Quinazoline and Quinoline Derivatives
Quinazolines and quinolines are nitrogen-containing heterocyclic compounds with aromatic structures that play a key role in the synthesis of drugs with anticancer, antimicrobial, and anti-inflammatory activity. Their derivatives feature structural modifications that optimise bioavailability and selectivity, enabling the development of new active ingredients for various therapeutic applications. These compounds are used in the manufacture of APIs for the treatment of cancer, infections, neurodegenerative diseases, and cardiovascular conditions. Additionally, quinazoline and quinoline derivatives are essential in the research of enzyme inhibitors and the design of innovative bioactive molecules.
At CymitQuimica, we offer high-purity quinazoline and quinoline derivatives for applications in chemical synthesis, pharmaceutical development, and biotechnology.
Found 65941 products of "Quinazoline and Quinoline Derivatives"
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Avanafil
CAS:Controlled Product<p>Applications A phosphodiesterase (PDE5) inhibitor, used to treat erectile dysfunction.<br>References Hatzimouratidis, K., et al.: Drugs, 68, 231 (2008);<br></p>Formula:C23H26ClN7O3Color and Shape:WhiteMolecular weight:483.95Roxatidine Acetate Hydrochloride
CAS:Controlled Product<p>Applications A histamine H2-receptor antagonist. It is used to inhibit gastric acid secretion; an antiulcer agent.<br>References Tarutani, M. et al.: Arzneim.-Forsch., 35, 703 (1985); Yagita, M. et al.: Therap. Res., 7, 96 (1987); Asai, M. et al.: Gek. Yak., 50, 922 (2008);<br></p>Formula:C19H28N2O4·ClHColor and Shape:NeatMolecular weight:384.90(2-Amino-1H-benzimidazol-6-yl)(4-fluorophenyl)-methanone
CAS:Controlled Product<p>Applications The hydrolyzed form of Flubendazole (F418500), which is an anthelmintic.<br>References Thienpont, D., et al.: Arzneimittel-Forsch., 28, 605 (1978), Vanparijs, O., et al.: Vet. Parasitol, 5, 237 (1979),<br></p>Formula:C14H10FN3OColor and Shape:Off-WhiteMolecular weight:255.25(2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifl
CAS:Controlled Product<p>Applications Sitagliptin intermediate. A dipeptidyl peptidase-4 inhibitor and an anti-hypertensive agent for the treatment of diabetes and hypertension.<br>References Kim, D., et al.: J. Med. Chem., 48, 141 (2005), Ahren, B., et al.: Eur. J. Pharmacol., 521 164 (2005), Bergman, A., et al: Clin. Ther., 28, 55 (2006)<br></p>Formula:C16H13F6N5OColor and Shape:WhiteMolecular weight:405.30Etoricoxib-d3
CAS:Controlled Product<p>Applications A specific inhibitor of COX-2 .<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References McGeer, P.L., et al.: Exp. Gerontol., 37, 925 (2002), Chenevard, R., et al.: Circulation, 107, 405 (2003)<br></p>Formula:C182H3H12ClN2O2SColor and Shape:NeatMolecular weight:361.865-Nitro-2-furaldehyde
CAS:Controlled Product<p>Applications 5-Nitro-2-furaldehyde is an intermediate in the synthesis of Nifurtimox (N458800), an antiprotozoal. Showing anti-Trypanosoma cruzi activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sastry, C.S.P., et. al.: Talanta, 41, 1957 (1994)<br></p>Formula:C5H3NO4Color and Shape:NeatMolecular weight:141.08Flibanserin N-Oxide
CAS:Controlled ProductFormula:C20H21F3N4O2Color and Shape:NeatMolecular weight:406.401Loratadine Epoxide
CAS:Controlled ProductFormula:C22H23ClN2O3Color and Shape:White To Off-WhiteMolecular weight:398.88N-Desmethyl Deferiprone
CAS:Controlled ProductFormula:C6H7NO2Color and Shape:NeatMolecular weight:125.133-(1-Benzyl-4-hydroxypiperidin-4-yl)-2-chloroquinoline
