Purines and Pyrimidine Derivatives
Purines have a bicyclic structure, consisting of a six-membered ring fused to a five-membered ring, both containing nitrogen atoms in key positions. Purine derivatives, such as adenine and guanine, are essential for the formation of DNA and RNA. These compounds have therapeutic applications in cancer and viral disease treatments by inhibiting cell replication. Pyrimidines, on the other hand, have a monocyclic six-membered structure with two nitrogen atoms. Their derivatives, such as cytosine, thymine, and uracil, are also essential components of DNA and RNA and are used in chemotherapy and antiviral treatments.
At CymitQuimica, we offer purine and pyrimidine derivatives for research in molecular biology, genomics, and the development of innovative therapies.
Found 8898 products of "Purines and Pyrimidine Derivatives"
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Hydroxy Urea-15N
CAS:Controlled Product<p>Applications Labelled Hydroxyurea. An anti-neoplastic - inhibits ribonucleoside reductase and DNA replication. A potential therapy for sickle cell anemia which involves the nitrosylation of sickle cell hemoglobin. Horseradish peroxidase catalyzes nitric oxide formation from hydroxyurea in the presence of hydrogen peroxide.<br>References Ratcliffe, W., et al.: Lancet, 339, 164 (1992), Roodman, G., et al.: Cancer, 80, 1557 (1997), Horwitz, M., et al.: J. Clin. Endocrinol. Metab., 2003, 88, 1603 (2003),<br></p>Formula:CH415NNO2Color and Shape:NeatMolecular weight:77.052-Oxo Clopidogrel-13C,d3 Hydrochloride(Mixture of Diastereomers)
CAS:Controlled ProductFormula:C1513CH14D3Cl2NO3SColor and Shape:NeatMolecular weight:378.29rac-Clopidogrel Hydrogen Sulfate
CAS:Controlled Product<p>Applications rac-Clopidogrel Hydrogen Sulfate is used in the synthesis of Clopidogrel derivatives as platelet aggregation inhibitors.<br>References Chen, J., et. al.: Hecheng Huaxue, 18, 586 (2010); Defreyn, G. et al.: Thromb. Haemo., 65, 186 (1991);<br></p>Formula:C16H16ClNO2S·H2O4SColor and Shape:Off-WhiteMolecular weight:419.90Febuxostat Acyl-β-D-glucuronide
CAS:<p>Applications A metabolite of Febuxostat (F229000), a novel nonpurine selective inhibitor of Xanthin Oxidase.<br>References Grabowski, B., et al.: J. Clin. Pharmacol., 51, 189 (2011); Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993); Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003); Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005); Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005)<br></p>Formula:C22H24N2O9SColor and Shape:Off White PowderMolecular weight:492.50Mono-POC Tenofovir 6-Isopropyl Carbamate (Mixture of Diastereomers)
CAS:Controlled Product<p>Stability Very Hygroscopic<br>Applications Tenofovir (T018500) impurity.<br></p>Formula:C18H28N5O9PColor and Shape:White SolidMolecular weight:489.42Descarboxyl Febuxostat
CAS:Controlled ProductFormula:C15H16N2OSColor and Shape:NeatMolecular weight:272.37[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]monophenylester
CAS:Controlled Product<p>Applications [[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]monophenylester is an antiviral agent and a Tenofovir (T018500) intermediate. Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor, used as an anti-HIV agent.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005); Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006); Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);<br></p>Formula:C15H18N5O4PColor and Shape:NeatMolecular weight:363.31nPOC-POC Tenofovir(Mixture of Diastereomers)
CAS:Controlled Product<p>Applications An impurity of Tenofovir (T018500(P)). Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent. Antiviral.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);<br></p>Formula:C19H30N5O10PColor and Shape:NeatMolecular weight:519.44Tenofovir Bis(L-alanine Isopropyl Ester) Amide
CAS:Controlled ProductFormula:C21H36N7O6PColor and Shape:NeatMolecular weight:513.53D-Alanine Isopropyl Ester Hydrochloride
CAS:Controlled Product<p>Applications D-Alanine Isopropyl Ester Hydrochloride is a chiral reagent used in the synthesis of nucleotide prodrugs such as (PSI-7977) for the treatment of hepatitis C. Also used in the preparation of synthetic sweeteners.<br>References Sofia, M. et al.: J. Med. Chem., 53, 7202 (2010); Mazur, R. et al.: J. Med. Chem., 16, 1284 (1973);<br></p>Formula:C6H14ClNO2Purity:~90%Color and Shape:NeatMolecular weight:167.63Glycylglycyl-L-tyrosine
CAS:<p>Applications Fungal tyrosinases and their capability to oxidize peptide-bound tyrosine residues is important in a view of applicability of tyrosinases.<br>References Bowness, J., et al.: Biochem. J., 53, 620 (1953), Cuff, M., et al.: J. Mol. Biol., 278, 855 (1998), Kubo, I., et al.: Bioorg. Med. Chem., 12, 5349 (2004),<br></p>Formula:C13H17N3O5Color and Shape:NeatMolecular weight:295.2912(S)-9-[2-(Hydroxypropyl] Adenine
