Quinazoline and Quinoline Derivatives
Quinazolines and quinolines are nitrogen-containing heterocyclic compounds with aromatic structures that play a key role in the synthesis of drugs with anticancer, antimicrobial, and anti-inflammatory activity. Their derivatives feature structural modifications that optimise bioavailability and selectivity, enabling the development of new active ingredients for various therapeutic applications. These compounds are used in the manufacture of APIs for the treatment of cancer, infections, neurodegenerative diseases, and cardiovascular conditions. Additionally, quinazoline and quinoline derivatives are essential in the research of enzyme inhibitors and the design of innovative bioactive molecules.
At CymitQuimica, we offer high-purity quinazoline and quinoline derivatives for applications in chemical synthesis, pharmaceutical development, and biotechnology.
Found 65580 products of "Quinazoline and Quinoline Derivatives"
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(S)-4-Hydroxy Propranolol Hydrobromide
CAS:Controlled Product<p>Applications (S)-4-Hydroxy Propranolol is the main metabolite of (S)-Propranolol (P831795).<br>References Shwed, J., et al.: Xenobiotica, 22, 973 (1992), Fujita, K., et al.: Biol. Pharm. Bull., 22, 446 (1999), Walle, U., et al.: Drug Metab. Dispos., 30, 564 (2002),<br></p>Formula:C16H21NO3·ClHColor and Shape:NeatMolecular weight:311.80R-Mirtazapine
CAS:Controlled Product<p>Applications R-Mirtazapine is an enantiomer of Mirtazapine (M365000); an antidepressant. R-Mirtazapine showed antinociceptive effects in acute thermal nociception, whereas S-Mirtazapine showed pronociceptive effects.<br>References Muth-Selbach, Uta., et al.: Brain Res. Bull., 79(1), 63-68 (2009); Smith, Donald F., et al.: Psychopharmacology, 200(2), 273-279 (2008); Freynhagen, Rainer., et al.: Brain Res. Bull., 69(2), 168-173 (2006)<br></p>Formula:C17H19N3Color and Shape:NeatMolecular weight:265.351-(3,4-Dimethylphenyl)ethanol
CAS:Controlled Product<p>Applications 1-(3,4-Dimethylphenyl)ethanol is an intermediate in the production of Medetomidine (M203250), α2-Adrenergic agonist. Sedative; analgesic.<br>References Kagechika, H., et al.: J. Med. Chem., 32, 1098 (1989), ; Scheinin, M., et al.: Br. J. Clin. Pharmacol., 24, 443 (1987),<br></p>Formula:C10H14OColor and Shape:NeatMolecular weight:150.224-Amino-2-fluoro-N-methylbenzamide
CAS:Controlled Product<p>Stability Moisture Sensitive<br>Applications 4-Amino-2-fluoro-N-methylbenzamide acts as a reagent in the design, synthesis and biological evaluation of novel 5-oxo-2-thioxoimidazolidine derivatives as potent androgen receptor antagonists. Also, in the preparation and structure-activity relationship of chiral benzyloxypyridinone derivatives as c-Met kinase inhibitors<br>References Ivachtchenko, A. V., et al.: Eur. J. Med. Chem., 99, 51 (2015); Zhang, D., et al.: Bioorg. Med. Chem. Lett., 23, 2408 (2013)<br></p>Formula:C8H9FN2OColor and Shape:NeatMolecular weight:168.17Dasatinib-d8 N-Oxide
CAS:Controlled Product<p>Applications The labelled oxidative metabolite of Dasatinib (M5 metabolite). It is a COVID19-related research product.<br>References Cashman, J.R., et al.: Chem. Res. Toxicol., 8, 165 (1995), Aasmoe, L., et al.: Toxicol. Appl. Pharmacol., 150, 86 (1998), Galetin, A., et al.: J. Pharmacol. Exp. Ther., 314, 180 (2005), Christopher, L.J., et al.: Drug Metab. Dispos., 36, 1357 (2008),<br></p>Formula:C22H18D8ClN7O3SColor and Shape:NeatMolecular weight:512.052,5-Bis(trifluoromethyl)aniline
CAS:Controlled Product<p>Applications 2,5-Bis(trifluoromethyl)aniline is a haloalkul substituted aniline used in the preparation of anti-benign prostatic hyperplasia drug, Dutasteride (D735000).<br>References Liang, Y. et al.: Jil. Dax. Xueb. Lixeub., 45, 1035 (2007);<br></p>Formula:C8H5F6NColor and Shape:ColourlessMolecular weight:229.12N-(4-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine
CAS:Controlled Product<p>Applications Intermediate in the preparation of Imatinib impurities. It is a COVID19-related research product.<br></p>Formula:C16H15N5Color and Shape:NeatMolecular weight:277.324-Cyano Loratadine