CAS:Purity:98%Molecular weight:352.8599853515625(R)-Rabeprazole Sodium Salt
CAS:Controlled Product<p>Applications A partially reversible gastric proton pump inhibitor.<br>References Moda, T., et al.: Lett. Drug Des. Discov., 4, 502 (2007), Belaz, K., et al.: J. Pharm. Biomed. Anal., 47, 81 (2008),<br></p>Formula:C18H20N3NaO3SColor and Shape:NeatMolecular weight:381.42Stiripentol-d9
CAS:Controlled Product<p>Applications An labelled epilepsy drug. It has been used as co-therapy for treatment of epilepsy. It inhibits the enzymes responsible for metabolism of other anti-convulsant agents.<br>References Laurie, D., et al.: J. Neurosci., 12, 4151 (1992), Smith, A., et al.: J. Pharmacol. Exp. Therap., 311, 601 (2004), Trojnar, M., et al.: Pharm. Rep., 57, 154 (2005), Drafts, B., et al.: J. Pharm. Exp. Ther., 318, 1094 (2006), Picton, A., et al.: Brain Res., 1165, 40 (2007),<br></p>Formula:C14H9D9O3Color and Shape:White SolidMolecular weight:243.35(1-(4-Methylphenyl)-3-(4-(methylthio)phenyl)-1H-pyrazol-4-yl)methanol
CAS:Molecular weight:310.4200134277344Palbociclib-d4
CAS:Controlled Product<p>Applications Palbociclib-d4 is an isotope labelled compound of Palbociclib (P139900). Palbociclib (P139900) is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.<br>References Finn, R., et al.: Breast Cancer Res., 11, 5 (2009)<br></p>Formula:C24H25D4N7O2Color and Shape:Light YellowMolecular weight:451.56Aripiprazole N4-Oxide
CAS:Controlled Product<p>Impurity Aripiprazole Impurity 9<br>Applications Aripiprazole N4-Oxide is a metabolite of anti-psychotic drug, Aripiprazole (A771000). Aripiprazole Impurity 9<br>References Rowley, M., et al.: J. Med. Chem., 44, 477 ( 2001), Ozdemir, V., et al.: Curr. Opin. Invest Drugs 2002, 3, 113,,,4) Jordan, S; European Journal Pharmacol 2002, 441, 137<br></p>Formula:C23H27Cl2N3O3Color and Shape:NeatMolecular weight:464.385-p-Tolyl-1H-pyrazole-3-carboxylic acid methyl ester
CAS:Purity:95.0%Molecular weight:216.240005493164064-phenyl-3-(2-thienyl)-1,2,4-triazoline-5-thione 98%
CAS:Purity:98.0%Molecular weight:259.3500061035156Valsartan
CAS:<p>Stability Hygroscopic<br>Applications A nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.<br>References Criscione, L., et al.: Brit. J. Pharmacol., 110, 761 (1993), Muller, P., et al.: Eur. J. Clin. Pharmacol., 47, 231 (1994)<br></p>Formula:C24H29N5O3Color and Shape:NeatMolecular weight:435.52ETHYL 2-(3-METHYL-4-OXO-3,4-DIHYDROPHTHALAZIN-1-YL)ACETATE
CAS:Purity:95.0%Molecular weight:246.26600646972656Cimetidine Sulfoxide
CAS:Controlled Product<p>Impurity Cimetidine EP Impurity E<br>Applications Cimetidine Sulfoxide (Cimetidine EP Impurity E) is a metabolite of the H2-receptor antagonist Cimetidine (C441650). Cimetidine Sulfoxide is detected in the blood and urine of patients with kidney diseases.<br>References Luksa, J. et al.: J. Chrom. B Biomed. Appl., 667, 321 (1995); Lee, R.M. et al.: J. Chrom. Biomed. Appl., 146, 354 (1978);<br></p>Formula:C10H16N6OSColor and Shape:NeatMolecular weight:268.34rac Efavirenz-d5 (major)
CAS:Controlled Product<p>Applications Labelled Efavirenz (E42500). A nonnucleoside HIV-1 reverse transcriptase inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995),<br></p>Formula:C14H4D5ClF3NO2Color and Shape:White To BeigeMolecular weight:320.716-Methyl Risperidone
CAS:Controlled Product<p>Impurity Risperidone EP Impurity E<br>Applications 6-Methyl Risperidone (Risperidone EP Impurity E) is a Risperidone (R525000) impurity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Formula:C24H29FN4O2Color and Shape:Light YellowMolecular weight:424.518-Hydroxy Mirtazapine β-D-Glucuronide 90%
