infections caused by parasites such as helminths. However, it should not be used in combination with drugs that are metabolized by cytochrome P450 enzymes because it can inhibit their activity.</p>Formula:C12H15N3O3SPurity:Min. 97 Area-%Color and Shape:White PowderMolecular weight:281.33 g/molLansoprazole N-oxide
CAS:<p>Lansoprazole N-oxide is a prodrug that is converted to lansoprazole sulfone in vivo. Lansoprazole N-oxide is used as a diluent in chromatographic experiments. It has been shown to be more sensitive than the parent compound, lansoprazole, for the diagnosis of reflux oesophagitis. Lansoprazole N-oxide also has a validation wavelength of 240 nm and can be detected by liquid chromatography. The active form of lansoprazole, lansoprazole sulfone, can be detected by gas chromatography mass spectrometry (GCMS).</p>Formula:C16H14F3N3O3SPurity:Min. 95%Color and Shape:White PowderMolecular weight:385.36 g/mol6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5(2H,4H)-dione
CAS:<p>6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5(2H,4H)-dione is a chlorinating agent that converts alcohols to alkyl chlorides. It is used for the conversion of diazotizable aromatic compounds to diazo compounds. This compound has been shown to be neuroprotective in animal models and provides protection against glutamate excitotoxicity. 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5(2H,4H)-dione also reacts with nitrite ions to form the corresponding nitroso derivatives. These derivatives can cause DNA damage and are mutagenic. 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5(2H,4H)-dione has been shown to react with aminoguanidine to produce a chromat</p>Formula:C9H5Cl2N3O2Purity:Min. 95%Color and Shape:PowderMolecular weight:258.06 g/mol5,6-Dimethoxy-2-(4-piperidinyl)methyleneindan-1-one (donepezil impurity)
CAS:<p>5,6-Dimethoxy-2-(4-piperidinyl)methyleneindan-1-one (donepezil impurity) is an analytical standard used as a reference in HPLC assays for donepezil. It is also a metabolite of donepezil and has been found to have pharmacological activity similar to that of the parent compound. This impurity is present in donepezil drug products at levels up to 0.5%.</p>Formula:C17H21NO3Purity:Min. 95%Molecular weight:287.35 g/molN-(2-Phenethyl)benzamide
CAS:<p>N-(2-Phenethyl)benzamide (NPEB) is a molecule that belongs to the group of reactive molecules. It has been shown to be toxic to gram-positive bacteria, such as Staphylococcus aureus and Bacillus subtilis, but not gram-negative bacteria such as Escherichia coli. NPEB also has been shown to have locomotor activity in animals, which may be due to its ability to inhibit the mitochondrial electron transport chain and inhibit ATP production. NPEB's biological properties are well characterized. FTIR spectroscopy showed that this molecule has an amide functional group and is a small molecule with a molecular weight of 176.4 g/mol. This molecule was also found to be able to bind to mitochondria in animals.</p>Formula:C15H15NOPurity:Min. 97 Area-%Color and Shape:PowderMolecular weight:225.29 g/mol2-Hydroxybenzimidazole
CAS:<p>2-Hydroxybenzimidazole is a benzimidazole compound that is used in the treatment of nervous system diseases. It has been shown to have anti-inflammatory properties and can be used in the treatment of syncytial virus infection. 2-Hydroxybenzimidazole inhibits the production of reactive oxygen species and nitric oxide, which are involved in neurodegenerative disorders. The mechanism of action for 2-Hydroxybenzimidazole involves the formation of hydrogen bonds with hydroxyl groups on proteins. It also has been shown to reduce locomotor activity and increase sleep time in mice, which may be due to inhibition of acetylcholine release from cholinergic neurons.</p>Formula:C7H6N2OPurity:Min. 97.5 Area-%Color and Shape:Off-White PowderMolecular weight:134.14 g/molCarbendazim