CAS:Controlled Product<p>Applications Intermediate for the synthesis of 4-Hydroxymethyl Loratadine.<br>References Cerrada, V., et al.: ARKIVOC, 9, 200 (2005).<br></p>Formula:C23H22ClN3O2Color and Shape:NeatMolecular weight:407.89(E/Z)-Chlorprothixene-d6 Hydrochloride(Mixture)
CAS:Controlled Product<p>Applications Labelled cis/trans-Chlorprothixene (C424850). Antipsychotic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rudy, B.C., et al.: Anal. Profiles Drug Subs., 2, 63 (1973), Bagli, M., et al.: Arzneim.-Forsch., 46, 247 (1996),<br></p>Formula:C18H13D6Cl2NSColor and Shape:NeatMolecular weight:358.36Dimenhydrinate
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications An antihistamine with antiemetic properties used to prevent nausea and motion sicknes composed of two drugs 8-Chlorotheophylline (C411440) and Diphenhydramine (D486900).<br>References Sibel, K. et al.: Arzneim.-Forsch. , 52, 529 (2002); Pytel, J. et al.: Clin. Therap., 29, 84 (2007); Scholtz, A.W. et al.: Clin. Therap., 26, 866 (2004);<br></p>Formula:C17H21NO·C7H7ClN4O2Color and Shape:NeatMolecular weight:469.96Tofogliflozin
CAS:Controlled Product<p>Applications A novel, potent, and highly selective SGLT2 inhibitor that has been shown to improve glycemic control in diabetic mice and rats.<br></p>Formula:C22H26O6Color and Shape:NeatMolecular weight:386.44N-Ethyl-3-buteno-o-toluidide
CAS:Controlled ProductFormula:C13H17NOColor and Shape:NeatMolecular weight:203.281-Methyl-1H-indazole-3-carboxylic Acid Anhydride
CAS:Controlled Product<p>Applications 1-Methyl-1H-indazole-3-carboxylic Acid Anhydride is an impurity of Granisetron (G780000), a specific serotonin (5HT3) receptor antagonist and a antiemetic agent.<br>References Kilpatrick, G.J., et al.: Nature, 330, 746 (1987); Durig, T., et al.: J. Pharm. Sci., 86, 1092 (1997); Yuasa, H., et al.: Chem. Pharm. Bull., 44, 1361 (1996); Vishnu, E.V.R., et al.: Lett. Org. Chem., 8, 722 (2011);<br></p>Formula:C18H14N4O3Color and Shape:Off-WhiteMolecular weight:334.334-Hydroxy Phenylbutazone
CAS:<p>Applications Impurity in the production of Phenylbutazone (P319570)<br>References Fricoteaux, R., et al.: J. Pharm. Biomed. Anal., 7, 1585 (1989), Segrestaa, J., et al.: Chem. Pharm. Bull., 50, 744 (2002),<br></p>Formula:C19H20N2O3Color and Shape:White To Off-WhiteMolecular weight:324.37Benzoin
CAS:Controlled Product<p>Applications Benzoin has been used as a catalyst in photoinitiation.<br>References Voll, D., et. al.: Macromolecules, 44, 2542 (2011)<br></p>Formula:C14H12O2Color and Shape:Off-WhiteMolecular weight:212.24Palbociclib
CAS:<p>Applications Palbociclib (also known as compound number PD-0332991) is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.<br>References Finn, R., et al.: Breast Cancer Res., 11, 5 (2009);<br></p>Formula:C24H29N7O2Color and Shape:NeatMolecular weight:447.53Afatinib-des(4-dimethylamino-2-en-1-oxo)butyl (Contained ~8.5% Ethanol)
CAS:Formula:C18H16ClFN4O2Color and Shape:NeatMolecular weight:374.8Telmisartan tert-Butyl Ester
CAS:Controlled Product<p>Impurity Telmisartan EP Impurity C<br>Applications Telmisartan tert-Butyl Ester (Telmisartan EP Impurity C) is an impurity of Telmisartan (T017000). Telmisartan impurity C.<br>References Ruth, R., et al.: J. Med. Chem., 39, 625 (1996), Merlos, M., et al.: J. Drugs Future, 22, 1112 (1997), Battershill, A., et al.: J. Drugs, 66, 51 (2006),<br></p>Formula:C37H38N4O2Color and Shape:White To Off-WhiteMolecular weight:570.72trans-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolane-4-methanol
CAS:Controlled Product<p>Applications trans-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolane-4-methanol is an impurity of Ketoconazole (K186000).<br>References Ryu, J., et al. Bull. Korean Chem. Soc., 24, 460 (2003)<br></p>Formula:C14H14Cl2N2O3Color and Shape:NeatMolecular weight:329.18Plerixafor Hydrochloride (1:8)
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Plerixafor Hydrochloride (1:8), is an immunostimulant used to mobilize hematopoietic stem cells in cancer patients. It is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α).<br>References Xie, T., et al.: Science, 290, 328 (2000), Leone, D., et al.: J. Pharmacol. Exp. Ther., 305, 1150 (2003), Chigaev, A., et al.: J. Immunol. 178, 6828 (2007), Kiel, M., et al.: Cell Stem Cell, 1, 204 (2007),<br></p>Formula:C28H54N8·8ClHColor and Shape:NeatMolecular weight:794.473-O-Benzyl-4,5-O-(1-methylethyldiene)-β-D-fructopyranose
