Quinazoline and Quinoline Derivatives
Quinazolines and quinolines are nitrogen-containing heterocyclic compounds with aromatic structures that play a key role in the synthesis of drugs with anticancer, antimicrobial, and anti-inflammatory activity. Their derivatives feature structural modifications that optimise bioavailability and selectivity, enabling the development of new active ingredients for various therapeutic applications. These compounds are used in the manufacture of APIs for the treatment of cancer, infections, neurodegenerative diseases, and cardiovascular conditions. Additionally, quinazoline and quinoline derivatives are essential in the research of enzyme inhibitors and the design of innovative bioactive molecules.
At CymitQuimica, we offer high-purity quinazoline and quinoline derivatives for applications in chemical synthesis, pharmaceutical development, and biotechnology.
Found 65615 products of "Quinazoline and Quinoline Derivatives"
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3-Bromo-5-(3-cyclopropyl-[1,2,4]oxadiazol-5-yl)-pyridine
Purity:95.0%Molecular weight:266.09799194335942-((1-(4-Phenoxyphenoxy)propan-2-yl)oxy)pyridine
CAS:Purity:99.0%Color and Shape:SolidMolecular weight:321.3760070800781(AlphaR)-α-Methyl-N-[3-(3-methylphenyl)propyl]-1-naphthalenemethanamine Hydrochloride
CAS:Controlled Product<p>Applications (αR)-α-Methyl-N-[3-(3-methylphenyl)propyl]-1-naphthalenemethanamine, is an impurity of Cinacalcet (C441800), which is a drug that acts as a calcimimetic, and is used to treat secondary hyperparathyroidism (elevated parathyroid hormone levels).<br>References Franceschini N., et al.: Expert Opin. Invest. Drugs, 12, 1413 (2003), Block, G.A., et al.: N. Engl. J. Med. 350, 1516 (2004),<br></p>Formula:C22H25NColor and Shape:NeatMolecular weight:303.44Fluazuron
CAS:Controlled Product<p>Applications A pesticide, like other BPUs it interferes with chitin synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yamada, R., et al.: Biosci., Biotechnol., Biochem., 70, 54 (2006), Kryger, U., et al.: Vet. Parasitol., 143, 380 (2007), Arakawa, T., et al.: App. Entomol. Zool., 43, 167 (2008),<br></p>Formula:C20H10Cl2F5N3O3Color and Shape:White To Off-WhiteMolecular weight:506.21Reserpine
CAS:Controlled Product<p>Applications An indole alkaloid found in Rauwolfia serpentina. Inhibits vesicular uptake of catecholamines and serotonin. Reserpine is reasonably anticipated to be a human carcinogen. Antihypertensive.<br>References Muller, J.M., et al.: Experientia, 8, 338 (1952), Schirmer, R.E., et al.: Anal. Profiles Drug Subs., 4, 384 (1975), Diener, R.M., et al.: Toxicol. Pathol., 8, 1 (1980),<br></p>Formula:C33H40N2O9Color and Shape:Off-WhiteMolecular weight:608.68Mosapride N-Oxide
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications A metabolite of Mosapride (M731000).<br>References Chen, H., et al.: J. Pharm. Biomed. Anal., 40, 142 (2006), Pedraglio, S., et al.: J. Pharm. Biomed. Anal., 44, 665 (2007), Christopher, L., et al.: Drug Metab. Dispos., 36, 1341 (2008), Curran, M., et al.: Drugs, 68, 981 (2008),<br></p>Formula:C21H25ClFN3O4Color and Shape:NeatMolecular weight:437.89N-Desmethyl Imatinib Dimesylate