CAS:<p>Carbendazim is a fungicide that inhibits the growth of fungi and bacteria. It has been shown to be potent inducers of polymerase chain reaction (PCR) amplification, with a rate constant of 0.0103 per minute. Carbendazim also has a significant effect on electrochemical impedance spectroscopy (EIS). The EIS analysis was used to compare carbendazim-treated cells with untreated cells, which showed that carbendazim causes an increase in the resistance across the cell membrane. This research suggests that carbendazim may be genotoxic, as it increased the amount of DNA damage observed in wild-type strains and altered the optical properties of DNA. Carbendazim is also an effective inhibitor of nitrite ion oxidation and colloidal gold deposition, which has led to its use as a water vapor control agent for plants.</p>Formula:C9H9N3O2Purity:Min. 95%Color and Shape:PowderMolecular weight:191.19 g/mol6-(2,4-Dichlorophenyl)-1,2,4-triazine-3,5-diamine
CAS:<p>6-(2,4-Dichlorophenyl)-1,2,4-triazine-3,5-diamine is a metabolite that can be found in the urine and blood of humans. It has been shown to have cytotoxic effects on human lymphocytes and erythrocytes. 6-(2,4-Dichlorophenyl)-1,2,4-triazine-3,5-diamine is used as an impurity standard for HPLC analysis and as a reference compound for pharmacopoeia. This chemical is also used in the synthesis of some drugs. 6-(2,4-Dichlorophenyl)-1,2,4-triazine-3,5-diamine is not listed in any pharmacopoeia or natural product database.</p>Formula:C9H7Cl2N5Purity:Min. 95%Color and Shape:White PowderMolecular weight:256.09 g/mol4-Isobutyl-2-pyrrolidinone
CAS:<p>4-Isobutyl-2-pyrrolidinone is a colorless liquid that belongs to the category of phosphites. It has a high boiling point, which makes it suitable for use in organic solvents and as a heat transfer agent. The thermodynamic properties of 4-Isobutyl-2-pyrrolidinone have been evaluated using the protonation theory. It can be protonated at either the nitrogen or the methyl group, and both forms are present in solution. This means that 4-Isobutyl-2-pyrrolidinone is acidic and can react with other compounds to form salts called lactams. There are two isomers of this compound: cis and trans. Both isomers exist in equilibrium; however, the cis isomer predominates at room temperature. The most common impurities of 4-Isobutyl-2-pyrrolidinone are dehydration products formed during synthesis or</p>Formula:C8H15NOPurity:Min. 95%Color and Shape:White PowderMolecular weight:141.21 g/mol2-[[[3-Methyl-4-(methylthio)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole
CAS:<p>2-[[[3-Methyl-4-(methylthio)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole is a synthetic, nonsteroidal anti-inflammatory drug. It is soluble in methanol and ethanol, not soluble in water. The impurity standard of 2-[[[3-Methyl-4-(methylthio)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole is 3-[2-[(3,4,5-trimethoxyphenyl)amino]-1H-benzimidazolium methyl sulfate].</p>Formula:C15H15N3OS2Purity:Min. 95%Molecular weight:317.43 g/mol10,11-Dihydroxy-d10 Carbamazepine
Controlled Product<p>10,11-Dihydroxy-d10 Carbamazepine is a drug product that is used as an analytical reference standard. It is natural and synthetic impurity in the API (active pharmaceutical ingredient) Carbamazepine. The CAS number for 10,11-Dihydroxy-d10 Carbamazepine is 513-81-5. This compound has been synthesized by custom synthesis and is an impurity standard for HPLC analysis of carbamazepine. 10,11-Dihydroxy-d10 Carbamazepine is also a research and development chemical for the drug development industry. It has been classified as a niche chemical due to its high purity and pharmacopoeia grade.</p>Purity:Min. 95%2-[[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl]thio]-1H-benzimidazole