CAS:Controlled Product<p>Applications Intermediate in the preparation of 2,3-Desisopropylidene Topiramate, a metabolite of Topiramate<br></p>Formula:C16H22O6Color and Shape:NeatMolecular weight:310.34Methyl 5,6,7,8-Tetradehydro Risperidone
CAS:Controlled Product<p>Applications An internal standard for Risperidone (R525000).<br>References Jannssen, P.A.J., et al.: J. Pharmacol. Exp. Ther., 244, 685 (1988), Gelders, Y.G., et al.: Pharmacopsychiatry, 23, 206 (1990), Green, B.: Curr. Med. Res. Opin., 16, 57 (2000)<br></p>Formula:C24H25FN4O2Color and Shape:White To Off WhiteMolecular weight:420.48(S)-5-Chloro-a-(cyclopropylethynyl)-2-[[(4-methoxyphenyl)methyl]amino]-a-(trifluoromethyl)benzenemethanol
CAS:Controlled Product<p>Applications (S)-5-Chloro-α-(cyclopropylethynyl)-2-[[(4-methoxyphenyl)methyl]amino]-α-(trifluoromethyl)benzenemethanol is the S enantiomer of rac-5-Chloro-α-(cyclopropylethynyl)-2-[[(4-methoxyphenyl)methyl]amino]-α-(trifluoromethyl)benzenemethanol (C365145). (S)-5-Chloro-α-(cyclopropylethynyl)-2-[[(4-methoxyphenyl)methyl]amino]-α-(trifluoromethyl)benzenemethanol is also an impurity of Efavirenz (E425000), an HIV-1 reverse transcriptase inhibitor.<br>References Pierce, M., et al.: J. Org. Chem., 63, 8536 (1998)<br></p>Formula:C21H19ClF3NO2Color and Shape:NeatMolecular weight:409.83rac N-Desmethyl Mephenytoin-D5 (Major)
CAS:Controlled Product<p>Applications An anticonvulsant, hypnotic. A labelled metabolite of Mephentoin.A representative lot was 85% d5; 15% d4 1% d3 with no detectable d0.<br>References Karlaganis, G., et al.: Drug Metab. Dispos., 8, 173 (1980), Knabe, J., et al.: Arch. Phar., 313, 538 (1980),<br></p>Formula:C112H5H7N2O2Color and Shape:NeatMolecular weight:209.264-Hydroxy Ramelteon
CAS:<p>Applications A metabolite of Ramelteon (R110051)<br></p>Formula:C16H21NO3Color and Shape:Off White SolidMolecular weight:275.34Iso Fluconazole
CAS:Controlled Product<p>Impurity Fluconazole EP Impurity A<br>Applications Iso Fluconazole (Fluconazole EP Impurity A) is an impurity of Fluconazole (F421000). Fluconazole USP impurity A.<br>References Rogers, T., et al.: Antimicrob. Agents Chemother., 30, 418 (1986), Itoh, H., et al.: Chem. Pharmaceut. Bull., 48, 1148 (2000),<br></p>Formula:C13H12F2N6OColor and Shape:Off-WhiteMolecular weight:306.27Dimethylamine (40% aq.)
CAS:Controlled Product<p>Applications Dimethylamine (40% aq.) is a compound often used in industry as a precursor to Nitrosodimethylamine (N525625), a potent carcinogen that is produced during disinfection of wastewater effluent, and is also present in trace amounts in food and polluted air. Dimethylamine is also present in human urine and can be indicative of certain disorders.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gereke, A. & Sedlak, D.: Env. Sci. Tech., 37, 1331 (2003); Mitch, W., et al.: Env. Eng. Sci., 20, 389 (2003); Tsikas, D., et al.: J. Chromatogr. B, 851, 229 (2007)<br></p>Formula:C2H7NColor and Shape:NeatMolecular weight:45.08Indomethacin 1-Menthol ester
CAS:Controlled Product<p>Applications Indomethacin terpenoids' esters were synthesized and assessed both in vitro and in vivo as indomethacin dermal prodrugs.<br>References Bonina,, Francesco. , et al.: European Journal of Pharmaceutical Sciences, 14, 123 (2001),<br></p>Formula:C29H34ClNO4Color and Shape:NeatMolecular weight:496.038(S)-(-)-Felodipine
CAS:Controlled Product<p>Applications A dihydropyridine calcium channel blocker. Enantiomer S of Felodipine.<br>References Berntsson, P.B., et al.: Acta Pharm. Suec., 18, 221 (1981), Kratochwil, N., et al.: Biochem. Pharmacol., 64, 1355 (2002), O'Brien, S., et al.: J. Med. Chem., 48, 1287 (2005), Castilho, M., et al.: Bioorg. Med. Chem., 14, 516 (2006),<br></p>Formula:C18H19Cl2NO4Color and Shape:White To Off-WhiteMolecular weight:384.25Loratadine-d5
CAS:Controlled Product<p>Applications Loratadine-d5 is the labeled analogue of Loratadine (L469575), a nonsedating-type histamine H1-receptor.<br>References Bruttmann, G., et al.: J. Allergy Clin. Immunol., 83, 411 (1989); Haria, M., et al.: Drugs, 48, 617 (1994)<br></p>Formula:C22H18D5ClN2O2Color and Shape:NeatMolecular weight:387.91N-Nitro-1,2,3,4-tetradehydro Argatroban