CAS:<p>Applications (S)-9-[2-(Hydroxypropyl] Adenine is an inhibitor of adenosine deaminase. (S)-9-[2-(Hydroxypropyl] Adenine is used in the preparation of antiviral acyclic nucleoside thiophosphonates such as (S)-Tenofovir Disoproxil Fumarate (T018506).<br>References Roux, L. et al.: Eur. J. Med. Chem., 63, 869 (2013); Schaeffer, H. et al.: J. Med. Chem., 15, 456 (1972); Schaeffer, H. & Vince, R.: J. Med. Chem., 10, 689 (1967)<br></p>Formula:C8H11N5OColor and Shape:Off White SolidMolecular weight:193.2065-Aminoimidazole-4-carboxamide-13C2,15N Hydrochloride Salt
CAS:Controlled Product<p>Stability Very Hygroscopic<br>Applications A labelled metabolite of Temozolomide.<br>References Jaeken, J., et al.: Lancet, 2, 1058 (1984), Baggott, J., et al.: Biochem. J., 236, 193 (1986), Baggott, J., et al.: Arch. Dermatol., 135, 813 (1999),<br></p>Formula:C2C2H615NN3O·HClColor and Shape:BrownMolecular weight:165.556Methotrexate-d3 (Technical Grade) (100ug/mL in Methanol with 1% 0.1N NaOH)
CAS:Controlled ProductFormula:C20H19D3N8O5Color and Shape:Single SolutionMolecular weight:457.46Methotrexate-d3 Pentaglutamate Trifluoroacetate (>90%)
CAS:Controlled Product<p>Applications Methotrexate-d3 Pentaglutamate is the isotope labelled analog of Methotrexate Pentaglutamate (M260735); a metabolite of Methotrexate (M260675) which is a folic acid antagonist, antineoplastic, and antirheumatic.<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958); Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985)<br></p>Formula:C40H47D3N12O17(C2HF3O2)xColor and Shape:NeatMolecular weight:973.918-13C-Uric Acid (contains ~1.5% unlabelled)
CAS:Controlled Product<p>Applications 8-13C-Uric Acid is the labeled analogue of Uric Acid (U829200), a heterocyclcic compound that is created when purine nucleotides are broken down of by the human body. High blood concetration of Uric Acid is known as hyperuricemia and is often associated with a wide range of disorders and medical conditions such as gout, diabetes and metabolic syndrome. Uric acid may be a marker of oxidative stress and may have a potential therapeutic role as an antioxidant.<br>References Heinig, M. et al.: Cle. Clin. J. Med., 73, 1059 (2006); Glantzounis, G.K. et al.: Curr. Pharmac. Des., 11, 4145 (2005); Dehghan, A. et al.: Diab. Care, 31, 361 (2008); Nakagawa, T. et al.: Am. J. Physiol. Renal Physiol., 290, F625 (2006)<br></p>Formula:C413CH4N4O3Color and Shape:NeatMolecular weight:169.1(N,N-Dimethyl-1-butanamine) Zolmitriptan Dimer
CAS:Controlled Product<p>Impurity Zolmitriptan USP Related Compound F<br>Stability Hygroscopic<br>Applications (N,N-Dimethyl-1-butanamine) Zolmitriptan Dimer (Zolmitriptan USP Related Compound F) is an impurity from the synthesis of Zolmitriptan (Z639000). Zolmitriptan is a Serotonin 5HTID-receptor agonist.<br>References Glen, R.C., et al.: J. Med. Chem., 38, 3566 (1995), Seaber, E., et al.: Brit. J. Clin. Pharmacol., 41, 141 (1996), Tepper, S.J., et al.: Curr. Med. Res. Opin., 15, 254 (1999)<br></p>Formula:C38H53N7O4Purity:>90%Color and Shape:NeatMolecular weight:671.874-Hydroxy-1,3-benzenedicarbonitrile
CAS:Controlled Product<p>Applications 4-Hydroxy-1,3-benzenedicarbonitrile is used in the preparation of febuxostat (F229000), a non-purine xanthine oxidase inhibitor used as a treatment for hyperuricaemia and chronic gout.<br>References Smith, C.J., et al.: Bioorg. Med. Chem. Lett., 20, 346 (2010); Cramp. S., et al.: BIoorg. Med. Chem. Lett., 20, 2516 (2010); Sato, T., et al.: Bioorg. Med. Chem. Lett., 19, 184 (2009);<br></p>Formula:C8H4N2OColor and Shape:NeatMolecular weight:144.13N10-Monodesmethyl Rizatriptan
CAS:Controlled Product<p>Impurity Rizatriptan EP Impurity I<br>Applications N10-Monodesmethyl Rizatriptan (Rizatriptan EP Impurity I) is a metabolite of Rizatriptan.<br>References Dechant, K., et al.: Drugs, 43, 776 (1992), Castro, J., et al.: Bioorg. Med. Chem. Lett., 3, 993 (1993), Lee, Y., et al.: Biopharm. Drug Dispos., 19, 577 (1998), Chen, J., et al.: J. Pharm. Biomed. Anal., 35, 639 (2004),<br></p>Formula:C14H17N5Color and Shape:NeatMolecular weight:255.324-[2-(4-Chlorobutylidene)hydrazinyl]-N-methylbenzenemethanesulfonamide
CAS:Controlled Product<p>Stability Hygroscopic, Temperature Sensitive<br>Applications 4-[2-(4-Chlorobutylidene)hydrazinyl]-N-methylbenzenemethanesulfonamide is an intermediate in the synthesis of 3-(2-Aminoethyl)-N-methyl-1H-indole-5-methanesulfonamide (Didesmethyl Sumatriptan) (Sumatriptan EP Impurity E) (A609165), which is an antimigraine agent. A Sumatriptan intermediate.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Formula:C12H18ClN3O2SColor and Shape:NeatMolecular weight:303.81
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