CAS:<p>Applications A metabolite of Mirtazapine (M365000). This compounds contains some of the alpha anomer.<br>References Sandker, G., et al.: Xenobiotica, 24, 143 (1994), Dahl, M., et al.: Clin. Drug Invest., 13, 37 (1997),<br></p>Formula:C23H27N3O7Purity:90%Color and Shape:NeatMolecular weight:457.48TEMPO
CAS:Controlled Product<p>Applications TEMPO is a stable radical prepared through the oxidation of 2,2,6,6-tetramethylpiperidine. TEMPO has a wide range of applications including use as a free radical scavenger, a reagent in organic synthesis and as a structural probe in electron spin resonance spectroscopy. TEMPO can also be used as a mediator in free radical polymerization.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Seaton, T.A. et al.: Brain Res., 777, 110 (1997); Tanielyan, S.K. et al.: Top. Catal., 55, 556 (2012); Wolinska-Grabczyk, A. et al.: Polymer, 46, 2461 (2005); Keoshkerian, B. et al.: Polym. Prep., 35, 675 (1994);<br></p>Formula:C9H18NOColor and Shape:NeatMolecular weight:156.25Valsartan N1-Glucuronide
Controlled ProductFormula:C30H37N5O9Color and Shape:NeatMolecular weight:611.6433-(3-Methoxyphenyl)-1-(p-tolyl)-1H-pyrazole-4-carboxylic acid
CAS:Purity:98%Molecular weight:308.33700561523441,5-Dimethyl-1H-pyrazol-4-amine hydrochloride
CAS:Formula:C5H10ClN3Purity:95%Color and Shape:SolidMolecular weight:147.61Hydroxy Dehydro Nifedipine Lactone
CAS:Controlled ProductFormula:C16H12N2O6Color and Shape:NeatMolecular weight:328.28(R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic Acid
CAS:Controlled Product<p>Applications (R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic Acid has been used as a reactant for the preparation of dipeptidyl peptidase-4 (DPP4) inhibitors for the treatment of type 2 diabetes, such as sitagliptin.<br>References Kim, H.J., et. al.: Bioorg. Med. Chem. Lett., 22, 5545 (2012)<br></p>Formula:C15H18F3NO4Color and Shape:NeatMolecular weight:333.30Dimethylaminomethylfurylmethylthioethyl Ranitidine
CAS:Controlled Product<p>Impurity Ranitidine EP impurity A<br>Applications Dimethylaminomethylfurylmethylthioethyl Ranitidine (Ranitidine EP impurity A) is a Ranitidine (R120000) impurity.<br>References Evans, M., et al.: J. Pharm. Biomed. Anal., 7, 1 (1989), Mellors, J., et al.: Anal. Chem., 76, 5441 (2004),<br></p>Formula:C22H35N5O4S2Color and Shape:NeatMolecular weight:497.676-Hydroxy-2-[6-[N-(tert-butoxycarbonyl)-N-methylamino]pyridin-3-yl]quinoline
CAS:Purity:98%Molecular weight:351.406005859375(R)-Sitagliptin rac-Fumarate Adduct (mixture of diastereomers)
CAS:<p>Impurity Sitagliptin Tablets EP Impurity FP-A<br>Applications Sitagliptin Fumarate Adduct is an impurity of Sitagliptin (S491000), a trizolopyrazine dipeptidyl peptidase IV inhibitor. Sitagliptin has recently been approved for the therapy of type II diabetes.<br>References Kim, D., et al.: J. Med. Chem. 48, 141 (2005), Ahren, B., et al.: Eur. J. Pharmacol. 521 164 (2005), Bergman, A., et al: Clin. Ther. 28, 55 (2006)<br></p>Formula:C20H19F6N5O5Color and Shape:White To Off-WhiteMolecular weight:523.385-Methyl-2-phenoxypyridine
CAS:Controlled ProductFormula:C12H11NOColor and Shape:NeatMolecular weight:185.234-(4-Phenylbutoxy)benzoic Acid
CAS:Controlled Product<p>Applications 4-(4-PHENYLBUTOXY)BENZOIC ACID (cas# 30131-16-9) is a useful research chemical.<br></p>Formula:C17H18O3Color and Shape:NeatMolecular weight:270.323-[4-(2,4-Bis-trifluoromethyl-phenyl)-pyridin-2-yl]-4-(2,2-dimethyl-butyryl)-4H-[1,2,4]oxadiazol-5-one