CAS:Controlled Product<p>Applications N-Nitro-1,2,3,4-tetradehydro Argatroban is an intermediate in the preparation of Argatroban (A769000).<br></p>Formula:C23H31N7O7SColor and Shape:White To Off-WhiteMolecular weight:549.60Efavirenz 1-Desamine-1-oxy
Controlled Product<p>Applications Efavirenz 1-Desamine-1-oxy is an analog of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral.<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)<br></p>Formula:C14H8ClF3O3Color and Shape:NeatMolecular weight:316.663-Chloro-N-(3-hydroxyphenyl)propanamide
CAS:Controlled Product<p>Applications 3-chloro-N-(3-hydroxyphenyl)propanamide (cas# 50297-40-0) is a useful research chemical.<br></p>Formula:C9H10NO2ClColor and Shape:NeatMolecular weight:199.63rac Methotrimeprazine Sulfoxide
CAS:Controlled Product<p>Applications A metabolite of Methotrimeprazine (M260785).<br>References Haddad, P., et al.: Drugs, 62, 1649 (2002),<br></p>Formula:C19H24N2O2SColor and Shape:NeatMolecular weight:344.47(2R,5R)-1,6-Diphenylhexane-2,5-diamine Dihydrochloride
CAS:Controlled ProductFormula:C18H24N2·2ClHColor and Shape:NeatMolecular weight:341.3184Des(methylpiperazinyl-N-methyl) Imatinib Dimer Impurity
CAS:<p>Applications Des(methylpiperazinyl-N-methyl) Imatinib Dimer is an impurity of Imatinib (Gleevec) (G407000). Imatinib impurity E. It is a COVID19-related research product.<br></p>Formula:C52H48N12O2Color and Shape:White To Off-WhiteMolecular weight:873.02N-trifluoroacetyl Varenicline
CAS:Controlled Product<p>Applications 7,8,9,10-Tetrahydro-8-(trifluoroacetyl)-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine is used to prepare varenicline, which is a smoking cessation. It is a Varenicline protected impurity.<br>References Coe, J., et al.: J. Med. Chem., 48, 3474 (2005) ;<br></p>Formula:C15H12F3N3OColor and Shape:NeatMolecular weight:307.2705Desmethyl 7-Methoxycarbonyl Nintedanib (Nintedanib Impurity C)
Controlled Product<p>Applications Desmethyl 7-Methoxycarbonyl Nintedanib is an impurity of Intedanib (I666650), which is an indolinone derivative potently blocking VEGF-, PDGF-, and FGF-receptor kinases. it is an indolinone as triple angiokinase inhibitors and an antitumor agent.<br>References Sun, L., et al.: J. Med. Chem., 41, 2588 (1998); Xie, H., et al.: J. Med. Chem., 50, 4898 (2007); Hilberg, F., et al.: Cancer Res., 68, 4774 (2008); Roth, G., et al.: J. Med. Chem., 58, 1053 (2015)<br></p>Formula:C30H31N5O4Color and Shape:NeatMolecular weight:525.598N-Desethyl N-Methyl Rivastigmine
CAS:Controlled Product<p>Impurity Rivastigmine EP Impurity B<br>Applications N-Desethyl N-Methyl Rivastigmine (Rivastigmine EP Impurity B) is an impurity of Rivastigmine (R541000), a brain selective acetylcholinesterase inhibitor. Nootropic.<br>References Rosler, M., et al.: Brit. Med. J., 318, 633 (1999), Enz, A., et al.: Prog. Brain Res., 98, 431 (1993),<br></p>Formula:C13H20N2O2Color and Shape:NeatMolecular weight:236.32Nitroso Valsartan Methyl Ester
CAS:Controlled Product<p>Applications Nitroso Valsartan Methyl Ester is an impurity of Valsartan (V095750) a nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.<br>References Criscione, L., et al.: Brit. J. Pharmacol., 110, 761 (1993), Muller, P., et al.: Eur. J. Clin. Pharmacol., 47, 231 (1994)<br></p>Formula:C20H22N6O3Color and Shape:NeatMolecular weight:394.427Dipyridamole Mono-O-b-D-glucuronide
CAS:Controlled Product<p>Applications A metabolite of Dipyridamole.<br>References Zak, S.B., et al.: J. Pharmacol. Exp. Ther., 141, 392 (1963),<br></p>Formula:C30H48N8O10Color and Shape:NeatMolecular weight:680.755-[(2-Chloroethyl)(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic Acid Ethyl Ester
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Bendamustine (B132500) impurity.<br></p>Formula:C18H26ClN3O3Color and Shape:NeatMolecular weight:367.87Agomelatine-d3 (acetamide-2,2,2-d3)
CAS:Controlled Product<p>Applications Agomelatine-d3 (acetamide-2,2,2-d3) (CAS# 1079389-38-0) is a useful isotopically labeled research compound.<br></p>Formula:C15D3H14NO2Color and Shape:NeatMolecular weight:246.32Ofloxacin N-Oxide Hydrochloride
CAS:Controlled ProductFormula:C18H20FN3O5·ClHColor and Shape:Off-WhiteMolecular weight:413.83Carmustine-D8-Nitroso