Controlled Product<p>Stability Hygroscopic<br>Applications N-Desmethyl Imatinib Dimesylate is a by-product of the synthesis of N-Desmethyl Imatinib Mesylate (D292345), a metabolite of Gleevec, a tyrosine kinase inhibitor which is highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It is a COVID19-related research product.<br>References Schindler, T., et al.: Science, 289, 1938 (2000); Drucker, B.J., et al.: N. Engl. J. Med., 344, 1031 (2001)<br></p>Formula:C28H29N7O•C3H8O2SColor and Shape:NeatMolecular weight:479.58210816Captopril
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Orally active angiotensin-converting enzyme (ACE) inhibitor. Neuroprotective & Neuroresearch Product.<br>References Rubin, B., et al.: Eur. J Pharmacol., 51, 377 (1978),<br></p>Formula:C9H15NO3SColor and Shape:NeatMolecular weight:217.29N-Demethyl Ivabradine Hydrochloride
CAS:Controlled ProductFormula:C26H34N2O5·ClHColor and Shape:NeatMolecular weight:491.02rac-Monepantel Sulfone
CAS:Controlled Product<p>Stability Light Sensitive<br>Applications rac-Monepantel Sulfone is a derivative of Monepantel (M515800), a recently discovered anthelmitic used in the treatment of parasitic nematodes via stun or kill without damaging the host entity.<br>References Baur, R. et al.: Mol. Pharm., 87, 96 (2015); Stuchlikova, L. et al.: Chemico. Biol. Interact., 227, 63 (2015);<br></p>Formula:C20H13F6N3O4SColor and Shape:NeatMolecular weight:505.39endo-9-Methyl-9-azabicyclo[3.3.1]nonan-3-amine
CAS:Controlled Product<p>Impurity Granisetron EP Impurity E<br>Applications Granisetron impurity E. An intermediate of Granisetron.<br>References McCallum, R., et al.: Drugs, 36, 652 (1988), Kaumann, A., et al.: Br. J. Pharmacol., 100, 879 (1990), Mohr, K., et al.: Pharmacol. Toxicol., 70, 198 (1992), Van, W.A., et al.: Nucl. Med. Biol., 21, 41 (1994), Mize, A., et al.: Brain Res., 836, 229 (1999),<br></p>Formula:C9H18N2Color and Shape:NeatMolecular weight:154.2532-De(dimethylamino)-2-vinyl Dimetindene
CAS:<p>Applications Dimetindene derivative, a histaminic H1 receptor antagonist.<br></p>Formula:C18H17NColor and Shape:Light YellowMolecular weight:247.3343Dronedarone Hydrochloride
CAS:<p>Stability Hygroscopic<br>Applications A drug used for the treatment of atrial fibrillation and atrial flutter in patients who have suffered cardiac arrhythmias.<br>References Singh, B., et al.: J. Cardiovas. Pharmacol., 52, 300 (2008), Hoy, S., et al.: Drugs, 69, 1647 (2009), Hohnloser, S., et al.: New Eng. J. Med., 360, 668 (2009),<br></p>Formula:C31H44N2O5S·ClHColor and Shape:NeatMolecular weight:593.22Desmethyl Amisulpride Hydrobromide
CAS:Controlled ProductFormula:C16H26BrN3O4SColor and Shape:NeatMolecular weight:436.36Rivastigmine N-Oxide (Technical Grade)
CAS:Controlled Product<p>Applications Rivastigmine N-Oxide is an impurity of Rivastigmine (R541000, Tartrate Salt) which is a brain selective acetylcholinesterase inhibitor.<br>References Rosler, M., et al.: Brit. Med. J., 318, 633 (1999), Enz, A., et al.: Prog. Brain Res., 98, 431 (1993)<br></p>Formula:C14H22N2O3Color and Shape:Light Yellow LiquidMolecular weight:266.343-Nitrophthalic Acid
CAS:<p>Applications 3-Nitrophthalic Acid is a useful chemical in organic synthesis. It is also an impurity of Apremilast.<br>References Zhang, Xu, et al.: Chinese J. of Structural Chem., 35(5), 765-773 (2016);Cheng, Xiao-Yue, et al.: Inorg. Chem. Comm., 86, 192-199 (2017)<br></p>Formula:C8H5NO6Color and Shape:BeigeMolecular weight:211.13Sitagliptin Triazecine Analog