CAS:<p>Rabeprazole is a proton pump inhibitor that is used to treat acid-related disorders such as gastroesophageal reflux disease and peptic ulcers. Rabeprazole inhibits the production of gastric acid by blocking the hydrogen/potassium ATPase that is found in the parietal cells of the stomach. The main mechanism of action for rabeprazole is competitive inhibition of the proton pump, which leads to decreased gastric acid secretion. Rabeprazole can be administered orally or intravenously, with a half-life of about 2 hours. It has been shown to have an effect on human liver cytochrome P450s, but does not affect the activity of recombinant cytochrome P450 3A4 (CYP3A4). In clinical studies, rabeprazole was shown to have no adverse effects on CYP3A4 activity and may even increase it slightly.</p>Formula:C18H21N3O2SPurity:Min. 95%Color and Shape:White PowderMolecular weight:343.44 g/mol1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylidene)methylpiperidine
CAS:<p>1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylidene)methylpiperidine is an analytical standard and a drug product. It is a synthetic compound that has been shown to have pharmacological effects similar to those of the analgesic or opioid drugs. 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylidene)methylpiperidine can be used as an impurity standard for HPLC analyses as well as metabolic studies. This compound is also known to have potential interactions with other drugs.</p>Formula:C24H27NO3Purity:Min. 98 Area-%Color and Shape:PowderMolecular weight:377.48 g/mol2-(3-(1-Benzylpiperidin-4-yl)-2-oxopropyl)-4,5-dimethoxybenzoic acid sodium salt
<p>2-(3-(1-Benzylpiperidin-4-yl)-2-oxopropyl)-4,5-dimethoxybenzoic acid sodium salt is a white to off-white crystalline powder. It is soluble in water and sparingly soluble in alcohol. This product is used as an analytical standard and has been found to be a metabolite of the drug clozapine. 2-(3-(1-Benzylpiperidin-4-yl)-2-oxopropyl)-4,5-dimethoxybenzoic acid sodium salt has also been found to be an impurity in the drug product lamotrigine.</p>Formula:C24H29NO5•NaPurity:Min. 95%Molecular weight:434.49 g/molVarenicline
CAS:<p>Varenicline (CP 526555) is a selective partial agonist of the α4β2 nAChR and a full agonist of the α3β4 nAChR and α7 nAChR.</p>Formula:C13H13N3Purity:99.76%Color and Shape:SolidMolecular weight:211.266-Bromo-3-methoxy-1H-indazole
CAS:Formula:C8H7BrN2OPurity:96%Color and Shape:SolidMolecular weight:227.0614-BROMO-7-METHYL-1H-INDAZOLE
CAS:Formula:C8H7BrN2Purity:98%Color and Shape:SolidMolecular weight:211.0621-(5-Bromo-1H-indazol-3-yl)ethanone
CAS:Formula:C9H7BrN2OPurity:97%Color and Shape:No data available.Molecular weight:239.0726-METHYL-1H-INDAZOL-5-YL-5-BORONIC ACID
CAS:Formula:C8H9BN2O2Purity:98%Color and Shape:SolidMolecular weight:175.98TERT-BUTYL 5-(TRIFLUOROMETHOXY)-1H-INDAZOLE-1-CARBOXYLATE
CAS:Formula:C13H13F3N2O3Purity:95%Molecular weight:302.2536-Bromo-1-methyl-1H-benzo[d]imidazol-2(3H)-one
CAS:Formula:C8H7BrN2OPurity:95%Molecular weight:227.0614-Bromo-6-iodo-1H-indazole
CAS:Formula:C7H4BrIN2Purity:95%Color and Shape:SolidMolecular weight:322.9315-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazol-3-amine
CAS:Formula:C13H18BN3O2Purity:95%Color and Shape:SolidMolecular weight:259.121-Ethyl-1H-imidazole-5-carbaldehyde hydrochloride
CAS:Formula:C6H9ClN2OPurity:97%Molecular weight:160.65-Bromo-6-methyl-1H-indazole
CAS:Formula:C8H7BrN2Purity:98%Color and Shape:SolidMolecular weight:211.062H-D-His-OH
CAS:<p>M02972 - H-D-His-OH</p>Formula:C6H9N3O2Purity:98%Color and Shape:Solid, CrystallineMolecular weight:155.1571-Boc-5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole
CAS:Formula:C18H25BN2O4Purity:97%Color and Shape:SolidMolecular weight:344.22Chloro [1,3-Bis(2,6-di-I-propyl-phenyl)imidazol-2-ylidene]copper(1)
CAS:Formula:C27H36ClCuN2Purity:95%Color and Shape:SolidMolecular weight:487.65-Bromo-1-methyl-1,3-dihydro-2H-benzo[d]imidazol-2-one
CAS:Formula:C8H7BrN2OPurity:95%Color and Shape:SolidMolecular weight:227.061
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