Controlled ProductFormula:C5HD8Cl2N3O2Color and Shape:NeatMolecular weight:193.101Paliperidone N-Oxide
CAS:Controlled Product<p>Impurity Paliperidone USP Related Compound D<br>Applications One of the major degradation product of Risperidone in bulk drug and pharmaceutical dosage forms. Paliperidone USP Related Compound D.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Leysen, J., et al.: J. Pharmacol. Exp. Ther., 247, 661 (1988), Huang, M., et al.: Pharm. Drug Dispos., 54, 257 (1993), Smyth, W., et al.: Anal. Bioanal. Chem., 378, 1305 (2004),<br></p>Formula:C23H27FN4O4Color and Shape:NeatMolecular weight:442.484,6-Dichloro-5-nitro-2-(propylthio)pyrimidine
CAS:<p>Stability Unstable in DMSO Solution<br>Applications 4,6-Dichloro-5-nitro-2-(propylthio)pyrimidine is used as a reactnat in the synthesis of carba-nucleosides as potent antagonists of ADP purinergic receptor P2Y12 on human platelets.<br>References Ye, H., et al.: ChemMedChem, 3, 732 (2008);<br></p>Formula:C7H7Cl2N3O2SColor and Shape:NeatMolecular weight:268.1205-Acetyl-2-propyl-1H-Imidazole-4-carboxylic Acid Ethyl Ester
CAS:Controlled Product<p>Applications 5-Acetyl-2-propyl-1H-Imidazole-4-carboxylic Acid Ethyl Ester is used in the synthetic preparation of imidazole-5-carboxylic acids bearing alkyl, alkenyl, and hydroxyalkyl substituents at the 4-position and their related compounds.<br>References Yanagisawa, H., et al.: J. Med. Chem., 39, 323 (1996);<br></p>Formula:C11H16N2O3Color and Shape:NeatMolecular weight:224.264-[((2R)-Hydroxy-3-phthalimido)propylamine]phenyl-3-morpholinone
CAS:Controlled ProductFormula:C21H21N3O5Color and Shape:NeatMolecular weight:395.41Zuclopenthixol (1 mg/mL In Methanol)
CAS:Formula:C22H25ClN2OSColor and Shape:Single SolutionMolecular weight:400.96(R,R)-Dihydro Bupropion β-D-Glucuronide
<p>Applications (R,R)-Dihydro Bupropion β-D-Glucuronide is a glucuronide metabolite of the drug Bupropion (B689625, HCl salt). Bupropion is a selective inhibitor of dopamine uptake.<br>References Soroko, F., et al.: J. Pharm. Pharmacol., 29, 769 (1977), Tucker, W.E., J. Clin. Psychiatry, 44, 60 (1983), Hsyu, P-H., et al.: J. Clin. Pharmacol., 37, 737 (1997), West, R., et al.: Expert Opin. Pharmacother., 4, 533 (2003),<br></p>Formula:C19H28ClNO7Color and Shape:NeatMolecular weight:417.881,4,8,11-Tetraazacyclotetradecane
CAS:Controlled Product<p>Applications 1,4,8,11-Tetraazacyclotetradecane is macrocyclic ligand that is used as an antioxidant in rubber and has been shown to suppress oxidation catalyzed by some metal ions.<br>References Goh, S.H.: Poly, Degrad, Stab., 8, 123 (1984);<br></p>Formula:C10H24N4Color and Shape:NeatMolecular weight:200.32N-Nitroso Cyamemazine Impurity
Controlled ProductFormula:C18H18N4OSColor and Shape:NeatMolecular weight:338.427Safinamide-d4
CAS:Controlled Product<p>Applications Safinamide-d4 is a labelled analogue of Safinamide. Safinamide is a potent and selective MAO-B inhibitor, and is used as an add-on treatment to treat Parkinson’s disease.<br>References Finberg, J.P.M., et al.: Front Pharmacol., 7, 340-54 (2016);<br></p>Formula:C17D4H15FN2O2Color and Shape:NeatMolecular weight:306.368(S)-4-Phenyl-2-oxazolidinone
CAS:Controlled Product<p>Applications S)-4-Phenyl-2-oxazolidinone is an intermediate for the synthesis and development for cholesterol absorption inhibitor AZD4121.<br>References Soloshonok, V.A., et al.: Tetrahedron. Lett., 46, 1107 (2005); Luo, Y., et al.: Chinese. Chem. Lett., 17, 1551 (2006); Karlsson, S., et al.: Org. Process.Res. Develop., 16, 586 (2012);<br></p>Formula:C9H9NO2Color and Shape:NeatMolecular weight:163.1733Lacidipine Monomethyl Ester
CAS:Controlled Product<p>Applications Lacidipine Monomethyl Ester is an impurity of Lacidipine (L098000); a dihydropyridine calcium channel blocker. Antihypertensive.<br>References Mohan, Arivozhi., et al.: J. AOAC Int., 94(6), 1800-1806 (2011); Safar, M., et al.: Clin. Pharmacol. Ther., 46, 94 (1989); Kharat, V.R., et al.: J. Pharm. Biomed. Anal., 28, 789 (2002); McCormack, A.J., et al.: Drugs, 63, 2327 (2003)<br></p>Formula:C25H31NO6Color and Shape:NeatMolecular weight:441.52N-Desmethyl 4-Benzyloxy Toremifene Hydrochloride