CAS:Controlled Product<p>Impurity Sitagliptin Tablets EP Impurity FP-B<br>Applications Sitagliptin Triazecine Analog is related to the family of Sitagliptin compounds which has recently been approved for the therapy of type II diabetes.<br>References Ahren, B., et al.: Eur. J. Pharmacol. 521 164 (2005), Bergman, A., et al: Clin. Ther. 28, 55 (2006)<br></p>Formula:C16H13F6N5O2Color and Shape:NeatMolecular weight:421.30N-Nitrosodiethylamine (1 mg/mL in Methanol)
CAS:Formula:C4H10N2OColor and Shape:Single SolutionMolecular weight:102.14Acrivastine
CAS:Controlled Product<p>Applications Acrivastine is an allergy medication that is histamine H2 antagonists.<br>References Manna, V.K., et al.: J. Int. Med. Res., 20, 106 (1992);<br></p>Formula:C22H24N2O2Color and Shape:Off White PowderMolecular weight:348.44Robenidine-d8
CAS:Controlled Product<p>Applications Labelled Robenidine (R639000). Robenidine is used as a coccidiostat.<br>References Kantor, et al.: Science, 373, 168 (1970), Wong, et al.: Biochem. Biophys. Res. Commun., 46, 621 (1972)<br></p>Formula:C15H5D8Cl2N5Color and Shape:YellowMolecular weight:342.25Benzarone
CAS:Controlled Product<p>Applications Benzarone is an EYA (Eyes Absents), multifunctional protein involved in organogenesis, inhibitor which makes it a potent anticancer agent. EYA’s are over expressed in ovarian and breast cancers. As well it is involved in the synthesis of Human Uric Acid Transporter 1 inhibitors which may be used to treat kidney diseases.<br>References Tadjuidje, E. et al.: PLoS One., 7, 34806 (2012); M, Wempe, et al.: J. Med. Chem., 54, 2701 (2011);<br></p>Formula:C17H14O3Color and Shape:NeatMolecular weight:266.29Riociguat
CAS:Controlled Product<p>Applications Riociguat is used in the treatment for pulmonary hypertension.<br>References Frey, R. et al.: J. Clin. Pharmacol., 51, 1051 (2011);<br></p>Formula:C20H19FN8O2Color and Shape:NeatMolecular weight:422.4157N-Boc-Sitagliptin
CAS:Controlled Product<p>Applications N-Boc-Sitagliptin is the N-Boc protected derivative of Sitagliptin (S490990), a dipeptidyl peptidase-4 inhibitor that is used for glycemic control for patients with type 2 diabetes.<br>References Aschner, P., et al.: Diabetes Care, 29, 2632 (2006); Charbonnel, B., et al.: Diabetes Care, 29, 2638 (2006)<br></p>Formula:C21H23F6N5O3Color and Shape:NeatMolecular weight:507.43Quizalofop
CAS:<p> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Formula:C17H13ClN2O4Color and Shape:Off-White To Light YellowMolecular weight:344.75(2R,3S)-rel-Nadolol-N-[(2R,3S)-rel-Nadolol-de(N-tert-butyl)]
CAS:<p>Applications (2R,3S)-rel-Nadolol-N-[(2R,3S)-rel-Nadolol-de(N-tert-butyl)]is an impurity of Nadolol (N201050), a β-Adrenergic blocker. Antihypertensive; antianginal.<br>References Dreyfuss, J., et al.: J. Clin. Pharmacol., 17, 300 (1977); Sibley, P.L., et al.: Toxicol. Appl. Pharmacol., 44, 379 (1978); Slusarek, L., et al.: Anal. Profiles Drug Subs., 9, 455 (1980)<br></p>Formula:C30H43NO8Color and Shape:White SolidMolecular weight:545.66(R)-1-(2-Bromopyridin-4-yl)ethanamine dihydrochloride
CAS:Purity:97.0%Molecular weight:273.9800109863281N-Phenoxycarbonylparoxetine
CAS:Controlled Product<p>Applications N-Phenoxycarbonylparoxetine is an impurity of Paroxetine (P205750), a selective serotonin reuptake inhibitor. Used as an antidepressant.<br>References Lassen, J.B.: Eur. J. Pharmacol., 47, 351 (1978), Lund, J., et al.: Acta Pharmacol. Toxicol., 51, 351, (1982),<br></p>Formula:C26H24FNO5Color and Shape:NeatMolecular weight:449.47aR-Brivaracetam