Purity:95.0%Molecular weight:473.375Piperazin-1-yl(quinoxalin-6-yl)methanone hydrochloride
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:278.739990234375Ramelteon Metabolite M-II-d3 (mixture of R and S at the hydroxy position)
CAS:Controlled Product<p>Applications The major metabolite of Ramelteon in serum (M-II).<br>References Karim, A., et al.: J. Clin. Pharmacol., 44, 1210 (2004), Prescott, E., et al.: Drug Metab. Rev., 36, 203 (2004), Kato, K., et al.: Neuropharmacology, 48, 301 (2005), Karim, A., et al.: J. Clin. Pharmacol., 46, 140 (2006),<br></p>Formula:C16D3H18NO3Color and Shape:NeatMolecular weight:278.362-(((5-((Dimethylamino)methyl)furan-2-yl)methyl)thio)ethanamine Fumarate (2:1)
CAS:Controlled Product<p>Impurity USP Ranitidine Related Compound A<br>Applications 2-(((5-((Dimethylamino)methyl)furan-2-yl)methyl)thio)ethanamine (E)-2-Butenedioate is an impurity of Ranitidine (R120000), a histamine H2-receptor antagonist which inhibits gastric acid secretion. Antiulcerative.<br>References Bradshaw, J., et al.: Brit. J. Pharmacol., 66, 464 (1979), Berstad, A., et al.: Scand. J. Gastroenterol, 15, 637 (1980), Hohnjec, M., et al.: Anal. Profiles Drug Subs., 15, 533 (1986),<br></p>Formula:C10H18N2OS·C4H4O4Color and Shape:WhiteMolecular weight:544.72766-Chloro-2-cyclopropyl-4-(trifluoromethyl)-quinoline
CAS:Controlled Product<p>Impurity Efavirenz USP Related Compound C/ Efavirenz Quinoline Impurity<br>Applications 6-Chloro-2-cyclopropyl-4-(trifluoromethyl)-quinoline is an impurity of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor and antiviral agent.<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995), Jiang, B., et al.: Euro. J. Org. Chem., 16, 2693 (2008); Ribeiro, J.A., et al.: J. Pharma. Biomed. Anal., 43, 298 (2007);<br></p>Formula:C13H9ClF3NColor and Shape:NeatMolecular weight:271.67Clozapine-d8
CAS:Controlled Product<p>Applications An antipsychotic.A representative lot was 92% d8, 8% d7.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Stille, et al: Farnaco, Ed. Prat., 26, 603 (1971), Hane, J.M., et al.: Psychopharmacol. Bull., 24, 62 (1988), Meltzer, H.Y.: J. Clin. Psychiatry, 55, Suppl. B, 47 (1994)<br></p>Formula:C18H11D8ClN4Color and Shape:Light Yellow To YellowMolecular weight:334.87Paliperidone Z-Oxime
CAS:Controlled Product<p>Applications Paliperidone Z-oxime is an impurity of Paliperidone (P141000), a known orally active antipsychotic agent.<br>References Rao, J., et al.: Pharmacia Lettre, 3, 240 (2011);<br></p>Formula:C23H28F2N4O3Color and Shape:NeatMolecular weight:446.495,5',5''-(1,3,5-Triazine-2,4,6-triyl)tris(pyridin-2-amine)
CAS:Purity:95%Color and Shape:SolidMolecular weight:357.3810119628906Alogliptin
CAS:Controlled Product<p>Applications Alogliptin is an oral antihyperglycemic agent that is a selective inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4).Antidiabetic agent.<br>References Lynn, F., et al.: Diabetes, 50, 1004 (2001); Trumper, A., et al.: J. Endocrinol., 174, 233 (2002); Vollmer, K., et al.: J. Clin. Endocrinol. Metab., 94, 1379 (2009);<br></p>Formula:C18H21N5O2Color and Shape:WhiteMolecular weight:339.39Cimetidine Amide Dihydrochloride
CAS:Controlled Product<p>Impurity Cimetidine EP Impurity C<br>Applications Cimetidine Amide Dihydrochloride (Cimetidine EP Impurity C) is an impurity of Cimetidine.<br>References Durant, G.J., et al.: J. Med. Chem., 18, 830 (1975), Pounder, R.E., et al.: Br. Med. J., 2, 307 (1975),<br></p>Formula:C10H18N6OS·2ClHColor and Shape:White To Off-WhiteMolecular weight:343.28
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