CAS:Controlled Product<p>Applications Toremifene (T547500) derivative. A triphenylalkene derivative with anti-estrogenic, and anti-tumor properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Formula:C32H33Cl2NO2Color and Shape:NeatMolecular weight:534.52Fluphenazine β-D-Glucuronide
CAS:Controlled ProductFormula:C28H34F3N3O7SColor and Shape:NeatMolecular weight:613.65Ambroxol Cycloimine Impurity
CAS:Controlled Product<p>Applications 4-(6,8-Dibromo-3(4H)-quinazolinyl)-cyclohexanol is an impurity of Ambroxol (A575900), a bronchosecretolytic drug.<br>References Jauch, R., et al.: Arzneim-Forsch., 13, 474 (1963)<br></p>Formula:C14H16Br2N2OColor and Shape:NeatMolecular weight:388.09762-Aminobiphenyl
CAS:<p>Applications Has a mutagenic potency.<br>References Cash, G., et al.: Mutat. Res., 491, 31 (2001), Cash, G., et al.: Environ. Toxicol. Chem., 21, 2095 (2002), Glende, C., et al.: Mutat. Res., 515, 15 (2002),<br></p>Formula:C12H11NColor and Shape:NeatMolecular weight:169.22rac N-Methyl Epinephrine-d6 Hydrochloride (>90%)
CAS:Controlled Product<p>Applications Labelled N-Methylepinephrine, the N-methylated analogue of the sympathomimetic hormone Epinephrine (E588585). Recent studies suggest that N-Methylepinephrine may be synthesized from Epinephrine by phenylethanolamine N-methyltransferase present in the brain.<br>References Kajita, M. et al.: Nip. Iyo Masu Sup. Gak. Kon., 19, 107 (1994); Plummer, C.J. et al.: Eur. J. Med. Chem., 148, 481 (1988);<br></p>Formula:C10H9D6NO3•HClPurity:>90%Color and Shape:Off-White To Light GreenMolecular weight:203.273646N-Nitroso Amodiaquine-D10
Controlled ProductFormula:C20D10H11ClN4O2Color and Shape:NeatMolecular weight:394.921(7-(4-{4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butoxy}butoxy)-3,4-dihydroquinolin-2(1H)-one)
CAS:Controlled Product<p>Impurity Aripiprazole USP Related Compound H<br>Applications (7-(4-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}butoxy)-3,4-dihydroquinolin-2(1H)-one) is an impurity of Aripiprazole (A771000), a selective dopamine D2-receptor antagonist with dopamine autoreceptor agonist activity. Aripiprazole USP Related Compound H.<br>References Zeidan, T.A., et al.: Crystal. Growth. Design., 13, 2036 (2013); Nagasaka, Y., et al.: Biopharma. Drug. Dispo., 33, 304 (2012); Chen, X., et al.: J. Med. Chem., 55, 7141 (2012);<br></p>Formula:C27H35Cl2N3O3Color and Shape:WhiteMolecular weight:520.492-Thiopheneacetic Acid
CAS:Controlled ProductFormula:C6H6O2SColor and Shape:NeatMolecular weight:142.18N-[4-(Aminocarbonyl)-3-fluorophenyl]-2-methylalanine Methyl Ester
CAS:Controlled ProductFormula:C12H15FN2O3Color and Shape:NeatMolecular weight:254.26N-Ethyl-N-nitroso-2-propanamine (100 μg/mL in Methanol)
CAS:Controlled ProductFormula:C5H12N2OColor and Shape:ColourlessMolecular weight:116.16163-(Trifluoromethoxy)aniline
CAS:Controlled Product<p>Applications 3-(Trifluoromethoxy)aniline is reactant in the synthesis of pyrazolone-quinazolone hybrids as human hydroxyphenylpyruvate dioxygenase inhibitors which is a potential treatment for type I tyrosinemia.<br>References Xu, Y., et. al.: Bioorg. Med. Chem., 22, 5194 (2014)<br></p>Formula:C7H6F3NOColor and Shape:NeatMolecular weight:177.12(S)-(-)-Tolvaptan
CAS:Controlled Product<p>Applications An enantiomer of Tolvaptan. It is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).<br>References Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000), Udelson, J., et al.: Circulation, 104, 2417 (2001), Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005), Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006),<br></p>Formula:C26H25ClN2O3Color and Shape:Off White SolidMolecular weight:448.94(R)-(+)-Verapamil-d6 Hydrochloride
CAS:Controlled ProductFormula:C27H32D6N2O4•HClColor and Shape:Off-WhiteMolecular weight:460.653646Methyl 4-Hydroxy-2-methyl-2H-Thieno[2,3-e]-1,2-thiazine-3-carboxylic Acid 1,1-Dioxide Ester
CAS:Formula:C9H9NO5S2Color and Shape:NeatMolecular weight:275.30Hydroxy Varenicline N-Trifluoroacetic Acid Salt
CAS:Controlled Product<p>Applications Protected Varenicline metabolite.<br></p>Formula:C15H12F3N3O2Color and Shape:NeatMolecular weight:323.27(R)-Propranolol-d7 Hydrochloride