CAS:Controlled Product<p>Applications αR-Brivaracetam acts as a reagent for the preparation of 2-Oxo-1-pyrrolidine derivatives and their anticonvulsants activity. Also, is an impurity of Brivaracetam (B677645), a 4-n-propyl analog of levetiracetam (L331500), and a racetam derivative with anticonvulsant properties.<br>References Differding, E., et al.: PCT Int. Appl. (2001), WO 2001062726 A2 20010830; Rosenstiel, P., et al.:Neurotherapeutics, 4 (1), 84 (2007); Malawska, B., et al.:, Curr. Opin. Investig. Drugs, 6(7), 740 (2005);<br></p>Formula:C11H20N2O2Color and Shape:NeatMolecular weight:212.29(5S,6R)-6-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-5-(4-fluorophenyl)-3-morpholinone [Aprepit
CAS:Controlled Product<p>Applications Aprepitant-M3 is an active metabolite of Aprepitant.<br>References Ballard, T., et al.: Eur. J. Pharmacol., 412, 255 (2001), Campos, D., et al.: J. Clin. Oncol., 19, 1759 (2001), Severini, C., et al.: Pharmacol. Rev., 54, 285 (2002),<br></p>Formula:C20H16F7NO3Color and Shape:NeatMolecular weight:451.33Dolutegravir intermediate-1
CAS:Controlled ProductFormula:C13H17NO8Color and Shape:Light YellowMolecular weight:315.282-(2-Aminoethoxy)anisole
CAS:Controlled Product<p>Applications 2-(2-Aminoethoxy)anisole is used as an additive to vinylphosphonic acid esters and acrylonitrile forming compounds displaying hypotensive activity. An impurity from the process of Carvedilol (C184625)<br>References Reznik, V. et al.: Russ. Chem. Bull., 48, 979, (1999); Hirohashi, M., et al.: Arzneim.-Forsch., 40, 735 (1990), Packer, M., et al.: N. Engl. J. Med., 334, 1349 (1996),<br></p>Formula:C9H13NO2Color and Shape:NeatMolecular weight:167.204'-Ethoxyacetophenone
CAS:<p>Applications 4'-Ethoxyacetophenone, is an acetophenone derivative that can be used as an antibacterial agent. It is a reagent for plymerization. It can also be used as a flavoring agent in fabricating cigarettes with flavored filter tips.<br>References Sivakumar, P., et al.: Chem. Bio. Drug Design, 72, 303 (2008); Mathis, D. E., Beitraege zur Tabakforschung Int., 12, 1 (1983);<br></p>Formula:C10H12O2Color and Shape:White To Off-WhiteMolecular weight:164.20Valsartan-d9 (Major)
CAS:Controlled Product<p>Applications An isotopically labelled version of Valsartan (V095750), a nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.<br>References Criscione, L., et al.: Brit. J. Pharmacol., 110, 761 (1993), Muller, P., et al.: Eur. J. Clin. Pharmacol., 47, 231 (1994)<br></p>Formula:C24H20D9N5O3Color and Shape:Off WhiteMolecular weight:444.572',6'-Picolinoxylidide
CAS:Controlled ProductFormula:C14H14N2OColor and Shape:NeatMolecular weight:226.27Anastrozole Mono Acid
CAS:<p>Impurity Anastrozole Monoacid Impurity<br>Applications Anastrozole Mono Acid is an impurity of Anastrozole (A637435), an aromatase enzyme inhibitor and antineoplastic agent. Anastrozole Monoacid Impurity<br>References Plourde, P.V., et al.: Breast Cancer Res. Treat., 30, 103 (1994), Buzdar, A.U., et al.: Cancer, 79, 730 (1997)<br></p>Formula:C17H20N4O2Color and Shape:Off-WhiteMolecular weight:312.37rac-5-Bromo Naproxen
CAS:Controlled ProductFormula:C14H13BrO3Color and Shape:NeatMolecular weight:309.165,5-Diphenyl Hydantoin
CAS:<p>Applications Diphenyl Hydantoin is an anticonvulsant agent that suppresses abnormal brain activity associated with seizure. It is used to treat ulcers, epidermolysis bullosa, chorea, Parkinson’s syndrome, trigeminal neuralgia, acute alcoholism, and inflammatory conditions (1,2).<br>References (1) Kim, S. H., et al.: Birth Defects Res B Dev Reprod Toxicol. 95, 337 (2012)(2) Younes, N., et al.: Dermatol Online J. 12, 5 (2006)<br></p>Formula:C15H12N2O2Color and Shape:WhiteMolecular weight:252.27Ethosuximide-d3