CAS:Controlled Product<p>Applications The labelled R-enantiomer of Propranolol (P831800). β−Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).<br>References Bond, et al.: Nature, 213, 721 (1967), Hansteen, V., et al.: Br. Med. J., 284, 155 (1982), Diamond, S., et al.: J. Clin. Pharmacol., 28, 193 (1988),<br></p>Formula:C16H15D7ClNO2Color and Shape:NeatMolecular weight:302.85a,a,a-Trifluorotoluene
CAS:Controlled Product<p>Applications α,α,α-Trifluorotoluene, is used as a specialty solvent in organic synthesis and an intermediate in the production of pesticides and pharmaceuticals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Skelly, P. D., et al.: Handbook for Critical Cleaning, 1, 191 (2011);<br></p>Formula:C7H5F3Color and Shape:ColourlessMolecular weight:146.11De(methypiperazinyl) Sildenafil Dimer Impurity
CAS:Controlled Product<p>Applications A related dimeric impurity of Sildenafil (S435000).<br></p>Formula:C34H38N8O6SColor and Shape:NeatMolecular weight:686.78(alphaS)-N,N,α-Trimethyl-3-(4-nitrophenoxy)benzenemethanamine
CAS:Controlled Product<p>Applications (αS)-N,N,α-Trimethyl-3-(4-nitrophenoxy)benzenemethanamine is an impurity of Rivastigmine Tartrate (R541000). Rivastigmine Tartrate is a brain selective acetylcholinesterase inhibitor.<br>References Rosler, M., et al.: Brit. Med. J., 318, 633 (1999); Enz, A., et al.: Prog. Brain Res., 98, 431 (1993)<br></p>Formula:C16H18N2O3Color and Shape:OrangeMolecular weight:286.33(S)-Rivastigmine
CAS:<p>Applications S-Rivastigmine is an isomer of Rivastigmine ( an acetylcholinesterase inhibitor used in the treatment of neurological disorders such as Alzheimer’s disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Howes, L et al.: Drug. Safe., 37, 391 (2014); Shahar, O. et al.: Nucl. Acids Res., 42, 5869 (2014);<br></p>Formula:C14H22N2O2Color and Shape:ColourlessMolecular weight:250.34Carisoprodol (1 mg/ml in Methanol)
CAS:Controlled ProductFormula:C12H24N2O4Color and Shape:ColourlessMolecular weight:260.331-Benzo[b]thien-4-yl-piperazine Monohydrochloride
CAS:Controlled Product<p>Applications 1-Benzo[b]thien-4-yl-piperazine is the starting material to prepare piperazine-substituted benzothiophenes useful in treatment and prevention of mental disorders including CNS disorders.<br>References Yamashita, H., et al.: PCT Int. Appl., WO 2006112464 A1 20061026 (2006)<br></p>Formula:C12H14N2S·ClHColor and Shape:NeatMolecular weight:254.78Lansoprazole Sulfone N-Oxide
CAS:Controlled Product<p>Applications An impurity of Lansoprazole.<br>References Barradell, L., et al.: Drugs, 44, 225 (1992), Aydogmus, Z., et al.: Acta Pharm. Sci., 48, 45 (2006), El-Sherif, Z., et al.: Chem. Pharm. Bull., 54, 814 (2006),<br></p>Formula:C16H14F3N3O4SColor and Shape:WhiteMolecular weight:401.363-Oxo-4-aza-5-androstene-17β-carboxylic Acid
CAS:Controlled ProductFormula:C19H27NO3Color and Shape:NeatMolecular weight:317.42(2R,6S)-rel-2,6-Dimethyl-4-(2-methyl-3-phenylpropyl)morpholine Hydrochloride
CAS:<p>Impurity Amorolfine EP Impurity C<br>Stability Hygroscopic<br>Applications (2R,6S)-rel-2,6-Dimethyl-4-(2-methyl-3-phenylpropyl)morpholine Hydrochloride (1:1), is used in the preparation of Amorolfine (A634170), a morpholine antifungal drug.<br>References Rotta, I., et al.: JAMA Dermatol., 149, 341 (2013); Espinel-Ingroff, A., et al.: Antimicrob. Agents Ch., 26, 5 (1984)<br></p>Formula:C16H26ClNOColor and Shape:NeatMolecular weight:283.84Repirinast (>80%)
CAS:Controlled ProductFormula:C20H21NO5Purity:>80%Color and Shape:NeatMolecular weight:355.38t-Butyl 4-Bromobutanoate
CAS:Controlled Product<p>Applications t-Butyl 4-bromobutanoate is a useful research chemical for organic synthesis and other chemical and pharmaceutical processes.<br>References Brudeli, B., et al.: Bioorg. Med. Chem., 18, 8600 (2010); Colak, S., et al.: Macromolecules, 41, 8436 (2008)<br></p>Formula:C8H15BrO2Color and Shape:NeatMolecular weight:223.111-Bromo-2-(bromomethyl)-4,5-dimethoxybenzene
CAS:Controlled Product<p>Applications 1-Bromo-2-(bromomethyl)-4,5-dimethoxybenzene is used in the synthesis of novel histone deacetylase 1 inhibitors (HDAC 1). Also used in the synthesis of antibacterial gemifloxacin derivatives.<br>References Sun, Q. et al.L: Bioorg. Med. Chem. Lett., 23, 3295 (2013); Feng, L. et al. Eur. J. Med. Chem., 55, 125 (2012);<br></p>Formula:C9H10Br2O2Color and Shape:NeatMolecular weight:309.984-(Methylamino)-3-nitrobenzoic Acid
CAS:Controlled Product<p>Applications 4-(Methylamino)-3-nitrobenzoic Acid (cas# 41263-74-5) is a compound useful in organic synthesis.<br></p>Formula:C8H8N2O4Color and Shape:NeatMolecular weight:196.163-(Dibenzo[b,e]oxepin-11(6H)yl)-N,N-dimethylpropan-1-amine Hydrochloride
CAS:Controlled Product<p>Applications 3-(Dibenzo[b,e]oxepin-11(6H)yl)-N,N-dimethylpropan-1-amine Hydrochloride is an impurity of Doxepin (D550000), which is used clinically to treat anxiety and depression and is classified as an antidepressant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ribbentrop, A., et al.: Arzneim.-Forsch., 15, 863 (1965); Hobbs, D.C., et al.: Biochem. Pharmacol., 18, 1941 (1969); Pinder, R.M., et al.: Drugs, 13, 161 (1977); Shrivastava, R.K., et al.: Clin. Ther., 7, 181 (1985)<br></p>Formula:C19H23NO•(HCl)Color and Shape:NeatMolecular weight:281.393646Ticagrelor Sulfone
CAS:Controlled Product<p>Applications Ticagrelor Sulfone is an impurity of ticagrelor (T437700). Ticagrelor, the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007),<br></p>Formula:C23H28F2N6O6SColor and Shape:NeatMolecular weight:554.57Elvitegravir-d6 (Major)
CAS:Controlled Product<p>Applications A novel labelled inhibitor of human immunodeficiency virus type 1 integrase.<br>References Chou, T., et al.: Eur. J. Biochem., 115, 207 (1981), Baba, M., et al.: Antimicrob. Agents Chemother., 31, 1613 (1987), Craigie, R., et al.: J. Biol. Chem., 276, 23213 (2001), Chen, X., et al.: J. Mol. Biol., 380, 504 (2008),<br></p>Formula:C23H17D6ClFNO5Color and Shape:NeatMolecular weight:453.914-Fluoro-2-(hydroxymethyl)phenol
CAS:Controlled Product<p>Applications 4-Fluoro-2-(hydroxymethyl)phenol can be used in preparation of naphthyridine derivatives as chemokine receptor antagonists useful in the treatment of pain.<br>References Wang, X., et al.: PCT Int. Appl., WO 2013010453 A1 20130124 (2013)<br></p>Formula:C7H7FO2Color and Shape:NeatMolecular weight:142.128N-Nitroso Amodiaquine
Controlled ProductFormula:C20H21ClN4O2Color and Shape:NeatMolecular weight:384.859rac-7-Oxo-pramipexole Dihydrochloride
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications An impurity of Pramipexole production.<br>References Jancic, B., et al.: Acta Chim. Slov., 54, 49 (2007),<br></p>Formula:C10H17Cl2N3OSColor and Shape:NeatMolecular weight:225.31 + 2(36.46)3-Amino-4-(2,4,5-trifluorophenyl)butanyl Sitagliptin
CAS:Controlled Product<p>Applications 3-Amino-4-(2,4,5-trifluorophenyl)butanyl Sitagliptin is an impurity of Sitagliptin (S490990). Sitagliptin is a trizolopyrazine dipeptidyl peptidase IV inhibitor. It has recently been approved for the therapy of type II diabetes.<br>References Kim, D., et al.: J. Med. Chem., 48, 141 (2005), Ahren, B., et al.: Eur. J. Pharmacol., 521 164 (2005), Bergman, A., et al: Clin. Ther., 28, 55 (2006)<br></p>Formula:C26H23F9N6O2Color and Shape:NeatMolecular weight:622.48543-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine Hydrochloride
CAS:<p>Applications Sitagliptin intermediate.<br>References Mohri, K., et al.: Chem. Pharm. Bull., 30, 3097 (1982), Sarges, R., et al.: J. Med. Chem., 33, 2240 (1990), Cameron, M., et al.: J. Pharm. Biomed. Anal., 28, 137 (2002),<br></p>Formula:C6H7F3N4·ClHColor and Shape:WhiteMolecular weight:228.601-Ethyl-2-[(methylamino)methyl]pyrrolidine
CAS:<p>Applications 1-Ethyl-2-[(methylamino)methyl]pyrrolidine is an intermediate of the neuroleptic drug Amisulpride (A633250).<br>References Tahara, T., et al.: Chem. Pharmaceut. Bull., 38, 1609 (1990);<br></p>Formula:C8H18N2Color and Shape:Colourless OilyMolecular weight:142.242(R)-Levetiracetam
CAS:Controlled Product<p>Impurity Levetiracetam EP Impurity D<br>Applications (R)-Levetiracetam [REV] (Levetiracetam EP Impurity D), is the enantiomer to Levetiracetam [LEV] (L331500), the antiepileptic drug that is highly enantioselective. It is apparent that [LEV] is more potent than [REV] in terms of antiepileptic potency.<br>References Isoherranen, N. et al.: Epilepsia, 42, 825 (2001); Isoherranen, N. et al.: Epilepsia, 44, 1280 (2003);<br></p>Formula:C8H14N2O2Color and Shape:NeatMolecular weight:170.21
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