CAS:Controlled ProductFormula:C7H8D3NO2Color and Shape:White To Light YellowMolecular weight:144.19Celecoxib-d4
CAS:Controlled Product<p>Applications A labelled selective cyclooxygenase-2 (COX-2) inhibitor. Anti-inflammatory. Used in the treatment of familial adenomatous polyposis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Simon, L.S., et al.: Arthritis Rheum., 41, 1591 (1998), Silverstein, F.E., et al.: J. Am. Med. Assoc., 284, 1247 (2000), Steinbach, G., et al.: N. Engl. J. Med., 342, 1946 (2000),<br></p>Formula:C17H10D4F3N3O2SColor and Shape:White To Light YellowMolecular weight:385.4Lisinopril (S,S,R)-Diketopiperazine (~90%)
CAS:<p>Impurity Lisinopril EP Impurity D<br>Stability Hygroscopic<br>Applications Lisinopril (S,S,R)-Diketopiperazine (Lisinopril EP Impurity D) is an impurity of Lisinopril (L468985), an orally active angiotensin-converting enzyme (ACE) inhibitor (1).<br>References 1. Goa, K. et al.: Drugs. 1996 Oct;52(4):564-88.<br></p>Formula:C21H29N3O4Purity:~90%Color and Shape:White To Off-WhiteMolecular weight:387.47Bis(2-aminoethylthio)methane Dihydrochloride
CAS:Controlled Product<p>Applications Bis(2-aminoethylthio)methane is a potential inhibitor of γ-glutamylcysteine synthetase, the first enzyme in the glutathione biosynthesis pathway.<br>References Sweetman, B.J., et al.: J. Med. Chem., 12, 888 (1969); Seelig, G.F., et al.: J. Biol. Chem., 259, 3534 (1984);<br></p>Formula:C5H14N2S2·2(HCl)Color and Shape:NeatMolecular weight:239.22N-Butyl-N-methylnitrosamine (1 mg/mL in Methanol)
CAS:Formula:C5H12N2OColor and Shape:Single SolutionMolecular weight:116.16Pyrimethamine-d3
CAS:Controlled Product<p>Applications Dihydrofolate reductase inhibitor; generally used in combination with other antimicrobial agents. Antiprotozoal (Toxoplasma); antimalarial.<br>References Loutfy, M.A., et al.: Anal. Profiles Drug Subs., 12, 463 (1983), Leport, C., et al.: Am. J. Med., 84, 94 (1988), McIntosh, H.M., et al.: Ann. Trop. Med., Parasitol., 93, 265 (1998), Plowe, C.V., et al.: Br. Med. J., 328, 545 (2004),<br></p>Formula:C12H10D3ClN4Color and Shape:Off-WhiteMolecular weight:251.73Agomelatine Dimer Urea
CAS:<p>Impurity Agomelatine Impurity 4<br>Applications Agomelatine Dimer Urea is an impurity of Agomelatine (A430020). Agomelatine Impurity 4<br>References Depreux, P., et al.: J. Med. Chem., 37, 3231 (1994); Wregget, K., et al.: J. Biol. Chem., 270, 22488 (1995); Ying, S., et al.: Eur. J. Pharmacol., 296, 33 (1996);<br></p>Formula:C27H28N2O3Color and Shape:NeatMolecular weight:428.528(9)-Methoxy-1,3-dimethyl-12-thioxopyrido[1’,2’:3,4]imidazo[1,2-a]benzimidazol-2-(12H)-one (Mixture of Regioisomers)
CAS:Controlled Product<p>Impurity Omeprazole EP Impurity F+Omeprazole EP Impurity G<br>Stability Sample unstable under MS condition<br>Applications 8(9)-Methoxy-1,3-dimethyl-12-thioxopyrido[1’,2’:3,4]imidazo[1,2-a]benzimidazol-2-(12H)-one(Mixture of Regioisomers) (Omeprazole EP Impurity F+Omeprazole EP Impurity G) is a mixture of regioisomers of Omeprazole Impurity.<br>References Rackur, G., et al.: Biochem. Biophys. Res. Commmun., 128, 477 (1985),<br></p>Formula:C16H13N3O2SColor and Shape:NeatMolecular weight:311.36
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